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公开(公告)号：US09551600B2
公开(公告)日：2017-01-24
申请号：US13697739
申请日：2011-06-14
Applicant: Grant C. Howes , Collin A. Rich
Inventor： Grant C. Howes , Collin A. Rich
CPC classification number: G01F1/00 , G01F25/0007 , G01N15/14 , G01N35/00871 , G06F17/00 , G06F19/28
Abstract: A system for creating a flow cytometer network includes: a flow cytometer with an interrogation zone and a fixed gain detection system that collects sample data from the interrogation zone; a flow cytometer data center that stores and manages sample-related data from the flow cytometer; and a network communication module that communicates sample-related data between the flow cytometer and the data center. The system may include a second flow cytometer and a second network communication module, where the first and second flow cytometers are calibrated to have substantially identical fixed gain settings. A method for creating a flow cytometer network includes: calibrating first and second flow cytometers with a calibration solution; collecting sample data with a fixed gain detection system; uploading data to a flow cytometer data center; retrieving data from the data center; and performing data analysis on the retrieved data.
Abstract translation: 用于产生流式细胞仪网络的系统包括：具有询问区的流式细胞仪和从询问区收集样本数据的固定增益检测系统; 流式细胞仪数据中心，用于存储和管理来自流式细胞仪的样品相关数据; 以及在流式细胞仪和数据中心之间传送样本相关数据的网络通信模块。 该系统可以包括第二流式细胞仪和第二网络通信模块，其中第一和第二流式细胞仪被校准以具有基本相同的固定增益设置。 创建流式细胞仪网络的方法包括：用校准溶液校准第一和第二流式细胞仪; 用固定增益检测系统收集样本数据; 将数据上传到流式细胞仪数据中心; 从数据中心检索数据; 并对所检索的数据执行数据分析。
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公开(公告)号：US08715573B2
公开(公告)日：2014-05-06
申请号：US11872676
申请日：2007-10-15
Applicant: Jack T. Ball , Collin A. Rich
Inventor： Jack T. Ball , Collin A. Rich
CPC classification number: G01N15/1404 , Y10T137/85978
Abstract: The fluidic system 10 of the preferred embodiment includes a sheath pump 12 to pump sheath fluid 14 from a sheath container 16 through a sample port 34 into an interrogation zone 18 and a waste pump 20 to pump the sheath fluid 14 and a sample fluid 26 as waste fluid 22 from the interrogation zone 18 into a waste container 24, and a processor 30 to calculate a time window based on the flow rate of the sample fluid 26. Preferably the processor 30 also calculates a time window for the sample fluid to reach the interrogation zone 18 from the sample port 34 based on the flow rate of the sample fluid 26. The interrogation zone 18 functions to provide a location for the fluidic system 10 and an optical analysis system 32 of the flow cytometer to cooperatively facilitate the analysis of the sample fluid 26.
Abstract translation: 优选实施例的流体系统10包括护套泵12，其将护套流体14从鞘容器16通过样品端口34泵送到询问区域18和废水泵20，以将鞘液14和样品流体26泵送为 从询问区18到废物容器24的废液22以及基于样品流体26的流速计算时间窗的处理器30.优选地，处理器30还计算样品流体到达的时间窗口 询问区18基于样品流体26的流速从采样端口34询问。询问区18用于提供流体系统10的位置和流式细胞计数器的光学分析系统32，以便协调地促进对 样品流体26。
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公开(公告)号：US08017402B2
公开(公告)日：2011-09-13
申请号：US11370714
申请日：2006-03-08
Applicant: Collin A. Rich
Inventor： Collin A. Rich
CPC classification number: G01N15/1404 , G01N2015/1413 , G05D7/0682 , Y10T436/25375
Abstract: The fluidic system of the preferred embodiment includes a sheath pump to pump sheath fluid from a sheath container into an interrogation zone and a waste pump to pump waste fluid from the interrogation zone into a waste container. The sheath pump and/or the waste pump draw sample fluid from a sample container into the interrogation zone. The fluidic system also includes a controller to adjust the flow rate of the sample fluid from the sample container into the interrogation zone. The fluidic system is preferably incorporated into a flow cytometer with a flow cell that includes the interrogation zone.
