公开(公告)号：US08639322B2

公开(公告)日：2014-01-28

申请号：US13484060

申请日：2012-05-30

申请人： Ronald W. Heil, Jr. ,  Avram Scheiner ,  Imad Libbus

发明人： Ronald W. Heil, Jr. ,  Avram Scheiner ,  Imad Libbus

IPC分类号： A61N1/36

CPC分类号： A61N1/36117 ,  A61N1/3627 ,  A61N1/36564

摘要： Various aspects of the present subject matter provide an implantable medical device. In various embodiments, the device comprises a pulse generator, a lead, a sensor, and a controller. The pulse generator generates a baroreflex stimulation signal as part of a baroreflex therapy. The lead is adapted to be electrically connected to the pulse generator and to be intravascularly fed into a heart. The lead includes an electrode to be positioned in or proximate to the heart to deliver the baroreflex signal to a baroreceptor region in or proximate to the heart. The sensor senses a physiological parameter regarding an efficacy of the baroreflex therapy and provides a signal indicative of the efficacy. The controller is connected to the pulse generator to control the baroreflex stimulation signal and to the sensor to receive the signal indicative of the efficacy of the baroreflex therapy. Other aspects are provided herein.

摘要翻译： 本主题的各个方面提供可植入医疗装置。 在各种实施例中，该装置包括脉冲发生器，引线，传感器和控制器。 脉冲发生器产生压力反射刺激信号作为压力反射治疗的一部分。 引线适于电连接到脉冲发生器并且被血管内馈送到心脏中。 引线包括位于心脏中或靠近心脏的电极以将压力反射信号传递到心脏中或心脏附近的压力感受器区域。 传感器感测关于压力反射治疗的功效的生理参数，并提供指示功效的信号。 控制器连接到脉冲发生器以控制压力反射刺激信号和传感器以接收指示压力反射治疗功效的信号。 本文提供了其他方面。

公开(公告)号：US08509902B2

公开(公告)日：2013-08-13

申请号：US13192914

申请日：2011-07-28

申请人： Yong K. Cho ,  Shaileshkumar Musley ,  Avram Scheiner

发明人： Yong K. Cho ,  Shaileshkumar Musley ,  Avram Scheiner

IPC分类号： A61N1/365

CPC分类号： A61N1/3655 ,  A61N1/3601 ,  A61N1/3611 ,  A61N1/36521

摘要： Medical devices and methods for providing breathing therapy (e.g., for treating heart failure, hypertension, etc.) may determine at least the inspiration phase of one or more breathing cycles based on the monitored physiological parameters and control delivery of a plurality of breathing therapy sessions (e.g., each of the breathing therapy sessions may be provided during a defined time period). Further, each of the plurality of breathing therapy sessions may include delivering stimulation after the start of the inspiration phase of each of a plurality of breathing cycles to prolong diaphragm contraction during the breathing cycle.

摘要翻译： 用于提供呼吸治疗（例如，用于治疗心力衰竭，高血压等）的医疗装置和方法可以基于所监测的生理参数和多个呼吸治疗会话的控制递送来至少确定一个或多个呼吸周期的吸气阶段 （例如，可以在限定的时间段内提供每个呼吸治疗会话）。 此外，多个呼吸治疗会话中的每一个可以包括在多个呼吸周期中的每一个呼吸循环的启动阶段开始之后递送刺激，以在呼吸循环期间延长膜片收缩。

公开(公告)号：US20130046195A1

公开(公告)日：2013-02-21

申请号：US13657224

申请日：2012-10-22

申请人： Aaron R. McCabe ,  Avram Scheiner ,  Geng Zhang ,  Quan Ni ,  Douglas R. Daum ,  Yi Zhang

发明人： Aaron R. McCabe ,  Avram Scheiner ,  Geng Zhang ,  Quan Ni ,  Douglas R. Daum ,  Yi Zhang

