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公开(公告)号:US20200069426A1
公开(公告)日:2020-03-05
申请号:US16549957
申请日:2019-08-23
Applicant: Edwards Lifesciences Corporation
Inventor: Brian S. Conklin , Maria L. Saravia , Adam J. Yestrepsky , Derrick Johnson , Rodolfo Rodriguez , Sai Prasad Uppalapati , Louis A. Campbell
IPC: A61F2/24
Abstract: Systems, apparatuses, and methods disclosed herein are provided for medical treatment, including transcatheter medical treatments and/or for treatment of dilated hearts (e.g., dilated left ventricle) or functional mitral valve regurgitation within a human heart. The systems, apparatuses, and methods disclosed herein may include applying one or more heart splints to the patient's heart to apply pressure to the heart to reshape the heart. Anchors disclosed herein may be utilized in plugs for treating openings in a septum between two chambers of a heart, e.g., ventricular septal defects (VSD), atrial septal defects (ASD), and patent foramen ovale (PFO). In addition, the anchors disclosed herein may be utilized to reshape an annulus of a patient's heart valve, including a tricuspid valve of a patient's heart. The anchors disclosed herein may also be utilized to reposition a heart valve leaflet to reduce heart valve leaflet prolapse.
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公开(公告)号:US20200060816A1
公开(公告)日:2020-02-27
申请号:US16666348
申请日:2019-10-28
Applicant: Edwards Lifesciences Corporation
Inventor: Louis A. Campbell , Donald E. Bobo, JR. , Gregory A. Wright , Tak G. Cheung
Abstract: A valved conduit including a bioprosthetic valve, such as a heart valve, and a tubular conduit sealed with a bioresorbable material. The bioprosthetic heart valve includes prosthetic tissue that has been treated such that the tissue may be stored dry for extended periods without degradation of functionality of the valve. The bioprosthetic heart valve may have separate bovine pericardial leaflets or a whole porcine valve. The sealed conduit includes a tubular matrix impregnated with a bioresorbable medium such as gelatin or collagen. The valved conduit is stored dry in packaging in which a desiccant pouch is supplied having a capacity for absorbing moisture within the packaging limited to avoid drying the bioprosthetic tissue out beyond a point where its ability to function in the bioprosthetic heart valve is compromised. The heart valve may be sewn within the sealed conduit or coupled thereto with a snap-fit connection.
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公开(公告)号:US10555810B2
公开(公告)日:2020-02-11
申请号:US15905625
申请日:2018-02-26
Applicant: Edwards Lifesciences Corporation
Inventor: Rafael Pintor , Mark Chau , Travis Zenyo Oba , August R. Yambao , Louis A. Campbell , Tammy Huntley , Qinggang Zeng , Carey L. Cristea , Faisal Kalam
IPC: A61F2/24
Abstract: A quick-connect heart valve prosthesis that can be quickly and easily implanted is provided. The heart valve includes a substantially non-expandable, non-compressible prosthetic valve and a plastically-expandable coupling stent, thereby enabling attachment to the annulus without sutures. A small number of guide sutures may be provided for aortic valve orientation. The prosthetic valve may be a commercially available valve with a sewing ring with the coupling stent attached thereto. The coupling stent may expand from a conical deployment shape to a conical expanded shape, and may include web-like struts connected between axially-extending posts. A system and method for deployment includes a hollow two-piece handle through which a balloon catheter passes. A valve holder is stored with the heart valve and the handle easily attaches thereto to improve valve preparation steps.
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公开(公告)号:US20200000586A1
公开(公告)日:2020-01-02
申请号:US16570797
申请日:2019-09-13
Applicant: Edwards Lifesciences Corporation
Inventor: Bin Tian , Rodolfo Rodriguez , Louis A. Campbell , Steven M. Claessens , Carolyn Sue Martinez
IPC: A61F2/24
Abstract: Systems, devices, kits, and methods are described for securing a bioprosthetic heart valve within an anatomical feature of a patient. Kits can comprise a bioprosthetic heart valve, a curable composition, and an applicator configured to deliver the curable composition to a target area. The bioprosthetic heart valve can comprise a support structure and one or more valve leaflets coupled thereto. The support structure can comprise a sewing portion peripheral of the bioprosthetic heart valve. The support structure and the valve leaflets can define a central flow orifice. The curable composition can comprise a pre-polymer composition and an initiator. Methods can comprise positioning the bioprosthetic heart valve within the anatomical feature of a patient, applying the curable composition to one or both of the bioprosthetic heart valve and the anatomical feature, and curing the curable composition for a cure time. The applying can be performed before or after the positioning.
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公开(公告)号:US10231646B2
公开(公告)日:2019-03-19
申请号:US15462386
申请日:2017-03-17
Applicant: Edwards Lifesciences Corporation
Inventor: Louis A. Campbell , Travis Zenyo Oba , Rafael Pintor
Abstract: A device for measuring an expanded internal orifice of a patient includes an orifice-expanding device, a pressure measuring device, and a size-measuring device. The size-measuring device measures a dimension of the orifice after it has been expanded by the orifice-expanding device.
