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51.发明申请公开(公告)号：US20120150049A1
公开(公告)日：2012-06-14
申请号：US13314594
申请日：2011-12-08
IPC分类号： A61B5/02
CPC分类号： A61B5/027 , A61B5/0002 , A61B5/0295 , A61B5/0538 , A61B18/1492 , A61B2017/00026 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00875
摘要： An implantable medical device system and associated method deliver drive signals having different frequencies to establish vector fields comprising an arterial volume and a venous volume corresponding to targeted portion of a patient's body. Impedance signals are determined in response to drive signals having different frequencies. Impedance parameter values are determined over time. A change in the hemodynamic status of a targeted portion of the patient's body is identified in response to the impedance parameter values.
摘要翻译： 可植入医疗装置系统和相关方法提供具有不同频率的驱动信号以建立包括对应于患者身体的目标部分的动脉体积和静脉体积的矢量场。 响应于具有不同频率的驱动信号来确定阻抗信号。 阻抗参数值随时间确定。 响应于阻抗参数值来识别患者身体的目标部分的血液动力学状态的变化。
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公开(公告)号：US20090299198A1
公开(公告)日：2009-12-03
申请号：US12129955
申请日：2008-05-30
IPC分类号： A61B5/0215 , A61B5/021
CPC分类号： A61B5/0215 , A61B5/02028
摘要： A method for estimating pulmonary artery diastolic pressure, for a single heart beat, includes establishing a time window for sampling and storing pressure data points from a right ventricular pressure transducer. The time window may be established according to predetermined parameters and/or according to one or more triggering events. An approximate time at which the pulmonary artery valve opens is determined, either via the sampled pressure data points, or via another form of more direct monitoring, during the time window, in order to estimate the pulmonary artery diastolic pressure. A plurality of sets of N pressure data points may be collected, from the sampled data, and, for each collected set, a weighted sum is calculated. Each weighted sum may be employed to evaluate a quality of the sampled data and/or to estimate the pulmonary artery diastolic pressure, if the more direct monitoring of the pulmonary artery valve is not employed.
摘要翻译： 用于估计单次心跳的肺动脉舒张压的方法包括建立用于从右心室压力传感器采样和存储压力数据点的时间窗口。 可以根据预定参数和/或根据一个或多个触发事件建立时间窗口。 通过采样的压力数据点或在时间窗口期间通过另一种形式的更直接的监测来确定肺动脉瓣打开的大致时间，以便估计肺动脉舒张压。 可以从采样数据收集多组N个压力数据点，并且对于每个收集的集合，计算加权和。 如果不采用更直接的肺动脉瓣监测，则每个加权和可用于评估采样数据的质量和/或估计肺动脉舒张压。
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公开(公告)号：US20060167358A1
公开(公告)日：2006-07-27
申请号：US11043819
申请日：2005-01-26
IPC分类号： A61B5/02
CPC分类号： A61B5/0215 , A61B5/4519 , A61B5/7239
摘要： The present invention provides an apparatus and method for monitoring muscle function based on an index derived from a pressure or force signal. The muscle function index is derived from an instantaneous muscle stiffness ratio computed as the ratio of the first time derivative of the pressure or force waveform to the corresponding instantaneous pressure or force. The instantaneous stiffness ratio, {dot over (E)}/E(t), is in units of 1/sec and relates to the rate of strong bond formation and will be influenced by calcium handling properties of the muscle fibers and the intracellular calcium concentration. As such, an index derived from {dot over (E)}/E(t) provides a measure of the inotropic status of the muscle.
