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    Spectroscopic imaging probes, devices, and methods
    51.
    发明授权
    Spectroscopic imaging probes, devices, and methods 有权
    光谱成像探针，装置和方法

    公开(公告)号：US08953911B1

    公开(公告)日：2015-02-10

    申请号：US13284369

    申请日：2011-10-28

    申请人： Chenyang Xu ,  Joseph M. Schmitt

    发明人： Chenyang Xu ,  Joseph M. Schmitt

    IPC分类号： G02B6/26 ,  G02B6/00

    CPC分类号： G02B6/264 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/0084 ,  G02B6/00 ,  G02B6/26 ,  G02B6/262 ,  G02B6/3604 ,  G02B6/4206 ,  G02B6/4214 ,  G02B6/4215 ,  G02B6/4287 ,  H04B10/0775

    摘要： In part, the invention relates to a single clad fiber to multi-clad optical fiber connector for use in applying excitation light to a sample and obtaining reflected light from the sample. The connector can include a dual clad optical fiber portion and a single clad optical fiber portion in optical communication with the dual clad optical fiber portion. In one embodiment, a core of the dual clad optical fiber portion and a core of the single clad optical fiber portion have substantially similar indices of refraction. In one embodiment, excitation light is propagated by the core of the dual clad optical fiber. Further, in one embodiment, light reflected by the sample is propagated by the first cladding layer of the dual clad optical fiber portion.

    摘要翻译： 部分地，本发明涉及用于向样品施加激发光并获得来自样品的反射光的单包层光纤到多包层光纤连接器。 连接器可以包括双包层光纤部分和与双包层光纤部分光通信的单包层光纤部分。 在一个实施例中，双包层光纤部分的芯和单包层光纤部分的芯具有基本相似的折射率。 在一个实施例中，激发光由双包层光纤的芯传播。 此外，在一个实施例中，由样品反射的光由双包层光纤部分的第一包层传播。

    CATHETER RF ABLATION USING SEGMENTATION-BASED 2D-3D REGISTRATION
    52.
    发明申请
    CATHETER RF ABLATION USING SEGMENTATION-BASED 2D-3D REGISTRATION 有权
    使用基于分段的2D-3D注册的导管射频消除

    公开(公告)号：US20110069063A1

    公开(公告)日：2011-03-24

    申请号：US12821235

    申请日：2010-06-23

    申请人： Rui Liao ,  Norbert Strobel ,  Chenyang Xu

    发明人： Rui Liao ,  Norbert Strobel ,  Chenyang Xu

    IPC分类号： G06T15/00 ,  G06K9/00 ,  G06K9/32

    CPC分类号： A61B6/5235 ,  A61B6/487 ,  A61B6/504 ,  A61B6/5247 ,  A61B18/1492 ,  A61B90/37 ,  A61B2090/364 ,  A61B2090/376 ,  A61B2090/3764 ,  G06T3/0068 ,  G06T7/33 ,  G06T2207/10072 ,  G06T2207/10121 ,  G06T2207/20041 ,  G06T2207/30048

    摘要： A method for registering a two-dimensional image of a cardiocirculatory structure and a three-dimensional image of the cardiocirculatory structure includes acquiring a three-dimensional image including the cardiocirculatory structure using a first imaging modality. The acquired three-dimensional image is projected into two-dimensions to produce a two-dimensional projection image of the cardiocirculatory structure. A structure of interest is segmented either from the three-dimensional image prior to projection or from the projection image subsequent to projection. A two-dimensional image of the cardiocirculatory structure is acquired using a second imaging modality. The structure of interest is segmented from the acquired two-dimensional image. A first distance map is generated based on the two-dimensional projection image and a second distance map is generated based on the acquired two-dimensional image. A registration of the three-dimensional image and the two-dimensional image is performed by minimizing a difference between the first and second distance maps.

