公开(公告)号：US11033476B2

公开(公告)日：2021-06-15

申请号：US16566932

申请日：2019-09-11

Applicant: Colgate-Palmolive Company

Inventor： Jennifer Gronlund ,  Guofeng Xu ,  Venda Porter Maloney ,  Junhong Mao ,  Shaotang Yuan ,  Suman Chopra ,  Jodie Parker ,  Rajnish Kohli ,  Robert Dicosimo ,  Kari A. Fosser ,  Sharon L. Haynie ,  Mark S. Payne ,  John T. Gannon

IPC: A61K8/66 ,  A61K8/81 ,  A61K8/37 ,  A61K8/25 ,  A61Q11/00 ,  A61K8/22

Abstract: An oral care composition including an orally acceptable vehicle is disclosed. The orally acceptable vehicle includes a source of hydrogen peroxide, an acyl donor, and an enzyme that catalyzes the generation of peracetic acid between the source of hydrogen peroxide and the acyl donor.

公开(公告)号：US20210137803A1

公开(公告)日：2021-05-13

申请号：US17248200

申请日：2021-01-14

Applicant: Colgate-Palmolive Company

Inventor： Shaoyi Zhang ,  Saide Tang ,  Carl Myers ,  Guofeng Xu

IPC: A61K8/21 ,  A61K8/19 ,  A61K8/20 ,  A61K8/27 ,  A61K8/41 ,  A61K8/55 ,  A61Q11/00

Abstract: This application relates to novel aqueous oral care compositions useful for combining and delivering incompatible stannous fluoride or stannous chloride and potassium salts in a high-water composition, for example, to provide effective caries prevention, protection against dental erosion, and relief from dental hypersensitivity. The compositions comprise stannous fluoride or stannous chloride, nitric acid or a water-soluble nitrate salt, a water-soluble alkali metal polyphosphate and more than 10% water, by weight of the composition.

公开(公告)号：US10918580B2

公开(公告)日：2021-02-16

申请号：US16840857

申请日：2020-04-06

Applicant: Colgate-Palmolive Company

Inventor： Shaoyi Zhang ,  Saide Tang ,  Carl Myers ,  Guofeng Xu

IPC: A61K8/21 ,  A61K8/20 ,  A61K8/19 ,  A61Q11/00 ,  A61K8/41 ,  A61K8/55 ,  A61K8/27

Abstract: This application relates to novel aqueous oral care compositions useful for combining and delivering incompatible stannous fluoride or stannous chloride and potassium salts in a high-water composition, for example, to provide effective caries prevention, protection against dental erosion, and relief from dental hypersensitivity. The compositions comprise stannous fluoride or stannous chloride, nitric acid or a water-soluble nitrate salt, a water-soluble alkali metal polyphosphate and more than 10% water, by weight of the composition.

公开(公告)号：US10758462B2

公开(公告)日：2020-09-01

申请号：US15352614

申请日：2016-11-16

Applicant: COLGATE-PALMOLIVE COMPANY

Inventor： Shaotang Yuan ,  Guofeng Xu ,  LaTonya Kilpatrick-Liverman

IPC: A61K8/23 ,  A61Q11/00 ,  A61K8/86 ,  A61K8/81

Abstract: An oral care composition, including from about 0.01% to about 40% peroxysulfate whitening agent and from about 1% to about 99% non-aqueous dispersant.

公开(公告)号：US10716742B2

公开(公告)日：2020-07-21

申请号：US15352618

申请日：2016-11-16

Applicant: COLGATE-PALMOLIVE COMPANY

Inventor： Shaotang Yuan ,  Guofeng Xu ,  LaTonya Kilpatrick-Liverman

IPC: A61K8/23 ,  A61Q11/00 ,  A61K8/81 ,  A61K8/86

Abstract: An oral care composition, including a peroxysulfate whitening agent, a non-aqueous dispersant having a non-aqueous liquid, and a structural builder.

公开(公告)号：US10596098B2

公开(公告)日：2020-03-24

申请号：US15344394

申请日：2016-11-04

Applicant: COLGATE-PALMOLIVE COMPANY

Inventor： Rong Dong ,  Guofeng Xu ,  Shaotang Yuan

IPC: A61Q11/00 ,  A61K8/81 ,  A61Q11/02 ,  A61K8/29 ,  A61K8/02 ,  A61K8/97

Abstract: Disclosed is a durable dental film-forming composition including an acrylate/octylacrylamide copolymer, wherein the acrylate/octylacrylamide copolymer is present in an amount of about 0.1% to about 50% by weight, an adhesive, and an orally acceptable solvent. Methods of using the composition are also disclosed.

