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公开(公告)号：US20240285402A1
公开(公告)日：2024-08-29
申请号：US18656808
申请日：2024-05-07
发明人： Tamir S. Levi
CPC分类号： A61F2/2427 , A61F2/95 , A61M25/0113 , A61M25/013 , A61B2017/00469 , A61M25/09041 , A61M2025/09116
摘要： In one representative embodiment, a gripping and pushing device for a medical instrument comprises an elongated main body defining a lumen. The elongated main body comprises one or more deflectable portions that can be pressed radially inwardly toward a shaft of the medical instrument extending through the lumen. One or more elastomeric gripping layers can be secured to the inner surface of a respective deflectable portion at axially spaced apart attachment locations. The one or more gripping layers are axially deformable relative to the one or more deflectable portions between the attachment locations when manual pressure is applied to the one or more deflectable portions to press the one or more gripping layers against the shaft and move the shaft longitudinally into a patient's body.
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公开(公告)号：US20240173123A1
公开(公告)日：2024-05-30
申请号：US18433626
申请日：2024-02-06
发明人： Noam Nir , Elena Sherman , Tamir S. Levi , Michael Bukin
CPC分类号： A61F2/2415 , A61F2/2418 , B29C65/62 , B29C66/1142 , A61F2220/0075 , A61F2240/001 , B29L2031/7534
摘要： Assembly methods for installing a leaflet assembly to an expandable frame of a prosthetic heart valve are described. The leaflet assembly comprises a plurality of leaflets coupled together at adjacent tabs, which form respective commissure tab assemblies. The commissure tab assemblies are inserted into corresponding windows of support members of the expandable frame. One or more wedge members are inserted into the commissure tab assembly, e.g., between the adjacent tabs or with the adjacent tabs therebetween, to restrain radial motion of the commissure tab assembly with respect to the window. The window can be a closed window, and the wedge member insertion can be after the commissure tab assembly is inserted into the window. Alternatively, the window can be an open window or channel, and the wedge member insertion can be before the commissure tab assembly is installed in the window.
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公开(公告)号：US11969340B2
公开(公告)日：2024-04-30
申请号：US17706419
申请日：2022-03-28
发明人： Tamir S. Levi
IPC分类号： A61F2/24
CPC分类号： A61F2/2418
摘要： Prosthetic devices and frames for implantation at a cardiac valve annulus are provided that include an annular frame (having an inflow end and an outflow end) and a plurality of axial frame members that bridge two circumferentially extending rows of angled struts. The axial frame members can include a plurality of axially extending leaflet attachment members and a plurality of axial struts in a 1:1 ratio. Along each of the two rows, the frame can have at least three angled struts between adjacent axial frame members.
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公开(公告)号：US11969338B2
公开(公告)日：2024-04-30
申请号：US17229143
申请日：2021-04-13
发明人： Tamir S. Levi
CPC分类号： A61F2/2409 , A61F2/2415 , A61F2/2418 , A61L27/3625 , A61L27/50 , A61L27/56 , A61F2/2427 , A61F2230/0054 , A61F2240/001 , A61F2250/0063 , A61F2250/0069 , A61L2430/20
摘要： In one embodiment, a method of manufacturing a prosthetic heart valve can comprise providing a piece of pericardial tissue comprising a fibrous parietal layer and a serous parietal layer. The method can further comprise reducing the thickness of the piece of pericardial tissue by removing a portion of the serous parietal layer, the fibrous parietal layer defining a first surface of the piece of pericardial tissue and the serous parietal layer defining a second surface of the piece of pericardial tissue. The method can further comprise positioning the pericardial tissue around an outer surface of a frame of the prosthetic heart valve and securing it thereto such that the first surface is facing away from the frame and the second surface is facing towards the frame.
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公开(公告)号：US20240024099A1
公开(公告)日：2024-01-25
申请号：US18234865
申请日：2023-08-16
发明人： Tamir S. Levi , Son V. Nguyen , Netanel Benichou , David Maimon , Ziv Yohanan , Nikolai Gurovich , Bella Felsen , Larisa Dadonkina , Ron Sharoni , Elena Sherman
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2433 , A61F2/2412 , A61F2220/0075 , A61F2250/0097 , A61F2230/0054 , A61F2250/0036
摘要： Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A prosthetic heart valve includes a valve structure and a frame. The valve structure includes a plurality of leaflets, and the leaflets are configured to move from an open configuration to a closed configuration. The valve structure is coupled to the frame. The frame includes an inflow end, an outflow end, a longitudinal axis extending from the inflow end to the outflow end, and a plurality of struts forming a plurality of rows of cells. Each row of cells extends in a circumferential direction perpendicular to the longitudinal axis. Adjacent cells in a row of cell are coupled together at a junction of the struts defining the adjacent cells, and at least one junction in one row of cells has a shape that is different than at least one other junction of the one row of cells.
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公开(公告)号：US20230355378A1
公开(公告)日：2023-11-09
申请号：US18222923
申请日：2023-07-17
发明人： Hanoch Cohen-Tzemach , Tamir S. Levi , Noam Nir , Bella Felsen
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2210/0014 , A61F2220/0075 , A61F2230/0017 , A61F2230/0026 , A61F2230/0069 , A61F2250/0069 , A61F2250/0098
摘要： Embodiments of a prosthetic heart valve are disclosed. An implantable prosthetic valve may be radially collapsible to a collapsed configuration and radially expandable to an expanded configuration. The prosthetic valve may comprise an annular frame, a leaflet structure positioned within the frame and a plurality of outer skirts positioned around an outer surface of the frame, each outer skirt comprising an inflow edge secured to the frame and an outflow edge secured at intervals to the frame. The plurality of outer skirts may include a first outer skirt and a second outer skirt, wherein in the expanded configuration the first and second outer skirts include openings unsecured to the frame between the intervals. The inflow edge of the first annular outer skirt may be secured to the frame with sutures including radiopaque material. The first annular outer skirt may include radiopaque dye.
