公开(公告)号：US20070174922A1

公开(公告)日：2007-07-26

申请号：US10373512

申请日：2003-02-24

申请人： Nico Ghilardi ,  Frederic de Sauvage ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  William Wood

发明人： Nico Ghilardi ,  Frederic de Sauvage ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  William Wood

IPC分类号： A01K67/027 ,  C12Q1/68 ,  G01N33/567 ,  C07H21/04 ,  C12P21/06 ,  C12N5/06 ,  C07K14/705 ,  C07K16/28

CPC分类号： C07K14/7158

摘要： The present invention is directed to novel polypeptides having sequence similarity to Interleukin 6 receptor and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及与白细胞介素6受体具有序列相似性的新型多肽和编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US20070136829A1

公开(公告)日：2007-06-14

申请号：US11548639

申请日：2006-10-11

申请人： Nico Ghilardi ,  Frederic De Sauvage ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  William Wood

发明人： Nico Ghilardi ,  Frederic De Sauvage ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  William Wood

IPC分类号： A01K67/027 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/567 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705

CPC分类号： C07K14/7158

摘要： The present invention is directed to novel polypeptides and variants thereof of GLM-R polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Also provided are methods for detecting agents that modulate the activity of GLM-R. Also provided are methods for diagnosing and for treating disorders characterized by the over or under abundance of monocytes or macrophages.

摘要翻译： 本发明涉及GLM-R多肽的新型多肽及其变体以及编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 还提供了用于检测调节GLM-R的活性的试剂的方法。 还提供了用于诊断和治疗特征在于单核细胞或巨噬细胞过度或不丰富的疾病的方法。

公开(公告)号：US20060177897A1

公开(公告)日：2006-08-10

申请号：US11191669

申请日：2005-07-27

申请人： Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  Colin Watanabe ,  William Wood

发明人： Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  Colin Watanabe ,  William Wood

IPC分类号： C12P21/06 ,  C07H21/04 ,  C07K14/705 ,  C12N1/21 ,  C12N5/06 ,  C12N15/74 ,  C12N1/18

CPC分类号： C07K14/705 ,  C07K16/28 ,  C07K2317/24 ,  C07K2319/30 ,  C07K2319/40

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US20070160594A1

公开(公告)日：2007-07-12

申请号：US11612263

申请日：2006-12-18

申请人： Ellen Filvaroff ,  J. Grimaldi ,  William Wood ,  Audrey Goddard

发明人： Ellen Filvaroff ,  J. Grimaldi ,  William Wood ,  Audrey Goddard

IPC分类号： A61K38/48 ,  G01N33/567 ,  C07H21/04 ,  C12P21/06 ,  C12N9/64

CPC分类号： C07K14/8114 ,  A61K38/00 ,  C07K2319/00 ,  C12N2501/998

摘要： The present invention is directed to novel polypeptides having sequence similarity to human inter-alpha-trypsin inhibitor and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods of using the polypeptide to diagnose and treat damage to cartilage resulting from injury and/or cartilaginous disorders.

摘要翻译： 本发明涉及与人α间胰蛋白酶抑制剂和编码这些多肽的核酸分子具有序列相似性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了使用多肽来诊断和治疗由损伤和/或软骨障碍引起的软骨损伤的方法。

公开(公告)号：US20050032693A1

公开(公告)日：2005-02-10

申请号：US10811080

申请日：2004-03-26

申请人： Mary Gerritsen ,  Audrey Goddard ,  J. Grimaldi ,  Fuad Mehraban

发明人： Mary Gerritsen ,  Audrey Goddard ,  J. Grimaldi ,  Fuad Mehraban

IPC分类号： G01N33/50 ,  A61K31/7088 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P7/00 ,  A61P9/10 ,  A61P17/00 ,  A61P35/00 ,  C07K14/47 ,  C07K16/18 ,  C07K16/46 ,  C12M1/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N7/00 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  C12R1/91 ,  C12R1/93 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  G01N37/00 ,  A61K38/17 ,  C07H21/04

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K2319/00 ,  C12N2799/027

摘要： The present invention is directed to novel polypeptides critical for angiogenesis and vascularization, and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or neo- or cardio-vascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds; various cancers, and disorders of the vessels including atherosclerosis.

摘要翻译： 本发明涉及对血管生成和血管形成临界的新型多肽以及编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 公开了用于刺激或抑制哺乳动物（包括人）中的血管发生和/或新生血管或心脏血管形成的组合物和方法。 药物组合物基于已被鉴定为一种或多种这些用途的多肽或其拮抗剂。 可以通过本文组合物诊断，预防或治疗的疾病包括创伤，例如伤口; 各种癌症和包括动脉粥样硬化的血管紊乱。

公开(公告)号：US20060210556A1

公开(公告)日：2006-09-21

申请号：US10554680

申请日：2004-04-08

申请人： Daryl Baldwin ,  Hilary Clark ,  Henry Chiu ,  Grazyna Fedorowicz ,  Sherman Fong ,  J. Grimaldi ,  Wenjun Quyang ,  P. Williams

发明人： Daryl Baldwin ,  Hilary Clark ,  Henry Chiu ,  Grazyna Fedorowicz ,  Sherman Fong ,  J. Grimaldi ,  Wenjun Quyang ,  P. Williams

IPC分类号： A61K39/395 ,  A61K39/00 ,  G01N33/567 ,  C07H21/04 ,  C12P21/06 ,  C07K14/74 ,  C07K16/28

CPC分类号： G01N33/56972 ,  C07K14/47 ,  G01N33/6863 ,  G01N2500/00 ,  G01N2800/24

摘要： The present invention relates to compositions of matter and methods for the treatment and diagnosis of immune related diseases, including those mediated by cytokines released primarily either Th1 or Th2 cells in response to antigenic stimulation. The present invention further relates to methods for biasing the differentiation of T-cells in either the Th1 subtype or the Th2 subtype based on the relative expression levels of the gene PRO92726, and its agonists or antagonists. The present invention further relates to a method of diagnosing Th1- and Th2-mediated diseases.

摘要翻译： 本发明涉及用于治疗和诊断免疫相关疾病的物质组合物和方法，包括由主要由Th1或Th2细胞响应于抗原性刺激释放的细胞因子介导的物质组成。 本发明还涉及基于PRO92726及其激动剂或拮抗剂的相对表达水平来偏置Th1亚型或Th2亚型中T细胞分化的方法。 本发明还涉及诊断Th1-和Th2介导的疾病的方法。

公开(公告)号：US20070154475A1

公开(公告)日：2007-07-05

申请号：US11709185

申请日：2007-02-20

申请人： J. Grimaldi ,  Somasekar Seshagiri ,  Jeremy Stinson ,  William Wood ,  Zemin Zhang

发明人： J. Grimaldi ,  Somasekar Seshagiri ,  Jeremy Stinson ,  William Wood ,  Zemin Zhang

IPC分类号： A61K39/395 ,  C07K16/38 ,  C07K16/28

CPC分类号： A61K39/395

摘要： The present invention is directed to novel polypeptides having sequence similarity to GDNFR and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及与GDNFR具有序列相似性的新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。