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公开(公告)号:US20190069999A1
公开(公告)日:2019-03-07
申请号:US16184234
申请日:2018-11-08
Applicant: Edwards Lifesciences Corporation
Inventor: Louis A. Campbell , Donald E. Bobo, JR. , Gregory A. Wright , Tak G. Cheung
CPC classification number: A61F2/2418 , A61F2/0095 , A61F2/06 , A61F2/2409 , A61F2/2412 , A61F2/2415 , A61F2/2427 , A61F2210/0004 , A61F2220/0075 , A61F2310/00371 , A61F2310/00383 , A61L27/222 , A61L27/24 , A61L27/3625 , A61L27/3687 , A61L27/507 , A61L2430/20 , A61L2430/40
Abstract: A valved conduit including a bioprosthetic valve, such as a heart valve, and a tubular conduit sealed with a bioresorbable material. The bioprosthetic heart valve includes prosthetic tissue that has been treated such that the tissue may be stored dry for extended periods without degradation of functionality of the valve. The bioprosthetic heart valve may have separate bovine pericardial leaflets or a whole porcine valve. The sealed conduit includes a tubular matrix impregnated with a bioresorbable medium such as gelatin or collagen. The valved conduit is stored dry in packaging in which a desiccant pouch is supplied having a capacity for absorbing moisture within the packaging limited to avoid drying the bioprosthetic tissue out beyond a point where its ability to function in the bioprosthetic heart valve is compromised. The heart valve may be sewn within the sealed conduit or coupled thereto with a snap-fit connection.
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公开(公告)号:US20170281337A1
公开(公告)日:2017-10-05
申请号:US15494239
申请日:2017-04-21
Applicant: Edwards Lifesciences Corporation
Inventor: Louis A. Campbell
IPC: A61F2/24
CPC classification number: A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2/2433 , A61F2/2448 , A61F2210/0014 , A61F2220/0025 , A61F2230/0054 , A61F2250/006 , A61F2250/0063 , A61F2250/0096
Abstract: A spacer for creating a docking station for a transcatheter heart valve is provided. The spacer changes an effective diameter and/or a shape of an implanted bioprosthetic structure such as a bioprosthetic heart valve or annuloplasty ring, providing a supporting structure into which the transcatheter valve expands without over expanding. The spacer may be deployed through an interventional technique either through transseptal access, transfemoral access, or transapical access and is typically deployed at least in part on an inflow portion of the implanted bioprosthetic structure.
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公开(公告)号:US20170188889A1
公开(公告)日:2017-07-06
申请号:US15462386
申请日:2017-03-17
Applicant: Edwards Lifesciences Corporation
Inventor: Louis A. Campbell , Travis Zenyo Oba , Rafael Pintor
CPC classification number: A61B5/1076 , A61B5/6853 , A61B5/6858 , A61B5/6885 , A61B90/08 , A61B2090/061 , A61B2090/064 , A61B2090/0811 , A61F2/2496
Abstract: A device for measuring an expanded internal orifice of a patient includes an orifice- expanding device, a pressure measuring device, and a size-measuring device. The size- measuring device measures a dimension of the orifice after it has been expanded by the orifice-expanding device.
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公开(公告)号:US09603553B2
公开(公告)日:2017-03-28
申请号:US13762232
申请日:2013-02-07
Applicant: Edwards Lifesciences Corporation
Inventor: Louis A. Campbell , Travis Zenyo Oba , Rafael Pintor
CPC classification number: A61B5/1076 , A61B5/6853 , A61B5/6858 , A61B5/6885 , A61B90/08 , A61B2090/061 , A61B2090/064 , A61B2090/0811 , A61F2/2496
Abstract: A device for measuring an expanded internal orifice of a patient includes an orifice-expanding device, a pressure measuring device, and a size-measuring device. The size-measuring device measures a dimension of the orifice after it has been expanded by the orifice-expanding device.
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公开(公告)号:US20170071731A1
公开(公告)日:2017-03-16
申请号:US15357990
申请日:2016-11-21
Applicant: Edwards Lifesciences Corporation
Inventor: Jeffrey S. Dove , Bin Tian , Ralph Schneider , Jeffrey S. Cohen , Ivan Jankovic , John F. Migliazza , Gregory A. Wright , James M. Young , Louis A. Campbell
CPC classification number: A61F2/2415 , A61B18/20 , A61F2/02 , A61F2/24 , A61F2/2409 , A61F2/2418 , A61F2002/30324 , A61F2250/0036 , A61L27/3604 , A61L27/3625 , A61L27/3691 , A61L27/507 , A61L2300/60 , A61L2430/20 , B65B55/18 , B65B63/02
Abstract: Methods for the conditioning of bioprosthetic material employ bovine pericardial membrane. A laser directed at the fibrous surface of the membrane and moved relative thereto reduces the thickness of the membrane to a specific uniform thickness and smoothes the surface. The wavelength, power and pulse rate of the laser are selected which will smooth the fibrous surface as well as ablate the surface to the appropriate thickness. Alternatively, a dermatome is used to remove a layer of material from the fibrous surface of the membrane. Thinning may also employ compression. Stepwise compression with cross-linking to stabilize the membrane is used to avoid damaging the membrane through inelastic compression. Rather, the membrane is bound in the elastic compressed state through addition cross-linking. The foregoing several thinning techniques may be employed together to achieve strong thin membranes.
Abstract translation: 生物假体材料调理方法采用牛心包膜。 指向膜的纤维表面并相对于其移动的激光将膜的厚度减小到特定的均匀厚度并平滑表面。 选择激光器的波长,功率和脉冲速率,这将使纤维表面平滑,并将表面烧蚀到合适的厚度。 或者,使用皮肤表面从膜的纤维表面去除一层材料。 变薄也可能采用压缩。 使用交联以稳定膜的逐步压缩来避免通过非弹性压缩损伤膜。 相反,膜通过加成交联结合在弹性压缩状态。 上述几种稀释技术可以一起使用以获得强的薄膜。
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