公开(公告)号：US20130204538A1

公开(公告)日：2013-08-08

申请号：US13820968

申请日：2011-10-25

Applicant: Collin A. Rich

Inventor： Collin A. Rich

IPC: G06F19/10

CPC classification number: G01N15/1434 ,  G01J3/0208 ,  G01J3/0229 ,  G01J3/18 ,  G01J3/36 ,  G01N15/14 ,  G01N15/1404 ,  G01N15/1429 ,  G06F19/10 ,  G06F19/12 ,  G06F19/26 ,  G06M11/02

Abstract: Systems in a flow cytometer having an interrogation zone and illumination impinging the interrogation zone include: a lens subsystem including a collimating element that collimates light from the interrogation zone, a light dispersion element that disperses collimated light into a light spectrum, and a focusing lens that focuses the light spectrum onto an array of adjacent detection points; a detector array, including semiconductor detector devices, that collectively detects a full spectral range of input light signals, in which each detector device detects a subset spectral range of the full spectral range of light signals; and a user interface that enables a user to create a set of virtual detector channels by grouping detectors in the detector array, such that each virtual detector channel corresponds to a detector group and has a virtual detector channel range including the sum of subset spectral ranges of the detectors in the corresponding detector group.

Abstract translation: 具有询问区和照射询问区的照明的流式细胞仪中的系统包括：透镜子系统，包括准直来自询问区的光的准直元件，将准直光分散到光谱中的光分散元件和聚焦透镜， 将光谱聚焦到相邻检测点的阵列上; 检测器阵列，包括半导体检测器装置，其共同地检测输入光信号的全光谱范围，其中每个检测器装置检测光信号的全光谱范围的子集光谱范围; 以及用户界面，其使得用户能够通过对检测器阵列中的检测器进行分组来创建一组虚拟检测器通道，使得每个虚拟检测器通道对应于检测器组并且具有虚拟检测器通道范围，该虚拟检测器通道范围包括 相应检测器组中的检测器。

公开(公告)号：US08149402B2

公开(公告)日：2012-04-03

申请号：US12197192

申请日：2008-08-22

Applicant: Collin A. Rich ,  Richard L. Fisher ,  Nathaniel C. Bair

Inventor： Collin A. Rich ,  Richard L. Fisher ,  Nathaniel C. Bair

IPC: G01N21/00

CPC classification number: G01N21/53 ,  G01N15/1434 ,  G01N2021/6497 ,  Y10T436/115831

Abstract: The preferred embodiments of the invention is an optical system for a flow cytometer including a flow channel with an interrogation zone, and an illumination source that impinges the flow channel in the interrogation zone from a particular direction. The optical system preferably includes a lens system and a detection system. The lens system preferably includes multiple lens surfaces arranged around the flow channel and adapted to collect and collimate light from the interrogation zone. The detection system preferably includes multiple detectors adapted to detect light from the lens system. Each detector preferably includes a local filter that independently filters for specific wavelengths. Thus, the user may easily swap the filters in any order to achieve the same detection parameters.

Abstract translation: 本发明的优选实施例是用于流式细胞仪的光学系统，其包括具有询问区的流动通道，以及照射源，其将特定方向上的询问区中的流动通道入射。 光学系统优选地包括透镜系统和检测系统。 透镜系统优选地包括围绕流动通道布置的多个透镜表面，并且适于收集和准直来自询问区域的光。 检测系统优选地包括适于检测来自透镜系统的光的多个检测器。 每个检测器优选地包括独立地滤波特定波长的局部滤波器。 因此，用户可以以任何顺序容易地交换滤波器以实现相同的检测参数。

公开(公告)号：US20110306031A1

公开(公告)日：2011-12-15

申请号：US13178776

申请日：2011-07-08

Applicant: Collin A. Rich

Inventor： Collin A. Rich

IPC: C12Q3/00 ,  C12M1/36

CPC classification number: G01N15/1404 ,  G01N2015/1413 ,  G05D7/0682 ,  Y10T436/25375

Abstract: The fluidic system of the preferred embodiment includes a sheath pump to pump sheath fluid from a sheath container into an interrogation zone and a waste pump to pump waste fluid from the interrogation zone into a waste container. The sheath pump and/or the waste pump draw sample fluid from a sample container into the interrogation zone. The fluidic system also includes a controller to adjust the flow rate of the sample fluid from the sample container into the interrogation zone. The fluidic system is preferably incorporated into a flow cytometer with a flow cell that includes the interrogation zone.

