公开(公告)号：US11850150B2

公开(公告)日：2023-12-26

申请号：US17702233

申请日：2022-03-23

Applicant: Edwards Lifesciences Corporation

Inventor： Netanel Benichou

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2/2409 ,  A61F2210/0076 ,  A61F2220/0075 ,  A61F2230/0054

Abstract: An implantable prosthetic valve has an upper frame section and a lower frame section. The upper frame section has a plurality of struts and a first leaflet receiving surface at a lower portion of the upper frame section. The lower frame section has a second leaflet receiving surface at an upper portion of the lower frame section. An edge of a flexible leaflet is disposed between the first and second leaflet receiving surfaces to attach the leaflet to the upper and lower frame sections.

公开(公告)号：US20230277310A1

公开(公告)日：2023-09-07

申请号：US18196389

申请日：2023-05-11

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Ilia Hariton ,  Netanel Benichou ,  Yaacov Nitzan ,  Bella Felsen ,  Diana Nguyen-Thien-Nhon ,  Rajesh A. Khanna ,  Son V. Nguyen ,  Tamir S. Levi ,  Itai Pelled

IPC: A61F2/24 ,  A61F2/95 ,  B05B1/18 ,  E03C1/02 ,  E03C1/06

CPC classification number: A61F2/2418 ,  A61F2/2412 ,  A61F2/2433 ,  A61F2/95 ,  B05B1/185 ,  E03C1/025 ,  E03C1/066 ,  A61F2/2475 ,  Y10T29/49863 ,  A61F2220/0075 ,  A61F2220/005 ,  A61F2230/0054 ,  A61F2/9522 ,  A61F2220/0033

Abstract: An implantable prosthetic valve includes a radially collapsible and expandable annular frame having three commissure attachment portions and at least three rows of angled struts. The rows include a first row, a second row downstream of the first row, and a third row downstream of the second row. Each row of struts includes angled struts arranged in a zig-zag pattern defining a plurality of crowns. A leaflet structure includes three leaflets forming three commissures, each commissure being connected to one of the commissure attachment portions via sutures extending through apertures in the commissure attachment portions, wherein all of the apertures are located along the length of the frame between a first plane defined by the crowns of the second row of struts and a second plane defined by the crowns of the third row of struts.

公开(公告)号：US20230190469A1

公开(公告)日：2023-06-22

申请号：US18172806

申请日：2023-02-22

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Emil Karapetian ,  Maria Charles Vija Stanislaus ,  Gregory Bak-Boychuk ,  Christopher J. Olson ,  Cristobal R. Hernandez ,  William C. Brunnett ,  Netanel Benichou ,  Lauren R. Freschauf ,  Alexander J. Siegel ,  Stanton J. Rowe ,  Alison S. Curtis

IPC: A61F2/24 ,  A61F2/88 ,  A61F2/07

CPC classification number: A61F2/246 ,  A61F2/2466 ,  A61F2/2409 ,  A61F2/88 ,  A61F2/07 ,  A61F2/2436 ,  A61F2/2454 ,  A61F2/2427 ,  A61F2/2418 ,  A61F2002/825

Abstract: This application relates to methods, systems, and apparatus for replacing native heart valves with prosthetic heart valves and treating valvular insufficiency. In a representative embodiment, a support frame configured to be implanted in a heart valve comprises a main body formed by formed by a plurality of inner members forming an inner clover and a plurality of outer members forming an outer clover. The support frame can include gaps located between inner members of the plurality of inner members and outer members of the plurality of outer members. The inner clover can be radially inside the outer clover, and the outer clover can have larger dimensions than the inner clover. The support frames herein can be radially expandable and collapsible.

公开(公告)号：US11540918B2

公开(公告)日：2023-01-03

申请号：US17456355

申请日：2021-11-23

Applicant: Edwards Lifesciences Corporation

Inventor： David Alon ,  Netanel Benichou ,  Oded Meiri

IPC: A61F2/24 ,  A61F2/95

Abstract: Prosthetic heart valves and methods of implantation thereof are disclosed herein. In embodiments, a prosthetic heart valve includes a self-expandable frame configured to support of valve member and comprising a plurality of interconnected strut members forming a mesh structure. An inflow end and outflow end portions of the mesh structure respectively define an inflow terminal end and an outflow terminal end of the frame. A portion of the frame tapers inwardly from the inflow terminal end to form a reduced diameter section. In implementations, the frame increases in diameter from the reduced diameter section to an intermediate section. In implementations, the valve member is secured to the frame at the inflow end portion. In implementations, the frame further comprises a plurality of retaining arms that extend from the outflow terminal end and are configured to engage with a valve retaining mechanism of a delivery apparatus.

公开(公告)号：US20220211498A1

公开(公告)日：2022-07-07

申请号：US17706253

申请日：2022-03-28

Applicant: Edwards Lifesciences Corporation

Inventor： Netanel Benichou ,  Stanton J. Rowe ,  Sean Chow

IPC: A61F2/24

Abstract: Prosthetic heart valves are described. Prosthetic heart valves can include radially expandable and compressible inner and outer metal frames. The inner frame can be disposed within a lumen of the outer frame and can be coupled to the outer frame. An outflow end of the inner frame can be coupled to and/or located at an outflow end of the outer frame. An end portion of the inner frame can be spaced radially inwardly from an inner surface of the outer frame, such that a radial gap exists between the inner surface of the outer frame and an outer surface of the inner frame. Prosthetic heart valves can further include a plurality of leaflets disposed within and supported by the inner frame, such as by commissure posts of the inner frame.

