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公开(公告)号：US08666770B2
公开(公告)日：2014-03-04
申请号：US13060450
申请日：2009-09-04
摘要： Methods of developing equations for objectively assigning or predicting an apparent age are disclosed. Advantageously, the equations of objective apparent age may be based on a relatively small number of critical parameters combined in a way that accounts for all or most of the apparent skin aging in a defined population or sub-population. Despite the relatively small data collection requirements, the present invention includes an objective model of apparent age that is useful for evaluation of products, useful for predicting treatment outcomes and useful for predicting the effects of deteriorative factors. The formalization of an Objective Apparent Age Score allows one to identify the biophysical and biochemical parameters that mostly influence an individual's apparent age, and can be used to select specific anti-aging treatments with increased chances of visible success. The Objective Apparent Age Score may also be used to support marketing claims.
摘要翻译： 公开了客观分配或预测表观年龄的方程的方法。 有利地，客观表观年龄的方程可以基于相对较少数量的关键参数，其组合方式考虑了定义的群体或子群体中的所有或大部分明显的皮肤老化。 尽管数据收集要求相对较小，但是本发明包括可用于评估产品的明显年龄的客观模型，对预测治疗结果有用，并且可用于预测恶化因素的影响。 客观表观年龄分数的形式化允许人们识别主要影响个体表观年龄的生物物理和生物化学参数，并且可以用于选择具有可见成功机会的特定抗衰老治疗。 客观表观年龄分数也可用于支持营销声明。
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52.发明申请Cholesterol Sulfate And Amino Sugar Compositions For Enhancement Of Stratum Corneum Function 审中-公开用于增强角质层功能的硫酸胆固醇和氨基糖组合物公开(公告)号：US20100247692A1
公开(公告)日：2010-09-30
申请号：US12410130
申请日：2009-03-24
申请人： Daniel H. Maes , Jules Zecchino
发明人： Daniel H. Maes , Jules Zecchino
CPC分类号： A61Q19/08 , A61K8/36 , A61K8/361 , A61K8/4973 , A61K8/60 , A61K8/63 , A61K8/97 , A61K31/19 , A61K31/201 , A61K31/202 , A61K31/56 , A61K31/575 , A61K31/70 , A61K31/7008 , A61K45/06 , A61K2800/28 , A61Q17/00 , A61Q19/00 , A61K2300/00
摘要： The present invention provides compositions containing a mixture of cholesterol sulfate and an exfoliant. The exfoliant can be N-acetyl-D-glucosamine, N-acetylgalactosamine, or a combination thereof. The combination of cholesterol sulfate with the exfoliant surprisingly enhances the skin barrier even though the activity of each of the components is opposite the other. In addition, because of the ability to enhance or repair the skin barrier function, methods of maintaining or improving a healthy skin barrier are included in the present invention by apply to the skin an effective amount of the mixture of cholesterol sulfate with the exfoliant. The mixture can also be useful in treating or preventing damage to the skin, where the damage is caused by a comprised skin barrier function. As a result of improved skin barrier function, the appearance of lines and wrinkles is generally reduced; rough and dry skin conditions are also improved.
摘要翻译： 本发明提供含有胆固醇硫酸盐和去角质剂的混合物的组合物。 去角质剂可以是N-乙酰基-D-葡糖胺，N-乙酰半乳糖胺或其组合。 胆固醇硫酸盐与去角质剂的组合令人惊讶地增强了皮肤屏障，即使每个组分的活性与另一组分相反。 此外，由于能够增强或修复皮肤屏障功能，本发明通过将有效量的胆固醇硫酸盐与去角质剂的混合物应用于皮肤来包括维持或改善健康皮肤屏障的方法。 该混合物还可用于治疗或预防对包含的皮肤屏障功能引起的损伤的皮肤损伤。 由于皮肤屏障功能改善，线条和皱纹的出现通常会降低; 粗糙和干燥的皮肤状况也得到改善。
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公开(公告)号：US07223382B2
公开(公告)日：2007-05-29
申请号：US10451565
申请日：2002-05-29
摘要： The present invention relates to a topical composition comprising a malodor-reducing effective amount of a rosemary extract, or active fraction thereof, in combination with a self-tanning effective amount of DHA. The invention also provides a method of reducing the potential for malodor generation of a DHA composition comprising adding to the composition an effective amount of rosemary extract or active fraction thereof.