Abstract translation: 优选实施例的流体系统包括护套泵，以将护套流体从护套容器泵送到询问区域，以及废物泵将废液从询问区泵送到废物容器中。 护套泵和/或废水泵将样品流体从样品容器中抽入询问区。 流体系统还包括控制器，用于调节样品流体从样品容器进入询问区域的流速。 流体系统优选地结合到具有包括询问区的流动池的流式细胞仪中。
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公开(公告)号：US20100319786A1
公开(公告)日：2010-12-23
申请号：US12857405
申请日：2010-08-16
Applicant: Nathaniel C. Bair , Collin A. Rich
Inventor： Nathaniel C. Bair , Collin A. Rich
CPC classification number: F04B23/04 , F04B43/0081 , F04B43/12 , F04B2201/1201 , F04B2205/09 , G01N15/1404 , G01N2015/1413 , G05D7/0682 , Y10T137/0352 , Y10T137/0379 , Y10T137/0402 , Y10T137/85986 , Y10T436/115831 , Y10T436/117497
Abstract: The fluidic system with an unclogging feature of the preferred embodiment includes a flow channel, a sheath pump to pump sheath fluid from a sheath container into an interrogation zone, and a waste pump to pump waste fluid from the interrogation zone into a waste container. The sheath pump and/or the waste pump draw sample fluid from a sample container into the interrogation zone. The fluidic system also includes a controller to adjust the flow rate of the sample fluid from the sample container into the interrogation zone. The pump and controller cooperate to propagate a pulsation through the flow channel from the pump if the flow channel is clogged. The fluidic system is preferably incorporated into a flow cytometer with a flow cell that includes the interrogation zone.
Abstract translation: 具有优选实施例的不记录特征的流体系统包括流动通道，用于将护套流体从鞘容器泵送到询问区域的护套泵以及将废液从询问区泵送到废物容器中的废水泵。 护套泵和/或废水泵将样品流体从样品容器中抽入询问区。 流体系统还包括控制器，用于调节样品流体从样品容器进入询问区域的流速。 如果流道被堵塞，泵和控制器协同传播来自泵的流动通道的脉动。 流体系统优选地结合到具有包括询问区的流动池的流式细胞仪中。
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公开(公告)号：US20100319469A1
公开(公告)日：2010-12-23
申请号：US12857290
申请日：2010-08-16
Applicant: Collin A. Rich
Inventor： Collin A. Rich
CPC classification number: G01N1/14 , G01N15/06 , G01N15/1404 , G01N2015/1413 , G05D7/0682 , Y10T137/0402 , Y10T137/85978 , Y10T137/85986 , Y10T436/115831 , Y10T436/117497
Abstract: The fluidic system including a sheath pump that pumps sheath fluid from a sheath container into an interrogation zone, a waste pump that pumps waste fluid from the interrogation zone to a waste container, in which the flow rate of the sheath fluid is different from the flow rate of the waste fluid thereby drawing a sample fluid from a sample container into the interrogation zone, a detection system that provides a data set of input signals from the sample fluid, an analysis engine that recognizes aggregate particle events in the data set, and a controller that automatically adjusts the flow rate of the sample fluid into the interrogation zone based on the recognition of aggregate particle events, by controlling at least one of the flow rates of the sheath fluid and the waste fluid.