公开(公告)号：US10517705B2

公开(公告)日：2019-12-31

申请号：US15344450

申请日：2016-11-04

Applicant: COLGATE-PALMOLIVE COMPANY

Inventor： Rong Dong ,  Guofeng Xu ,  Shaotang Yuan ,  James Thomas ,  Kevern Fraser

IPC: A61C19/06 ,  A61M11/00 ,  A61C3/00

Abstract: Disclosed is a method of forming a uniform coating onto a tooth surface, which method includes: forming droplets by spraying an orally acceptable coating material through a spray nozzle, and depositing the droplets onto the tooth surface to thereby form a uniform coating. In the method, the droplets have a volume-averaged droplet size of about 1 μm to about 100 μm, a spray including the droplets travels from a tip of the spray nozzle towards the tooth surface at a spray rate of less than about 10 milliliters/minute, and the droplets include a film-forming polymer, a therapeutic agent and/or a cosmetic agent.

公开(公告)号：US10238590B2

公开(公告)日：2019-03-26

申请号：US14365088

申请日：2012-12-19

Applicant: COLGATE-PALMOLIVE COMPANY

Inventor： Guofeng Xu ,  Steven Miller ,  Jennifer Gronlund

IPC: A61K8/22 ,  A61K8/362 ,  A61Q11/00 ,  A61K8/36 ,  A61K8/73 ,  A61K8/81 ,  A61K8/88 ,  A61K8/02 ,  A61K8/49 ,  A61Q19/10

Abstract: Described herein are compositions comprising an unactivated liquid, an immobilized sparingly soluble acid or base, such that during storage the unactivated liquid is not in contact with the immobilized sparingly soluble acid or base, but upon use, the unactivated liquid contacts the immobilized sparingly soluble acid or base, whereby the pH of the liquid is altered, thereby activating the liquid to provide a benefit; together with variant and alternative designs, methods of making and using the compositions, and components thereof.

公开(公告)号：US10098824B2

公开(公告)日：2018-10-16

申请号：US14364738

申请日：2012-12-18

Applicant: Colgate-Palmolive Company ,  E.I. DU PONT DE NEMOURS AND COMPANY

Inventor： Thomas Boyd ,  Guofeng Xu ,  Richard Adams ,  Robert Pierce ,  Derek Samaroo ,  David Viscio ,  Kari A. Fosser ,  Robert Dicosimo ,  Hong Wang

IPC: A61K8/66 ,  A61K8/22 ,  A61K8/37 ,  A61C15/04 ,  C07H21/04 ,  A61K8/38 ,  A61Q11/00 ,  A61K8/04 ,  B65D35/22 ,  B65D81/32

Abstract: Described herein are packages for storing and dispensing multi-part tooth whitening formulations, comprising a deformable material configured to form two or more sealed chambers, e.g., wherein the first chamber contains a low viscosity liquid solution comprising an enzyme having perhydrolytic activity, and the second chamber contains a peroxide source and a at least one acyl donor substrate. Particular multi-part tooth whitening formulations using this principle and methods of use thereof are also provided.

公开(公告)号：US20150328112A1

公开(公告)日：2015-11-19

申请号：US14653885

申请日：2012-12-19

Applicant: COLGATE-PALMOLIVE COMPANY

Inventor： Guofeng Xu ,  Zhiqiang Liu ,  Long Pan ,  LaTonya Kilpatrick-Liverman ,  Ying Yang ,  Michael A. Stranick ,  Zhigang Hao

IPC: A61K8/44 ,  A61K8/21 ,  A61Q11/00 ,  A61K8/27 ,  A61K8/20

CPC classification number: A61K8/27 ,  A61K8/20 ,  A61K8/21 ,  A61K8/44 ,  A61K2800/58 ,  A61K2800/92 ,  A61Q11/00

Abstract: Described herein are oral care compositions comprising a mixture of zinc oxide and trimethylglycine, in free or orally acceptable salt form. Methods of making and using the compositions are also provided.

Abstract translation: 本文描述了包含游离或口服可接受的盐形式的氧化锌和三甲基甘氨酸的混合物的口腔护理组合物。 还提供了制备和使用组合物的方法。