公开(公告)号：US20060051337A1

公开(公告)日：2006-03-09

申请号：US11100328

申请日：2005-04-06

申请人： Paul Johnson ,  Hsiuchin Yang ,  Charles Derby ,  Phang Tai

发明人： Paul Johnson ,  Hsiuchin Yang ,  Charles Derby ,  Phang Tai

IPC分类号： A61K38/44 ,  C12N9/02 ,  C07H21/04 ,  C12P21/06

CPC分类号： C12N9/0022 ,  A61K38/00 ,  C07K14/43504 ,  C12Y104/03002

摘要： The present invention provides an isolated polypeptide (escapin), and fragments thereof, from the sea hare Aplysia californica that have antimicrobial action directed against fungi, yeast, bacteria, and cyanobacteria. Further, the present invention provides an isolated nucleic acid, and fragments thereof, that encode the polypeptide and fragments thereof. Also provided are primers for detecting the nucleic acids of the present invention. A method of inhibiting microbial growth and inhibiting biofilm formation on a surface is also provided.

摘要翻译： 本发明提供了具有针对真菌，酵母，细菌和蓝细菌的抗微生物作用的来自海兔蚜虫的分离的多肽（escapin）及其片段。 此外，本发明提供编码多肽及其片段的分离的核酸及其片段。 还提供了用于检测本发明的核酸的引物。 还提供了抑制微生物生长并抑制表面生物膜形成的方法。

公开(公告)号：US20060024806A1

公开(公告)日：2006-02-02

申请号：US11175689

申请日：2005-07-07

申请人： Timothy Stinear ,  Stewart Cole ,  Peter Leadlay ,  Pamela Small ,  Paul Johnson ,  Grant Jenkin ,  John Davies ,  Stephen Haydock

发明人： Timothy Stinear ,  Stewart Cole ,  Peter Leadlay ,  Pamela Small ,  Paul Johnson ,  Grant Jenkin ,  John Davies ,  Stephen Haydock

IPC分类号： C07H21/04 ,  C12N9/02

CPC分类号： C12N15/52

摘要： The present invention relates to Mycobacterium ulcerans virulence plasmid, pMUM001 and particularly to a cluster of genes carried by this plasmid that encode polyketide synthases (PKSs) and polyketide-modifying enzymes necessary and sufficient for mycolactone biosynthesis. More particularly this invention is directed to novel purified or isolated polypeptides, the polynucleotides encoding such polypeptides, processes for production of such polypeptides, antibodies generated against these polypeptides, the use of such polynucleotides and polypeptides in Diagnostic methods, kits, vaccines, therapy and for the production of mycolactone derivatives or novel polyketides by combinatorial synthesis.

摘要翻译： 本发明涉及溃疡分枝杆菌毒力质粒pMUM001，特别涉及由该质粒携带的编码聚酮内酯合成酶（PKS）和聚酮化合物修饰酶的基因簇，其对于霉酚酸内酯生物合成是必需和足够的。 更具体地说，本发明涉及新的纯化或分离的多肽，编码这些多肽的多核苷酸，产生此类多肽的方法，针对这些多肽产生的抗体，在诊断方法，试剂盒，疫苗，治疗中用于此类多核苷酸和多肽 通过组合合成生产莫考内酯衍生物或新型聚酮化合物。

公开(公告)号：US20060002455A1

公开(公告)日：2006-01-05

申请号：US11212322

申请日：2005-08-25

申请人： Paul Johnson ,  John Lovberg

发明人： Paul Johnson ,  John Lovberg

IPC分类号： H04B1/38

CPC分类号： H04B1/408 ,  H04B1/38

摘要： A high data rate free space communication link operating at millimeter wave frequency ranges. A quasi-optical grid amplifier is used provide increased transmitter output power. In preferred embodiments that output power is greater than 1 watt. Links include two transceivers, the first transceiver transmitting at a first frequency range and receiving at a second frequency range and a second transceiver transmitting at the second frequency range and receiving at the first frequency range. Each of the two transceivers has a primary tunable oscillator providing a basic frequency signal that is precisely the same for both transceivers. Preferably the primary tunable oscillator in one of the transceivers, the slave oscillator, is slaved to the primary tunable oscillator, the master oscillator, in the other transceiver and the two transceivers are locked in frequency and phase.

