摘要:
A semiconductor imaging device comprising MOS or CMOS pixel circuits having pixel pads separated by insulating material and having a conductive migration blocking layer applied over the pixel pads. The conductive migration blocking layer comprises an electrically conductive material that is inert with respect to selected photoelectric conversion layer materials, and may be formed as individual contacts, or formed as a deposited layer and etched to form distinct pixels covering the underlying pixel pad material. Thereafter, a photoelectric conversion layer is applied over the migration blocking layer material. The basic device is completed by applying a field electrode layer over the photoelectric conversion layer.
摘要:
A solid state radiation detection unit for producing pixel data from electron-hole producing radiation using a photoelectric conversion layer. One aspect of the invention includes a photoelectric conversion layer that is deposited in direct contact with an array of doped semiconductor pixel contacts. Another aspect of the invention uses a buried field electrode formed within a photoelectric conversion layer. The two inventive concepts can be used separately or combined in a single embodiment.
摘要:
An imaging device for producing images from electron-hole producing radiation. Electron-hole pairs are produced in a radiation absorbing layer comprised of a photoconductive material. This layer covers an array of metal oxide semiconductor pixel circuits which are incorporated into and on a crystalline semiconductor substrate. Each pixel circuit has a charge collecting pixel electrode, a capacitor connected to the electrode to store the charges and a charge measuring transistor circuit. A voltage source provides an electric field across the radiation absorbing layer between the pixel electrodes and a radiation transparent surface electrode covering the radiation absorbing layer. A data acquisition system acquires and stores data derived from charge measurements and in a preferred embodiment a computer computes images from the data. The image may be displayed on a monitor or printed out on a printer. Preferred embodiments provide images from x-ray, ultraviolet and visible light.
摘要:
The invention provides a digital x-ray mammography device capable of imaging a full breast. A movable aperture coupled with a movable x-ray image detector permits x-ray image data to be obtained with respect to partially overlapping x-ray beam paths from an x-ray source passing through a human breast. A digital computer programmed with a stitching algorithm produces a composite image of the breast from the image data obtained with respect to each path. In a preferred embodiment, a Schmidt camera images visible light produced at an x-ray to visible light conversion surface onto a digital detector array to produce an overlapping image pane with respect to each overlapping beam path.
摘要:
This invention provides an imaging system for producing images from electromagnetic radiation such as x-rays. The system includes a detector comprised of a radiation-absorbing layer sandwiched between an array of CMOS integrated circuits (which we call pixel circuits) and a surface electrode layer transparent to the radiation. Each of the pixel circuits in the array has a charge collecting electrode. An external voltage applied between the surface electrode layer and the charge collecting electrodes produces an electric field across the thickness of the absorbing layer. Radiation passing through the transparent surface electrode layer is absorbed in the absorbing layer creating electron/hole pairs in the absorbing layer. A portion of the liberated holes (or electrons) migrates under the influence of the electric field toward the charge collecting electrodes, which collect the holes and store them as charges on small capacitors located within each circuit. This process results in a discrete distribution of stored voltages across the array proportional to the distribution of radiation photons incident on the absorbing layer. Circuitry in each pixel provides for the voltage on each pixel capacitor to be recorded via readout circuitry and permits the resetting of the pixel capacitors. Preferred embodiments provide fine resolution with a large number of pixels with dimensions about the size of the thickness of human hair.
摘要:
Methods and devices for the measurement of molecular binding interactions. Preferred embodiments provide real-time measurements of kinetic binding and disassociation of molecules including binding and disassociation of protein molecules with other protein molecules and with other molecules. In preferred embodiments ligands are immobilized within pores of a porous silicon interaction region produced in a silicon substrate, after which analytes suspended in a fluid are flowed over the porous silicon region. Binding reactions occur when analyte molecules diffuse closely enough to the ligands to become bound. Preferably the binding and subsequent disassociation reactions are observed utilizing a white light source and thin film interference techniques with spectrometers arranged to detect changes in indices of refraction in the region where the binding and disassociation reactions occur. In preferred embodiments both ligands and analytes are delivered by computer controlled robotic fluid flow control techniques to the porous silicon interaction regions through microfluidic flow channels.