Abstract translation: 优选实施例的流体系统包括护套泵，以将护套流体从护套容器泵送到询问区域，以及废物泵将废液从询问区泵送到废物容器中。 护套泵和/或废水泵将样品流体从样品容器中抽入询问区。 流体系统还包括控制器，用于调节样品流体从样品容器进入询问区域的流速。 流体系统优选地结合到具有包括询问区的流动池的流式细胞仪中。

公开(公告)号：US08077310B2

公开(公告)日：2011-12-13

申请号：US11848229

申请日：2007-08-30

Applicant: David C. Olson ,  Collin A. Rich

Inventor： David C. Olson ,  Collin A. Rich

IPC: G01J3/30

CPC classification number: G01J3/4338 ,  G01N21/645 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441

Abstract: The invention includes a system and a method for capturing multi source excitations from a single location on a flow channel. The system preferably includes a light subsystem that emits light onto a single location on a flow channel, a detector subsystem to detect light emitted from the single location on the flow channel, and a processor to separate the detected light. The method preferably includes emitting light onto a single location on a flow channel, detecting light emitted from the single location on the flow channel, and separating the detected light.

Abstract translation: 本发明包括一种用于从流通道上的单个位置捕获多源兴奋的系统和方法。 该系统优选地包括将光发射到流动通道上的单个位置的光子系统，用于检测从流动通道上的单个位置发射的光的检测器子系统以及用于分离检测到的光的处理器。 该方法优选地包括将光发射到流动通道上的单个位置，检测从流动通道上的单个位置发射的光并分离检测到的光。

公开(公告)号：US08031340B2

公开(公告)日：2011-10-04

申请号：US12887392

申请日：2010-09-21

Applicant: Collin A. Rich ,  Nathaniel C. Bair

Inventor： Collin A. Rich ,  Nathaniel C. Bair

IPC: G01N21/00

CPC classification number: G01N21/53 ,  G01N15/1434 ,  G01N21/532 ,  G01N21/645 ,  G01N2021/4707 ,  G01N2021/4711 ,  G01N2021/4726 ,  G01N2021/6497 ,  Y10T436/12

Abstract: An optical system for a flow cytometer having a flow channel with an interrogation zone and an illumination source that impinges the flow channel in the interrogation zone includes a lens system and a detection system. The lens system preferably includes at least two lens surfaces located on opposite sides of the flow channel and configured to collect and collimate light from the interrogation zone. The detection system, configured to detect light from the lens system, preferably includes first and second detectors, a first filter that passes a first wavelength of light and reflects a second wavelength of light, and a second filter that reflects the first wavelength of light and passes the second wavelength of light, wherein the first and second filters are aligned such that light reflected from the first filter passes into the second detector and light reflected from the second filter passes into the first detector.

公开(公告)号：US08014865B2

公开(公告)日：2011-09-06

申请号：US11459065

申请日：2006-07-21

Applicant: Nader Najafi ,  Collin A. Rich

Inventor： Nader Najafi ,  Collin A. Rich

IPC: A61B5/0215

CPC classification number: A61B5/0031 ,  A61B5/01 ,  A61B5/0215 ,  A61B5/14532 ,  A61B5/14542 ,  A61B2560/0219 ,  A61N1/37223

Abstract: A method of monitoring physiological parameters for diagnosis and treatment of congestive heart failure in a patient. The method includes implanting at least one sensing device in a cavity of the patient's cardiovascular system, preferably so that the sensing device passes through and is anchored to a septum of the heart and, to minimize the risk of thrombogenicity, a larger portion of the sensing device is located in the right side of the heart and a smaller portion of the sensing device is located in the left side of the heart. Electromagnetic telecommunication and/or wireless powering of the sensing device is performed with an external readout device. The method can be used to perform effective monitoring, management, and tailoring of treatments for patients suffering from congestive heart failure, as well as many other diseases.

Abstract translation: 监测患者充血性心力衰竭诊断和治疗的生理参数的方法。 该方法包括将至少一个感测装置植入患者心血管系统的空腔中，优选地使得感测装置通过并锚定到心脏的隔膜，并且为了使血栓形成的风险最小化，感测的较大部分 装置位于心脏的右侧，感测装置的较小部分位于心脏的左侧。 用外部读出装置执行感测装置的电磁通信和/或无线供电。 该方法可用于对患有充血性心力衰竭的患者以及许多其他疾病进行有效的监测，管理和定制治疗。

公开(公告)号：US20110151608A1

公开(公告)日：2011-06-23

申请号：US12974349

申请日：2010-12-21

Applicant: David F. Lemmerhirt ,  Collin A. Rich

Inventor： David F. Lemmerhirt ,  Collin A. Rich

IPC: H01L21/56

CPC classification number: B06B1/0292 ,  A61B8/00 ,  A61B8/4472

Abstract: The integrated circuit/transducer device of the preferred embodiment includes a substrate, a complementary-metal-oxide-semiconductor (CMOS) circuit that is fabricated on the substrate, and a capacitive micromachined ultrasonic transducer (cMUT) element that is also fabricated on the substrate. The CMOS circuit and cMUT element are fabricated during the same foundry process and are connected. The cMUT includes a lower electrode, an upper electrode, a membrane structure that support the upper electrode, and a cavity between the upper electrode and lower electrode.

