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    Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
    51.
    发明授权
    Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors 失效
    取代的吡唑并[1,5-a]嘧啶作为蛋白激酶抑制剂

    公开(公告)号：US07642266B2

    公开(公告)日：2010-01-05

    申请号：US11542852

    申请日：2006-10-04

    申请人： Timothy J. Guzi ,  Kamil Paruch ,  Michael P. Dwyer

    发明人： Timothy J. Guzi ,  Kamil Paruch ,  Michael P. Dwyer

    IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P35/04

    CPC分类号： C07D487/04

    摘要： In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a] pyrimidine compounds as inhibitors of protein and/or checkpoint kinases, methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of preparing pharmaceutical formulations including one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the protein or checkpoint kinases using such compounds or pharmaceutical compositions. An illustrative compound is shown below:

    摘要翻译： 在其许多实施方案中，本发明提供了一类新颖的吡唑并[1,5-a]嘧啶化合物作为蛋白质和/或检查点激酶的抑制剂，制备此类化合物的方法，包含一种或多种这类化合物的药物组合物， 制备包括一种或多种这样的化合物的药物制剂，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与蛋白质或检查点激酶相关的一种或多种疾病的方法。 示例性化合物如下所示：

    Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
    52.
    发明授权
    Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors 有权
    取代的吡唑并[1,5-a]嘧啶作为蛋白激酶抑制剂

    公开(公告)号：US07601724B2

    公开(公告)日：2009-10-13

    申请号：US11542833

    申请日：2006-10-04

    申请人： Timothy J. Guzi ,  Kamil Paruch ,  Michael P. Dwyer

    发明人： Timothy J. Guzi ,  Kamil Paruch ,  Michael P. Dwyer

    IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P35/04

    CPC分类号： C07D487/04

    摘要： In its many embodiments, the present invention provides a class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases (CDKs), methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions. An illustrative compound of the invention is shown below:

    摘要翻译： 在其许多实施方案中，本发明提供了一类作为细胞周期蛋白依赖性激酶（CDK）抑制剂的吡唑并[1,5-a]嘧啶化合物，制备这些化合物的方法，含有一种或多种这类化合物的药物组合物，制备方法 包含一种或多种这样的化合物的药物制剂，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与CDK相关的一种或多种疾病的方法。 本发明的说明性化合物如下所示：

    Imidazopyrazines as cyclin dependent kinase inhibitors
    56.
    发明授权
    Imidazopyrazines as cyclin dependent kinase inhibitors 失效
    咪唑吡嗪作为细胞周期蛋白依赖性激酶抑制剂

    公开(公告)号：US07432265B2

    公开(公告)日：2008-10-07

    申请号：US11047524

    申请日：2005-01-31

    申请人： Kamil Paruch ,  Timothy J. Guzi ,  Michael P. Dwyer ,  Ronald J. Doll ,  Viyyoor M. Girijavallabhan ,  Alan Mallams

    发明人： Kamil Paruch ,  Timothy J. Guzi ,  Michael P. Dwyer ,  Ronald J. Doll ,  Viyyoor M. Girijavallabhan ,  Alan Mallams

    IPC分类号： C07D487/04 ,  A61K31/495

    CPC分类号： C07D487/04

    摘要： In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyrazine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

    摘要翻译： 在其许多实施方案中，本发明提供了一类新颖的咪唑并[1,2-a]吡嗪化合物作为细胞周期蛋白依赖性激酶的抑制剂，制备此类化合物的方法，含有一种或多种此类化合物的药物组合物，制备药物制剂的方法 包括一种或多种这样的化合物，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与CDK相关的一种或多种疾病的方法。

    Pyrazolotriazines as kinase inhibitors
    57.
    发明授权
    Pyrazolotriazines as kinase inhibitors 有权
    吡唑啉三嗪作为激酶抑制剂

    公开(公告)号：US07354921B2

    公开(公告)日：2008-04-08

    申请号：US11546766

    申请日：2006-10-12

    申请人： Timothy J. Guzi ,  Kamil Paruch

    发明人： Timothy J. Guzi ,  Kamil Paruch

    IPC分类号： A61K31/53 ,  A61P35/00 ,  A61P19/02 ,  C07D251/72

    CPC分类号： C07D487/04

    摘要： In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]triazine compounds as inhibitors of kinases such as, for example, cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the kinases using such compounds or pharmaceutical compositions.

    摘要翻译： 在其许多实施方案中，本发明提供了一类新颖的吡唑并[1,5-a]三嗪化合物作为激酶抑制剂，例如细胞周期蛋白依赖性激酶，制备这些化合物的方法，含有一种或多种这样的化合物的药物组合物 化合物，制备包含一种或多种这样的化合物的药物制剂的方法，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与激酶相关的一种或多种疾病的方法。

    Pyrazolotriazines as kinase inhibitors
    59.
    发明授权
    Pyrazolotriazines as kinase inhibitors 有权

    公开(公告)号：US07166602B2

    公开(公告)日：2007-01-23

    申请号：US11335383

    申请日：2006-01-19

    申请人： Timothy J. Guzi ,  Kamil Paruch

    发明人： Timothy J. Guzi ,  Kamil Paruch

    IPC分类号： A61K31/53 ,  A61P19/02 ,  C07D251/72 ,  C07D487/04

    CPC分类号： C07D487/04

    摘要： In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]triazine compounds as inhibitors of kinases such as, for example, cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the kinases using such compounds or pharmaceutical compositions.