摘要翻译： 本发明提供了一种基于从压力或力信号导出的指标来监测肌肉功能的装置和方法。 肌肉功能指数来源于以压力或力波形的第一次导数与相应的瞬时压力或力的比值计算的瞬时肌肉僵直比。 瞬时刚度比（E / E（t））以1 /秒为单位，与强键形成速率有关，并受肌肉纤维的钙处理性能和细胞内钙浓度的影响。 因此，从{dot over（E / E（t））得到的指数提供肌肉肌力状态的量度。
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公开(公告)号：US08702604B2
公开(公告)日：2014-04-22
申请号：US13017307
申请日：2011-01-31
CPC分类号： G06F19/3406 , A61B5/02116 , A61B5/02125 , A61B5/7217 , A61B5/7239 , G06K9/0053 , G16H40/63
摘要： A medical device system including a physiological sensor is configured to perform a method for detecting signal artifact in a signal waveform acquired by the sensor. A signal waveform is sensed in a patient using the physiological sensor and a fiducial point associated with the sensed waveform is identified. A point value is established using the fiducial point. Signal artifact is detected in response to the established point value and an established threshold, and at least a portion of the signal waveform is rejected in response to detecting signal artifact.
摘要翻译： 包括生理传感器的医疗装置系统被配置为执行用于检测由传感器获取的信号波形中的信号伪影的方法。 使用生理传感器在患者中感测到信号波形，并且识别与感测波形相关联的基准点。 使用基准点建立点值。 响应于建立的点值和建立的阈值检测信号伪像，并且响应于检测到信号伪影而拒绝信号波形的至少一部分。
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公开(公告)号：US20130030498A1
公开(公告)日：2013-01-31
申请号：US13192256
申请日：2011-07-27
IPC分类号： A61N1/36
CPC分类号： A61N1/3611 , A61N1/36139 , A61N1/36178
摘要： A system and associated method deliver a respiration therapy. Stimulation pulses are delivered to activate a right portion of a patient's diaphragm and to activate a left portion of a patient's diaphragm. A control processor determines dyssynchrony of a respiratory response to the stimulation pulses and adjusts a stimulation control parameter controlling the delivering of the stimulation pulses in response to dyssynchrony of the respiratory response.
摘要翻译： 系统和相关方法提供呼吸治疗。 输送刺激脉冲以激活患者隔膜的右侧部分并激活患者隔膜的左侧部分。 控制处理器确定对刺激脉冲的呼吸响应的不同步，并且调整响应于呼吸响应的不同步来控制刺激脉冲的传递的刺激控制参数。
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56.发明申请METHOD AND APPARATUS FOR BLOOD PRESSURE WAVEFORM BASELINE ESTIMATION AND REMOVAL 审中-公开血压波形基线估计和去除方法与装置公开(公告)号：US20110152698A1
公开(公告)日：2011-06-23
申请号：US12646019
申请日：2009-12-23
IPC分类号： A61B5/0215
CPC分类号： A61B5/0215 , A61B5/0402 , A61B5/686 , A61B5/7239 , A61B5/7246 , A61B5/7282 , A61N1/36564
摘要： An implantable medical device system including an implantable blood pressure sensor extracts a baseline signal from the sensed blood pressure signal and subtracts the extracted baseline signal from the sensed blood pressure signal to obtain a corrected pressure monitoring signal. The corrected pressure signal is monitored to detect a cardiac-related condition.
摘要翻译： 包括可植入血压传感器的可植入医疗装置系统从感测到的血压信号中提取基线信号，并从感测到的血压信号中减去所提取的基线信号，以获得校正的压力监测信号。 监视校正的压力信号以检测心脏相关状况。
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57.发明申请METHOD AND SYSTEM FOR INTERPRETING HEMODYNAMIC DATA INCORPORATING PATIENT POSTURE INFORMATION 审中-公开用于解释患有病人信息的血液动力学数据的方法和系统公开(公告)号：US20100217135A1
公开(公告)日：2010-08-26
申请号：US12714850
申请日：2010-03-01
CPC分类号： A61N1/3702 , A61N1/36535 , A61N1/36542
摘要： Systems and methods for improving hemodynamic data interpretation by accounting for the effects of patient posture is disclosed. In certain embodiments, a posture signal is acquired and used to categorize hemodynamic data according to posture to facilitate distinguishing posture-related changes in acquired hemodynamic data from those due to pathophysiologic changes. Posture information may be used to normalize data acquired in various postures to facilitate interpretation of such data. Baseline measurements of hemodynamic data acquired in various postures may also be used to subsequently detect changes in patient posture without the need for an implanted posture sensor.
