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公开(公告)号：US06468765B1
公开(公告)日：2002-10-22
申请号：US08487429
申请日：1995-06-07
IPC分类号： G12P2102
CPC分类号： C07K14/285
摘要： The present invention provides the sequencing of the entire genome of Haemophilus influenzae Rd, SEQ ID NO:1. The present invention further provides the sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use. In addition to the entire genomic sequence, the present invention identifies over 1700 protein encoding fragments of the genome and identifies, by position relative to a unique Not I restriction endonuclease site, any regulatory elements which modulate the expression of the protein encoding fragments of the Haemophilus genome.
摘要翻译： 本发明提供了流感嗜血杆菌Rd，SEQ ID NO：1的整个基因组的测序。 本发明还提供存储在计算机可读介质上的序列信息，以及便于其使用的基于计算机的系统和方法。 除了整个基因组序列之外，本发明鉴定了基因组的超过1700个蛋白质编码片段，并且通过相对于独特的Not I限制性内切核酸酶位点的位置鉴定调节嗜血杆菌蛋白编码片段的表达的任何调节元件 基因组
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公开(公告)号：US06251648B1
公开(公告)日：2001-06-26
申请号：US09054989
申请日：1998-04-03
申请人： Craig Rosen , Steven M. Ruben , Mark D. Adams
发明人： Craig Rosen , Steven M. Ruben , Mark D. Adams
IPC分类号： C12N922
摘要： A human DNase polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating bronchopulmonary conditions. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
摘要翻译： 公开了人DNase多肽和编码这种多肽的DNA（RNA），以及通过重组技术产生这种多肽的方法。 还公开了利用这种多肽来预防和/或治疗支气管肺疾病的方法。 还公开了用于鉴定编码本发明多肽的核酸序列中突变和用于检测本发明多肽的改变水平的诊断测定。
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公开(公告)号：US5849286A
公开(公告)日：1998-12-15
申请号：US464604
申请日：1995-06-05
申请人： Jian Ni , Reiner Gentz , Mark D. Adams
发明人： Jian Ni , Reiner Gentz , Mark D. Adams
CPC分类号： C12N9/93 , C12Y603/02019 , A61K38/00
摘要： Human UCE 7, UCE 8 and UCE 9 polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods of utilizing such polypeptide for the treatment of the proliferation of malignant cells. Antagonists against such polypeptides and their uses as a therapeutic to treat Alzheimer's disease, atrophying skeletal muscle, African swine fever virus and apoptotic cell death are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in UCE 7, 8 and 9 nucleic acid sequences and the concentration of polypeptides encoded by such sequences.
摘要翻译： 公开了人类UCE 7，UCE 8和UCE 9多肽和编码这些多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽来治疗恶性细胞增殖的方法。 还公开了抗这种多肽的拮抗剂及其作为治疗性阿尔茨海默氏病，萎缩性骨骼肌，非洲猪瘟病毒和凋亡性细胞死亡的治疗剂的用途。 还公开了用于检测与UCE 7,8和9核酸序列中的突变相关的疾病的诊断测定以及由这些序列编码的多肽的浓度。
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公开(公告)号：US5830744A
公开(公告)日：1998-11-03
申请号：US468012
申请日：1995-06-06
申请人： Craig A. Rosen , Steven M. Ruben , Mark D. Adams
发明人： Craig A. Rosen , Steven M. Ruben , Mark D. Adams
CPC分类号： C12N9/22
摘要： A human DNase polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating bronchopulmonary conditions. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
摘要翻译： 公开了人DNase多肽和编码这种多肽的DNA（RNA），以及通过重组技术产生这种多肽的方法。 还公开了利用这种多肽来预防和/或治疗支气管肺疾病的方法。 还公开了用于鉴定编码本发明多肽的核酸序列中突变和用于检测本发明多肽的改变水平的诊断测定。
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公开(公告)号：US5710019A
公开(公告)日：1998-01-20
申请号：US464340
申请日：1995-06-05
申请人： Yi Li , Mark D. Adams , Owen R. White
发明人： Yi Li , Mark D. Adams , Owen R. White
IPC分类号： A61K38/00 , C07K14/705 , C12P21/02 , C12N15/12
CPC分类号： C07K14/705 , A61K38/00 , C12N2799/026
摘要： Disclosed are human K.sub.+ channel polypeptides and DNA (RNA) encoding such K.sub.+ channel polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques. Agonists for such K.sub.+ channel polypeptides are also disclosed. Such agonists may be used to treat epilepsy, stroke, hypertension, asthma, Parkinson's disease, schizophrenia, anxiety, depression and neurodegeneration. Also disclosed are antagonists against such polypeptides which may be used to treat AIDS, SLE, diabetes, multiple sclerosis and cancer. Also disclosed are diagnostic assays for detecting mutations in the polynucleotide sequences of the present invention.
