公开(公告)号：US20130267534A1

公开(公告)日：2013-10-10

申请号：US13830926

申请日：2013-03-14

Applicant: ABBVIE INC.

Inventor： Milan Bruncko ,  Hong Ding ,  George A. Doherty ,  Steven W. Elmore ,  Lisa A. Hasvold ,  Laura Hexamer ,  Aaron R. Kunzer ,  Xiaohong Song ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-Fu Tao ,  Gary T. Wang ,  Le Wang ,  Xilu Wang ,  Michael D. Wendt ,  Robert Mantei ,  Todd M. Hansen

IPC: C07D471/04

CPC classification number: C07D401/12 ,  A61K31/496 ,  C07D209/82 ,  C07D401/14 ,  C07D403/12 ,  C07D471/04 ,  C07D519/00 ,  Y02A50/463

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：US20130267514A1

公开(公告)日：2013-10-10

申请号：US13831184

申请日：2013-03-14

Applicant: ABBVIE INC.

Inventor： Milan Bruncko ,  Hong Ding ,  George A. Doherty ,  Steven W. Elmore ,  Lisa A. Hasvold ,  Laura Hexamer ,  Aaron R. Kunzer ,  Xiaohong Song ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-Fu Tao ,  Gary T. Wang ,  Le Wang ,  Xilu Wang ,  Michael D. Wendt ,  Robert Mantei ,  Todd M. Hansen

IPC: C07D471/04

CPC classification number: C07D471/04 ,  C07D491/052 ,  C07D519/00

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：US20240043404A1

公开(公告)日：2024-02-08

申请号：US18462355

申请日：2023-09-06

Applicant: AbbVie Inc. ,  Genentech, Inc. ,  The Walter and Eliza Hall Institute of Medical Research

Inventor： Milan Bruncko ,  Hong Ding ,  George A. Doherty ,  Steven W. Elmore ,  Lisa A. Hasvold ,  Laura Hexamer ,  Aaron R. Kunzer ,  Xiaohong Song ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-Fu Tao ,  Gary T. Wang ,  Le Wang ,  Xilu Wang ,  Michael D. Wendt ,  Robert Mantei ,  Todd M. Hansen

IPC: C07D401/12 ,  C07D401/14 ,  C07D519/00 ,  C07D471/04 ,  C07D209/82 ,  C07D403/12 ,  A61K31/496

CPC classification number: C07D401/12 ,  C07D401/14 ,  C07D519/00 ,  C07D471/04 ,  C07D209/82 ,  C07D403/12 ,  A61K31/496 ,  Y02A50/30

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：US20200291027A1

公开(公告)日：2020-09-17

申请号：US16827026

申请日：2020-03-23

Applicant: AbbVie Inc.

Inventor： Steven D. Fidanze ,  Dachun Liu ,  Robert A. Mantei ,  Keith F. McDaniel ,  John Pratt ,  George S. Sheppard ,  Le Wang ,  Andrew Bogdan ,  James H. Holms ,  Justin D. Dietrich ,  Jasmina Marjanovic ,  Lisa A. Hasvold ,  Yujia Dai

IPC: C07D471/22 ,  A61P15/16 ,  A61P31/18 ,  A61P13/12 ,  A61P35/00 ,  C07D471/16

Abstract: The present invention provides for compounds of formula (I) wherein R1, R2, R6, Y1, Y2, Y3, A1, A2, A3, and A4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).

公开(公告)号：US20200048220A1

公开(公告)日：2020-02-13

申请号：US16341358

申请日：2016-10-14

Applicant: AbbVie Inc.

Inventor： Andrew Bogdan ,  Steven Fidanze ,  Keith McDaniel ,  John Pratt ,  Le Wang

IPC: C07D401/12 ,  C07D213/64 ,  C07D401/04

Abstract: Provided are compounds of formula (I), wherein R1, Y, X1, X2, R2, R3, R4, R5, R6 and m have any of the values defined in the specification and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising compounds of formula (I).

公开(公告)号：US20190382383A1

公开(公告)日：2019-12-19

申请号：US16341352

申请日：2016-10-14

Applicant: AbbVie Inc.

