公开(公告)号：US20120031832A1

公开(公告)日：2012-02-09

申请号：US13265280

申请日：2010-04-21

申请人： Hiroaki Yamaguchi ,  Satoshi Ishii ,  Moriyuki Komatsu

发明人： Hiroaki Yamaguchi ,  Satoshi Ishii ,  Moriyuki Komatsu

IPC分类号： B01D39/14

CPC分类号： B01D29/111 ,  B01D29/21 ,  B01D29/216 ,  B01D29/58 ,  B01D39/163 ,  B01D39/2017 ,  B01D46/0024 ,  B01D46/2411 ,  B01D2239/0233 ,  B01D2239/065 ,  B01D2239/0654 ,  B01D2239/0695 ,  B01D2275/10 ,  B01D2275/105

摘要： To improve particle capturing performance and classification filtering capacity of a cylindrical filter. A cylindrical filter includes a hollow cylindrical filter body configured by suitably combining a plurality of cylindrical first filter sections having mutually different inner diameters, each first filter section including a glass fiber as a major component, and a plurality of cylindrical second filter sections having mutually different inner diameters, each second filter section including a resin fiber as a major component, with each other. The first filter sections and the second filter sections are disposed in a concentrically superimposed manner and alternately arranged in a radial direction relative to each other. The cylindrical filter further includes a pair of seal members fixedly provided on the opposite axial ends of the first and second filter sections.

摘要翻译： 提高圆柱形过滤器的颗粒捕集性能和分级过滤能力。 圆柱形过滤器包括中空圆柱形过滤器主体，其通过适当地组合具有相互不同内径的多个圆柱形第一过滤器部分，每个第一过滤部分包括玻璃纤维作为主要部件，以及多个具有相互不同的圆柱形第二过滤部分 每个第二过滤器部分包括作为主要成分的树脂纤维。 第一过滤器部分和第二过滤器部分以同心重叠的方式设置并且相对于彼此沿径向交替布置。 圆柱形过滤器还包括固定地设置在第一和第二过滤器部分的相对轴向端部上的一对密封件。

公开(公告)号：US20100137229A1

公开(公告)日：2010-06-03

申请号：US12624026

申请日：2009-11-23

申请人： Jian-Qiang Fan ,  Satoshi Ishii

发明人： Jian-Qiang Fan ,  Satoshi Ishii

IPC分类号： A61K31/7004 ,  C12N5/071 ,  C12N5/02 ,  A61K31/445 ,  A61K31/40

CPC分类号： A61K31/445 ,  A61K31/70 ,  A61K31/7008 ,  C07D451/06 ,  C12N9/2465

摘要： A method of enhancing the activity of lysosomal α-Galactosidase A (α-Gal A) in mammalian cells and for treatment of Fabry disease by administration of 1-deoxy-galactonojirimycin and related compounds.

摘要翻译： 一种增强哺乳动物细胞中溶酶体α-半乳糖苷酶A（α-GalA）的活性并通过给予1-脱氧半乳糖吉非霉素及相关化合物治疗法布里病的方法。

公开(公告)号：US07281883B2

公开(公告)日：2007-10-16

申请号：US10690654

申请日：2003-10-21

申请人： Satoshi Ishii ,  Takeshi Watanabe

发明人： Satoshi Ishii ,  Takeshi Watanabe

IPC分类号： B23C5/10

CPC分类号： B23C5/1009 ,  B23C2210/0421 ,  B23C2226/125 ,  Y10T407/1908 ,  Y10T407/1924 ,  Y10T407/1948

摘要： In a ball end mill, cutting can be carried out with high precision, and abrasion or breakage of the cutting blade can be reduced. The ball end mill is provided with a cutting blade section having a cutting blade, which is U-shaped in front view, at the end section of a shank. The cutting blade is provided on a flat surface deviated by a predetermined distance from the shank axis, and comprises blade faces having rake faces, which become negative angles at the time of cutting. In cross-section intersecting the cutting blade, all the blade faces have the same shape.