IPC分类号： A61B5/0408

CPC分类号： A61B5/0402 ,  A61N1/365 ,  A61N1/3756

摘要： An implantable medical device such as an implantable pacemaker or implantable cardioverter/defibrillator includes a programmable sensing circuit providing for sensing of a signal approximating a surface electrocardiogram (ECG) through implanted electrodes. With various electrode configurations, signals approximating various standard surface ECG signals are acquired without the need for attaching electrodes with cables onto the skin. The various electrode configurations include, but are not limited to, various combinations of intracardiac pacing electrodes, portions of the implantable medical device contacting tissue, and electrodes incorporated onto the surface of the implantable medical device.

摘要翻译： 诸如可植入起搏器或植入式心律转复/除颤器的可植入医疗装置包括可编程感测电路，用于通过植入电极感测接近表面心电图（ECG）的信号。 通过各种电极配置，获取近似各种标准表面ECG信号的信号，而不需要将电极与电缆连接在皮肤上。 各种电极配置包括但不限于心脏内起搏电极，可植入医疗器械接触组织的部分和结合到可植入医疗装置的表面上的电极的各种组合。

公开(公告)号：US08315702B2

公开(公告)日：2012-11-20

申请号：US13402196

申请日：2012-02-22

申请人： Abhi V. Chavan ,  Anthony V. Caparso ,  Avram Scheiner

发明人： Abhi V. Chavan ,  Anthony V. Caparso ,  Avram Scheiner

IPC分类号： A61N1/00

摘要： One aspect of the present subject matter relates to an implantable medical device. An embodiment of the device comprises a rechargeable power supply adapted to be recharged through an ultrasound signal, a neural stimulator connected to the rechargeable power supply, and a controller connected to the rechargeable power supply. The neural stimulator is adapted to generate a neural stimulation signal for delivery to a neural stimulation target through an electrode. The controller is further connected to the neural stimulator to control the neural stimulator according to a neural stimulation protocol. Other aspects are provided herein.

公开(公告)号：US20120265273A1

公开(公告)日：2012-10-18

申请号：US13532469

申请日：2012-06-25

申请人： Imad Libbus ,  Avram Scheiner

发明人： Imad Libbus ,  Avram Scheiner

IPC分类号： A61N1/36

CPC分类号： A61N1/36057 ,  A61B5/021 ,  A61B5/024 ,  A61N1/0551 ,  A61N1/36114 ,  A61N1/36135 ,  A61N1/37217 ,  A61N1/37282 ,  A61N1/37288

摘要： An embodiment relates to a method for delivering a unidirectional afferent nerve stimulation treatment. A test neural stimulation is delivered, and a physiologic response to the test neural stimulation is monitored. At least one neural stimulation parameter for the test neural stimulation is adjusted if the test neural stimulation does not elicit a desired physiologic response. If the test neural stimulation does elicit the desired physiologic response, at least one treatment parameter for a unidirectional afferent nerve stimulation is determined using the at least one neural stimulation parameter for the test neural stimulation that provided the desired physiologic response. The unidirectional afferent nerve stimulation is delivered using the at least one treatment parameter.

摘要翻译： 一个实施方案涉及用于递送单向传入神经刺激治疗的方法。 传递测试神经刺激，并监测对测试神经刺激的生理反应。 如果测试神经刺激不引起所需的生理反应，则调整用于测试神经刺激的至少一个神经刺激参数。 如果测试神经刺激确实引起所需的生理反应，则使用提供所需生理反应的测试神经刺激的至少一个神经刺激参数确定单向传入神经刺激的至少一个治疗参数。 使用至少一个治疗参数递送单向传入神经刺激。

