公开(公告)号：US20110306031A1

公开(公告)日：2011-12-15

申请号：US13178776

申请日：2011-07-08

Applicant: Collin A. Rich

Inventor： Collin A. Rich

IPC: C12Q3/00 ,  C12M1/36

CPC classification number: G01N15/1404 ,  G01N2015/1413 ,  G05D7/0682 ,  Y10T436/25375

Abstract: The fluidic system of the preferred embodiment includes a sheath pump to pump sheath fluid from a sheath container into an interrogation zone and a waste pump to pump waste fluid from the interrogation zone into a waste container. The sheath pump and/or the waste pump draw sample fluid from a sample container into the interrogation zone. The fluidic system also includes a controller to adjust the flow rate of the sample fluid from the sample container into the interrogation zone. The fluidic system is preferably incorporated into a flow cytometer with a flow cell that includes the interrogation zone.

Abstract translation: 优选实施例的流体系统包括护套泵，以将护套流体从护套容器泵送到询问区域，以及废物泵将废液从询问区泵送到废物容器中。 护套泵和/或废水泵将样品流体从样品容器中抽入询问区。 流体系统还包括控制器，用于调节样品流体从样品容器进入询问区域的流速。 流体系统优选地结合到具有包括询问区的流动池的流式细胞仪中。

公开(公告)号：US08077310B2

公开(公告)日：2011-12-13

申请号：US11848229

申请日：2007-08-30

Applicant: David C. Olson ,  Collin A. Rich

Inventor： David C. Olson ,  Collin A. Rich

IPC: G01J3/30

CPC classification number: G01J3/4338 ,  G01N21/645 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441

Abstract: The invention includes a system and a method for capturing multi source excitations from a single location on a flow channel. The system preferably includes a light subsystem that emits light onto a single location on a flow channel, a detector subsystem to detect light emitted from the single location on the flow channel, and a processor to separate the detected light. The method preferably includes emitting light onto a single location on a flow channel, detecting light emitted from the single location on the flow channel, and separating the detected light.

Abstract translation: 本发明包括一种用于从流通道上的单个位置捕获多源兴奋的系统和方法。 该系统优选地包括将光发射到流动通道上的单个位置的光子系统，用于检测从流动通道上的单个位置发射的光的检测器子系统以及用于分离检测到的光的处理器。 该方法优选地包括将光发射到流动通道上的单个位置，检测从流动通道上的单个位置发射的光并分离检测到的光。

公开(公告)号：US08031340B2

公开(公告)日：2011-10-04

申请号：US12887392

申请日：2010-09-21

Applicant: Collin A. Rich ,  Nathaniel C. Bair

Inventor： Collin A. Rich ,  Nathaniel C. Bair

IPC: G01N21/00

CPC classification number: G01N21/53 ,  G01N15/1434 ,  G01N21/532 ,  G01N21/645 ,  G01N2021/4707 ,  G01N2021/4711 ,  G01N2021/4726 ,  G01N2021/6497 ,  Y10T436/12

Abstract: An optical system for a flow cytometer having a flow channel with an interrogation zone and an illumination source that impinges the flow channel in the interrogation zone includes a lens system and a detection system. The lens system preferably includes at least two lens surfaces located on opposite sides of the flow channel and configured to collect and collimate light from the interrogation zone. The detection system, configured to detect light from the lens system, preferably includes first and second detectors, a first filter that passes a first wavelength of light and reflects a second wavelength of light, and a second filter that reflects the first wavelength of light and passes the second wavelength of light, wherein the first and second filters are aligned such that light reflected from the first filter passes into the second detector and light reflected from the second filter passes into the first detector.

公开(公告)号：US08014865B2

公开(公告)日：2011-09-06

申请号：US11459065

申请日：2006-07-21

Applicant: Nader Najafi ,  Collin A. Rich

Inventor： Nader Najafi ,  Collin A. Rich

IPC: A61B5/0215

CPC classification number: A61B5/0031 ,  A61B5/01 ,  A61B5/0215 ,  A61B5/14532 ,  A61B5/14542 ,  A61B2560/0219 ,  A61N1/37223

Abstract: A method of monitoring physiological parameters for diagnosis and treatment of congestive heart failure in a patient. The method includes implanting at least one sensing device in a cavity of the patient's cardiovascular system, preferably so that the sensing device passes through and is anchored to a septum of the heart and, to minimize the risk of thrombogenicity, a larger portion of the sensing device is located in the right side of the heart and a smaller portion of the sensing device is located in the left side of the heart. Electromagnetic telecommunication and/or wireless powering of the sensing device is performed with an external readout device. The method can be used to perform effective monitoring, management, and tailoring of treatments for patients suffering from congestive heart failure, as well as many other diseases.