Abstract translation: 流体系统包括将皮套流体从护套容器泵送到询问区域的护套泵，将废液从询问区泵送到废物容器的废水泵，其中护套流体的流速不同于流动 从而将样品流体从样品容器抽入询问区，提供来自样品流体的输入信号的数据集的检测系统，识别数据集中的聚集粒子事件的分析引擎和 控制器，通过控制鞘液和废液的流速中的至少一个，基于聚集颗粒事件的识别，自动调节进入询问区的样品流体的流量。
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Patent Agency Ranking
公开(公告)号：US07843561B2
公开(公告)日：2010-11-30
申请号：US12337517
申请日：2008-12-17
Applicant: Collin A. Rich
Inventor： Collin A. Rich
IPC: G01N1/10
CPC classification number: G01N15/1434 , G01N15/1459
Abstract: The optical system of the preferred embodiments includes a first light source that creates a first beam of a first wavelength, a first collimating element that collimates the first beam, a second light source 102 that creates a second beam of a second wavelength, a second collimating element that collimates the second beam, a beam combining element that combines the collimated beams, and a focusing element that focuses the combined collimated beam to a single point.
Abstract translation: 优选实施例的光学系统包括产生第一波长的第一光束的第一光源，准直第一光束的第一准直元件，产生第二波长的第二光束的第二光源102，第二准直 对第二光束进行准直的元件，组合准直光束的光束组合元件以及将组合的准直光束聚焦到单个点的聚焦元件。
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公开(公告)号：US07776268B2
公开(公告)日：2010-08-17
申请号：US11549560
申请日：2006-10-13
Applicant: Collin A. Rich
Inventor： Collin A. Rich
CPC classification number: G01N15/1404 , G01N2015/1413 , G05D7/0682 , Y10T436/115831 , Y10T436/117497
Abstract: The fluidic system of the preferred embodiment includes a sheath pump to pump sheath fluid from a sheath container into an interrogation zone and a waste pump to pump waste fluid from the interrogation zone into a waste container. The sheath pump and/or the waste pump draw sample fluid from a sample container into the interrogation zone. The fluidic system also includes a controller to adjust the flow rate of the sample fluid from the sample container into the interrogation zone. The fluidic system is preferably incorporated into a flow cytometer with a flow cell that includes the interrogation zone.
Abstract translation: 优选实施例的流体系统包括护套泵，以将护套流体从护套容器泵送到询问区域，以及废物泵将废液从询问区泵送到废物容器中。 护套泵和/或废水泵将样品流体从样品容器中抽入询问区。 流体系统还包括控制器，用于调节样品流体从样品容器进入询问区域的流速。 流体系统优选地结合到具有包括询问区的流动池的流式细胞仪中。
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公开(公告)号：US20080156379A1
公开(公告)日：2008-07-03
申请号：US11958278
申请日：2007-12-17
Applicant: Collin A. Rich , Steven M. Martin
Inventor： Collin A. Rich , Steven M. Martin
IPC: F16K31/12
CPC classification number: F15B1/021 , F04B43/12 , F15B1/10 , F15B21/008 , F15B2201/205 , F15B2201/215 , F15B2201/3151 , G01N15/1404 , Y10T137/3118 , Y10T137/7792
Abstract: A pulsation attenuator for a fluidic system with a fluidic pump. The pulsation attenuator includes a fluidic channel, a first fluidic device adapted to attenuate pulsations with a shallow rolloff slope, and a second fluidic device adapted to attenuate pulsations with a shallow rolloff slope. The first fluidic device and the second fluidic device are connected to the fluidic channel such that they cooperatively attenuate pulsations with a steep rolloff slope. Preferably, the first fluidic device includes a first fluidic resistor and a first fluidic capacitor, and the second fluidic device includes a second fluidic resistor and a second fluidic capacitor. Preferably, the pulsation attenuator is arranged, similar a second-order low-pass filter, in the following order: (1) first fluidic resistor, (2) first fluidic capacitor, (3) second fluidic resistor, and (4) second fluidic capacitor.
