公开(公告)号：US20190099269A1

公开(公告)日：2019-04-04

申请号：US16202967

申请日：2018-11-28

Applicant: Edwards Lifesciences Corporation

Inventor： Ilia Hariton ,  Netanel Benichou ,  Yaacov Nitzan ,  Bella Felsen ,  Diana Nguyen-Thien-Nhon ,  Rajesh A. Khanna ,  Son V. Nguyen ,  Tamir S. Levi ,  Itai Pelled

IPC: A61F2/24 ,  A61F2/95

Abstract: A method of crimping an implantable prosthetic valve can include placing protective material over at least a portion of the implantable prosthetic valve. The protective material can be configured to occupy space between open cells of a frame of the implantable prosthetic valve to prevent damage to a leaflet structure of the implantable prosthetic valve. The method can also include crimping the implantable prosthetic valve with the protective material on the implantable prosthetic valve, and removing the protective material from between the frame and the leaflet structure of the implantable prosthetic valve.

公开(公告)号：US20160374802A1

公开(公告)日：2016-12-29

申请号：US15194375

申请日：2016-06-27

Applicant: Edwards Lifesciences Corporation

Inventor： Tamir S. Levi ,  Son V. Nguyen ,  Netanel Benichou ,  David Maimon ,  Ziv Yohanan ,  Nikolay Gurovich ,  Bella Felsen ,  Larisa Dadonkina ,  Ron Sharoni ,  Elena Sherman

IPC: A61F2/24

Abstract: Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A valve frame can have a tapered profile when mounted on a delivery shaft, with an inflow end portion having a smaller diameter than an outflow end portion. The valve can comprise generally V-shaped leaflets, reducing material within the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. A diagonally woven inner skirt can elongate axially with the frame. Side tabs of adjacent leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be depressed radially inward relative to surrounding frame portions when the valve is crimped onto a delivery shaft.

Abstract translation: 公开了径向可折叠和可扩张的假体心脏瓣膜的实施例。 当安装在输送轴上时，阀架可以具有锥形轮廓，流入端部的直径小于流出端部分的直径。 阀可以包括大致V形的小叶，在框架的流入端内还原材料。 外裙可以固定到框架的流入端部分的外部，当阀门膨胀时，外裙部具有纵向松弛，并且当阀门折叠时，外裙部平放在框架上。 对角编织的内裙可以与框架轴向伸长。 相邻小叶的侧翼可以延伸穿过并固定到框架的窗框部分以形成连合。 当阀被压接到输送轴上时，窗框部分可以相对于周围的框架部分径向向内按压。

公开(公告)号：US20140343671A1

公开(公告)日：2014-11-20

申请号：US14451264

申请日：2014-08-04

Applicant: Edwards Lifesciences Corporation

Inventor： Ziv Yohanan ,  Nikolay Gurovich ,  Bella Felsen ,  Itai Pelled ,  Oded Meiri

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2436 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/0065 ,  A61F2250/0069

Abstract: The present disclosure is directed to embodiments of catheter-based prosthetic heart valves, and in particular, prosthetic heart valves having sealing devices configured to seal the interface between the prosthetic valve and the surrounding tissue of the native annulus in which the prosthetic valve is implanted. In one embodiment, a prosthetic heart valve includes an annular sealing member that can be placed in a delivery orientation extending axially away from one end of the valve when the valve is in a radially compressed state. When the valve is expanded, the expansion of the frame causes the sealing member to be pulled to an operative orientation covering a portion of the frame. The present disclosure also discloses new mechanisms and techniques for mounting valve leaflets to a frame of a prosthetic heart valve.

Abstract translation: 本公开涉及基于导管的假体心脏瓣膜的具体实施方式，特别地，具有密封装置的假体心脏瓣膜被配置为密封假体瓣膜和植入人造瓣膜的天然环带的周围组织之间的界面。 在一个实施例中，假体心脏瓣膜包括环形密封构件，当阀处于径向压缩状态时，环形密封构件能够沿轴向远离阀的一端延伸的排放方向放置。 当阀膨胀时，框架的膨胀使得密封构件被拉到覆盖框架的一部分的操作取向。 本公开还公开了将瓣膜瓣安装到假体心脏瓣膜的框架的新机构和技术。

