公开(公告)号：US20250025293A1

公开(公告)日：2025-01-23

申请号：US18907065

申请日：2024-10-04

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Taylor Jacob Scheinblum ,  Mindy Lee Ann Black ,  Tamir S. Levi ,  Evan T. Schwartz ,  Waina Michelle Chu ,  Linda Thai ,  Hanoch Cohen-Tzemach ,  Michael Bukin

IPC: A61F2/24 ,  A61F2/95 ,  B25B27/02

Abstract: Embodiments are provided of an assembly having a prosthetic valve, the prosthetic valve having a radially expandable and compressible annular frame, and a crimping accessory device, and methods for using the assembly in compressing the prosthetic valve. The frame includes an outer surface and an inner surface. A leaflet assembly is supported inside the annular frame. The leaflet assembly includes a plurality of leaflets, each having an inner surface and an outer surface. The crimping accessory device has a plurality of axially-extending fingers. At least a first finger of the plurality of fingers is disposed between the outer surface of a first leaflet of the plurality of leaflets, and at least a second finger of the plurality of fingers is disposed radially-inwardly of the inner surface of the first leaflet.

公开(公告)号：US20250009506A1

公开(公告)日：2025-01-09

申请号：US18888516

申请日：2024-09-18

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： David Maimon ,  Michael R. Bialas ,  Mindy Lee Ann Black ,  Tamir S. Levi ,  Linda Thai ,  Yidong M. Zhu

IPC: A61F2/24 ,  A61F2/958

Abstract: Disclosed herein are embodiments of a balloon shaped to have one or more enlarged regions to selectively increase expansion forces on an implant. For example, the balloon may have a central portion that is enlarged to exert more force on the center of a stent-mounted prosthetic heart valve. This overcomes the stent-mounted prosthetic heart valve's tendency to expand with flared ends. This forms a more cylindrical or barrel shaped stent frame during expansion of the balloon—reducing or eliminating the instance wherein the cylindrical stent frame has flared ends. Alternatively, the balloon may have conical flares placed to cause or enhance flared ends of the cylindrical implant to enhance its anchoring capabilities.

公开(公告)号：US20240423793A1

公开(公告)日：2024-12-26

申请号：US18827555

申请日：2024-09-06

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Dikla Kersh ,  Michael Bukin ,  Tamir S. Levi ,  Noam Nir

IPC: A61F2/24

Abstract: A prosthetic valve assembly includes a radially expandable and compressible annular frame. The frame includes a plurality of interconnected struts, which include a plurality of inner struts and a plurality of outer struts. The inner struts overlap adjacent outer struts at a plurality of pivot joints. Radial expansion or compression of the annular frame causes the inner struts to pivot relative to the outer struts at the pivot joints. The assembly also includes a valvular structure having a plurality of leaflets, each leaflet having a cusp edge portion. The assembly further includes one or more leaflet-supporting cords, each having a plurality of anchoring portions and a plurality of suspended portions, each suspended portion extending between two adjacent anchoring portions. The anchoring portions are affixed to respective anchoring features of the frame adjacent the pivot joints. The cusp edge portions of the leaflets are connected to the suspended portions.

公开(公告)号：US20240285402A1

公开(公告)日：2024-08-29

申请号：US18656808

申请日：2024-05-07

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Tamir S. Levi

IPC: A61F2/24 ,  A61B17/00 ,  A61F2/95 ,  A61M25/01 ,  A61M25/09

CPC classification number: A61F2/2427 ,  A61F2/95 ,  A61M25/0113 ,  A61M25/013 ,  A61B2017/00469 ,  A61M25/09041 ,  A61M2025/09116

Abstract: In one representative embodiment, a gripping and pushing device for a medical instrument comprises an elongated main body defining a lumen. The elongated main body comprises one or more deflectable portions that can be pressed radially inwardly toward a shaft of the medical instrument extending through the lumen. One or more elastomeric gripping layers can be secured to the inner surface of a respective deflectable portion at axially spaced apart attachment locations. The one or more gripping layers are axially deformable relative to the one or more deflectable portions between the attachment locations when manual pressure is applied to the one or more deflectable portions to press the one or more gripping layers against the shaft and move the shaft longitudinally into a patient's body.

公开(公告)号：US20240173123A1

公开(公告)日：2024-05-30

申请号：US18433626

申请日：2024-02-06

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Noam Nir ,  Elena Sherman ,  Tamir S. Levi ,  Michael Bukin

IPC: A61F2/24 ,  B29C65/00 ,  B29C65/62 ,  B29L31/00

CPC classification number: A61F2/2415 ,  A61F2/2418 ,  B29C65/62 ,  B29C66/1142 ,  A61F2220/0075 ,  A61F2240/001 ,  B29L2031/7534

Abstract: Assembly methods for installing a leaflet assembly to an expandable frame of a prosthetic heart valve are described. The leaflet assembly comprises a plurality of leaflets coupled together at adjacent tabs, which form respective commissure tab assemblies. The commissure tab assemblies are inserted into corresponding windows of support members of the expandable frame. One or more wedge members are inserted into the commissure tab assembly, e.g., between the adjacent tabs or with the adjacent tabs therebetween, to restrain radial motion of the commissure tab assembly with respect to the window. The window can be a closed window, and the wedge member insertion can be after the commissure tab assembly is inserted into the window. Alternatively, the window can be an open window or channel, and the wedge member insertion can be before the commissure tab assembly is installed in the window.