Abstract translation: 一种具有流体泵的流体系统的脉动衰减器。 脉动衰减器包括流体通道，适于衰减具有浅滚降斜率的脉动的第一流体装置，以及适于以浅滚降斜率衰减脉动的第二流体装置。 第一流体装置和第二流体装置连接到流体通道，使得它们以陡峭的滚降斜率协同地衰减脉动。 优选地，第一流体装置包括第一流体电阻器和第一流体电容器，并且第二流体装置包括第二流体电阻器和第二流体电容器。 优选地，按照以下顺序将脉动衰减器类似于二阶低通滤波器：（1）第一流体电阻器，（2）第一流体电容器，（3）第二流体电阻器，和（4）第二流体电阻器 电容器。
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公开(公告)号：US08779387B2
公开(公告)日：2014-07-15
申请号：US13033299
申请日：2011-02-23
Applicant: Clare E. Rogers , Jack T. Ball , Collin A. Rich
Inventor： Clare E. Rogers , Jack T. Ball , Collin A. Rich
CPC classification number: G01N15/1429 , G01N15/1459
Abstract: A method for detecting fluorochromes in a flow cytometer, including: receiving a sample including particles each tagged with at least one of a first fluorochrome and a second fluorochrome, in which the first and second fluorochromes having distinct spillover coefficients; detecting the particles, including detecting the first and second fluorochromes with a first detector and a second detector; forming a data set for detected particles based on the detection of the first and second fluorochromes; characterizing a detected spillover coefficient for each detected fluorochrome from the data set; and sorting the detected particles into predicted fluorochrome populations based on the detected spillover coefficients. A system for detecting fluorochromes in a flow cytometer, including a flow cell, a fixed gain detection system, and a processor that generates a detected spillover coefficient for each detected particle and sorts the detected particle into predicted fluorochrome populations based on the detected spillover coefficient.
Abstract translation: 一种用于在流式细胞仪中检测荧光染料的方法，包括：接收包含每个标记有第一荧光染料和第二荧光染料中的至少一种的颗粒的样品，其中第一和第二荧光染料具有不同的溢出系数; 检测颗粒，包括用第一检测器和第二检测器检测第一和第二荧光染料; 基于第一和第二荧光色素的检测形成检测到的颗粒的数据集; 表征来自数据集的每个检测到的荧光染料的检测到的溢出系数; 并且基于检测到的溢出系数将检测到的颗粒分选成预测的荧光染色体群体。 一种用于在流式细胞仪中检测荧光染料的系统，包括流动池，固定增益检测系统和处理器，其产生每个检测到的颗粒的检测到的溢出系数，并且基于检测到的溢出系数将检测到的颗粒分解成预测的荧光染色体群。
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公开(公告)号：US08658453B2
公开(公告)日：2014-02-25
申请号：US11612659
申请日：2006-12-19
Applicant: David F. Lemmerhirt , Collin A. Rich
Inventor： David F. Lemmerhirt , Collin A. Rich
IPC: H01L21/00
CPC classification number: B06B1/0292
Abstract: The first integrated circuit/transducer device 36 of the handheld probe includes CMOS circuits 110 and cMUT elements 112. The cMUT elements 112 function to generate an ultrasonic beam, detect an ultrasonic echo, and output electrical signals, while the CMOS circuits 110 function to perform analog or digital operations on the electrical signals generated through operation of the cMUT elements 112. The manufacturing method for the first integrated circuit/transducer device 36 of the preferred embodiment includes the steps of depositing the lower electrode S102; depositing a sacrificial layer S104; depositing a dielectric layer S106; removing the sacrificial layer S108, followed by the steps of depositing the upper electrode S110 and depositing a protective layer on the upper electrode S112.
Abstract translation: 手持式探头的第一集成电路/传感器装置36包括CMOS电路110和cMUT元件112.CMUT元件112用于产生超声波束，检测超声回波并输出电信号，同时CMOS电路110用于执行 对通过cMUT元件112的操作产生的电信号进行模拟或数字操作。优选实施例的第一集成电路/换能器装置36的制造方法包括以下步骤：沉积下电极S102; 沉积牺牲层S104; 沉积介电层S106; 去除牺牲层S108，随后沉积上电极S110并在上电极S112上沉积保护层的步骤。
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