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108 条记录 (耗时 0.036 秒)

    Method and apparatus for performing equality comparison in redundant form arithmetic
    51.
    发明授权
    Method and apparatus for performing equality comparison in redundant form arithmetic 有权
    用于在冗余形式算术中执行等式比较的方法和装置

    公开(公告)号：US06813628B2

    公开(公告)日：2004-11-02

    申请号：US09746771

    申请日：2000-12-22

    申请人： Bharat Bhushan ,  Edward Grochowski ,  Vinod Sharma ,  John Crawford

    发明人： Bharat Bhushan ,  Edward Grochowski ,  Vinod Sharma ,  John Crawford

    IPC分类号： G06F704

    CPC分类号： G06F7/5095 ,  G06F7/02 ,  G06F7/026 ,  G06F7/48 ,  G06F7/4824

    摘要： A method and apparatus is disclosed to compare numbers for equality. The numbers represented in a redundant form, including numbers received from a bypass circuit are subtracted. More specifically, a complemented form is generated and supplied to an arithmetic circuit for at least one number represented in the redundant form. Input to the arithmetic circuit is adjusted to augment a result generated through the arithmetic circuit to generate a valid outcome represented in the redundant form as a result of a subtraction operation. Results of the subtraction operation are compared to zero in redundant form using a non-propagative circuit and without requiring carry propagation, thereby producing an equality comparison of the number in redundant form.

    摘要翻译： 公开了一种方法和装置，用于比较相等的数字。 减去以冗余形式表示的数字，包括从旁路电路接收的数字。更具体地，产生补码形式并将其提供给用冗余形式表示的至少一个数字的运算电路。 调整运算电路的输入以增加通过算术电路产生的结果，以产生作为减法运算的结果以冗余形式表示的有效结果。 使用非传播电路将减法操作的结果与冗余形式进行比较，而不需要进位传播，从而产生冗余形式的数量的等式比较。

    Methods for treating cardiac pacing conditions
    54.
    发明授权
    Methods for treating cardiac pacing conditions 有权
    治疗心脏起搏病症的方法

    公开(公告)号：US08734780B2

    公开(公告)日：2014-05-27

    申请号：US13096135

    申请日：2011-04-28

    申请人： Vinod Sharma ,  Xiaohong Qiu

    发明人： Vinod Sharma ,  Xiaohong Qiu

    IPC分类号： A61K31/7088 ,  A61K35/00 ,  A61P9/00 ,  C12N5/10

    CPC分类号： C12N15/86 ,  A61K35/13 ,  A61K48/005 ,  A61K48/0075 ,  C07K14/4705 ,  C12N2750/14143

    摘要： The method may include administering to a subject in need thereof an effective amount of an HCN polynucleotide. The HCN polynucleotide includes a nucleotide sequence encoding an HCN polypeptide having channel activity. The amino acid sequence of the HCN polypeptide and the amino acid sequence of a reference polypeptide have at least 80% identity, where the reference polypeptide begins with an amino acid selected from amino acids 92-214 and ends with an amino acid selected from amino acids 723-1188 of SEQ ID NO:8. An example of a reference polypeptide is amino acids 214-723 of SEQ ID NO:8. The HCN polynucleotide may be DNA or RNA.

    摘要翻译： 该方法可以包括向有需要的受试者施用有效量的HCN多核苷酸。 HCN多核苷酸包括编码具有通道活性的HCN多肽的核苷酸序列。 HCN多肽的氨基酸序列和参考多肽的氨基酸序列具有至少80％的同一性，其中参考多肽以选自氨基酸92-214的氨基酸开始，并以选自氨基酸的氨基酸结束 SEQ ID NO：8的723-1188。 参考多肽的实例是SEQ ID NO：8的氨基酸214-723。 HCN多核苷酸可以是DNA或RNA。

    Genetic modification of targeted regions of the cardiac conduction system
    55.
    发明授权
    Genetic modification of targeted regions of the cardiac conduction system 有权
    心脏传导系统目标区域的遗传修饰

    公开(公告)号：US08642747B2

    公开(公告)日：2014-02-04

    申请号：US13224593

    申请日：2011-09-02

    申请人： Vinod Sharma ,  Walter H. Olson

    发明人： Vinod Sharma ,  Walter H. Olson

    IPC分类号： A61K48/00 ,  C12N15/00 ,  C07H21/02

    CPC分类号： C12N15/86 ,  A61K38/177 ,  A61K48/00 ,  A61K48/005 ,  C12N2750/14143

    摘要： Disclosed are methods and systems for preventing or treating cardiac dysfunction, particularly cardiac pacing dysfunction by genetic modification of the conduction system of the heart. In one embodiment, the invention provides a method of genetically modifying the cells by delivering to the cells one or more coding sequence in a genetic construct capable of modifying the expression of ion channels of the cells.