摘要翻译： 在球头铣刀中，可以高精度地进行切割，并且可以减少切割刀片的磨损或破损。 球头铣刀设置有切割刀片部分，刀片部分在柄部的端部处具有在前视图中为U形的切割刀片。 切割刀片设置在与柄轴线偏离预定距离的平坦表面上，并且包括具有前刀面的刀片面，在切削时成为负角。 在与切割刀片相交的横截面中，所有刀片面具有相同的形状。

公开(公告)号：US07271976B2

公开(公告)日：2007-09-18

申请号：US11265004

申请日：2005-11-01

申请人： Satoshi Ishii ,  Tetsuo Ueda ,  Isao Yoneda

发明人： Satoshi Ishii ,  Tetsuo Ueda ,  Isao Yoneda

IPC分类号： G11B21/02

CPC分类号： G11B5/5547

摘要： Embodiments of the invention reduce the noise occurring when the lubricating layer on the magnetic disk is smoothed. In one embodiment, a magnetic disk drive has a read/write mode parameter table for generating an electric current to be supplied to a voice coil motor when the magnetic head performs data read/write operations on the magnetic disk. The magnetic disk drive also has a smoothing mode parameter table for generating another electric current to be supplied to the voice coil motor when neither a data read nor a write operation is performed on the magnetic disk. The CPU refers to either the read/write mode parameter table or the smoothing mode parameter table and controls the electric current to be supplied to the voice coil motor. When a lubricating-layer smoothing event occurs, the CPU refers to the smoothing mode parameter table and after generating the associated electric current to be supplied to the voice coil motor, moves the magnetic head to seek between the outermost and innermost tracks on the surface of the magnetic disk to perform a smoothing process for the lubricating layer.

摘要翻译： 本发明的实施例减少了当磁盘上的润滑层平滑时产生的噪声。 在一个实施例中，当磁头对磁盘执行数据读/写操作时，磁盘驱动器具有用于产生要提供给音圈电机的电流的读/写模式参数表。 磁盘驱动器还具有平滑模式参数表，用于当不对磁盘执行数据读取或写入操作时，产生要提供给音圈电机的另一电流。 CPU指的是读/写模式参数表或平滑模式参数表，并控制提供给音圈电机的电流。 当发生润滑层平滑事件时，CPU参考平滑模式参数表，并且在产生要提供给音圈电机的相关联的电流之后，移动磁头以在表面上的最外侧和最内侧的轨道之间寻找 该磁盘对润滑层进行平滑处理。

公开(公告)号：US07141582B2

公开(公告)日：2006-11-28

申请号：US10989258

申请日：2004-11-16

申请人： Jian-Qiang Fan ,  Satoshi Ishii ,  Naoki Asano

发明人： Jian-Qiang Fan ,  Satoshi Ishii ,  Naoki Asano

IPC分类号： A61K31/445 ,  A61K31/70 ,  A61K31/435

CPC分类号： A61K31/445 ,  A61K31/70 ,  A61K31/7008 ,  C07D451/06 ,  C12N9/2465

摘要： Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance the activity of the enzyme. Preferred compounds for use in the method are imino sugars and related compounds. In particular, C8–12-alkyl derivatives of N-alkyl-deoxynojirimycin, isofagomine compounds, and calystegine compounds are effective to enhance glucocerebrosidase activity.

摘要翻译： 通过以有效增加酶的活性的量施用葡糖脑苷脂酶的竞争性抑制剂，在哺乳动物细胞中增强与戈谢病相关的酶的活性的方法。 用于该方法的优选化合物是亚氨基糖和相关化合物。 特别地，N-烷基脱氧野尻霉素的C8-12-烷基衍生物，异佛胺化合物和钙半胱氨酸化合物对增强葡糖脑苷脂酶活性是有效的。