摘要翻译： 在毫米波频率范围内工作的高数据速率自由空间通信链路。 使用准光栅放大器提供增加的发射机输出功率。 在优选实施例中，输出功率大于1瓦特。 链路包括两个收发器，第一收发器在第一频率范围内发送并在第二频率范围进行接收，而第二收发器在第二频率范围内发射并在第一频率范围接收。 两个收发器中的每一个具有主要可调谐振荡器，其提供两个收发器精确相同的基本频率信号。 优选地，收发器中的一个收发器中的主可调谐振荡器（从属振荡器）从属于主可调谐振荡器，另一个收发器中的主振荡器和两个收发器被锁定在频率和相位上。

公开(公告)号：US20050248832A1

公开(公告)日：2005-11-10

申请号：US10874559

申请日：2004-06-23

申请人： Rad Sommer ,  Michael Scobey ,  Rance Fortenberry ,  Toby Reid ,  Paul Johnson

发明人： Rad Sommer ,  Michael Scobey ,  Rance Fortenberry ,  Toby Reid ,  Paul Johnson

IPC分类号： H04B10/294 ,  H01S3/00

CPC分类号： H04B10/2941

摘要： A gain-flattening filter for in-line compensation of the spectral gain profile of an optical amplifier comprises: a first GFF component having a transmission curve with a spectral loss profile corresponding to the spectral gain profile of an optical amplifier, and a second GFF component having a transmission curve with a spectral loss profile corresponding to the error function of the first GFF component. A method of producing a gain-flattening filter for use with an optical amplifier comprises: designing a first GFF component to have a transmission curve with a spectral loss profile corresponding to a target loss profile for the optical amplifier; manufacturing the first GFF component; determining the error function of the first GFF component; designing a second GFF component to have a transmission curve with a spectral loss profile corresponding to the error function of the first GFF component (unpackaged or as packaged with other components of the GFF apparatus and/or other components of a gain-flattened optical amplifier); manufacturing the second GFF component; and combining the first and second GFF components.

摘要翻译： 用于线性补偿光放大器的光谱增益分布的增益平坦化滤波器包括：具有与光放大器的光谱增益分布对应的光谱损耗分布的传输曲线的第一GFF分量和第二GFF分量 具有对应于第一GFF分量的误差函数的频谱损耗曲线的传输曲线。 一种制造用于光放大器的增益平坦滤波器的方法包括：设计第一GFF分量以使具有对应于光放大器的目标损耗曲线的光谱损耗曲线的透射曲线; 制造第一个GFF组件; 确定第一GFF组件的误差函数; 设计第二GFF组件以具有与第一GFF组件的误差函数对应的频谱损耗曲线的传输曲线（未封装或与GFF装置的其他组件和/或增益平坦化的光放大器的其它组件一起封装） ; 制造第二个GFF组件; 并组合第一和第二GFF组件。

公开(公告)号：US20050003862A1

公开(公告)日：2005-01-06

申请号：US10799225

申请日：2004-03-12

申请人： Paul Johnson ,  John Lovberg ,  Kenneth Tang ,  Randall Olsen ,  Vladimir Kolinko

发明人： Paul Johnson ,  John Lovberg ,  Kenneth Tang ,  Randall Olsen ,  Vladimir Kolinko

IPC分类号： H01Q1/12 ,  H01Q19/10 ,  H04B1/38 ,  H04B7/04

CPC分类号： H04B1/3805 ,  H01Q1/125 ,  H01Q19/10 ,  H04B7/0408 ,  Y02D70/40 ,  Y02D70/444

摘要： A wireless cellular communication system in which groups of cellular base stations communicate with a central office via a narrow-band millimeter wave trunk line. The transceivers are equipped with antennas providing beam divergence small enough to ensure efficient spatial and directional partitioning of the data channels so that an almost unlimited number of transceivers will be able to simultaneously use the same millimeter wave spectrum. In a preferred embodiment the trunk line communication link operates within the 92 to 95 GHz portion of the millimeter spectrum. A large number of base stations are each allocated a few MHz portion of a 900 MHz bandwidth of the millimeter wave trunk line. A first transceiver transmits at a first bandwidth and receives at a second bandwidth both within the above spectral range. A second transceiver transmits at the second bandwidth and receives at the first bandwidth. Antennas are described to maintain beam directional stability to less than one-half the half-power beam width. In a preferred embodiment the first and second spectral ranges are 92.3-93.2 GHz and 94.1-95.0 GHz and the half power beam width is about 0.36 degrees or less. Thus, in this system the low frequency band width is efficiently utilized over and over again by dividing a territory into small cells and using low power antenna. And a higher frequency bandwidth is efficiently utilized over and over again by using transmitting antennae that are designed to produce very narrow beams directed at receiving antennae. In a preferred embodiment cellular base stations are prepackaged for easy quick installation at convenient locations such as the tops of commercial buildings.