Abstract translation: 优选实施例的集成电路/换能器装置包括衬底，在衬底上制造的互补金属氧化物半导体（CMOS）电路，以及还制造在衬底上的电容微机械超声换能器（cMUT）元件 。 CMOS电路和cMUT元件在相同的铸造过程中制造并连接。 cMUT包括下电极，上电极，支撑上电极的膜结构，以及上电极和下电极之间的空腔。

公开(公告)号：US07888709B2

公开(公告)日：2011-02-15

申请号：US12420683

申请日：2009-04-08

Applicant: David F. Lemmerhirt ,  Collin A. Rich

Inventor： David F. Lemmerhirt ,  Collin A. Rich

IPC: H01L29/84

CPC classification number: B06B1/0292 ,  A61B8/00 ,  A61B8/4472

Abstract: The integrated circuit/transducer device of the preferred embodiment includes a substrate, a complementary-metal-oxide-semiconductor (CMOS) circuit that is fabricated on the substrate, and a capacitive micromachined ultrasonic transducer (cMUT) element that is also fabricated on the substrate. The CMOS circuit and cMUT element are fabricated during the same foundry process and are connected. The cMUT includes a lower electrode, an upper electrode, a membrane structure that support the upper electrode, and a cavity between the upper electrode and lower electrode.

Abstract translation: 优选实施例的集成电路/换能器装置包括衬底，制造在衬底上的互补金属氧化物半导体（CMOS）电路，以及还制造在衬底上的电容微加工超声换能器（cMUT）元件 。 CMOS电路和cMUT元件在相同的铸造过程中制造并连接。 cMUT包括下电极，上电极，支撑上电极的膜结构，以及上电极和下电极之间的空腔。

公开(公告)号：US20090293910A1

公开(公告)日：2009-12-03

申请号：US12476860

申请日：2009-06-02

Applicant: Jack T. Ball ,  Aaron Kehrer ,  Nathaniel C. Bair ,  Collin A. Rich

Inventor： Jack T. Ball ,  Aaron Kehrer ,  Nathaniel C. Bair ,  Collin A. Rich

IPC: B08B9/02 ,  B08B9/023 ,  B08B9/027

CPC classification number: G01N15/1404 ,  B01L3/02 ,  B01L3/5027 ,  B01L99/00 ,  G01N2015/1413 ,  G05D7/0682 ,  Y10T436/25375

Abstract: A method for cleaning a fluidic system of a flow cytometer having a sheath pump to pump sheath fluid towards an interrogation zone and a waste pump to pump the sheath fluid and a sample fluid as waste fluid from the interrogation zone, wherein the sheath pump and/or the waste pump draw sample fluid into the flow cytometer through a drawtube towards the interrogation zone. The method includes controlling the sheath pump and the waste pump to cooperatively flush a fluid out through the drawtube, thereby cleaning the fluidic system of the flow cytometer.

Abstract translation: 一种用于清洗流式细胞仪的流体系统的方法，所述流式细胞仪具有护套泵以将鞘液朝向询问区泵送，而废泵泵送鞘液和作为来自询问区的废液的样品流体，其中护套泵和/ 或废泵将样品流体通过拉管朝向询问区抽入流式细胞仪。 该方法包括控制护套泵和废水泵通过抽吸管共同冲洗流体，从而清洗流式细胞仪的流体系统。

公开(公告)号：US20080071292A1

公开(公告)日：2008-03-20

申请号：US11858796

申请日：2007-09-20

Applicant: Collin A. Rich

Inventor： Collin A. Rich

IPC: A61B19/00

CPC classification number: A61B90/36 ,  A61B2017/3413 ,  A61B2034/107

Abstract: The present invention includes a system and a method of displaying the trajectory of an instrument and the position of a body within a volume. The preferred method includes the steps of creating a representation of at least a portion of the volume, calculating a trajectory of the instrument relative to a position of the body, and displaying the trajectory of the instrument and the position of the body. The preferred system includes an instrument, an ultrasonic device, a processor coupled to the ultrasonic device, and a display adapted to display the trajectory of the instrument and the position of the body.

Abstract translation: 本发明包括显示仪器的轨迹和体内体内位置的系统和方法。 优选的方法包括以下步骤：创建体积的至少一部分的表示，相对于身体的位置计算器械的轨迹，以及显示器械的轨迹和身体的位置。 优选的系统包括仪器，超声波设备，耦合到超声波设备的处理器以及适于显示仪器的轨迹和身体位置的显示器。