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56.发明授权
公开(公告)号：US5597709A
公开(公告)日：1997-01-28
申请号：US187756
申请日：1994-01-27
IPC分类号： G01N33/53 , A61K31/70 , A61K35/76 , A61K38/00 , A61K38/27 , A61K39/395 , A61K48/00 , A61P3/00 , A61P3/04 , A61P5/00 , A61P13/12 , A61P19/00 , A61P31/00 , A61P31/12 , A61P31/18 , A61P35/00 , A61P43/00 , C07H21/04 , C07K14/61 , C07K16/26 , C12N1/15 , C12N1/19 , C12N1/21 , C12N15/09 , C12N15/18 , C12P21/02 , C12R1/19 , C07H21/02 , C12N15/63 , C12P21/06
摘要： There is provided a DNA (or RNA) polynucleotide sequences encoding naturally occurring splice variants of human growth hormone, hGHV-2(88) and hGHV-3(53) as well as analogs and derivatives thereof, which both lack nucleotide sequences normally present in the gene which codes for wild-type hGH. The growth hormone variants of the present invention are of human origin and are useful for diagnostic preventative and therapeutic purposes with respect to certain human diseases. The present invention is also related to a method for producing the human growth hormone variants by recombinant DNA techniques. A method of generating an antibody directed against and therefore inhibiting the activity of wild-type growth hormone is also provided.
摘要翻译： 提供了编码人生长激素，hGHV-2（88）和hGHV-3（53）的天然存在的剪接变体的DNA（或RNA）多核苷酸序列以及其类似物和衍生物，其缺乏通常存在于 编码野生型hGH的基因。 本发明的生长激素变体是人源的，并且对于某些人类疾病的诊断预防和治疗目的是有用的。 本发明还涉及通过重组DNA技术生产人生长激素变体的方法。 还提供了产生针对并因此抑制野生型生长激素的活性的抗体的方法。
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公开(公告)号：US07198944B2
公开(公告)日：2007-04-03
申请号：US11260166
申请日：2005-10-28
申请人： Haodong Li , Mark D. Adams
发明人： Haodong Li , Mark D. Adams
IPC分类号： C12N15/63
CPC分类号： C07K16/24 , A61K38/00 , A61K2039/505 , C07K14/523 , G01N33/564 , G01N33/57426 , G01N33/6863 , G01N2333/52
摘要： Human Ckβ-9 polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Ckβ-9 polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Diagnostic assays are also disclosed which detect the presence of mutations in the Ckβ-9 coding sequence and over-expression of the Ckβ-9 protein.
摘要翻译： 公开了人Ckbeta-9多肽和编码这种趋化因子多肽的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种Ckbeta-9多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这些多肽的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的治疗剂的用途。 还公开了诊断测定法，其检测Ckbeta-9编码序列中突变的存在和Ckbeta-9蛋白的过表达。
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公开(公告)号：US07138498B2
公开(公告)日：2006-11-21
申请号：US10646770
申请日：2003-08-25
申请人： Haodong Li , Mark D. Adams , Solange H. Gentz , Ralph Alderson , Yuling Li , David Parmelee , John R. White , Edward R. Appelbaum
发明人： Haodong Li , Mark D. Adams , Solange H. Gentz , Ralph Alderson , Yuling Li , David Parmelee , John R. White , Edward R. Appelbaum
IPC分类号： C07K16/24
CPC分类号： C07K14/52 , C07K14/523 , Y10S930/14
摘要： Human chemokine polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.
摘要翻译： 公开了人趋化因子多肽和编码这种趋化因子多肽的DNA（RNA）和通过重组技术产生此类多肽的方法。 还公开了利用这种趋化因子多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化因子多肽的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素依赖性发烧和骨髓衰竭的治疗剂的用途。
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公开(公告)号：US06653446B2
公开(公告)日：2003-11-25
申请号：US09189833
申请日：1998-11-12
IPC分类号： C07K100
CPC分类号： C12N9/1077 , A61K38/00
摘要： A human HPRT-2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of nephrolithiasis, anemia, precocious gout, kidney stones, Lesch-Nyhan syndrome, renal failure and uricaciduria. Antagonists against such polypeptides and their use as a therapeutic to treat disorders associated with excessive purine synthesis are also disclosed. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
摘要翻译： 公开了编码这种多肽的人HPRT-2多肽和DNA（RNA），以及通过重组技术产生这种多肽的方法。 还公开了利用这种多肽治疗肾结石，贫血，早熟性痛风，肾结石，莱斯 - 尼汉综合征，肾衰竭和尿酸尿的方法。 还公开了抗这些多肽的拮抗剂及其作为治疗用于治疗与过量嘌呤合成相关的疾病的用途。 还公开了用于鉴定编码本发明多肽的核酸序列中突变和用于检测本发明多肽的改变水平的诊断测定。
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公开(公告)号：US06569660B1
公开(公告)日：2003-05-27
申请号：US09662746
申请日：2000-09-15
申请人： Craig A. Rosen , Steven M. Ruben , Mark D. Adams
发明人： Craig A. Rosen , Steven M. Ruben , Mark D. Adams
IPC分类号： C12N922
摘要： A human DNase polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating bronchopulmonary conditions. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
摘要翻译： 公开了人DNase多肽和编码这种多肽的DNA（RNA），以及通过重组技术产生这种多肽的方法。 还公开了利用这种多肽来预防和/或治疗支气管肺疾病的方法。 还公开了用于鉴定编码本发明多肽的核酸序列中突变和用于检测本发明多肽的改变水平的诊断测定。
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