摘要翻译： 一种无线蜂窝通信系统，其中蜂窝基站组经由窄带毫米波干线与中心局通信。 收发器配备有提供足够小的光束发散的天线，以确保数据信道的有效的空间和方向分配，使得几乎无限数量的收发器将能够同时使用相同的毫米波频谱。 在优选实施例中，干线通信链路在毫米波段的92至95GHz部分内工作。 大量的基站每个被分配为毫米波干线的900MHz带宽的几MHz部分。 第一收发机以第一带宽传输并在上述频谱范围内以第二带宽接收。 第二收发器以第二带宽发送并以第一带宽进行接收。 天线被描述为将波束方向稳定性维持在半功率波束宽度的一半以下。 在优选实施例中，第一和第二光谱范围为92.3-93.2GHz和94.1-95.0GHz，半功率波束宽度为约0.36度或更小。 因此，在该系统中，通过将领域划分为小单元并使用低功率天线，低频带宽被一次又一次地有效地利用。 并且通过使用被设计为产生指向接收天线的非常窄的波束的发射天线，一次又一次地有效地利用了更高的频率带宽。 在一个优选实施例中，预先包装蜂窝式基站，以便在诸如商业建筑物的顶部的便利位置容易地快速安装。

公开(公告)号：USD472786S1

公开(公告)日：2003-04-08

申请号：US29154962

申请日：2001-07-23

申请人： Michael J. Cech ,  Carl A. Hoffman ,  Paul Johnson

设计人： Michael J. Cech ,  Carl A. Hoffman ,  Paul Johnson

公开(公告)号：US06416471B1

公开(公告)日：2002-07-09

申请号：US09292405

申请日：1999-04-15

申请人： Harpal S. Kumar ,  Paul Johnson ,  Michael D. Llewellyn ,  William J. Mullarkey ,  William New, Jr. ,  Laurence J. Nicolson ,  William G. O'Brien ,  John D. Place ,  Peter M. Relph

发明人： Harpal S. Kumar ,  Paul Johnson ,  Michael D. Llewellyn ,  William J. Mullarkey ,  William New, Jr. ,  Laurence J. Nicolson ,  William G. O'Brien ,  John D. Place ,  Peter M. Relph

IPC分类号： A61B500

CPC分类号： G06F19/3418 ,  A61B5/0006 ,  A61B5/0022 ,  A61B5/7232 ,  A61B2560/0209 ,  G06F19/00 ,  G16H10/65 ,  Y02A90/22 ,  Y02A90/26 ,  Y10S128/903 ,  Y10S128/904

摘要： A system and method for monitoring vital signs and capturing data from a patient remotely using radiotelemetry techniques. The system is characterized by a cordless, disposable sensor band with sensors form measuring full waveform ECG, full waveform respiration, skin temperature, and motion, and transmission circuitry for the detection and transmission of vital signs data of the patient. A small signal transfer unit that can either be worn by the patient, e.g., on his or her belt, or positioned nearby receives data from the sensor band, which it then forwards by e.g., radio transmission to a base station that can be located up to 60 meters away. The base station receives data transmissions from the signal transfer unit and is designed to connect to conventional phone lines for transferring the collected data to a remote monitoring station. The base station may also capture additional clinical data, such as blood pressure data, and to perform data checks. Patient safety is enhanced by the ability of the base station to compare clinical data, e.g., ECG, against given profiles and to mark events when appropriate or when the base station is programmed to do so. Such events are indicated to the physician and could be indicated to the patient by reverse transmission to the signal transfer unit. A remote monitoring station allows the presentation and review of data (including events) forwarded by the sensor band. ECG analysis software and a user-friendly graphical user interface are provided to remotely analyze the transmitted data and to permit system maintenance and upkeep. The system of the invention has useful application to the collection of patient clinical data during drug trials and medical testing for regulatory approvals as well as management of patients with chronic diseases.