摘要翻译： 本发明涉及包含恶臭降低有效量的迷迭香提取物或其活性组分与自晒黑有效量的DHA组合的局部组合物。 本发明还提供了降低DHA组合物恶臭产生潜力的方法，包括向组合物中加入有效量的迷迭香提取物或其活性组分。
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公开(公告)号：US06680062B2
公开(公告)日：2004-01-20
申请号：US09971561
申请日：2001-10-05
IPC分类号： A61K600
CPC分类号： A61Q19/00 , A61K8/35 , A61K8/368 , A61K8/41 , A61K8/73 , A61K8/97 , A61K8/9706 , A61K8/987 , A61K31/122 , A61K31/203 , A61K31/60 , A61K31/70 , A61K36/82 , A61K2800/59 , A61K2800/75 , Y10S514/887 , A61K2300/00
摘要： The present invention relates to a cosmetic or pharmaceutical composition for topical application to the skin afflicted with rosacea and treated with a retinoid. The composition for treating rosacea comprises an anti-irritating component and several other components for treating rosacea. The other components form a mixture of a salicylic acid, a phytosphingosine, green tea, hinokitiol, gorgonian extract, and polysaccharide. The invention also provides a method for decreasing the irritation on the skin caused by the heightened sensitivity experienced by skin suffering from rosacea. The other components are effective in treating the rosacea condition, but particularly, in treating the telangiectasic symptom of rosacea.
摘要翻译： 本发明涉及用于局部应用于患有红斑痤疮并用类视黄醇治疗的皮肤的化妆品或药物组合物。 用于治疗酒渣鼻的组合物包含用于治疗酒渣鼻的抗刺激成分和若干其它成分。 其他组分形成水杨酸，植物鞘氨醇，绿茶，桧醇，高戈贡提取物和多糖的混合物。 本发明还提供了一种降低由于患有红斑痤疮的皮肤所感受到的敏感性增加引起的皮肤刺激的方法。 其他成分可有效治疗红斑痤疮病症，特别是治疗红斑痤疮的毛细血管扩张症状。
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公开(公告)号：US20110202480A1
公开(公告)日：2011-08-18
申请号：US13060450
申请日：2009-09-04
摘要： Methods of developing equations for objectively assigning or predicting an apparent age are disclosed. Advantageously, the equations of objective apparent age may be based on a relatively small number of critical parameters combined in a way that accounts for all or most of the apparent skin aging in a defined population or sub-population. Despite the relatively small data collection requirements, the present invention includes an objective model of apparent age that is useful for evaluation of products, useful for predicting treatment outcomes and useful for predicting the effects of deteriorative factors. The formalization of an Objective Apparent Age Score allows one to identify the biophysical and biochemical parameters that mostly influence an individual's apparent age, and can be used to select specific anti-aging treatments with increased chances of visible success. The Objective Apparent Age Score may also be used to support marketing claims.
摘要翻译： 公开了客观分配或预测表观年龄的方程的方法。 有利地，客观表观年龄的方程可以基于相对较少数量的关键参数，其组合方式考虑了定义的群体或子群体中的所有或大部分明显的皮肤老化。 尽管数据收集要求相对较小，但是本发明包括可用于评估产品的明显年龄的客观模型，对预测治疗结果有用，并且可用于预测恶化因素的影响。 客观表观年龄分数的形式化允许人们识别主要影响个体表观年龄的生物物理和生物化学参数，并且可以用于选择具有可见成功机会的特定抗衰老治疗。 客观表观年龄分数也可用于支持营销声明。
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56.发明申请公开(公告)号：US20100203077A1
公开(公告)日：2010-08-12
申请号：US12306372
申请日：2008-11-21
CPC分类号： A61Q19/00 , A61K8/9706 , A61Q19/02
摘要： Compositions for treating skin containing at least one extract from the genus Trametes and at least one viscosity enhancing synthetic polymer, and methods for whitening skin, treating skin for improvement, or treating skin disorders associated with pigmentation such as uneven pigmentation, skin mottling, or age spots or other dermatological disorders such as eczema, rosacea, hyperkeratinization, and so on.