公开(公告)号：US20220211497A1

公开(公告)日：2022-07-07

申请号：US17705215

申请日：2022-03-25

Applicant: Edwards Lifesciences Corporation

Inventor： Stanton J. Rowe ,  Larry L. Wood ,  Henry Bourang ,  George Bakis ,  Benjamin Spenser ,  Netanel Benichou ,  Assaf Bash ,  Yaron Keidar

IPC: A61F2/24 ,  A61F2/90 ,  A61L27/36

Abstract: A two-stage or component-based valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The prosthetic valve comprises a support structure that is deployed at a treatment site. The prosthetic valve further comprises a valve member configured to be quickly connected to the support structure. The support structure may take the form of a stent that is expanded at the site of a native valve. If desired, the native leaflets may remain and the stent may be used to hold the native valve open. In this case, the stent may be balloon expandable and configured to resist the powerful recoil force of the native leaflets. The support structure is provided with a coupling means for attachment to the valve member, thereby fixing the position of the valve member in the body. The valve member may be a non-expandable type, or may be expandable from a compressed state to an expanded state. The system is particularly suited for rapid deployment of heart valves in a conventional open-heart surgical environment.

公开(公告)号：US20220211496A1

公开(公告)日：2022-07-07

申请号：US17705131

申请日：2022-03-25

Applicant: Edwards Lifesciences Corporation

Inventor： Netanel Benichou ,  Stanton J. Rowe ,  Sean Chow

IPC: A61F2/24

Abstract: Prosthetic heart valves are described. Prosthetic heart valves can include radially expandable and compressible inner and outer metal frames. The inner frame can be disposed within a lumen of the outer frame and can be coupled to the outer frame. An outflow end of the inner frame can be coupled to and/or located at an outflow end of the outer frame. An end portion of the inner frame can be spaced radially inwardly from an inner surface of the outer frame, such that a radial gap exists between the inner surface of the outer frame and an outer surface of the inner frame. Prosthetic heart valves can further include a plurality of leaflets disposed within and supported by the inner frame, such as by commissure posts of the inner frame.

公开(公告)号：US20220211494A1

公开(公告)日：2022-07-07

申请号：US17703328

申请日：2022-03-24

Applicant: Edwards Lifesciences Corporation

Inventor： Netanel Benichou

IPC: A61F2/24

Abstract: An implantable prosthetic valve has an upper frame section and a lower frame section. The upper frame section has a plurality of struts and a first leaflet receiving surface at a lower portion of the upper frame section. The lower frame section has a second leaflet receiving surface at an upper portion of the lower frame section. An edge of a flexible leaflet is disposed between the first and second leaflet receiving surfaces to attach the leaflet to the upper and lower frame sections.

公开(公告)号：US11284998B2

公开(公告)日：2022-03-29

申请号：US16666099

申请日：2019-10-28

Applicant: Edwards Lifesciences Corporation

Inventor： Stanton J. Rowe ,  Larry L. Wood ,  Henry Bourang ,  George Bakis ,  Benjamin Spenser ,  Netanel Benichou ,  Assaf Bash ,  Yaron Keidar

IPC: A61F2/24 ,  A61F2/90 ,  A61L27/36

Abstract: A two-stage or component-based valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The prosthetic valve comprises a support structure that is deployed at a treatment site. The prosthetic valve further comprises a valve member configured to be quickly connected to the support structure. The support structure may take the form of a stent that is expanded at the site of a native valve. If desired, the native leaflets may remain and the stent may be used to hold the native valve open. In this case, the stent may be balloon expandable and configured to resist the powerful recoil force of the native leaflets. The support structure is provided with a coupling means for attachment to the valve member, thereby fixing the position of the valve member in the body. The valve member may be a non-expandable type, or may be expandable from a compressed state to an expanded state. The system is particularly suited for rapid deployment of heart valves in a conventional open-heart surgical environment.

公开(公告)号：US20220008196A1

公开(公告)日：2022-01-13

申请号：US17486361

申请日：2021-09-27

Applicant: Edwards Lifesciences Corporation

Inventor： Ziv Yohanan ,  Tamir S. Levi ,  Netanel Benichou ,  Michael Bukin ,  Nikolay Gurovich ,  Elena Sherman

IPC: A61F2/24

Abstract: A method of implanting a prosthetic heart valve within a patient can comprise inserting a distal end portion of a delivery apparatus and a prosthetic heart valve into the patient and advancing the prosthetic heart valve to a deployment location within the heart of the patient and inflating one or more of a plurality of differently-sized balloons in a balloon-assembly on the distal end portion of the delivery apparatus. The prosthetic heart valve can be mounted on the balloon assembly in a crimped state and the inflating of the one or more of the plurality of differently-sized balloons can expand the prosthetic heart valve from the crimped state to a radially expanded state having a non-cylindrical shape.