公开(公告)号：US20250152175A1

公开(公告)日：2025-05-15

申请号：US19020029

申请日：2025-01-14

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Leonardo Paim Nicolau Da Costa ,  Emil Karapetian

IPC: A61B17/12

Abstract: A system for modulating blood flow includes a first inflation device sized for placement at least partially within a blood vessel, such as an inferior vena cava, a superior vena cava, or a hepatic vein of a heart. The first inflation device expands and contracts in a cyclic manner. A tube extends from the first inflation device to a second inflation device, which may be placed within a blood vessel or within a chamber of the heart. The tube allows a liquid or gas to pass between the first and second inflation devices. The system may be used to alter the flow rate and/or timing of blood flow. In alternative embodiments, stents may be used in addition to, or in place of, the inflation devices. In some embodiments, a power source may be used with the system to more precisely modulate the blood flow.

公开(公告)号：US20240389902A1

公开(公告)日：2024-11-28

申请号：US18796077

申请日：2024-08-06

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Emil Karapetian ,  Sam Chitsaz

IPC: A61B5/1455 ,  A61B5/00 ,  A61B5/145

Abstract: A medical implant device can comprise a light source and a light sensor, and a housing configured to receive the light source and the light sensor. The housing can comprise a first wall portion configured to be positioned over an extraluminal surface of a coronary sinus, the first wall portion comprising a first surface oriented toward the extraluminal surface. A first light-transparent region of the first wall portion can be configured to allow passage therethrough of an emitted light signal from the light source into the coronary sinus, and a second light-transparent region of the first wall portion can be configured to allow passage therethrough of a reflected light signal from within the coronary sinus for detection by the light sensor.

公开(公告)号：US12011353B2

公开(公告)日：2024-06-18

申请号：US16522605

申请日：2019-07-25

Applicant: Edwards Lifesciences Corporation

Inventor： Mark Chau ,  David M. Taylor ,  Alexander J. Siegel ,  Christopher J. Olson ,  Sergio Delgado ,  Alexander H. Cooper ,  Lauren R. Freschauf ,  Asher L. Metchik ,  Matthew T. Winston ,  Cristobal R. Hernandez ,  Emil Karapetian ,  Bao Khuu ,  Eric Robert Dixon

IPC: A61F2/24

CPC classification number: A61F2/246 ,  A61F2/2454 ,  A61F2/2463 ,  A61F2/2466 ,  A61F2220/0016 ,  A61F2310/00023

Abstract: In one representative embodiment, an implantable prosthetic device comprises a spacer body portion configured to be disposed between native leaflets of a heart, and an anchor portion configured to secure the native leaflets against the spacer body portion. The prosthetic device can be movable between multiple configurations. The spacer body can be configured to extend radially outwardly as the spacer body extends away from the distal end toward the proximal end. A delivery apparatus can have a first shaft and a second shaft, wherein movement of the first shaft relative to the second shaft moves the anchor portion relative to the spacer body.

公开(公告)号：US11950773B2

公开(公告)日：2024-04-09

申请号：US16418643

申请日：2019-05-21

Applicant: Edwards Lifesciences Corporation

Inventor： Emil Karapetian

IPC: A61B17/04 ,  A61F2/24 ,  A61B17/00

CPC classification number: A61B17/0401 ,  A61F2/2487 ,  A61B2017/00876 ,  A61B2017/0406 ,  A61B2017/0427 ,  A61B2017/0441 ,  A61B2017/0464 ,  A61F2220/0016

Abstract: An anchoring system comprises a first anchoring device comprising a first attachment mechanism and a plugging device and a second anchoring device comprising a second attachment mechanism, each of the first anchoring device and the second anchoring device being configured to enter a tissue wall at a proximal side of the tissue wall, the first anchoring device being configured to exit the tissue wall through a first hole on a distal side of the tissue wall, the second anchoring device being configured to exit the tissue wall at a second hole on the distal side of the tissue wall, the first attachment mechanism configured to attach to the second attachment mechanism outside of the distal side of the tissue wall, and the plugging device configured to cover the first hole and fit between at least a portion of the first anchoring device and the distal side of the tissue wall.

