公开(公告)号：US09156828B2

公开(公告)日：2015-10-13

申请号：US14419568

申请日：2013-08-07

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Tao Wang ,  Zhongxing Zhang ,  Zhiwei Yin ,  John F. Kadow ,  Nicholas A. Meanwell

IPC: A61K31/553 ,  C07D471/00 ,  C07D413/12 ,  C07D403/12 ,  A61K31/5513 ,  C07D471/04 ,  A61K45/06

CPC classification number: C07D413/12 ,  A61K31/5513 ,  A61K31/553 ,  A61K45/06 ,  C07D403/12 ,  C07D471/04

Abstract: Compounds of Formula I, including pharmaceutically acceptable salts thereof: (F) wherein A is selected from the group consisting of: (F) and; (F) and wherein Z is: (F) are useful as HIV attachment inhibitors.

Abstract translation: 式I化合物，包括其药学上可接受的盐：（F）其中A选自：（F）和 （F），其中Z是：（F）可用作HIV附着抑制剂。

公开(公告)号：US20150232481A1

公开(公告)日：2015-08-20

申请号：US14619728

申请日：2015-02-11

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： B. Narasimhulu Naidu ,  Michael A. Walker ,  Margaret E. Sorenson ,  Manoj Patel ,  Zhizhen Barbara Zheng ,  John F. Kadow ,  Bin Zheng ,  Martin D. Eastgate ,  Ke Chen ,  Francisco Gonzalez-Bobes

IPC: C07D498/22

CPC classification number: C07D498/22 ,  C07D211/48

Abstract: The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for making and using these compounds in the treatment of HIV infection.

Abstract translation: 本公开一般涉及式I化合物，包括用于治疗人类免疫缺陷病毒（HIV）感染的组合物和方法。 本公开提供了HIV的新型抑制剂，含有这些化合物的药物组合物，以及制备和使用这些化合物治疗HIV感染的方法。

公开(公告)号：US08962651B2

公开(公告)日：2015-02-24

申请号：US14204292

申请日：2014-03-11

Applicant: Bristol-Myers Squibb Company

Inventor： Kyle J. Eastman ,  Kyle E. Parcella ,  John F. Kadow

IPC: A61K31/44 ,  C07D471/02 ,  C07D491/02 ,  C07D498/02 ,  C07D491/048 ,  C07D491/04

CPC classification number: C07D491/048 ,  C07D491/04

Abstract: The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

Abstract translation: 本公开提供式I化合物，包括其盐，以及使用该化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。

公开(公告)号：US20130253196A1

公开(公告)日：2013-09-26

申请号：US13861804

申请日：2013-04-12

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yasutsugu Ueda ,  Timothy P. Connolly ,  John F. Kadow ,  Nicholas A. Meanwell ,  Tao Wang ,  Chung-Pin H. Chen ,  Kap-Sun Yeung ,  Zhongxing Zhang ,  David Kenneth Leahy ,  Shawn K. Pack ,  Nachimuthu Soundararajan ,  Pierre Sirard ,  Kathia Levesque ,  Dominique Thoraval

IPC: C07F9/6561

CPC classification number: A61K31/675 ,  A61K31/497 ,  A61K45/06 ,  C07D471/04 ,  C07F9/062 ,  C07F9/5728 ,  C07F9/65515 ,  C07F9/65586 ,  C07F9/6561

Abstract: This invention provides for prodrug Compounds I, pharmaceutical compositions thereof, and their use in treating HIV infection. wherein: X is C or N with the proviso that when X is N, R1 does not exist; W is C or N with the proviso that when W is N, R2 does not exist; V is C; E is hydrogen or a pharmaceutically acceptable salt thereof; and Y is selected from the group consisting of Also, this invention provides for intermediate Compounds II useful in making prodrug Compounds I. wherein: L and M are independently selected from the group consisting of C1-C6 alkyl, phenyl, benzyl, trialkylsilyl, -2,2,2-trichloroethoxy and 2-trimethylsilylethoxy.

公开(公告)号：US10570108B2

公开(公告)日：2020-02-25

申请号：US15551006

申请日：2016-02-17

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Tao Wang ,  Zhiwei Yin ,  John F. Kadow

IPC: C07D307/84 ,  C07D405/12 ,  C07D407/12 ,  C07H7/06 ,  C07F9/655

Abstract: Compounds of Formula I, including their salts, as well as compositions and methods of using the compounds are set forth. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV:

公开(公告)号：US10202403B2

公开(公告)日：2019-02-12

申请号：US15515170

申请日：2015-10-01

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Tao Wang ,  Zhongxing Zhang ,  John F. Kadow

IPC: C07D498/22 ,  C07D493/04 ,  C07D493/14 ,  C07D498/04

Abstract: Compounds of formula I, including their salts, as well as compositions and methods of using the compounds are set forth. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

公开(公告)号：US10150747B2

公开(公告)日：2018-12-11

申请号：US15551017

申请日：2016-02-19

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Kap-Sun Yeung ,  John F. Kadow ,  Rajesh Onkardas Bora ,  Prakash Anjanappa ,  Samayamunthula Venkata Satya Arun Kumar Gupta

IPC: C07D405/12 ,  C07D405/14 ,  C07D307/84 ,  C07D413/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07B59/00

Abstract: The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

公开(公告)号：US10131645B2

公开(公告)日：2018-11-20

申请号：US15551009

申请日：2016-02-17

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Tao Wang ,  Zhiwei Yin ,  John F. Kadow

IPC: C07D307/82 ,  C07D307/84 ,  C07D405/12

Abstract: Compounds of Formula (I), including their salts, as well as compositions and methods of using the compounds are set forth. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.

公开(公告)号：US09957278B2

公开(公告)日：2018-05-01

申请号：US15500110

申请日：2015-08-04

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Tao Wang ,  Kyle J. Eastman ,  Zhongxing Zhang ,  Kyle E. Parcella ,  John F. Kadow

IPC: C07D491/048 ,  A61K31/4355 ,  C07B59/00

CPC classification number: C07D491/048 ,  C07B59/002 ,  C07B2200/05

Abstract: Compounds of formula I, including their salts, as well as compositions and methods of using the compounds are set forth. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

公开(公告)号：US20180030056A1

公开(公告)日：2018-02-01

申请号：US15551015

申请日：2016-02-17

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Tao Wang ,  Zhiwei Yin ,  John F. Kadow

IPC: C07D487/04 ,  C07D405/10 ,  C07D487/10 ,  C07D471/04

CPC classification number: C07D487/04 ,  A61K31/4025 ,  A61K31/407 ,  A61K31/4162 ,  A61K31/4188 ,  A61K31/437 ,  A61K45/06 ,  C07D405/10 ,  C07D471/04 ,  C07D487/10

Abstract: Compounds of Formula I, including their salts, as well as compositions and methods of using the compounds are set forth. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV: Formula (I)