Abstract translation: 监测患者充血性心力衰竭诊断和治疗的生理参数的方法。 该方法包括将至少一个感测装置植入患者心血管系统的空腔中，优选地使得感测装置通过并锚定到心脏的隔膜，并且为了使血栓形成的风险最小化，感测的较大部分 装置位于心脏的右侧，感测装置的较小部分位于心脏的左侧。 用外部读出装置执行感测装置的电磁通信和/或无线供电。 该方法可用于对患有充血性心力衰竭的患者以及许多其他疾病进行有效的监测，管理和定制治疗。

公开(公告)号：US20110151608A1

公开(公告)日：2011-06-23

申请号：US12974349

申请日：2010-12-21

Applicant: David F. Lemmerhirt ,  Collin A. Rich

Inventor： David F. Lemmerhirt ,  Collin A. Rich

IPC: H01L21/56

CPC classification number: B06B1/0292 ,  A61B8/00 ,  A61B8/4472

Abstract: The integrated circuit/transducer device of the preferred embodiment includes a substrate, a complementary-metal-oxide-semiconductor (CMOS) circuit that is fabricated on the substrate, and a capacitive micromachined ultrasonic transducer (cMUT) element that is also fabricated on the substrate. The CMOS circuit and cMUT element are fabricated during the same foundry process and are connected. The cMUT includes a lower electrode, an upper electrode, a membrane structure that support the upper electrode, and a cavity between the upper electrode and lower electrode.

Abstract translation: 优选实施例的集成电路/换能器装置包括衬底，在衬底上制造的互补金属氧化物半导体（CMOS）电路，以及还制造在衬底上的电容微机械超声换能器（cMUT）元件 。 CMOS电路和cMUT元件在相同的铸造过程中制造并连接。 cMUT包括下电极，上电极，支撑上电极的膜结构，以及上电极和下电极之间的空腔。

公开(公告)号：US07888709B2

公开(公告)日：2011-02-15

申请号：US12420683

申请日：2009-04-08

Applicant: David F. Lemmerhirt ,  Collin A. Rich

Inventor： David F. Lemmerhirt ,  Collin A. Rich

IPC: H01L29/84

CPC classification number: B06B1/0292 ,  A61B8/00 ,  A61B8/4472

Abstract: The integrated circuit/transducer device of the preferred embodiment includes a substrate, a complementary-metal-oxide-semiconductor (CMOS) circuit that is fabricated on the substrate, and a capacitive micromachined ultrasonic transducer (cMUT) element that is also fabricated on the substrate. The CMOS circuit and cMUT element are fabricated during the same foundry process and are connected. The cMUT includes a lower electrode, an upper electrode, a membrane structure that support the upper electrode, and a cavity between the upper electrode and lower electrode.

Abstract translation: 优选实施例的集成电路/换能器装置包括衬底，制造在衬底上的互补金属氧化物半导体（CMOS）电路，以及还制造在衬底上的电容微加工超声换能器（cMUT）元件 。 CMOS电路和cMUT元件在相同的铸造过程中制造并连接。 cMUT包括下电极，上电极，支撑上电极的膜结构，以及上电极和下电极之间的空腔。

公开(公告)号：US20100271620A1

公开(公告)日：2010-10-28

申请号：US12770341

申请日：2010-04-29

Applicant: Clement James Goebel ,  Collin A. Rich

Inventor： Clement James Goebel ,  Collin A. Rich

IPC: G01N21/00

CPC classification number: G01N15/1459 ,  G01N2015/0092 ,  G01N2015/1477

Abstract: The detection system of the first preferred embodiment includes a detector, having a wide dynamic range, that receives photonic inputs from the interrogation zone and produces an analog signal; and an analog-to-digital converter (ADC), having a high bit resolution, that is coupled to the detector and converts an analog signal to a digital signal. The digital signal includes an initial data set of the full dynamic range of the input signals from the flow cytometer sample. The method of extracting and analyzing data from a flow cytometer system of the first preferred embodiment preferably includes the steps of: collecting a full dynamic range of input signals from a flow cytometer sample; recognizing and annotating aggregate particle events; and storing an initial data set and an annotated data set of the full dynamic range of the input signals from the flow cytometer sample.