公开(公告)号：US20240041602A1

公开(公告)日：2024-02-08

申请号：US18489666

申请日：2023-10-18

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Mark Chau ,  David M. Taylor ,  Alexander J. Siegel ,  Christopher J. Olson ,  Sergio Delgado ,  Alexander H. Cooper ,  Lauren R. Freschauf ,  Asher L. Metchik ,  Matthew T. Winston ,  Cristobal R. Hernandez ,  Emil Karapetian ,  Bao Khuu ,  Eric Robert Dixon ,  Amanda French ,  Philip P. Corso, JR.

IPC: A61F2/24

CPC classification number: A61F2/246 ,  A61F2/2466 ,  A61F2/2454 ,  A61F2/2463 ,  A61F2220/0016 ,  A61F2310/00023

Abstract: In one example, an implantable prosthetic device comprises a spacer body portion configured to be disposed between native leaflets of a heart, and an anchor portion configured to secure the native leaflets against the spacer body portion. The prosthetic device can be movable between multiple configurations. A size of the spacer body is configured to be adjusted after the spacer body is placed between the native valve leaflets and the pair of anchors are placed against the ventricular surfaces of the native heart valve leaflets. A delivery apparatus can have a first shaft and a second shaft, wherein movement of the first shaft relative to the second shaft moves the anchor portion relative to the spacer body.

公开(公告)号：US11666436B2

公开(公告)日：2023-06-06

申请号：US16415590

申请日：2019-05-17

Applicant: Edwards Lifesciences Corporation

Inventor： David Maimon ,  Ron Sharoni ,  Tamir S. Levi ,  Emil Karapetian ,  Tri D. Tran ,  Tung Le

IPC: B21D41/04 ,  B21D41/00 ,  A61F2/24 ,  A61B50/30 ,  A61B17/06 ,  B23P11/00 ,  A61F2/00 ,  B25B27/10 ,  B23P19/04 ,  A61F2/95

CPC classification number: A61F2/2427 ,  A61B17/06 ,  A61B50/30 ,  A61F2/0095 ,  A61F2/243 ,  A61F2/2433 ,  B21D41/00 ,  B21D41/04 ,  B23P11/00 ,  B23P19/04 ,  B25B27/10 ,  A61F2/9522 ,  Y10T29/5367 ,  Y10T29/53552 ,  Y10T29/53578

Abstract: A device for crimping a radially expandable and collapsible prosthetic valve comprises a crimping loop having a first end portion, a second end portion, and a loop portion extending between the first and second end portions and defining an opening configured to receive the prosthetic valve. The crimping loop is movable between a first state in which the opening has a first diameter and a second state in which the opening has a second diameter smaller than the first diameter such that when the prosthetic valve is positioned within the loop portion, movement of the crimping loop from the first state to the second state is effective to reduce a diameter of the prosthetic valve. A method for crimping a prosthetic valve comprises reducing a diameter of an opening of a crimping loop, thereby radially compressing an at least partially expanded prosthetic valve disposed within the opening.

公开(公告)号：US11589988B2

公开(公告)日：2023-02-28

申请号：US16735352

申请日：2020-01-06

Applicant: Edwards Lifesciences Corporation

Inventor： Emil Karapetian ,  Maria Charles Vija Stanislaus ,  Gregory Bak-Boychuk ,  Christopher J. Olson ,  Cristobal R. Hernandez ,  William C. Brunnett ,  Netanel Benichou ,  Lauren R. Freschauf ,  Alexander J. Siegel ,  Stanton J. Rowe ,  Alison S. Curtis

IPC: A61F2/24 ,  A61F2/88 ,  A61F2/07 ,  A61F2/82 ,  A61F2/91 ,  A61F2/958

Abstract: This application relates to methods, systems, and apparatus for replacing native heart valves with prosthetic heart valves and treating valvular insufficiency. In a representative embodiment, a support frame configured to be implanted in a heart valve comprises a main body formed by formed by a plurality of inner members forming an inner clover and a plurality of outer members forming an outer clover. The support frame can include gaps located between inner members of the plurality of inner members and outer members of the plurality of outer members. The inner clover can be radially inside the outer clover, and the outer clover can have larger dimensions than the inner clover. The support frames herein can be radially expandable and collapsible.