公开(公告)号：US11969340B2

公开(公告)日：2024-04-30

申请号：US17706419

申请日：2022-03-28

Applicant: Edwards Lifesciences Corporation

Inventor： Tamir S. Levi

IPC: A61F2/24

CPC classification number: A61F2/2418

Abstract: Prosthetic devices and frames for implantation at a cardiac valve annulus are provided that include an annular frame (having an inflow end and an outflow end) and a plurality of axial frame members that bridge two circumferentially extending rows of angled struts. The axial frame members can include a plurality of axially extending leaflet attachment members and a plurality of axial struts in a 1:1 ratio. Along each of the two rows, the frame can have at least three angled struts between adjacent axial frame members.

公开(公告)号：US11969338B2

公开(公告)日：2024-04-30

申请号：US17229143

申请日：2021-04-13

Applicant: Edwards Lifesciences Corporation

Inventor： Tamir S. Levi

IPC: A61F2/24 ,  A61L27/36 ,  A61L27/50 ,  A61L27/56

CPC classification number: A61F2/2409 ,  A61F2/2415 ,  A61F2/2418 ,  A61L27/3625 ,  A61L27/50 ,  A61L27/56 ,  A61F2/2427 ,  A61F2230/0054 ,  A61F2240/001 ,  A61F2250/0063 ,  A61F2250/0069 ,  A61L2430/20

Abstract: In one embodiment, a method of manufacturing a prosthetic heart valve can comprise providing a piece of pericardial tissue comprising a fibrous parietal layer and a serous parietal layer. The method can further comprise reducing the thickness of the piece of pericardial tissue by removing a portion of the serous parietal layer, the fibrous parietal layer defining a first surface of the piece of pericardial tissue and the serous parietal layer defining a second surface of the piece of pericardial tissue. The method can further comprise positioning the pericardial tissue around an outer surface of a frame of the prosthetic heart valve and securing it thereto such that the first surface is facing away from the frame and the second surface is facing towards the frame.

公开(公告)号：US20240024099A1

公开(公告)日：2024-01-25

申请号：US18234865

申请日：2023-08-16

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Tamir S. Levi ,  Son V. Nguyen ,  Netanel Benichou ,  David Maimon ,  Ziv Yohanan ,  Nikolai Gurovich ,  Bella Felsen ,  Larisa Dadonkina ,  Ron Sharoni ,  Elena Sherman

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2433 ,  A61F2/2412 ,  A61F2220/0075 ,  A61F2250/0097 ,  A61F2230/0054 ,  A61F2250/0036

Abstract: Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A prosthetic heart valve includes a valve structure and a frame. The valve structure includes a plurality of leaflets, and the leaflets are configured to move from an open configuration to a closed configuration. The valve structure is coupled to the frame. The frame includes an inflow end, an outflow end, a longitudinal axis extending from the inflow end to the outflow end, and a plurality of struts forming a plurality of rows of cells. Each row of cells extends in a circumferential direction perpendicular to the longitudinal axis. Adjacent cells in a row of cell are coupled together at a junction of the struts defining the adjacent cells, and at least one junction in one row of cells has a shape that is different than at least one other junction of the one row of cells.

公开(公告)号：US20230355378A1

公开(公告)日：2023-11-09

申请号：US18222923

申请日：2023-07-17

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Hanoch Cohen-Tzemach ,  Tamir S. Levi ,  Noam Nir ,  Bella Felsen

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2210/0014 ,  A61F2220/0075 ,  A61F2230/0017 ,  A61F2230/0026 ,  A61F2230/0069 ,  A61F2250/0069 ,  A61F2250/0098

Abstract: Embodiments of a prosthetic heart valve are disclosed. An implantable prosthetic valve may be radially collapsible to a collapsed configuration and radially expandable to an expanded configuration. The prosthetic valve may comprise an annular frame, a leaflet structure positioned within the frame and a plurality of outer skirts positioned around an outer surface of the frame, each outer skirt comprising an inflow edge secured to the frame and an outflow edge secured at intervals to the frame. The plurality of outer skirts may include a first outer skirt and a second outer skirt, wherein in the expanded configuration the first and second outer skirts include openings unsecured to the frame between the intervals. The inflow edge of the first annular outer skirt may be secured to the frame with sutures including radiopaque material. The first annular outer skirt may include radiopaque dye.

公开(公告)号：US11806234B2

公开(公告)日：2023-11-07

申请号：US17659169

申请日：2022-04-13

Applicant: Edwards Lifesciences Corporation

Inventor： Nikolai Gurovich ,  Michael Bukin ,  Elena Sherman ,  Tamir S. Levi ,  Ziv Yohanan ,  Gil Senesh ,  Dikla Kersh ,  Alexey Tsypenyuk ,  Waina Michelle Chu ,  Alexander Barash

IPC: A61F2/24 ,  A61F2/90

CPC classification number: A61F2/2418 ,  A61F2/2409 ,  A61F2/2433 ,  A61F2/2412 ,  A61F2/90 ,  A61F2220/0075 ,  A61F2230/0023 ,  A61F2230/0052 ,  A61F2250/0003 ,  A61F2250/0039 ,  A61F2250/0069 ,  A61F2310/00017 ,  A61F2310/00029 ,  A61F2310/00059

Abstract: A system can include a delivery catheter comprising a balloon and an implantable prosthetic heart valve. The prosthetic valve can have a plastically expandable and compressible unitary frame comprising a plurality of circumferentially extending rows of angled struts, including first, second, and third rows of angled struts forming rows of diamond-shaped cells, and a valvular structure comprising a plurality of leaflets. A cusp edge portion of each leaflet is connected to the frame by a skirt that is disposed between the frame and the cusp edge portions, the skirt being sutured to selected struts of the frame along diagonal paths extending from an inflow end portion toward an outflow end portion. Each diagonal path along which the skirt is sutured to the frame extends along the first, second, and third rows of angled struts.