公开(公告)号：US07739060B2

公开(公告)日：2010-06-15

申请号：US11963384

申请日：2007-12-21

Applicant: Clement James Goebel ,  Collin A. Rich

Inventor： Clement James Goebel ,  Collin A. Rich

IPC: G06F17/40 ,  G06F17/00

CPC classification number: G01N15/1459 ,  G01N2015/0092 ,  G01N2015/1477

Abstract: The detection system of the first preferred embodiment includes a detector, having a wide dynamic range, that receives photonic inputs from the interrogation zone and produces an analog signal; and an analog-to-digital converter (ADC), having a high bit resolution, that is coupled to the detector and converts an analog signal to a digital signal. The digital signal includes an initial data set of the full dynamic range of the input signals from the flow cytometer sample. The method of extracting and analyzing data from a flow cytometer system of the first preferred embodiment preferably includes the steps of: collecting a full dynamic range of input signals from a flow cytometer sample; recognizing and annotating aggregate particle events; and storing an initial data set and an annotated data set of the full dynamic range of the input signals from the flow cytometer sample.

Abstract translation: 第一优选实施例的检测系统包括具有宽动态范围的检测器，其接收来自询问区的光子输入并产生模拟信号; 以及具有高比特分辨率的模数转换器（ADC），其耦合到检测器并将模拟信号转换为数字信号。 数字信号包括来自流式细胞仪样本的输入信号的完整动态范围的初始数据集。 从第一优选实施例的流式细胞仪系统中提取和分析数据的方法优选地包括以下步骤：从流式细胞仪样品收集输入信号的完整动态范围; 识别和注释聚集粒子事件; 并存储来自流式细胞仪样本的输入信号的完整动态范围的初始数据集和注释数据集。

公开(公告)号：US20090293910A1

公开(公告)日：2009-12-03

申请号：US12476860

申请日：2009-06-02

Applicant: Jack T. Ball ,  Aaron Kehrer ,  Nathaniel C. Bair ,  Collin A. Rich

Inventor： Jack T. Ball ,  Aaron Kehrer ,  Nathaniel C. Bair ,  Collin A. Rich

IPC: B08B9/02 ,  B08B9/023 ,  B08B9/027

CPC classification number: G01N15/1404 ,  B01L3/02 ,  B01L3/5027 ,  B01L99/00 ,  G01N2015/1413 ,  G05D7/0682 ,  Y10T436/25375

Abstract: A method for cleaning a fluidic system of a flow cytometer having a sheath pump to pump sheath fluid towards an interrogation zone and a waste pump to pump the sheath fluid and a sample fluid as waste fluid from the interrogation zone, wherein the sheath pump and/or the waste pump draw sample fluid into the flow cytometer through a drawtube towards the interrogation zone. The method includes controlling the sheath pump and the waste pump to cooperatively flush a fluid out through the drawtube, thereby cleaning the fluidic system of the flow cytometer.

Abstract translation: 一种用于清洗流式细胞仪的流体系统的方法，所述流式细胞仪具有护套泵以将鞘液朝向询问区泵送，而废泵泵送鞘液和作为来自询问区的废液的样品流体，其中护套泵和/ 或废泵将样品流体通过拉管朝向询问区抽入流式细胞仪。 该方法包括控制护套泵和废水泵通过抽吸管共同冲洗流体，从而清洗流式细胞仪的流体系统。

公开(公告)号：US20080071292A1

公开(公告)日：2008-03-20

申请号：US11858796

申请日：2007-09-20

Applicant: Collin A. Rich

Inventor： Collin A. Rich

IPC: A61B19/00

CPC classification number: A61B90/36 ,  A61B2017/3413 ,  A61B2034/107

Abstract: The present invention includes a system and a method of displaying the trajectory of an instrument and the position of a body within a volume. The preferred method includes the steps of creating a representation of at least a portion of the volume, calculating a trajectory of the instrument relative to a position of the body, and displaying the trajectory of the instrument and the position of the body. The preferred system includes an instrument, an ultrasonic device, a processor coupled to the ultrasonic device, and a display adapted to display the trajectory of the instrument and the position of the body.

Abstract translation: 本发明包括显示仪器的轨迹和体内体内位置的系统和方法。 优选的方法包括以下步骤：创建体积的至少一部分的表示，相对于身体的位置计算器械的轨迹，以及显示器械的轨迹和身体的位置。 优选的系统包括仪器，超声波设备，耦合到超声波设备的处理器以及适于显示仪器的轨迹和身体位置的显示器。