摘要翻译： 公开了通过考虑患者姿势的影响来改善血液动力学数据解释的系统和方法。 在某些实施例中，获取姿势信号并用于根据姿势对血液动力学数据进行分类，以便于将所获得的血液动力学数据中的姿势相关变化与由于病理生理变化引起的姿势相关的变化区分开。 姿势信息可以用于对在各种姿势中获取的数据进行归一化，以便于解释这些数据。 在各种姿势中获取的血液动力学数据的基线测量也可用于随后检测患者姿势的变化，而不需要植入的姿势传感器。
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58.发明申请SYSTEM AND METHOD FOR SIMULTANEOUS CENTRAL AND BRACHIAL ARTERIAL PRESSURE MONITORING 审中-公开同时中央和手持式压力监测的系统和方法公开(公告)号：US20100113943A1
公开(公告)日：2010-05-06
申请号：US12262349
申请日：2008-10-31
IPC分类号： A61B5/0215
CPC分类号： A61B5/0215 , A61B5/0031 , A61B5/02125 , A61B5/02156 , A61B5/6846 , A61N1/36564
摘要： An implantable medical device system and corresponding method to monitor blood pressure by transforming a measured pressure signal to estimate a blood pressure metric or waveform corresponding to a target site. An implantable sensor generates a signal corresponding to blood pressure at a first arterial branch location and a processor receiving the signal applies a transfer function to the signal to derive a blood pressure metric or waveform at a target site.
摘要翻译： 一种可植入医疗装置系统和相应的方法，用于通过变换测量的压力信号来估计对应于目标部位的血压量度或波形来监测血压。 可植入传感器产生对应于第一动脉分支位置处的血压的信号，并且接收信号的处理器对信号施加传递函数以导出目标部位的血压度量或波形。
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公开(公告)号：US08805511B2
公开(公告)日：2014-08-12
申请号：US13192029
申请日：2011-07-27
IPC分类号： A61N1/08
CPC分类号： A61B5/686 , A61B5/0538 , A61B5/0809 , A61B5/14503 , A61N1/3611 , A61N1/36135
摘要： A medical device and associated method detect ischemia using stimulation delivered to induce respiration. A spontaneous breathing response to the stimulation-induced respiration is determined. Ischemia is detected in response to the spontaneous breathing response. The spontaneous breathing response is measured as a response to adjusting a parameter controlling the stimulation.
摘要翻译： 医疗装置和相关方法使用递送的刺激来检测缺血以诱导呼吸。 确定对刺激诱发的呼吸的自发呼吸反应。 根据自发性呼吸反应检测到缺血。 测量自发呼吸响应作为调整控制刺激的参数的响应。
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公开(公告)号：US08380295B2
公开(公告)日：2013-02-19
申请号：US12609455
申请日：2009-10-30
IPC分类号： A61B5/04
CPC分类号： A61N1/3702
摘要： An implantable medical device system including a physiological sensor detects signal artifact in a signal waveform acquired by the sensor. Features of individual waveforms in the sensor signal are extracted. Sample waveforms are classified by expert observation into at least two classes including an artifact class. A distribution range for each of the extracted features from the sample waveforms is determined for each of the classes. Waveform classification criteria are established in response to the determined distribution ranges.
摘要翻译： 包括生理传感器的可植入医疗装置系统检测由传感器获取的信号波形中的信号伪影。 提取传感器信号中各波形的特征。 通过专家观察将样本波形分类为至少两个类，包括神器类。 为每个类别确定来自采样波形的每个提取特征的分布范围。 响应于确定的分布范围建立波形分类标准。
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