COPOLYMERS HAVING 1-METHYL-2-METHOXYETHYL MOIETIES
    51.
    发明申请
    COPOLYMERS HAVING 1-METHYL-2-METHOXYETHYL MOIETIES 有权
    具有1-甲基-2-甲氧基乙烯醇的共聚物

    公开(公告)号:US20080125560A1

    公开(公告)日:2008-05-29

    申请号:US11942700

    申请日:2007-11-19

    申请人: Stephen Pacetti

    发明人: Stephen Pacetti

    IPC分类号: C08F218/04 A61F2/82

    摘要: The copolymers include a hydrophobic monomer and an acryloyl or methacryloyl ester of a propylene glycol monomethyl ether, also referred to as 1-methyl-2-methoxyethyl acrylate (“MMOEA”). The combination of the hydrophobic monomer and the MMOEA monomer advantageously provides desired mechanical strength, biocompatibility, and drug permeability in the copolymers. The copolymers can advantageously be used on medical devices.

    摘要翻译: 共聚物包括疏水单体和丙二醇单甲醚的丙烯酰基或甲基丙烯酰基酯,也称为丙烯酸1-甲基-2-甲氧基乙酯(“MMOEA”)。 疏水单体和MMOEA单体的组合有利地提供共聚物中期望的机械强度,生物相容性和药物渗透性。 共聚物可有利地用于医疗器械上。

    AMINO ACID MIMETIC COPOLYMERS AND MEDICAL DEVICES COATED WITH THE COPOLYMERS
    52.
    发明申请
    AMINO ACID MIMETIC COPOLYMERS AND MEDICAL DEVICES COATED WITH THE COPOLYMERS 有权
    氨基酸共聚物和与共聚物包衣的医疗装置

    公开(公告)号:US20080125514A1

    公开(公告)日:2008-05-29

    申请号:US11942705

    申请日:2007-11-19

    申请人: Stephen Pacetti

    发明人: Stephen Pacetti

    IPC分类号: A61F2/02

    摘要: Biocompatible polymers are manufactured to include an amino acid mimetic monomer and one or more hydrophobic acrylate monomers. The amino acid mimetic monomers are selected to mimic the side chain of the amino acids asparagine or glutamine. The amino acid mimetic monomer can be a methacryloyl or acryloyl derivative of 2-hydroxyacetamide, 3-hydroxypropionamide, alaninamide, lactamide, or glycinamide. These amide functional groups offer the advantage of moderate hydrophilicity with little chemical reactivity. The amino acid mimetic monomer can be copolymerized with one or more hydrophobic acrylate monomers to obtain desired coating properties.

    摘要翻译: 制造生物相容性聚合物以包括氨基酸模拟单体和一种或多种疏水丙烯酸酯单体。 选择氨基酸模拟单体以模拟氨基酸天冬酰胺或谷氨酰胺的侧链。 氨基酸模拟单体可以是2-羟基乙酰胺,3-羟基丙酰胺,丙烯酰胺,乳酰胺或甘氨酰胺的甲基丙烯酰基或丙烯酰基衍生物。 这些酰胺官能团具有中等的亲水性,几乎没有化学反应性的优点。 氨基酸模拟单体可以与一种或多种疏水丙烯酸酯单体共聚以获得所需的涂料性质。

    Poly(ester amide) filler blends for modulation of coating properties
    59.
    发明申请
    Poly(ester amide) filler blends for modulation of coating properties 有权
    用于调节涂层性能的聚(酯酰胺)填料混合物

    公开(公告)号:US20060093842A1

    公开(公告)日:2006-05-04

    申请号:US10976551

    申请日:2004-10-29

    摘要: Provided herein is a PEA polymer blend and coatings or implantable devices formed therefrom. The PEA polymer blend is formed of a PEA polymer and a material capable of hydrogen bonding with the PEA. The PEA polymer blend can form a coating on an implantable device, one example of which is a stent. The coating can optionally include a biobeneficial material and/or optionally with a bioactive agent. The implantable device can be used to treat or prevent a disorder such as one of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.

    摘要翻译: 本文提供了由其形成的PEA聚合物共混物和涂层或可植入装置。 PEA聚合物共混物由PEA聚合物和能够与PEA氢键合的材料形成。 PEA聚合物共混物可以在可植入装置上形成涂层,其一个实例是支架。 涂层可任选地包括生物有益材料和/或任选地含有生物活性剂。 可植入装置可用于治疗或预防动脉粥样硬化,血栓形成,再狭窄,出血,血管解剖或穿孔之一,血管动脉瘤,易损斑块,慢性完全闭塞,跛行,静脉和人造移植物的吻合增殖等障碍 导管阻塞,输尿管阻塞,肿瘤阻塞及其组合。