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公开(公告)号：US06849436B2
公开(公告)日：2005-02-01
申请号：US09902705
申请日：2001-07-12
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61K45/00 , A61P7/00 , A61P9/00 , A61P9/12 , A61P19/06 , A61P25/00 , C07K16/18 , C07K16/40 , C12N1/21 , C12N5/10 , C12N9/10 , C12N9/12 , C12P21/08 , C12R1/19 , C12R1/91 , C07H21/04 , C07K17/00 , C12N5/00 , C12P21/06
CPC分类号： C12N9/1077 , A61K38/00
摘要： A human HPRT-2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of nephrolithiasis, anemia, precocious gout, kidney stones, Lesch-Nyhan syndrome, renal failure and uricaciduria. Antagonists against such polypeptides and their use as a therapeutic to treat disorders associated with excessive purine synthesis are also disclosed. Diagnostic assays for identifying mutations in nucleic acid sequences encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
摘要翻译： 公开了编码这种多肽的人HPRT-2多肽和DNA（RNA），以及通过重组技术产生这种多肽的方法。 还公开了利用这种多肽治疗肾结石，贫血，早熟性痛风，肾结石，莱斯 - 尼汉综合征，肾衰竭和尿酸尿的方法。 还公开了抗这些多肽的拮抗剂及其作为治疗用于治疗与过量嘌呤合成相关的疾病的用途。 还公开了用于鉴定编码本发明多肽的核酸序列中的突变并检测本发明多肽的改变水平的诊断测定法。
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公开(公告)号：US06653446B2
公开(公告)日：2003-11-25
申请号：US09189833
申请日：1998-11-12
IPC分类号： C07K100
CPC分类号： C12N9/1077 , A61K38/00
摘要： A human HPRT-2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of nephrolithiasis, anemia, precocious gout, kidney stones, Lesch-Nyhan syndrome, renal failure and uricaciduria. Antagonists against such polypeptides and their use as a therapeutic to treat disorders associated with excessive purine synthesis are also disclosed. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
摘要翻译： 公开了编码这种多肽的人HPRT-2多肽和DNA（RNA），以及通过重组技术产生这种多肽的方法。 还公开了利用这种多肽治疗肾结石，贫血，早熟性痛风，肾结石，莱斯 - 尼汉综合征，肾衰竭和尿酸尿的方法。 还公开了抗这些多肽的拮抗剂及其作为治疗用于治疗与过量嘌呤合成相关的疾病的用途。 还公开了用于鉴定编码本发明多肽的核酸序列中突变和用于检测本发明多肽的改变水平的诊断测定。
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公开(公告)号：US20080261252A1
公开(公告)日：2008-10-23
申请号：US12136927
申请日：2008-06-11
CPC分类号： C07H21/04 , C07K14/7155
摘要： The present invention relates to a novel soluble IL-1 receptor accessory molecule (IL-1R AcM) protein which is a member of the Ig superfamily. In particular, isolated nucleic acid molecules are provided encoding the human IL-1R AcM protein. IL-1R AcM polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. Screening methods are further provided for identifying agonist and antagonists of IL-1 signal transduction. The invention further relates to methods for treating physiologic and pathologic disease conditions with IL-1R AcM antagonists.
摘要翻译： 本发明涉及作为Ig超家族成员的新型可溶性IL-1受体辅助分子（IL-1RACM）蛋白质。 特别地，提供编码人IL-1R AcM蛋白的分离的核酸分子。 还提供IL-1R AcM多肽，载体，宿主细胞和用于制备它们的重组方法。 还提供筛选方法用于鉴定IL-1信号转导的激动剂和拮抗剂。 本发明还涉及用IL-1R AcM拮抗剂治疗生理和病理疾病状况的方法。
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公开(公告)号：US07053190B2
公开(公告)日：2006-05-30
申请号：US09981876
申请日：2001-10-19
申请人： Steven M. Ruben , Craig A. Rosen , Carrie L. Fischer , Daniel R. Soppet , Kenneth C. Carter , Daniel P. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer , Yanggu Shi
发明人： Steven M. Ruben , Craig A. Rosen , Carrie L. Fischer , Daniel R. Soppet , Kenneth C. Carter , Daniel P. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer , Yanggu Shi
IPC分类号： C07K16/28 , C07K14/705
CPC分类号： C07K16/28 , A61K38/00 , C07K14/47 , C07K14/4702 , C07K14/4718 , C12N15/11 , G01N33/68
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
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公开(公告)号：US06974682B1
公开(公告)日：2005-12-13
申请号：US08917710
申请日：1997-08-26
CPC分类号： C07H21/04 , C07K14/7155
摘要： The present invention relates to a novel soluble IL-1 receptor accessory molecule (IL-1R AcM) protein which is a member of the Ig superfamily. In particular, isolated nucleic acid molecules are provided encoding the human IL-1R AcM protein IL-1R AcM polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. Screening methods are further provided for identifying agonist and antagonists of IL-1 signal transduction. The invention further relates to methods for treating physiologic and pathologic disease conditions with IL-1R AcM antagonists.