    摘要翻译： 公开了通过心脏传导系统的遗传修饰来预防或治疗心脏功能障碍，特别是心脏起搏功能障碍的方法和系统。 在一个实施方案中，本发明提供了通过向细胞递送能够修饰细胞的离子通道的表达的遗传构建体中的一个或多个编码序列来遗传修饰细胞的方法。

    Implantable medical device having optical fiber for sensing electrical activity
    58.
    发明授权
    Implantable medical device having optical fiber for sensing electrical activity 有权
    具有用于感测电活动的光纤的可植入医疗装置

    公开(公告)号：US08396539B2

    公开(公告)日：2013-03-12

    申请号：US11676128

    申请日：2007-02-16

    申请人： Vinod Sharma ,  Xiaohong Zhou

    发明人： Vinod Sharma ,  Xiaohong Zhou

    IPC分类号： A61B5/04

    CPC分类号： A61B5/0071 ,  A61B5/0084 ,  A61B5/0452

    摘要： An implantable medical device for optically sensing action potential signals in excitable body tissue. The device includes an elongated tubular lead body carrying an optical fiber extending from a proximal lead end to a distal lead end to position the optical fiber at a target site. The lead body additionally carries a conduit for dispensing a voltage-sensitive fluorescent dye into tissue surrounding the target site. The optical fiber transmits excitation light to the fluorescent dye to cause the dye to fluoresce with varying intensity as the transmembrane potentials of local tissue cells vary due to passing depolarization wavefronts. The optical fiber transmits the fluorescence signal to the device to generate an action potential signal or fiducial points of an action potential signal for use in accurately measuring and characterizing electrical activity of excitable tissue.

    摘要翻译： 一种用于在可兴奋的身体组织中光学感测动作电位信号的可植入医疗装置。 该装置包括细长的管状引线体，其承载从近侧引线端延伸到远端引线端的光纤，以将光纤定位在目标部位。 引线体还带有用于将电压敏感的荧光染料分配到靶区域周围的组织中的导管。 光纤将激发光透射到荧光染料，以使得染料以不同的强度发荧光，因为局部组织细胞的跨膜电位由于通过去极化波前而变化。 光纤将荧光信号传输到设备以产生动作电位信号或动作电位信号的基准点，用于精确测量和表征可兴奋组织的电活动。

    Queued Cooperative Wireless Networks Configuration Using Rateless Codes
    60.
    发明申请
    Queued Cooperative Wireless Networks Configuration Using Rateless Codes 有权
    排队的无线网络配置使用无线代码

    公开(公告)号：US20100296432A1

    公开(公告)日：2010-11-25

    申请号：US12550177

    申请日：2009-08-28

    申请人： Neelesh B. Mehta ,  Vinod Sharma ,  Gaurav Bansal

    发明人： Neelesh B. Mehta ,  Vinod Sharma ,  Gaurav Bansal

    IPC分类号： H04B7/14 ,  H04L12/56

    CPC分类号： H04B7/15 ,  H04B7/15592 ,  H04B7/2606 ,  H04L47/14 ,  H04W28/10

    摘要： A system using cooperative communication with rateless codes is presented that uses communication transmission aspects of cooperative communication with rateless codes over Rayleigh fading channels and queuing aspects for buffering messages at intermediate relays. The system transmits a subsequent message while a current message is en route to the destination by receiving and buffering the current message in queues at intermediate relays. A relay with a best instantaneous communication link to the source may receive a message first and forward the received message to the destination. Alternatively, if inter-relay communication links are strong, all relays may cooperate simultaneously.

    摘要翻译： 提出了一种使用与无码代码进行协作通信的系统，该系统使用通过Rayleigh衰落信道进行的无编码代码的通信传输方面的通信和用于在中间继电器处缓冲消息的排队方面。 通过在中间继电器上接收和缓冲当前消息的队列，当前消息正在路由到目的地时，系统发送后续消息。 具有到源的最佳瞬时通信链路的中继器可以首先接收消息，并将接收到的消息转发到目的地。 或者，如果中继间通信链路强，则所有中继可以同时协作。