公开(公告)号：US20210282923A1

公开(公告)日：2021-09-16

申请号：US17334464

申请日：2021-05-28

Applicant: Edwards Lifesciences Corporation

Inventor： Dustin P. Armer ,  Sean Chow ,  Jenny Nguyen ,  Emil Karapetian ,  Tri D. Tran

IPC: A61F2/24

Abstract: Anchor devices and methods used to secure a prosthetic valve to a native valve annulus are described. The anchor device can be a separate expandable element from the prosthetic valve that is first advanced to the annulus and deployed, after which an expandable prosthetic valve is advanced to within the annulus and deployed. The combination of the two elements can apply a clamping force to the valve leaflets which holds the prosthetic valve in place. The anchor device can have a lower or ventricular portion and an upper or atrial portion. The anchor device can include one or more leaflet clamping portions. One, two, or more upstanding vertical posts between the clamping portions can extend upward at the valve commissures and support the upper portion, which can include one or more structures for leak prevention.

公开(公告)号：US20190328512A1

公开(公告)日：2019-10-31

申请号：US16508625

申请日：2019-07-11

Applicant: Edwards Lifesciences Corporation

Inventor： Hamid Rafi ,  Russell T. Joseph ,  Robert Bowes ,  Uy D. Trinh ,  Emil Karapetian ,  Gregory Bak-Boychuk

IPC: A61F2/24

Abstract: Pinch devices and access systems that can be used to secure a prosthetic heart valve to a heart valve annulus and to treat valvular insufficiency. A pinch device can be a separate expandable element from the prosthetic heart valve that is first advanced to the annulus and deployed, after which an expandable prosthetic heart valve can be advanced to within the annulus and deployed. The two elements can clamp/pinch the heart valve leaflets to hold the prosthetic heart valve in place. The pinch device can have a flexible, expandable annular frame. A combined delivery system can deliver the pinch device and prosthetic heart valve with just a single access point and aid more accurate coaxial deployment. The pinch device can be mounted near distal end of an access sheath, and a catheter for delivering the prosthetic heart valve can be passed through a lumen of the same access sheath.

公开(公告)号：US20160022417A1

公开(公告)日：2016-01-28

申请号：US14802922

申请日：2015-07-17

Applicant: Edwards Lifesciences Corporation

Inventor： Emil Karapetian ,  Austin Bly ,  Stanton J. Rowe

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2409 ,  A61F2/2427 ,  A61F2/2457 ,  A61F2210/0014 ,  A61F2220/0008 ,  A61F2220/0033 ,  A61F2220/0041 ,  A61F2230/0034 ,  A61F2250/006

Abstract: Disclosed herein are prosthetic devices and related methods for implantation at the native mitral valve of the heart by drawing an atrial portion and a ventricular portion toward each other from opposite sides of the native mitral valve, clamping the native mitral valve therebetween. One or more retention members passing through the mitral valve orifice or through a puncture in the native valve anatomy can couple the atrial and ventricular members together and keep them anchored onto the native mitral valve anatomy. The atrial portion can seat against the atrial side of the mitral annulus while the ventricular portion can include hooks and/or a sub-annular ring that engage and capture the native mitral valve apparatus to provide anchorage. The described technology can avoid the need to use sutures to anchor a prosthetic device at the mitral valve region.

Abstract translation: 本文公开了用于通过从天然二尖瓣的相对侧将彼此相对的心房部分和心室部分拉入心脏的天然二尖瓣的手术装置和相关方法，将二尖瓣夹在其间。 穿过二尖瓣孔或通过穿刺在自然瓣膜解剖结构中的一个或多个保持构件可将心房和心室部件联接在一起，并将它们固定在原生二尖瓣解剖结构上。 心房部分可以抵靠二尖瓣环的心房侧，而心室部分可以包括钩和/或接合并捕获天然二尖瓣装置以提供锚固的子环。 所描述的技术可以避免使用缝合线来锚定二尖瓣区域的假体装置。