摘要翻译： 用于治疗皮肤的组合物，其含有至少一种来自所述属的提取物和至少一种增粘的合成聚合物，以及用于增白皮肤，治疗皮肤以改善或治疗与色素沉着相关的皮肤病症如色素沉着不均匀，皮肤斑驳或年龄的方法 斑点或其他皮肤病如湿疹，酒渣鼻，角化过度等。
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公开(公告)号：US06635285B2
公开(公告)日：2003-10-21
申请号：US10068950
申请日：2002-02-07
申请人： Éric Dupont , Paul Brazeau , Christina Juneau , Daniel H. Maes , Kenneth Marenus , Richard Béliveau
发明人： Éric Dupont , Paul Brazeau , Christina Juneau , Daniel H. Maes , Kenneth Marenus , Richard Béliveau
IPC分类号： A61K3534
CPC分类号： A61Q17/00 , A61K8/987 , A61K35/60 , A61Q19/00 , A61Q19/08 , Y10S514/859 , Y10S514/863 , Y10S530/857
摘要： The present invention relates to cartilage extracts and to a method of producing the same. Shark cartilage extracts having anti-angiogenic, anti-tumor, anti-inflammatory and anti-collagenolytic activities have been obtained by an improved process. The process comprises the steps of obtaining a crude cartilage extract in an aqueous solution, this crude extract being fractionated to recover molecules of a molecular weight less than about 500 kDa. Some of the biologically active components of the extract are prepared by further fractionation. The cartilage extract can be used for treating diseases or conditions having etiological components selected from the group consisting of tumor proliferation, angiogenesis, inflammation, metalloprotease activity and collagenolysis. Several cosmetic applications based on the capacity of the liquid extract to improve skin conditions are also disclosed. A simple and efficient process for the preparation of cartilage extracts is also disclosed.
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公开(公告)号：US5811083A
公开(公告)日：1998-09-22
申请号：US622730
申请日：1996-03-26
申请人： Edward Pelle , Daniel H. Maes
发明人： Edward Pelle , Daniel H. Maes
IPC分类号： A61K8/67 , A61K31/353 , A61Q5/00 , A61Q19/00 , A61Q19/08 , C07D311/66 , A61K7/40 , A61K31/355 , C07D311/04
CPC分类号： A61Q19/08 , A61K31/353 , A61K8/678 , A61Q19/00 , A61Q19/007 , A61Q19/02 , A61Q5/006 , C07D311/66 , Y10S514/844 , Y10S514/847
摘要： Novel tocopherol derivatives useful for regulating skin aging and other skin disorders, as well as compositions containing the derivatives and methods for their use are described. The tocopherol derivative is tocopherol-cysteamine. Such types of skin atrophy to be treated the thinning of the epidermis and/or general degradation of the dermis often characterized by hyperplasia and structural disorganization. Such skin maladies include but are not limited to dry skin, severe dry skin, terosis, dandruff, keratoses, psoriasis, eczema, pruritus, age spots, lentigines, melasmas, wrinkles, blemished skin, hyperpigmented skin, hyperkeratotic skin, inflammatory dermatoses and age-related skin changes.
