公开(公告)号：US11607461B2

公开(公告)日：2023-03-21

申请号：US16078332

申请日：2017-03-23

申请人： University of Maryland, Baltimore

发明人： Steven A. Fisher

IPC分类号： A61K48/00 ,  C12N15/113 ,  C12N15/10 ,  C12N15/86 ,  A61K35/761 ,  C12N9/22 ,  A01K67/027

摘要： The present invention provides a method of lowering blood pressure in a subject, comprising genetically modifying a myosin phosphatase target subunit (Mypt1) gene in a vascular smooth muscle cell of the subject, whereby the genetic modification of Mypt1 results in a deletion or inactivation of exon 24. The invention further provides vectors, host cells, and compositions useful for carrying out the methods of the invention.

公开(公告)号：US11583216B2

公开(公告)日：2023-02-21

申请号：US17003297

申请日：2020-08-26

申请人： University Of Maryland, Baltimore

发明人： Vijay Ivaturi ,  Jogarao Gobburu

IPC分类号： A61B5/361 ,  A61K31/18 ,  G16H50/30 ,  A61K9/00

摘要： Embodiments of the invention are broadly drawn to methods for determining an optimum dose of an antiarrhythmic drug, for example sotalol. In particular, the method involves titrating the dose of the drug gradually to determine the optimum plasma concentration for a patient, whether the patient has normal or abnormal renal function.

公开(公告)号：US11554105B2

公开(公告)日：2023-01-17

申请号：US16670218

申请日：2019-10-31

申请人： UNIVERSITY OF MARYLAND, BALTIMORE

发明人： Curt I. Civin ,  Blake S. Moses

IPC分类号： A61K31/343 ,  A61P35/02 ,  A61K45/06

摘要： Methods of treating cancer, such as leukemia, via administration of therapeutically effective amounts of artemisinins and one or more additional therapeutic agents are detailed herein. The artemisinins include artesunate, dihydroartemisinin, artemether, arteether, artelinate, ART-631, and ART-838. The one or more additional therapeutic agents include BCL-2 inhibitors such as ABT-199, ABT-263, and ABT-737; kinase inhibitors such as lestaurtinib, midostaurin, and sorafenib; and anti-neoplastic agents such as cytarabine, doxorubicin, etoposide, cyclophosphamide, triplotide, vinorelbine, cisplatin, and rituximab.

公开(公告)号：US11543371B2

公开(公告)日：2023-01-03

申请号：US17030088

申请日：2020-09-23

申请人： UNIVERSITY OF MARYLAND, BALTIMORE

发明人： Yihua (Bruce) Yu ,  Marc B. Taraban

IPC分类号： G01N24/08 ,  G01R33/46 ,  G01N33/15

摘要： A method of using the transverse relaxation rate (R2) of solvent NMR signal to detect filling errors of an alum-containing product in real-time in-line during manufacturing, for example during a fill-finish unit operation. This technique can be used for quality control in vaccine manufacturing to ensure the delivery of the correct concentration of alum-containing product to the product container such as a vial or pre-filled syringe.

公开(公告)号：US20220411656A1

公开(公告)日：2022-12-29

申请号：US17706765

申请日：2022-03-29

申请人： UNIVERSITY OF MARYLAND, BALTIMORE COUNTY

发明人： Deepa MADAN ,  Priyanshu BANERJEE ,  Jiyuan HUANG

IPC分类号： C09D105/00 ,  C09D11/08 ,  B41M1/12 ,  B41M7/00 ,  B41M1/30 ,  B41M1/34

摘要： An energy-efficient method of controlling the composite microstructure and resulting thermoelectric (TE) properties of TE composite films. The TE composite films, which include a small amount of naturally occurring chitosan binder that is sufficient to hold TE particles together, are modified by applying uniaxial mechanical pressure at low temperatures for a short duration. The TE composite films have high electrical conductivity and low thermal conductivity, making them ideal for use into high-performance energy harvesting thermoelectric devices.