公开(公告)号：US20060264361A1

公开(公告)日：2006-11-23

申请号：US10542217

申请日：2003-12-17

申请人： Takao Shimizu ,  Satoshi Ishii ,  Kyoko Noguchi

发明人： Takao Shimizu ,  Satoshi Ishii ,  Kyoko Noguchi

IPC分类号： A61K38/17 ,  G01N33/574 ,  C07K14/705

CPC分类号： G01N33/76 ,  C07K14/705 ,  G01N2333/726

摘要： It is intended to provide a novel receptor of LPA and a method of screening a drug such as an LPA receptor antagonist using the same. Use as a lysophosphatidic acid (LPA) receptor comprising a G protein-coupled protein p2y9. More specifically, use of the G protein-coupled protein p2y9 as a lysophosphatidic acid (LPA) receptor. A method of screening an agonist or an antagonist to the LPA receptor as described above by using the receptor.

摘要翻译： 旨在提供LPA的新型受体和使用其来筛选药物如LPA受体拮抗剂的方法。 用作包含G蛋白偶联蛋白质p2y9的溶血磷脂酸（LPA）受体。 更具体地，使用G蛋白偶联蛋白质p2y9作为溶血磷脂酸（LPA）受体。 通过使用受体来筛选上述LPA受体的激动剂或拮抗剂的方法。

公开(公告)号：US20060092549A1

公开(公告)日：2006-05-04

申请号：US11265004

申请日：2005-11-01

申请人： Satoshi Ishii ,  Tetsuo Ueda ,  Isao Yoneda

发明人： Satoshi Ishii ,  Tetsuo Ueda ,  Isao Yoneda

IPC分类号： G11B21/02

CPC分类号： G11B5/5547

摘要： Embodiments of the invention reduce the noise occurring when the lubricating layer on the magnetic disk is smoothed. In one embodiment, a magnetic disk drive has a read/write mode parameter table for generating an electric current to be supplied to a voice coil motor when the magnetic head performs data read/write operations on the magnetic disk. The magnetic disk drive also has a smoothing mode parameter table for generating another electric current to be supplied to the voice coil motor when neither a data read nor a write operation is performed on the magnetic disk. The CPU refers to either the read/write mode parameter table or the smoothing mode parameter table and controls the electric current to be supplied to the voice coil motor. When a lubricating-layer smoothing event occurs, the CPU refers to the smoothing mode parameter table and after generating the associated electric current to be supplied to the voice coil motor, moves the magnetic head to seek between the outermost and innermost tracks on the surface of the magnetic disk to perform a smoothing process for the lubricating layer.

摘要翻译： 本发明的实施例减少了当磁盘上的润滑层平滑时产生的噪声。 在一个实施例中，当磁头对磁盘执行数据读/写操作时，磁盘驱动器具有用于产生要提供给音圈电机的电流的读/写模式参数表。 磁盘驱动器还具有平滑模式参数表，用于当不对磁盘执行数据读取或写入操作时，产生要提供给音圈电机的另一电流。 CPU指的是读/写模式参数表或平滑模式参数表，并控制提供给音圈电机的电流。 当发生润滑层平滑事件时，CPU参考平滑模式参数表，并且在产生要提供给音圈电机的相关联的电流之后，移动磁头以在表面上的最外侧和最内侧轨迹之间寻找 该磁盘对润滑层进行平滑处理。

公开(公告)号：US20060055590A1

公开(公告)日：2006-03-16

申请号：US11019378

申请日：2004-12-23

申请人： Masayoshi Moriya ,  Satoshi Ishii ,  Tetsuo Seki ,  Kazuaki Hamada ,  Kenji Oka ,  Akihiro Ohta

发明人： Masayoshi Moriya ,  Satoshi Ishii ,  Tetsuo Seki ,  Kazuaki Hamada ,  Kenji Oka ,  Akihiro Ohta

IPC分类号： G01S13/08

CPC分类号： G01S13/20 ,  G01S13/18 ,  G01S13/227 ,  G01S13/24

摘要： In order to provide the method and the device for distance measurement by pulse radar that securely eliminates the false echo from the distance over the detectable limit determined by the pulse generation cycle, the pulse radar comprises the pulse signal sending unit that generates the pulse signals with different cycles at OSC 9a˜9c, switches to the predetermined intervals by OSC switch 10, and sends the pulse signal to targets, the reflected signal receiving unit that receives the reflected signals and stores the data in the RAM 25, the reflected signal data acquisition unit that obtains the data of each reflected signal, and the reflected signal identification unit that compares the intensity of the reflected signals obtained at the same lag time point during a certain time period after sending the pulse signal for reference and identifies the reflected signals of the sent pulse signal for reference.