摘要:
Method and device for digital x-ray tomosynthesis. Tomographic and/or three-dimensional images of an object are obtained with an x-ray source and a digital x-ray image sensor. The source, object and sensor are positioned relative to each other and attenuation data is obtained for a large number of rays of x-radiation through the object. A special algorithm is provided to convert the data into images. To calculate the images the algorithm uses iterative processes with a least squares type technique but with generalized (as opposed to specific) functions. The algorithm solves for the functions which are the images. Preferred embodiments include a system having an x-ray point source with a cone of diverging x-rays, a two-dimensional digital x-ray image sensor, two linear translation stages to independently move both the x-ray source and the digital x-ray image sensor, two rotation mechanisms to rotate the two linear translation stages, a microprocessor to control the data acquisition, and a computer programmed with a special algorithm to calculate the tomographic images. A plurality of sets of digital data (representing x-ray algorithm images of an object) are acquired by the digital x-ray image sensor, with the x-ray source and the digital x-ray image sensor located at different positions and angles relative to the object. The digital data representing the x-ray attenuation images is stored in the computer. Special mathematical algorithms then compute multiple images of the object using the acquired digital data. These images could include multiple tomographic images, a three-dimensional image, or a multiple three-dimensional images.
摘要:
Method and device for digital x-ray tomosynthesis. Tomographic and/or three-dimensional images of an object are obtained with an x-ray source and a digital x-ray image sensor. The source, object and sensor are positioned relative to each other and attenuation data is obtained for a large number of rays of x-radiation through the object. A special algorithm is provided to convert the data into images. To calculate the images the algorithm uses iterative processes with a least squares type technique but with generalized (as opposed to specific) functions. The algorithm solves for the functions which are the images. Preferred embodiments include a system having an x-ray point source with a cone of diverging x-rays, a two-dimensional digital x-ray image sensor, two linear translation stages to independently move both the x-ray source and the digital x-ray image sensor, two rotation mechanisms to rotate the two linear translation stages, a microprocessor to control the data acquisition, and a computer programmed with a special algorithm to calculate the tomographic images. A plurality of sets of digital data (representing x-ray algorithm images of an object) are acquired by the digital x-ray image sensor, with the x-ray source and the digital x-ray image sensor located at different positions and angles relative to the object. The digital data representing the x-ray attenuation images is stored in the computer. Special mathematical algorithms then compute multiple images of the object using the acquired digital data. These images could include multiple tomographic images, a three-dimensional image, or a multiple three-dimensional images.
摘要:
Methods and devices for the measurement of molecular binding interactions. Preferred embodiments provide real-time measurements of kinetic binding and disassociation of molecules including binding and disassociation of protein molecules with other protein molecules and with other molecules. In preferred embodiments ligands are immobilized within pores of a porous silicon interaction region produced in a silicon substrate, after which analytes suspended in a fluid are flowed over the porous silicon region. Binding reactions occur when analyte molecules diffuse closely enough to the ligands to become bound. Preferably the binding and subsequent disassociation reactions are observed utilizing a white light source and thin film interference techniques with spectrometers arranged to detect changes in indices of refraction in the region where the binding and disassociation reactions occur. In preferred embodiments both ligands and analytes are delivered by computer controlled robotic fluid flow control techniques to the porous silicon interaction regions through microfluidic flow channels.
摘要:
A CMOS image sensor with a many million pixel count. Applicants have developed techniques for combining its continuous layer photodiode CMOS sensor technology with CMOS integrated circuit lithography stitching techniques to provide digital cameras with an almost unlimited number of pixels. A preferred CMOS stitching technique exploits the precise alignment accuracy of CMOS stepper processes by using specialized mask sets to repeatedly produce a single pixel array pattern many times on a single silicon wafer with no pixel array discontinuities. The single array patterns are stitched together lithographically to form a pixel array of many million pixels. A continuous multilayer photodiode layer is deposited over the top of the many million pixel array to provide a many million pixel sensor with a fill factor of 100 percent or substantially 100 percent.