公开(公告)号：US20230363902A1

公开(公告)日：2023-11-16

申请号：US18223441

申请日：2023-07-18

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Ilia Hariton ,  Netanel Benichou ,  Yaacov Nitzan ,  Bella Felsen ,  Diana Nguyen-Thien-Nhon ,  Rajesh A. Khanna ,  Son V. Nguyen ,  Tamir S. Levi ,  Itai Pelled

IPC: A61F2/24 ,  A61F2/95 ,  B05B1/18 ,  E03C1/02 ,  E03C1/06

CPC classification number: A61F2/2418 ,  A61F2/2412 ,  A61F2/2433 ,  A61F2/95 ,  B05B1/185 ,  E03C1/025 ,  E03C1/066 ,  A61F2/2475 ,  Y10T29/49863 ,  A61F2220/0075 ,  A61F2220/005 ,  A61F2230/0054 ,  A61F2/9522 ,  A61F2220/0033

Abstract: An implantable prosthetic valve includes a radially collapsible and expandable annular frame having three commissure attachment portions and at least three rows of angled struts. The rows include a first row, a second row downstream of the first row, and a third row downstream of the second row. Each row of struts includes angled struts arranged in a zig-zag pattern defining a plurality of crowns. A leaflet structure includes three leaflets forming three commissures, each commissure being connected to one of the commissure attachment portions via sutures extending through apertures in the commissure attachment portions, wherein all of the apertures are located along the length of the frame between a first plane defined by the crowns of the second row of struts and a second plane defined by the crowns of the third row of struts.

公开(公告)号：US11793632B2

公开(公告)日：2023-10-24

申请号：US16516089

申请日：2019-07-18

Applicant: Edwards Lifesciences Corporation

Inventor： Tamir S. Levi ,  Son V. Nguyen ,  Netanel Benichou ,  David Maimon ,  Ziv Yohanan ,  Nikolay Gurovich ,  Bella Felsen ,  Larisa Dadonkina ,  Ron Sharoni ,  Elena Sherman

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2412 ,  A61F2/2433 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/0036 ,  A61F2250/0097

Abstract: Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A valve frame can have a tapered profile when mounted on a delivery shaft, with an inflow end portion having a smaller diameter than an outflow end portion. The valve can comprise generally V-shaped leaflets, reducing material within the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. A diagonally woven inner skirt can elongate axially with the frame. Side tabs of adjacent leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be depressed radially inward relative to surrounding frame portions when the valve is crimped onto a delivery shaft.

公开(公告)号：US11759320B2

公开(公告)日：2023-09-19

申请号：US17710836

申请日：2022-03-31

Applicant: Edwards Lifesciences Corporation

Inventor： Tamir S. Levi ,  Son V. Nguyen ,  Netanel Benichou ,  David Maimon ,  Ziv Yohanan ,  Nikolay Gurovich ,  Bella Felsen ,  Larisa Dadonkina ,  Ron Sharoni ,  Elena Sherman

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2412 ,  A61F2/2433 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/0036 ,  A61F2250/0097

Abstract: Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A valve frame can have a tapered profile when mounted on a delivery shaft, with an inflow end portion having a smaller diameter than an outflow end portion. The valve can comprise generally V-shaped leaflets, reducing material within the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. A diagonally woven inner skirt can elongate axially with the frame. Side tabs of adjacent leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be depressed radially inward relative to surrounding frame portions when the valve is crimped onto a delivery shaft.

公开(公告)号：US11744701B2

公开(公告)日：2023-09-05

申请号：US17018258

申请日：2020-09-11

Applicant: Edwards Lifesciences Corporation

Inventor： Ilia Hariton ,  Netanel Benichou ,  Yaacov Nitzan ,  Bella Felsen ,  Diana Nguyen-Thien-Nhon ,  Rajesh A. Khanna ,  Son V. Nguyen ,  Tamir S. Levi ,  Itai Pelled

IPC: A61F2/24 ,  A61F2/95 ,  B05B1/18 ,  E03C1/02 ,  E03C1/06

CPC classification number: A61F2/2418 ,  A61F2/2412 ,  A61F2/2433 ,  A61F2/2475 ,  A61F2/95 ,  B05B1/185 ,  E03C1/025 ,  E03C1/066 ,  A61F2/9522 ,  A61F2220/005 ,  A61F2220/0033 ,  A61F2220/0075 ,  A61F2230/0054 ,  Y10T29/49863