摘要翻译： 本发明涉及作为Ig超家族成员的新型可溶性IL-1受体辅助分子（IL-1RACM）蛋白质。 特别地，提供编码人IL-1R AcM蛋白的分离的核酸分子IL-1R也提供了如用于制备它们的载体，宿主细胞和重组方法的AcM多肽。 还提供筛选方法用于鉴定IL-1信号转导的激动剂和拮抗剂。 本发明还涉及用IL-1R AcM拮抗剂治疗生理和病理疾病状况的方法。
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公开(公告)号：US06590075B2
公开(公告)日：2003-07-08
申请号：US09148545
申请日：1998-09-04
申请人： Steven M. Ruben , Craig A. Rosen , Carrie L. Fischer , Daniel R. Soppet , Kenneth C. Carter , Daniel P. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer , Yanggu Shi
发明人： Steven M. Ruben , Craig A. Rosen , Carrie L. Fischer , Daniel R. Soppet , Kenneth C. Carter , Daniel P. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer , Yanggu Shi
IPC分类号： C07K100
CPC分类号： C07K14/4702 , A61K38/00 , C07K14/47 , C07K14/4718 , C12N15/11 , G01N33/68
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号：US20120122762A1
公开(公告)日：2012-05-17
申请号：US13359199
申请日：2012-01-26
申请人： Steven M. Ruben , Craig A. Rosen , Daniel R. Soppet , Kenneth C. Carter , Daniel P. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , D. Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Carrie L. Fischer , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , David W. LaFleur , Yi Li , Zhizhen Zeng , Hla Kyaw
发明人： Steven M. Ruben , Craig A. Rosen , Daniel R. Soppet , Kenneth C. Carter , Daniel P. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , D. Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Carrie L. Fischer , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , David W. LaFleur , Yi Li , Zhizhen Zeng , Hla Kyaw
IPC分类号： A61K38/17 , C12N15/63 , C07K14/435 , C07K16/18 , G01N33/53 , C12Q1/68 , C12P21/00 , G01N33/68 , C12N15/85 , C12N15/70 , C12N1/21 , C12N5/10 , A61P7/00 , A61P35/00 , A61P13/12 , A61P9/00 , A61P11/00 , A61P17/02 , A61P25/00 , A61P5/00 , A61P15/00 , A61P31/00 , A61P1/00 , C12N15/12
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/47 , G01N33/566 , G01N2800/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US20090011983A1
公开(公告)日：2009-01-08
申请号：US11745580
申请日：2007-05-08
申请人： Steven M. Ruben , Craig A. Rosen , Daniel R. Soppet , Kenneth C. Carter , Daniel P. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , D. Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Carrie L. Fischer , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , David W. LaFleur , Yi Li , Zhizhen Zeng , Hla Kyaw
发明人： Steven M. Ruben , Craig A. Rosen , Daniel R. Soppet , Kenneth C. Carter , Daniel P. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , D. Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Carrie L. Fischer , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , David W. LaFleur , Yi Li , Zhizhen Zeng , Hla Kyaw
IPC分类号： A61K38/00 , C12N15/11 , C12N15/00 , C12N15/63 , C12N5/06 , C12Q1/00 , A61P43/00 , G01N33/566 , C12Q1/68 , C07K14/00 , C07K16/18 , C12P21/04
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/47 , G01N33/566 , G01N2800/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US07390880B2
公开(公告)日：2008-06-24
申请号：US11066006
申请日：2005-02-25
CPC分类号： C07H21/04 , C07K14/7155
摘要： The present invention relates to a novel soluble IL-1 receptor accessory molecule (IL-1R AcM) protein which is a member of the Ig superfamily. In particular, isolated nucleic acid molecules are provided encoding the human IL-1R AcM protein. IL-1R AcM polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. Screening methods are futher provided for identifying agonist and antagonists of IL-1 signal transduction. The invention further relates to methods for treating physiologic and pathologic disease conditions with IL-1R AcM antagonists.
摘要翻译： 本发明涉及作为Ig超家族成员的新型可溶性IL-1受体辅助分子（IL-1RACM）蛋白质。 特别地，提供编码人IL-1R AcM蛋白的分离的核酸分子。 还提供IL-1R AcM多肽，载体，宿主细胞和用于制备它们的重组方法。 提供筛选方法用于鉴定IL-1信号转导的激动剂和拮抗剂。 本发明还涉及用IL-1R AcM拮抗剂治疗生理和病理疾病状况的方法。
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公开(公告)号：US6001806A
公开(公告)日：1999-12-14
申请号：US105039
申请日：1998-06-26
申请人： David M. Hilbert , Daniel P. Bednarik , Bernadetta Nardelli , Marianne Murphy , David Parmelee , Ann Gronowski , Robert Schreiber
发明人： David M. Hilbert , Daniel P. Bednarik , Bernadetta Nardelli , Marianne Murphy , David Parmelee , Ann Gronowski , Robert Schreiber
CPC分类号： C07K14/005 , A61K38/00 , C12N2710/14122
摘要： This invention relates to the use of the baculovirus glycoprotein, Interferon Stimulating Protein (ISP) (also known as gp67, gp64 EFP, or gp64), or the gene sequence encoding ISP, to stimulate production of interferon, such as for immunotherapy, anti-viral, anti-cancer, anti-bacterial, or anti-parasitic therapy. This invention also relates to novel mutant forms of ISP that show enhanced biological (i.e., anti-viral) activity, increased stability, higher yield or better solubility.
摘要翻译： 本发明涉及使用杆状病毒糖蛋白，干扰素刺激蛋白（ISP）（也称为gp67，gp64 EFP或gp64）或编码ISP的基因序列来刺激干扰素的产生，例如用于免疫治疗， 病毒，抗癌，抗细菌或抗寄生物治疗。 本发明还涉及显示增强的生物（即抗病毒）活性，增加的稳定性，更高的产量或更好的溶解度的ISP的新型突变体形式。
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