    摘要翻译： 用于记录心脏循环结构的二维图像和心脏循环结构的三维图像的方法包括使用第一成像模式获取包括心脏循环结构的三维图像。 所获取的三维图像被投影成二维以产生心脏循环结构的二维投影图像。 感兴趣的结构或者从投影之前的三维图像或投影之后的投影图像分割。 使用第二成像模式获取心脏循环结构的二维图像。 感兴趣的结构从获得的二维图像中分割出来。 基于二维投影图像生成第一距离图，并且基于所获取的二维图像生成第二距离图。 通过最小化第一和第二距离图之间的差异来执行三维图像和二维图像的配准。

    CO-REGISTRATION OF CORONARY ARTERY COMPUTED TOMOGRAPHY AND FLUOROSCOPIC SEQUENCE
    54.
    发明申请
    CO-REGISTRATION OF CORONARY ARTERY COMPUTED TOMOGRAPHY AND FLUOROSCOPIC SEQUENCE 审中-公开
    冠状动脉计算机断层扫描和荧光序列的共同注册

    公开(公告)号：US20100061611A1

    公开(公告)日：2010-03-11

    申请号：US12545922

    申请日：2009-08-24

    申请人： Chenyang Xu ,  Hari Sundar ,  Luc Duong ,  Rui Liao ,  Andreas Meyer ,  Ulrich Bill

    发明人： Chenyang Xu ,  Hari Sundar ,  Luc Duong ,  Rui Liao ,  Andreas Meyer ,  Ulrich Bill

    IPC分类号： G06K9/00 ,  G06T15/00 ,  G01N23/00

    CPC分类号： G06T19/00 ,  G06T7/136 ,  G06T7/187 ,  G06T7/337 ,  G06T7/38 ,  G06T2207/20101 ,  G06T2207/30101

    摘要： A method for displaying real-time imagery of coronary arteries including a chronic total occlusion (CTO) includes acquiring three-dimensional image data of coronary arteries using a three-dimensional medical imaging device, wherein the three-dimensional image data includes imagery of the CTO. A radiocontrast agent is administered to a patient. Real-time image data of the coronary arteries are acquired using one or more fluoroscopes. The real-time image data does not include imagery of the CTO and down-stream vessel structure. The three-dimensional image data is co-registered with the real-time image data using an image processing device within a vicinity of the CTO. The co-registered image data are displayed in real-time using a display device to accurately illustrate the location of the CTO within the context of the real-time image data.

    摘要翻译： 用于显示包括慢性完全闭塞（CTO）在内的冠状动脉的实时图像的方法包括采用三维医学成像装置获取冠状动脉的三维图像数据，其中三维图像数据包括CTO的图像 。 向患者施用放射性对比剂。 使用一个或多个荧光检查器获取冠状动脉的实时图像数据。 实时图像数据不包括CTO和下游血管结构的图像。 使用CTO附近的图像处理装置将三维图像数据与实时图像数据共同对准。 使用显示装置实时显示共同登记的图像数据，以准确地示出CTO在实时图像数据的上下文中的位置。

    TOOLS AND METHODS FOR VISUALIZATION AND MOTION COMPENSATION DURING ELECTROPHYSIOLOGY PROCEDURES
    55.
    发明申请
    TOOLS AND METHODS FOR VISUALIZATION AND MOTION COMPENSATION DURING ELECTROPHYSIOLOGY PROCEDURES 审中-公开
    电生理过程中可视化和运动补偿的工具和方法

    公开(公告)号：US20090163800A1

    公开(公告)日：2009-06-25

    申请号：US12335738

    申请日：2008-12-16

    申请人： Chenyang Xu ,  Rui Liao ,  Liron Yatziv ,  Norbert Strobel

    发明人： Chenyang Xu ,  Rui Liao ,  Liron Yatziv ,  Norbert Strobel

    IPC分类号： A61B6/00 ,  A61B5/05

    CPC分类号： A61B6/12 ,  A61B5/0422 ,  A61B6/466 ,  A61B6/503 ,  A61B6/504 ,  A61B6/5235 ,  A61B6/541 ,  A61B6/566 ,  A61B90/36 ,  A61B2017/00703 ,  A61B2090/376

    摘要： A method for real-time cardiac visualization includes acquiring fluoroscope imagery from two planes. The location of at least one electrophysiology (EP) device is marked within the fluoroscope imagery from each of the two planes. The location information for the at least one EP device is combined within each of the acquired fluoroscope images from the two planes to determine a 3D location for the at least one EP device. The fluoroscope imagery from at least one of the two planes is displayed with a visual aid superimposed thereon. The visual aid is based on the 3D location of the EP device.

