公开(公告)号：US20080132566A1

公开(公告)日：2008-06-05

申请号：US11795638

申请日：2006-01-20

申请人： Takao Sasaki ,  Masamichi Yano

发明人： Takao Sasaki ,  Masamichi Yano

IPC分类号： A61K31/352 ,  C07D493/02 ,  A61P3/00

CPC分类号： A61K36/752 ,  A23L33/105 ,  A61K31/37

摘要： A metabolic syndrome relieving agent that is free from a problem of side effects and can be taken for a long term is provided. Bergamottin is used as an agent for relieving a metabolic syndrome. Since bergamottin has functions of activating PPARα and PPARγ, promoting the secretion of adiponectin in adipocytes and inhibiting the generation of VLDLs in hepatic cells, it is possible to prevent or treat diseases such as insulin resistance, hyperinsulinism, type 2 diabetes, obesity, visceral fat obesity, hypertension, hyperlipemia, arteriosclerosis and the like and thus prevent or treat the metabolic syndrome. Also, as understood from the fact that citrus fruits such as a grapefruit or the like containing bergamottin have been eaten for many years, they have no problems in terms of safety and have a low calorie content, and therefore, they can be taken for a long term. Further, since bergamottin is tasteless and odorless, it does not impair the unique taste of a food when added to this food, so that it can be added to foods and taken.

摘要翻译： 提供了不存在副作用问题并可长期服用的代谢综合征缓解剂。 使用博加莫汀作为缓解代谢综合征的药物。 由于bergamottin具有激活PPARα和PPARγ的功能，促进脂肪细胞中脂联素的分泌和抑制肝细胞中VLDL的产生，可以预防或治疗诸如胰岛素抵抗，胰岛素抵抗，2型糖尿病，肥胖，内脏脂肪 肥胖症，高血压，高脂血症，动脉硬化等，从而预防或治疗代谢综合征。 另外，由于柑橘类水果例如葡萄柚等含有万古霉素已被吃掉多年，因此在安全性方面没有问题，并且卡路里含量低，因此可以将其用于 长期。 此外，由于香柠檬醇是无味无味的，因此当添加到食物中时，它不会损害食物的独特味道，从而可以将其加入到食物中并服用。

公开(公告)号：US20080119417A1

公开(公告)日：2008-05-22

申请号：US11795774

申请日：2006-01-20

申请人： Takao Sasaki

发明人： Takao Sasaki

IPC分类号： A61K31/7048 ,  A61K31/353

CPC分类号： A61K36/752 ,  A23L33/105 ,  A23V2002/00 ,  A61K8/498 ,  A61K31/37 ,  A61K2800/92 ,  A61Q19/00 ,  A23V2200/304 ,  A23V2200/328 ,  A23V2200/326 ,  A23V2200/318

摘要： A metabolic syndrome relieving agent that is free from a problem of side effects and can be taken for a long term is provided. Aurapten is used as an agent for relieving a metabolic syndrome. Since aurapten has functions of activating PPARα and PPARγ, promoting the secretion of adiponectin in adipocytes and inhibiting the generation of VLDLs in hepatic cells, it is possible to prevent or treat diseases such as insulin resistance, hyperinsulinism, type 2 diabetes, obesity, visceral fat obesity, hypertension, hyperlipemia, arteriosclerosis and the like and thus prevent or treat the metabolic syndrome. Also, as understood from the fact that citrus fruits such as a hassaku orange, a sweet summer orange or the like containing aurapten have been eaten for many years, they have no problems in terms of safety and have a low calorie content, and therefore, they can be taken for a long term. Further, since aurapten is tasteless and odorless, it does not impair the unique taste of a food when added to this food, so that it can be added to foods and taken.

摘要翻译： 提供了不存在副作用问题并可长期服用的代谢综合征缓解剂。 Aurapten用作缓解代谢综合征的药物。 由于aurapten具有激活PPARαα和PPARγ的功能，促进脂肪细胞中脂联素的分泌并抑制肝细胞中VLDL的产生，因此可以预防或治疗诸如胰岛素抵抗，高胰岛素血症， 2型糖尿病，肥胖症，内脏脂肪肥胖症，高血压，高脂血症，动脉硬化等，从而预防或治疗代谢综合征。 另外，由于柑橘类水果如橙子，含有刺槐的甜夏夏等已经吃了多年，因此在安全性方面没有问题，卡路里含量低， 他们可以长期服用。 此外，由于无纺布是无味无味的，因此当添加到食品中时不会损害食品的独特味道，从而可以将其加入到食品中并被摄取。

公开(公告)号：US06377118B1

公开(公告)日：2002-04-23

申请号：US09385721

申请日：1999-08-30

申请人： Masafumi Shigaki ,  Takao Sasaki

发明人： Masafumi Shigaki ,  Takao Sasaki

IPC分类号： H03F126

CPC分类号： H03F1/3276

摘要： A linearizer includes an input terminal, an output terminal, and a field-effect transistor having a gate connected to the input terminal, a drain connected to the output terminal and a source grounded. A supply voltage is supplied through a load circuit to the drain of the transistor. A gate voltage is supplied through a bias line to the gate of the transistor. The transistor is biased at a bias point at which a drain current of the transistor in response to the gate voltage is in an unsaturated region.