公开(公告)号：US08224436B2

公开(公告)日：2012-07-17

申请号：US11695189

申请日：2007-04-02

申请人： Imad Libbus ,  Avram Scheiner

发明人： Imad Libbus ,  Avram Scheiner

IPC分类号： A61N1/36

CPC分类号： A61N1/36057 ,  A61B5/021 ,  A61B5/024 ,  A61N1/0551 ,  A61N1/36114 ,  A61N1/36135 ,  A61N1/37217 ,  A61N1/37282 ,  A61N1/37288

摘要： An embodiment relates to a method for delivering a unidirectional afferent nerve stimulation treatment. A test neural stimulation is delivered, and a physiologic response to the test neural stimulation is monitored. At least one neural stimulation parameter for the test neural stimulation is adjusted if the test neural stimulation does not elicit a desired physiologic response. If the test neural stimulation does elicit the desired physiologic response, at least one treatment parameter for a unidirectional afferent nerve stimulation is determined using the at least one neural stimulation parameter for the test neural stimulation that provided the desired physiologic response. The unidirectional afferent nerve stimulation is delivered using the at least one treatment parameter.

摘要翻译： 一个实施方案涉及用于递送单向传入神经刺激治疗的方法。 传递测试神经刺激，并监测对测试神经刺激的生理反应。 如果测试神经刺激不引起所需的生理反应，则调整用于测试神经刺激的至少一个神经刺激参数。 如果测试神经刺激确实引起所需的生理反应，则使用提供所需生理反应的测试神经刺激的至少一个神经刺激参数确定单向传入神经刺激的至少一个治疗参数。 使用至少一个治疗参数递送单向传入神经刺激。

公开(公告)号：US20120150049A1

公开(公告)日：2012-06-14

申请号：US13314594

申请日：2011-12-08

申请人： Todd M. Zielinski ,  Douglas A. Hettrick ,  Avram Scheiner ,  Yong K. Cho ,  Mustafa Karamanoglu

发明人： Todd M. Zielinski ,  Douglas A. Hettrick ,  Avram Scheiner ,  Yong K. Cho ,  Mustafa Karamanoglu

IPC分类号： A61B5/02

CPC分类号： A61B5/027 ,  A61B5/0002 ,  A61B5/0295 ,  A61B5/0538 ,  A61B18/1492 ,  A61B2017/00026 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00875

摘要： An implantable medical device system and associated method deliver drive signals having different frequencies to establish vector fields comprising an arterial volume and a venous volume corresponding to targeted portion of a patient's body. Impedance signals are determined in response to drive signals having different frequencies. Impedance parameter values are determined over time. A change in the hemodynamic status of a targeted portion of the patient's body is identified in response to the impedance parameter values.

摘要翻译： 可植入医疗装置系统和相关方法提供具有不同频率的驱动信号以建立包括对应于患者身体的目标部分的动脉体积和静脉体积的矢量场。 响应于具有不同频率的驱动信号来确定阻抗信号。 阻抗参数值随时间确定。 响应于阻抗参数值来识别患者身体的目标部分的血液动力学状态的变化。

公开(公告)号：US08195289B2

公开(公告)日：2012-06-05

申请号：US12627562

申请日：2009-11-30

申请人： Ronald W. Heil, Jr. ,  Avram Scheiner ,  Imad Libbus

发明人： Ronald W. Heil, Jr. ,  Avram Scheiner ,  Imad Libbus

IPC分类号： A61N1/36

CPC分类号： A61N1/36117 ,  A61N1/3627 ,  A61N1/36564

摘要： Various aspects of the present subject matter provide an implantable medical device. In various embodiments, the device comprises a pulse generator, a lead, a sensor, and a controller. The pulse generator generates a baroreflex stimulation signal as part of a baroreflex therapy. The lead is adapted to be electrically connected to the pulse generator and to be intravascularly fed into a heart. The lead includes an electrode to be positioned in or proximate to the heart to deliver the baroreflex signal to a baroreceptor region in or proximate to the heart. The sensor senses a physiological parameter regarding an efficacy of the baroreflex therapy and provides a signal indicative of the efficacy. The controller is connected to the pulse generator to control the baroreflex stimulation signal and to the sensor to receive the signal indicative of the efficacy of the baroreflex therapy. Other aspects are provided herein.