摘要翻译： 一种用于使用无线电测量技术远程监测生命体征并从患者捕获数据的系统和方法。 该系统的特点是无绳，一次性传感器带，传感器形成测量全波形ECG，全波形呼吸，皮肤温度和运动，以及用于检测和传输患者生命体征数据的传输电路。 可以由患者穿戴的小信号传递单元，例如在他或她的皮带上，或者位于附近，从传感器带接收数据，然后传感器带通过例如无线电传输转发到可以位于上的基站 到60米远。 基站从信号传送单元接收数据传输，并被设计成连接到传统的电话线路，用于将收集的数据传送到远程监控站。 基站还可以捕获额外的临床数据，例如血压数据，并执行数据检查。 通过基站比较临床数据（例如ECG）与给定配置文件的能力以及在适当时或当基站进行编程时标记事件的能力来增强患者安全性。 向医生指示这种事件，并且可以通过向信号传送单元的反向传输向患者指示。 远程监控站允许呈现和检查由传感器带转发的数据（包括事件）。 提供ECG分析软件和用户友好的图形用户界面，以远程分析传输的数据并允许系统维护和维护。 本发明的系统可用于在药物试验期间收集患者临床数据，并进行监管批准的医疗检测以及慢性病患者的管理。

公开(公告)号：US6163030A

公开(公告)日：2000-12-19

申请号：US42485

申请日：1998-03-16

申请人： Paul Johnson ,  Brett Spivey ,  Lee Morsell ,  Peter Martin

发明人： Paul Johnson ,  Brett Spivey ,  Lee Morsell ,  Peter Martin

IPC分类号： H01L27/146 ,  G01T1/24

CPC分类号： H01L27/14687 ,  H01L27/1463 ,  H01L27/14643 ,  H01L27/14665

摘要： A solid state radiation detection unit for producing pixel data from electron-hole producing radiation using a photoelectric conversion layer. One aspect of the invention includes a photoelectric conversion layer that is deposited in direct contact with an array of doped semiconductor pixel contacts. Another aspect of the invention uses a buried field electrode formed within a photoelectric conversion layer. The two inventive concepts can be used separately or combined in a single embodiment.

摘要翻译： 一种固态放射线检测单元，用于使用光电转换层从产生电子发射的辐射产生像素数据。 本发明的一个方面包括与掺杂半导体像素触点阵列直接接触沉积的光电转换层。 本发明的另一方面使用形成在光电转换层内的掩埋场电极。 两个发明构思可以在单个实施例中单独使用或组合使用。

公开(公告)号：US6077922A

公开(公告)日：2000-06-20

申请号：US943152

申请日：1997-10-03

申请人： Paul Johnson ,  Abel Grosjean ,  Benoit Koch

发明人： Paul Johnson ,  Abel Grosjean ,  Benoit Koch

IPC分类号： C08F4/22 ,  C08F4/24 ,  C08F4/69 ,  C08F10/02 ,  C08F110/02 ,  C08F210/16

CPC分类号： C08F10/02 ,  C08F110/02

摘要： An ethylene polymer having a density greater than 959 kg/m3 and a resistance to slow cracking greater than 23 hours. A composition containing this polymer, hollow bodies obtained using at least one such ethylene polymer, and a process for the manufacture of said polymer.

摘要翻译： 密度大于959kg / m 3的乙烯聚合物和大于23小时的缓慢开裂性。 含有该聚合物的组合物，使用至少一种这样的乙烯聚合物获得的中空体，以及制造所述聚合物的方法。

公开(公告)号：US5936798A

公开(公告)日：1999-08-10

申请号：US881808

申请日：1997-05-30

申请人： Paul Johnson ,  David E. Jones

发明人： Paul Johnson ,  David E. Jones

IPC分类号： G11B33/02 ,  G11B17/02

CPC分类号： G11B33/02

摘要： A cover for a disk drive is provided. The cover comprises a body portion having a relative upper surface and relative inner surface. The upper surface defines a plurality of depressions and a window opening. The inner surface is adapted to be welded to a disk drive.

摘要翻译： 提供了一个用于磁盘驱动器的盖子。 该盖包括具有相对上表面和相对内表面的主体部分。 上表面限定多个凹陷和窗口。 内表面适于焊接到磁盘驱动器。