摘要翻译： 线性化器包括输入端子，输出端子和具有连接到输入端子的栅极的场效应晶体管，连接到输出端子的漏极和源极接地。 电源电压通过负载电路提供给晶体管的漏极。 栅极电压通过偏置线提供给晶体管的栅极。 晶体管偏置在晶体管的漏极电流响应于栅极电压处于不饱和区域的偏置点处。

公开(公告)号：US5218281A

公开(公告)日：1993-06-08

申请号：US667387

申请日：1991-03-25

申请人： Takao Sasaki ,  Kentaro Fujibayashi ,  Shouichi Sagara

发明人： Takao Sasaki ,  Kentaro Fujibayashi ,  Shouichi Sagara

IPC分类号： G05B19/416

CPC分类号： G05B19/416 ,  G05B2219/43009 ,  G05B2219/43058

摘要： An acceleration/deceleration control method for a numerical control device (CNC) which subjects a command value of a velocity in a tangential direction of a traveling path, which is instructed by a pre-interpolation feed command, to an acceleration/deceleration control. A command is read (S1), and an angle .theta. of a traveling direction of a tool with respect to an X axis is calculated (S2). Tangential accelerations .alpha.vx and .alpha.vy are derived based on preset maximum permissible accelerations for individual axes and the angle .theta. (S3). A smaller of the tangential accelerations .alpha.vx and .alpha.vy is set as a tangential acceleration .alpha.v (S4). The command velocity F is subjected to the acceleration/deceleration control by using the acceleration .alpha.v (S5), and then the interpolation is effected (S6). Since the tangential acceleration .alpha.v is set to a maximum value in a range in which the accelerations of the individual axes will not exceed the maximum permissible values thereof, the time required for effecting the acceleration/deceleration control can be reduced to a minimum value.

公开(公告)号：US5172040A

公开(公告)日：1992-12-15

申请号：US646716

申请日：1991-02-04

申请人： Takao Sasaki ,  Kentaro Fujibayashi ,  Haruhiko Kozai

发明人： Takao Sasaki ,  Kentaro Fujibayashi ,  Haruhiko Kozai

IPC分类号： G05B19/18 ,  G05B19/404 ,  G05B19/4093

CPC分类号： G05B19/40937 ,  G05B2219/36091 ,  G05B2219/36256 ,  G05B2219/45161 ,  G05B2219/49382 ,  Y02P90/265

摘要： Disclosed is a numerical control apparatus for controlling a chopping operation of a tool used in a grinding machine and the like. A programmed instruction value calculation circuit (2) outputs an upper dead point instruction (Zu) and a lower dead point instruction (Zl), a correction value calculation circuit (3) calculates and outputs correction values (.DELTA.Zu, .DELTA.Zl), and a chopping instruction calculation circuit (4) outputs a chopping control output to a manual control circuit (6) based on these instructions and correction values to operate a servo motor. When an instruction value (Zi) is input from a manual pulse generator (5) to the chopping instruction calculation circuit (4), the chopping is effected while continuously changing the upper and lower dead points, thereby enabling an operator to easily adjust the upper and lower dead points.

公开(公告)号：US5084660A

公开(公告)日：1992-01-28

申请号：US476412

申请日：1990-05-30

申请人： Takao Sasaki ,  Kunihiko Murakami

发明人： Takao Sasaki ,  Kunihiko Murakami

IPC分类号： G05B19/18 ,  G05B19/408

CPC分类号： G05B19/408 ,  G05B19/182 ,  G05B2219/50235

摘要： Disclosed is an NC command system of a CNC lathe having a plurality of tool posts, the position of which can be independently controlled, and a plurality of spindles an rpm of which can be independently controlled, wherein a coupling relationship during machining by the spindles (3, 5) and the tool posts (1, 2) can be established and switched by a machining program, and thus a more effective machining can be realized.