摘要翻译： 描述了可用于调节皮肤老化和其它皮肤病症的新型生育酚衍生物，以及含有其衍生物和其使用方法的组合物。 生育酚衍生物是生育酚 - 半胱胺。 这种类型的皮肤萎缩被治疗表皮的变薄和/或真皮的一般降解，其特征在于增生和结构紊乱。 这些皮肤疾病包括但不限于干性皮肤，严重干性皮肤，毛病，头皮屑，角化病，牛皮癣，湿疹，瘙痒，老年斑，斑点，黑斑病，皱纹，瑕疵皮肤，色素沉着过度皮肤，角化过度皮肤，炎性皮肤病和年龄 相关皮肤变化。
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公开(公告)号：US5736537A
公开(公告)日：1998-04-07
申请号：US527145
申请日：1995-09-12
申请人： Joseph Gubernick , Daniel H. Maes
发明人： Joseph Gubernick , Daniel H. Maes
IPC分类号： C07J1/00 , A61K31/565
CPC分类号： A61K8/63 , A61Q19/00 , A61Q19/007 , A61Q5/006 , C07J1/0011 , Y10S514/844 , Y10S514/859 , Y10S514/861 , Y10S514/863
摘要： Disclosed is the use of dehydroepiandrosterone salicylate in the treatment of skin atrophy. ##STR1## Such types skin atrophy to be treated include the thinning and/or general degradation of the dermis often characterized by a decrease in collagen and/or elastin as well as decreased number, size and doubling potential of fibroblast cells.
摘要翻译： 公开了使用脱水表雄酮水杨酸酯治疗皮肤萎缩。 这种类型的待治疗的皮肤萎缩包括真皮的变薄和/或一般降解，其特征在于胶原和/或弹性蛋白的减少以及成纤维细胞的数量，大小和倍数的减少。
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公开(公告)号：US5683705A
公开(公告)日：1997-11-04
申请号：US626769
申请日：1996-03-29
申请人： Daniel H. Maes , Jules Zecchino , Althea Knight
发明人： Daniel H. Maes , Jules Zecchino , Althea Knight
IPC分类号： A61K8/365 , A61K8/37 , A61K8/46 , A61K8/49 , A61K8/60 , A61K8/73 , A61K31/19 , A61K31/20 , A61K31/215 , A61K31/23 , A61Q19/00 , A61Q19/02 , A61Q19/08 , C07C323/41 , A61K7/48 , C07C233/00
CPC分类号： C07C323/41 , A61K31/19 , A61K31/20 , A61K31/215 , A61K31/23 , A61K8/365 , A61K8/37 , A61K8/375 , A61K8/46 , A61K8/4973 , A61K8/60 , A61K8/73 , A61Q19/00 , A61Q19/007 , A61Q19/02 , A61Q19/08 , A61Q5/006 , Y10S514/852 , Y10S514/859 , Y10S514/863 , Y10S514/944
摘要： Novel sulfhydryl group-containing amides and disulfide group-containing bis-amides useful for treating or preventing an abnormal biological condition or a disease, and/or improving the texture or appearance of the skin, as well as compositions containing amides and bis-amides and methods for their use are described. Such types of abnormal biological conditions or diseases include skin atrophy, i.e., the thinning and/or general degradation of the dermis often characterized by a decrease in collagen and/or elastin as well as decreased number, size and doubling potential of fibroblast cells, and other maladies including, but are not limited to dry skin, severe dry skin, dandruff, acne, keratoses, psoriasis, eczema, skin flakiness, pruritus, age spots, lentigines, melasmas, wrinkles, warts, blemished skin, hyperpigmented skin, hyperkeratotic skin, inflammatory dermatoses, age-related skin changes and skin in need of cleansers.
摘要翻译： 可用于治疗或预防异常生物学病症或疾病，和/或改善皮肤的质地或外观的新型含巯基的酰胺和含二硫基的双酰胺以及含有酰胺和双酰胺的组合物和 描述使用它们的方法。 这种类型的异常生物学条件或疾病包括皮肤萎缩，即真皮的变薄和/或一般降解，其特征在于胶原和/或弹性蛋白的减少以及成纤维细胞的数量，大小和倍数的减少，以及 其他疾病包括但不限于干性皮肤，严重干性皮肤，头皮屑，痤疮，角化病，牛皮癣，湿疹，皮肤瘙痒，瘙痒，老年斑，斑点，黑斑病，皱纹，疣，瑕疵皮肤，色素沉着过度皮肤，角化过度皮肤 ，炎性皮肤病，年龄相关的皮肤变化和需要清洁剂的皮肤。
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