摘要翻译： 为了提供通过脉冲雷达进行距离测量的方法和装置，从脉冲发生周期确定的可检测限度的距离安全地消除假回波，脉冲雷达包括产生脉冲信号的脉冲信号发送单元， 在OSC 9 a〜9 c处的不同周期，由OSC开关10切换到预定间隔，并将脉冲信号发送到目标，反射信号接收单元接收反射信号并将数据存储在RAM 25中，反射信号 数据获取单元，其获得每个反射信号的数据;以及反射信号识别单元，其在发送用于参考的脉冲信号之后的特定时间段内比较在相同滞后时间点获得的反射信号的强度，并且识别反射信号 的发送脉冲信号供参考。

公开(公告)号：US06583158B1

公开(公告)日：2003-06-24

申请号：US09604053

申请日：2000-06-26

申请人： Jian-Qiang Fan ,  Satoshi Ishii ,  Naoki Asano ,  Robert J. Desnick

发明人： Jian-Qiang Fan ,  Satoshi Ishii ,  Naoki Asano ,  Robert J. Desnick

IPC分类号： A61K31445

CPC分类号： A61K31/445 ,  A61K31/70 ,  A61K31/7008 ,  C07D451/06 ,  C12N9/2465

摘要： Method for enhancing in a mammalian cell the activity of an enzyme associated with a lysosomal storage disorder by administering a competitive inhibitor of the enzyme in an amount effective to enhance the activity of the enzyme. Preferred compounds for use in the method are imino sugars and related compounds.

公开(公告)号：US5680211A

公开(公告)日：1997-10-21

申请号：US525249

申请日：1995-09-08

申请人： Yasushi Kaneda ,  Koh Ishizuka ,  Hiroshi Kondo ,  Satoshi Ishii

发明人： Yasushi Kaneda ,  Koh Ishizuka ,  Hiroshi Kondo ,  Satoshi Ishii

IPC分类号： G01B11/00 ,  G01B11/24 ,  G01D5/38 ,  G01P3/36 ,  G01B11/02 ,  G01D5/34 ,  G01J9/00

CPC分类号： G01P3/36 ,  G01D5/38

摘要： A displacement detection apparatus includes a light source (1), a first diffraction grating (G1) which is arranged on the same substrate as a second diffraction grating (G2) so as to diffract and split light emitted from the light source and to irradiate .+-.1st-order diffracted light beams onto the second diffraction grating (G2), a third diffraction grating (G3) for synthesizing a +1st-order reflectively diffracted light beam generated by reflectively diffracting the +1st-order diffracted light beam by the second diffraction grating, and a -1st-order reflectively diffracted light beam generated by reflectively diffracting the +1st-order diffracted light beam by the second diffraction grating to form interference light, and a light-receiving element (3) for converting the interference light into a signal representing a displacement of the substrate.

摘要翻译： 位移检测装置包括光源（1），与第二衍射光栅（G2）配置在同一基板上的第一衍射光栅（G1），以衍射和分离从光源发出的光并照射+ / -1级衍射光束到第二衍射光栅（G2）上，第三衍射光栅（G3），用于合成通过第二级反射衍射+ 1级衍射光束而产生的+ 1级反射衍射光束 衍射光栅和通过第二衍射光栅反射衍射+ 1级衍射光束而产生的-1级反射衍射光束，以形成干涉光;以及光接收元件（3），用于将干涉光转换成 表示基板的位移的信号。