Abstract: A prosthetic heart valve comprises a radially collapsible and expandable annular frame and a leaflet structure comprising three leaflets. Each leaflet has an upper edge portion, a curved lower edge portion and two side flaps, wherein each side flap is connected to an adjacent side flap of another leaflet to form commissures of the leaflet structure, with each commissure being attached to the frame. An annular inner sleeve comprises three U-shaped portions positioned along the curved lower edge portions of the leaflets. An annular outer sleeve extends around are outer surface of the frame, wherein the outer sleeve is made of pericardium. The frame is made of Nitinol and the prosthetic valve can be radially crimped to a radially collapsed configuration inside a sheath for delivery into a patient's body and self-expand to a radially expanded configuration when released from the sheath inside the patient's body.

公开(公告)号：US11696826B2

公开(公告)日：2023-07-11

申请号：US17704660

申请日：2022-03-25

Applicant: Edwards Lifesciences Corporation

Inventor： Ilia Hariton ,  Netanel Benichou ,  Yaacov Nitzan ,  Bella Felsen ,  Diana Nguyen-Thien-Nhon ,  Rajesh A. Khanna ,  Son V. Nguyen ,  Tamir S. Levi ,  Itai Pelled

IPC: A61F2/24 ,  A61F2/95 ,  B05B1/18 ,  E03C1/02 ,  E03C1/06

CPC classification number: A61F2/2418 ,  A61F2/2412 ,  A61F2/2433 ,  A61F2/2475 ,  A61F2/95 ,  B05B1/185 ,  E03C1/025 ,  E03C1/066 ,  A61F2/9522 ,  A61F2220/005 ,  A61F2220/0033 ,  A61F2220/0075 ,  A61F2230/0054 ,  Y10T29/49863

Abstract: An implantable prosthetic valve includes a radially collapsible and expandable annular frame having three commissure attachment posts and four rows of circumferential struts. The rows include a first row, a second row downstream of the first row, a third row downstream of the second row, and a fourth row downstream of the third row and defining an outflow end of the frame. Each row of circumferential struts includes angled struts arranged in a zig-zag pattern. A leaflet structure includes three leaflets forming three commissures, each commissure being connected to one of the commissure attachment posts only at locations along the commissure attachment posts between a first plane that is perpendicular to a longitudinal axis of the frame and intersects crowns of the third row of struts and a second plane that is perpendicular to the longitudinal axis and intersects crowns of the fourth row of struts.

公开(公告)号：US20220226111A1

公开(公告)日：2022-07-21

申请号：US17710836

申请日：2022-03-31

Applicant: Edwards Lifesciences Corporation

Inventor： Tamir S. Levi ,  Son V. Nguyen ,  Netanel Benichou ,  David Maimon ,  Ziv Yohanan ,  Nikolay Gurovich ,  Bella Felsen ,  Larisa Dadonkina ,  Ron Sharoni ,  Elena Sherman

IPC: A61F2/24

Abstract: Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A valve frame can have a tapered profile when mounted on a delivery shaft, with an inflow end portion having a smaller diameter than an outflow end portion. The valve can comprise generally V-shaped leaflets, reducing material within the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. A diagonally woven inner skirt can elongate axially with the frame. Side tabs of adjacent leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be depressed radially inward relative to surrounding frame portions when the valve is crimped onto a delivery shaft.

公开(公告)号：US20210236279A1

公开(公告)日：2021-08-05

申请号：US17235230

申请日：2021-04-20

Applicant: Edwards Lifesciences Corporation

Inventor： Ziv Yohanan ,  Nikolay Gurovich ,  Bella Felsen ,  Itai Pelled ,  Oded Meiri

IPC: A61F2/24

Abstract: A prosthetic heart valve includes a collapsible and expandable annular frame. The frame includes a plurality of rows of hexagonal cells. Each of the hexagonal cells is defined by six struts, including: two opposing side struts extending parallel to each other, a first pair of angled struts extending from respective first ends of the side struts and converging to intersect with each other, and a second pair of angled struts extending from respective second ends of the side struts and converging to intersect with each other. The prosthetic heart valve can also include a valvular structure with a plurality of leaflets. The prosthetic heart valve can further include a sealing member.