摘要翻译： 本主题的各个方面提供可植入医疗装置。 在各种实施例中，该装置包括脉冲发生器，引线，传感器和控制器。 脉冲发生器产生压力反射刺激信号作为压力反射治疗的一部分。 引线适于电连接到脉冲发生器并且被血管内馈送到心脏中。 引线包括位于心脏中或靠近心脏的电极以将压力反射信号传递到心脏中或心脏附近的压力感受器区域。 传感器感测关于压力反射治疗的功效的生理参数，并提供指示功效的信号。 控制器连接到脉冲发生器以控制压力反射刺激信号和传感器以接收指示压力反射治疗功效的信号。 本文提供了其他方面。

公开(公告)号：US20120053474A1

公开(公告)日：2012-03-01

申请号：US13288105

申请日：2011-11-03

申请人： Aaron McCabe ,  Avram Scheiner ,  Geng Zhang ,  Quan Ni ,  Douglas R. Daum ,  Yi Zhang

发明人： Aaron McCabe ,  Avram Scheiner ,  Geng Zhang ,  Quan Ni ,  Douglas R. Daum ,  Yi Zhang

IPC分类号： A61B5/0452 ,  A61N1/365

CPC分类号： A61B5/0402 ,  A61N1/365 ,  A61N1/3756

摘要： An implantable medical device such as an implantable pacemaker or implantable cardioverter/defibrillator includes a programmable sensing circuit providing for sensing of a signal approximating a surface electrocardiogram (ECG) through implanted electrodes. With various electrode configurations, signals approximating various standard surface ECG signals are acquired without the need for attaching electrodes with cables onto the skin. The various electrode configurations include, but are not limited to, various combinations of intracardiac pacing electrodes, portions of the implantable medical device contacting tissue, and electrodes incorporated onto the surface of the implantable medical device.

摘要翻译： 诸如可植入起搏器或植入式心律转复/除颤器的可植入医疗装置包括可编程感测电路，用于通过植入电极感测接近表面心电图（ECG）的信号。 通过各种电极配置，获取近似各种标准表面ECG信号的信号，而不需要将电极与电缆连接在皮肤上。 各种电极配置包括但不限于心脏内起搏电极，可植入医疗器械接触组织的部分和结合到可植入医疗器械表面上的电极的各种组合。

公开(公告)号：US08024050B2

公开(公告)日：2011-09-20

申请号：US10746861

申请日：2003-12-24

申请人： Imad Libbus ,  Ronald W. Heil, Jr. ,  Avram Scheiner

发明人： Imad Libbus ,  Ronald W. Heil, Jr. ,  Avram Scheiner

IPC分类号： A61N1/05

CPC分类号： A61N1/0476 ,  A61N1/05 ,  A61N1/056 ,  A61N1/057 ,  A61N1/36117

摘要： An apparatus includes a flexible lead body extending from a proximal end to a distal end, an expandable electrode coupled proximate the distal end, the expandable electrode having an expanded diameter dimensioned to abut a wall of a pulmonary artery, and an implantable pulse generator electrically coupled to the expandable electrode. The expandable electrode includes a plurality of electrode zones. The implantable pulse generator is adapted to deliver a baroreflex stimulation signal to a baroreceptor in the pulmonary artery via the electrode.

摘要翻译： 一种装置包括从近端延伸到远端的柔性引线主体，靠近远端连接的可扩张电极，所述可扩张电极具有尺寸设计成邻接肺动脉壁的扩张直径，以及电耦合的可植入脉冲发生器 到可膨胀电极。 可膨胀电极包括多个电极区。 可植入脉冲发生器适于通过电极将压力反射刺激信号传递给肺动脉中的压力感受器。