公开(公告)号：US5083071A

公开(公告)日：1992-01-21

申请号：US476415

申请日：1990-06-29

申请人： Takao Sasaki ,  Kentaro Fujibayashi ,  Morimasa Sato

发明人： Takao Sasaki ,  Kentaro Fujibayashi ,  Morimasa Sato

IPC分类号： G05B19/18 ,  G05B19/408 ,  G05B19/414

CPC分类号： G05B19/4083 ,  G05B19/4144 ,  G05B2219/33128 ,  G05B2219/35392 ,  G05B2219/50235

摘要： Disclosed is a spindle control system of a numerical control apparatus capable of independently controlling a plurality of spindles by a plurality of paths. Connecting relationships between respective paths (11 to 14) and respective spindles (61 to 65) are defined in a region (3), the content of the region (3) is changed by a machining program to change the spindles (61 to 65) to be controlled by the respective paths (11 to 14), whereby a more effectively machining can be realized.

公开(公告)号：US4287460A

公开(公告)日：1981-09-01

申请号：US20197

申请日：1979-03-13

申请人： Ryoichiro Nozawa ,  Yoichi Amemiya ,  Mitsuo Kawamata ,  Shigeru Isohata ,  Takao Sasaki ,  Yoshitaka Takekoshi

发明人： Ryoichiro Nozawa ,  Yoichi Amemiya ,  Mitsuo Kawamata ,  Shigeru Isohata ,  Takao Sasaki ,  Yoshitaka Takekoshi

IPC分类号： B23Q5/36 ,  G05B19/416 ,  G05D3/12 ,  G05B19/24

CPC分类号： G05B19/416 ,  Y10T408/173

摘要： The time for positioning of a machine under numerical control is determined so that the positioning is finished at the moment when the amplitude of vibration of the machine is reduced to zero. In the thus predetermined time at least accelerating control and decelerating control are conducted to achieve control for positioning the machine at a commanded position.

摘要翻译： 确定在数值控制下定位机器的时间，使得定位在机器振动幅度降至零的时刻完成。 在这样预定的时间内，进行至少加速控制和减速控制以实现将机器定位在指令位置的控制。

公开(公告)号：US09573919B2

公开(公告)日：2017-02-21

申请号：US11800637

申请日：2007-05-07

申请人： Takao Sasaki

发明人： Takao Sasaki

IPC分类号： C07D311/30 ,  A61K31/352 ,  A61K36/752

CPC分类号： C07D311/30 ,  A61K31/352 ,  A61K36/752

摘要： The present invention provides a peroxisome proliferator-activated receptor (PPAR) activator, which is free from the problem of side effects, can be taken over a long term and has no characteristics taste. Nobiletin is employed as a PPAR activator. Nobiletin has an excellent PPAR activity and has an excellent adiponectin secretion-promoting effect, and is contained in a large amount in citrus fruits, in particular, in Shiikuwasha (Citrus depressa HAYATA) indigenous to Okinawa (Japan). Since citrus fruits have been consumed for many years, the safety of nobiletin has been proven and besides, nobiletin has a low calorie content. Therefore, it can be taken over a long term. Moreover, because of being tasteless and odorless, nobiletin would not damage the unique taste of a food when added thereto. Therefore, it can be added to foods and taken.

摘要翻译： 本发明提供一种无副作用的过氧化物酶体增殖物激活受体（PPAR）活化剂，可以长期服用，没有特征味道。 诺贝瑞林被用作PPAR激活剂。 诺贝利汀具有优异的PPAR活性，具有优异的脂联素分泌促进作用，并且大量含有柑橘类水果，特别是在冲绳（日本）本土的Shiikuwasha（Citrus depressa HAYATA）中。 由于柑橘类水果已经消耗了多年，所以已经证明了诺贝利的安全性，此外，诺贝利汀的卡路里含量低。 因此，它可以长期服用。 而且，由于无味无味，所以在添加食物时，诺贝利不会损害食物的独特味道。 因此，可以添加到食物中。

公开(公告)号：US20140183127A1

公开(公告)日：2014-07-03

申请号：US14009285

申请日：2012-03-28

申请人： Koji Nakatsuji ,  Masahiro Kimura ,  Takao Sasaki ,  Takafumi Ogawa

发明人： Koji Nakatsuji ,  Masahiro Kimura ,  Takao Sasaki ,  Takafumi Ogawa

IPC分类号： B01D71/56 ,  B01D63/10 ,  B01D69/10 ,  B01D69/12

CPC分类号： B01D71/56 ,  B01D63/10 ,  B01D69/10 ,  B01D69/12 ,  B01D69/125 ,  B01D2323/12 ,  B01D2325/04 ,  B01D2325/30

摘要： A composite semipermeable membrane in which a polyamide separation functional layer is formed on a porous support membrane includes a substrate and a porous support, wherein a standard deviation of a membrane thickness of the separation functional layer is 2.00 nm or less.

摘要翻译： 在多孔支撑膜上形成聚酰胺分离功能层的复合半透膜包括基材和多孔载体，其中分离功能层的膜厚的标准偏差为2.00nm以下。