    摘要翻译： 一种用于实时心脏可视化的方法包括从两个平面获取荧光成像。 至少一个电生理学（EP）装置的位置被标记在两个平面中的每一个的荧光图像内。 用于至少一个EP设备的位置信息在来自两个平面的所获取的荧光镜图像的每个中组合，以确定用于至少一个EP设备的3D位置。 来自两个平面中的至少一个的荧光图像以其上叠加的视觉辅助物显示。 视觉辅助是基于EP设备的3D位置。

    System and method for non-rigid multi-modal registration on the GPU
    59.
    发明授权
    System and method for non-rigid multi-modal registration on the GPU 有权
    在GPU上进行非刚性多模式注册的系统和方法

    公开(公告)号：US07813592B2

    公开(公告)日：2010-10-12

    申请号：US11692293

    申请日：2007-03-28

    申请人： Christoph Vetter ,  Christoph Guetter ,  Chenyang Xu

    发明人： Christoph Vetter ,  Christoph Guetter ,  Chenyang Xu

    IPC分类号： G06K9/32 ,  G06K9/00 ,  G06K9/40 ,  G09G5/00

    CPC分类号： G06K9/00986 ,  G06K9/44 ,  G06K9/6212

    摘要： A method for non-rigid multi-modal registration of digitized images includes providing a reference image and an alignment images acquired from different imaging modalities to a graphics processing unit (GPU), initializing a deformation field for registering said reference image and said alignment image, computing marginal and joint intensity histograms of the reference image and the alignment image as registered by said deformation field, computing gradients of the reference and registered alignment images and of their respective marginal and joint intensity histograms, smoothing said histograms and gradients using Gaussian filters, calculating a new deformation field using said smoothed gradients, and registering said alignment image to said reference image using said deformation field.

    摘要翻译： 一种用于数字化图像的非刚性多模态配准的方法包括：向图形处理单元（GPU）提供参考图像和从不同成像模态获取的对准图像，初始化用于登记所述参考图像和所述对准图像的变形场， 计算由所述变形场记录的参考图像和对准图像的边缘和联合强度直方图，计算参考和注册对准图像的梯度及其相应的边缘和联合强度直方图，使用高斯滤波器平滑所述直方图和梯度，计算 使用所述平滑梯度的新变形场，以及使用所述变形场将所述对准图像记录到所述参考图像。

    Contrast enhanced spectroscopic optical coherence tomography
    60.
    发明授权
    Contrast enhanced spectroscopic optical coherence tomography 有权
    对比增强光谱相干层析成像

    公开(公告)号：US07725169B2

    公开(公告)日：2010-05-25

    申请号：US11405005

    申请日：2006-04-14

    申请人： Stephen A. Boppart ,  Chenyang Xu

    发明人： Stephen A. Boppart ,  Chenyang Xu

    IPC分类号： A61B6/00

    CPC分类号： A61B5/0073 ,  A61B5/0066 ,  A61B5/7203 ,  A61B5/7257 ,  G01N21/4795 ,  G01N2021/1787

    摘要： A method of forming an image of a sample includes performing SOCT on a sample. The sample may include a contrast agent, which may include an absorbing agent and/or a scattering agent. A method of forming an image of tissue may include selecting a contrast agent, delivering the contrast agent to the tissue, acquiring SOCT data from the tissue, and converting the SOCT data into an image. The contributions to the SOCT data of an absorbing agent and a scattering agent in a sample may be quantified separately.

    摘要翻译： 形成样品图像的方法包括在样品上执行SOCT。 样品可以包括造影剂，其可以包括吸收剂和/或散射剂。 形成组织图像的方法可以包括选择造影剂，将造影剂输送到组织，从组织获取SOCT数据，以及将SOCT数据转换成图像。 对样品中吸收剂和散射剂的SOCT数据的贡献可以分别进行量化。