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公开(公告)号：US11806234B2
公开(公告)日：2023-11-07
申请号：US17659169
申请日：2022-04-13
发明人： Nikolai Gurovich , Michael Bukin , Elena Sherman , Tamir S. Levi , Ziv Yohanan , Gil Senesh , Dikla Kersh , Alexey Tsypenyuk , Waina Michelle Chu , Alexander Barash
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2433 , A61F2/2412 , A61F2/90 , A61F2220/0075 , A61F2230/0023 , A61F2230/0052 , A61F2250/0003 , A61F2250/0039 , A61F2250/0069 , A61F2310/00017 , A61F2310/00029 , A61F2310/00059
摘要： A system can include a delivery catheter comprising a balloon and an implantable prosthetic heart valve. The prosthetic valve can have a plastically expandable and compressible unitary frame comprising a plurality of circumferentially extending rows of angled struts, including first, second, and third rows of angled struts forming rows of diamond-shaped cells, and a valvular structure comprising a plurality of leaflets. A cusp edge portion of each leaflet is connected to the frame by a skirt that is disposed between the frame and the cusp edge portions, the skirt being sutured to selected struts of the frame along diagonal paths extending from an inflow end portion toward an outflow end portion. Each diagonal path along which the skirt is sutured to the frame extends along the first, second, and third rows of angled struts.
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公开(公告)号：US11666436B2
公开(公告)日：2023-06-06
申请号：US16415590
申请日：2019-05-17
发明人： David Maimon , Ron Sharoni , Tamir S. Levi , Emil Karapetian , Tri D. Tran , Tung Le
IPC分类号： B21D41/04 , B21D41/00 , A61F2/24 , A61B50/30 , A61B17/06 , B23P11/00 , A61F2/00 , B25B27/10 , B23P19/04 , A61F2/95
CPC分类号： A61F2/2427 , A61B17/06 , A61B50/30 , A61F2/0095 , A61F2/243 , A61F2/2433 , B21D41/00 , B21D41/04 , B23P11/00 , B23P19/04 , B25B27/10 , A61F2/9522 , Y10T29/5367 , Y10T29/53552 , Y10T29/53578
摘要： A device for crimping a radially expandable and collapsible prosthetic valve comprises a crimping loop having a first end portion, a second end portion, and a loop portion extending between the first and second end portions and defining an opening configured to receive the prosthetic valve. The crimping loop is movable between a first state in which the opening has a first diameter and a second state in which the opening has a second diameter smaller than the first diameter such that when the prosthetic valve is positioned within the loop portion, movement of the crimping loop from the first state to the second state is effective to reduce a diameter of the prosthetic valve. A method for crimping a prosthetic valve comprises reducing a diameter of an opening of a crimping loop, thereby radially compressing an at least partially expanded prosthetic valve disposed within the opening.
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公开(公告)号：US11666434B2
公开(公告)日：2023-06-06
申请号：US17658584
申请日：2022-04-08
发明人： Ziv Yohanan , Tamir S. Levi , Netanel Benichou , Michael Bukin , Nikolai Gurovich , Elena Sherman
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2/2433 , A61F2220/0075 , A61F2230/0013 , A61F2230/0054 , A61F2250/0036 , A61F2250/0039
摘要： A method of implanting a prosthetic heart valve within a patient can comprise inserting a distal end portion of a delivery apparatus and a prosthetic heart valve into the patient and advancing the prosthetic heart valve to a deployment location within the heart of the patient and inflating one or more of a plurality of differently-sized balloons in a balloon-assembly on the distal end portion of the delivery apparatus. The prosthetic heart valve can be mounted on the balloon assembly in a crimped state and the inflating of the one or more of the plurality of differently-sized balloons can expand the prosthetic heart valve from the crimped state to a radially expanded state having a non-cylindrical shape.
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公开(公告)号：US20230165677A1
公开(公告)日：2023-06-01
申请号：US17891928
申请日：2022-08-19
发明人： Ilia Hariton , Netanel Benichou , Yaacov Nitzan , Bella Felsen , Diana Nguyen-Thien-Nhon , Rajesh A. Khanna , Son V. Nguyen , Tamir S. Levi , Itai Pelled
CPC分类号： A61F2/2418 , A61F2/2412 , A61F2/2433 , A61F2/2475 , A61F2/95 , B05B1/185 , E03C1/066 , E03C1/025 , Y10T29/49863 , A61F2/9522 , A61F2220/005 , A61F2220/0033 , A61F2220/0075 , A61F2230/0054
摘要： An implantable prosthetic valve includes a radially collapsible and expandable annular frame having three commissure attachment posts and four rows of circumferential struts. The rows include a first row, a second row downstream of the first row, a third row downstream of the second row, and a fourth row downstream of the third row and defining an outflow end of the frame. Each row of circumferential struts includes angled struts arranged in a zig-zag pattern. A leaflet structure includes three leaflets forming three commissures, each commissure being connected to one of the commissure attachment posts only at locations along the commissure attachment posts between a first plane that is perpendicular to a longitudinal axis of the frame and intersects crowns of the third row of struts and a second plane that is perpendicular to the longitudinal axis and intersects crowns of the fourth row of struts.
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