公开(公告)号：US20220396549A1

公开(公告)日：2022-12-15

申请号：US17114374

申请日：2020-12-07

申请人： University of Maryland, Baltimore

发明人： Steven Fletcher ,  Maryanna Lanning ,  Lijia Chen

IPC分类号： C07C311/21 ,  C07D215/58 ,  C07C311/29 ,  C07C311/51 ,  C07C229/64 ,  C07D257/02 ,  C07D261/12 ,  C07D309/04 ,  A61P35/02

摘要： Compounds that inhibit Myeloid Cell Leukemia-1 (Mcl-1) oncoprotein, and methods of using the same, are provided for treating disease.

公开(公告)号：US20220387015A1

公开(公告)日：2022-12-08

申请号：US17337315

申请日：2021-06-02

申请人： Harpoon Medical, Inc. ,  University of Maryland, Baltimore

发明人： William Niland ,  Felino V. Cortez, JR. ,  James S. Gammie ,  Michael Nicholas D'ambra ,  Peter Wilson ,  Stephen Cournane

IPC分类号： A61B17/04 ,  A61B17/34

摘要： Described herein are devices for approximating targeted tissue by intertwining two or more sutures together. The sutures are attached to the targeted tissue and routed to a twister device. The twister device secures end portions of the sutures and twists them to intertwine the sutures. Controlling the number of twists provides control over the forces applied to the targeted tissue. In conjunction with visualization feedback, real-time adjustments can be made to achieved targeted results, such as elimination of mitral regurgitation when the disclosed methods and apparatus are applied to mitral valve repair.

公开(公告)号：US11504390B2

公开(公告)日：2022-11-22

申请号：US16823634

申请日：2020-03-19

申请人： Regeneron Pharmaceuticals, Inc. ,  University of Maryland, Baltimore

发明人： Alan Shuldiner ,  Nehal Gosalia ,  Cristopher Van Hout ,  Da-Wei Gong ,  James A. Perry

IPC分类号： C07H21/04 ,  A61K31/7105 ,  C12N9/22 ,  C12Q1/6827 ,  C12Q1/6853

摘要： The present disclosure provides methods of treating subjects having increased lipid levels, methods of identifying subjects having an increased risk of developing an increased lipid level, methods of detecting human Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) variant nucleic acid molecules and variant polypeptides, and SREBF1 variant nucleic acid molecules and variant polypeptides.

公开(公告)号：US20220358102A1

公开(公告)日：2022-11-10

申请号：US17734236

申请日：2022-05-02

申请人： University of Maryland, Baltimore County

发明人： Gunes Koru ,  Yili Zhang ,  Pratik Tamakuwala

IPC分类号： G06F16/215 ,  G06F16/25

摘要： Systems and methods of analyzing user-entered or machine-generated values in data for determining defective entries are disclosed. According to an aspect, a system includes a data entry analyzer comprising at least one processor and memory configured to receive data including a plurality of user-entered or machine-generated values, wherein each user-entered or machine-generated value is organized in at least one predetermined entry format. The data entry analyzer is also configured to determine an entry constraint for each of the at least one predetermined entry formats. Further, the data entry analyzer is configured to analyze each user-entered or machine-generated value based on the determined entry constraint associated with the predetermined entry format of that user-entered or machine-generated value. The system also includes a user interface configured to present notification of the one or more defective entries.

公开(公告)号：US11474097B2

公开(公告)日：2022-10-18

申请号：US16452767

申请日：2019-06-26

申请人： UNIVERSITY OF MARYLAND, BALTIMORE COUNTY ,  NATIONAL INSTITUTES OF HEALTH

发明人： Songon An ,  Danielle L. Schmitt ,  James Inglese ,  Patricia Dranchak

IPC分类号： G01N33/50 ,  G01N21/64 ,  C12N15/85

摘要： A cell-based quantitative high-throughput screening assay to monitor the formation of PFK1-mEGFP clusters by the action of small molecules to identify small molecules that promote intracellular PFK1 clustering in a cell cycle-dependent manner and may be used to treat cancer.