Inventor： Marlon Cowart ,  Steven Fidanze ,  Lisa Hasvold ,  Dachun Liu ,  Keith McDaniel ,  John Pratt ,  George Sheppard ,  Le Wang

IPC: C07D405/12 ,  C07D487/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14

Abstract: Provided herein are compounds of formula (I) wherein R1, Y, L1, G1, X1, X2, L2, R2, R3, and R4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, which are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising compounds of formula (I).

公开(公告)号：US20190084981A1

公开(公告)日：2019-03-21

申请号：US16192927

申请日：2018-11-16

Applicant: AbbVie Inc.

Inventor： Yujia Dai ,  Steven D. Fidanze ,  Lisa Hasvold ,  James Holms ,  Dachun Liu ,  William McClellan ,  Keith McDaniel ,  Jasmina Marjanovic ,  George Sheppard ,  Le Wang

IPC: C07D471/04 ,  A61K45/06 ,  A61K31/506 ,  A61K31/497 ,  A61K31/437 ,  A61K31/551 ,  A61K31/541 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/4545

Abstract: The present invention provides for compounds of formula (I) wherein Rx, Ry, Rx1, L1, G1, A1, A2, A3, and A4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).

公开(公告)号：US09994581B2

公开(公告)日：2018-06-12

申请号：US15103215

申请日：2014-12-10

Applicant: AbbVie Inc.

Inventor： Le Wang ,  Robin R. Frey ,  Todd M. Hansen ,  Dachun Liu ,  William J. McClellan ,  Keith F. McDaniel ,  John K. Pratt ,  Carol K. Wada

IPC: C07D491/22 ,  C07D491/056 ,  A61K45/06 ,  A61K31/4353 ,  C07D491/153

CPC classification number: C07D491/056 ,  A61K31/4353 ,  A61K45/06 ,  C07D491/153 ,  C07D491/22

Abstract: The present invention provides for compounds of formula (I) wherein Rx, X, Y, Y1, L1, A1, A2, A3, A4, A5, A6, A7, and A8, have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).

公开(公告)号：US20170015673A1

公开(公告)日：2017-01-19

申请号：US15103215

申请日：2014-12-10

Applicant: ABBVIE INC.

Inventor： Le Wang ,  Robin R. Frey ,  Todd M. Hansen ,  Dachun Liu ,  William J. McClellan ,  Keith F. McDaniel ,  John K. Pratt ,  Carol K. Wada

IPC: C07D491/056 ,  C07D491/153

CPC classification number: C07D491/056 ,  A61K31/4353 ,  A61K45/06 ,  C07D491/153 ,  C07D491/22

Abstract: The present invention provides for compounds of formula (I) wherein Rx, X, Y, Y1, L1, A1, A2, A3, A4, A5, A6, A7, and A8, have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).

Abstract translation: 本发明提供式（I）化合物，其中Rx，X，Y，Y1，L1，A1，A2，A3，A4，A5，A6，A7和A8具有说明书中定义的任何值， 其药学上可接受的盐，其可用作治疗疾病和病症（包括炎性疾病，癌症和AIDS）的药剂。 还提供了由一种或多种式（I）化合物组成的药物组合物。

公开(公告)号：US09428514B2

公开(公告)日：2016-08-30

申请号：US14564352

申请日：2014-12-09

Applicant: AbbVie Inc.

Inventor： Andrew Bogdan ,  Warren M. Kati ,  Keith F. McDaniel ,  Chang H. Park ,  George S. Sheppard ,  Le Wang

IPC: A01N43/54 ,  C07D487/04 ,  C07D211/86 ,  C07D405/04 ,  C07D401/04 ,  C07D417/04 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D213/69

CPC classification number: A61K31/506 ,  A61K31/4412 ,  A61K31/4433 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/497 ,  C07D211/86 ,  C07D213/69 ,  C07D401/04 ,  C07D401/12 ,  C07D405/04 ,  C07D405/12 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D487/04

Abstract: The present invention provides for compounds of formula (I) wherein Y1, Y2, R1, R2, R3, A1, A2, A3, and A4, have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).

Abstract translation: 本发明提供式（I）化合物，其中Y1，Y2，R1，R2，R3，A1，A2，A3和A4具有说明书中定义的任何值及其药学上可接受的盐，其是有用的 作为治疗疾病和病症的药剂，包括炎性疾病，癌症和艾滋病。 还提供了由一种或多种式（I）化合物组成的药物组合物。