公开(公告)号：US4835017A

公开(公告)日：1989-05-30

申请号：US194248

申请日：1988-05-16

申请人： Tsutomu Ishikawa ,  Muneo Nakayama ,  Akira Hashimoto ,  Toshihiro Nishimura

发明人： Tsutomu Ishikawa ,  Muneo Nakayama ,  Akira Hashimoto ,  Toshihiro Nishimura

IPC分类号： C08L83/02 ,  C08K5/59 ,  C08L83/04 ,  C09D4/00 ,  C09D183/00 ,  C09D183/02 ,  H01L23/29

CPC分类号： H01L23/29 ,  C09D4/00 ,  H01L2924/0002

摘要： A liquid coating composition for forming a silica-based coating film on the surface of a substrate such as a semiconductor silicon wafer. A partial hydrolysis product of an alkoxy silane and an alkoxy or phenoxy compound of pentavalent antimony are dissolved in an organic solvent. As compared with a trivalent antimony compound used in the prior art, the pentavalent antimony compound as an additive is very effective in respect of the improvements in the uniformity and increased thickness of the silica-based coating film prepared from the coating composition as well as storage stability of the coating composition over time.

摘要翻译： 一种用于在诸如半导体硅晶片的基板的表面上形成二氧化硅基涂层膜的液体涂料组合物。 将烷氧基硅烷和五价锑的烷氧基或苯氧基化合物的部分水解产物溶解在有机溶剂中。 与现有技术中使用的三价锑化合物相比，作为添加剂的五价锑化合物对于由涂料组合物制备的二氧化硅基涂层的均匀性和增加的厚度以及存储 涂料组合物随时间的稳定性。

公开(公告)号：US4694040A

公开(公告)日：1987-09-15

申请号：US902029

申请日：1986-08-25

申请人： Akira Hashimoto ,  Toshihiro Nishimura ,  Muneo Nakayama ,  Hisashi Nakane ,  Shozo Toda

发明人： Akira Hashimoto ,  Toshihiro Nishimura ,  Muneo Nakayama ,  Hisashi Nakane ,  Shozo Toda

IPC分类号： C08G77/00 ,  C08G77/06 ,  C09D183/04 ,  C09D183/14 ,  C08K5/05

CPC分类号： C09D183/14

摘要： The invention provides a novel means for providing a highly heat-resistant and corrosion-resistant coating film on the surface of a substrate such as a semiconductor silicon wafer or glass plate by coating the surface with a liquid coating composition which is a solution of an oligomeric organopolysiloxane as a partial dehydration-condensation product of a monohydrocarbylsilane triol RSi(OH).sub.3, optionally, with admixture of a dihydrocarbylsilane diol R.sub.2 Si(OH).sub.2, R being a monovalent hydrocarbon group, e.g. methyl or phenyl, in an organic solvent followed by baking of the coated substrate to convert the coating layer into a cured resin film.

摘要翻译： 本发明提供了一种用于通过用液体涂料组合物涂覆表面而在诸如半导体硅晶片或玻璃板的基材的表面上提供高耐热和耐腐蚀的涂膜的新颖方法，该液体涂料组合物是低聚物 作为单烃基硅烷三醇RSi（OH）3的部分脱水缩合产物的有机聚硅氧烷，任选地与二烃基硅烷二醇R2Si（OH）2的混合物，R是一价烃基，例如 甲基或苯基，然后烘烤涂布的基材，将涂层转化为固化的树脂膜。

公开(公告)号：US4597882A

公开(公告)日：1986-07-01

申请号：US615736

申请日：1984-05-31

申请人： Toshihiro Nishimura ,  Muneo Nakayama ,  Akira Hashimoto

发明人： Toshihiro Nishimura ,  Muneo Nakayama ,  Akira Hashimoto

IPC分类号： C08G65/00 ,  C08G65/30 ,  C08G65/46 ,  C10M175/00 ,  C10M107/38

CPC分类号： C08G65/30 ,  C08G65/007 ,  C08G65/46 ,  C10M175/0075

摘要： Waste oils of synthetic lubricants containing fluorine atom are admixed with a solvent containing fluorine atom compatible with the waste oils thereby causing contaminants contained in the waste oils to float up into the upper region on the mixed solution. The solvent containing fluorine atom is removed from the solution of the lower layer by way of evaporation, distillation or the like. The regenerated oils of the synthetic lubricants containing fluorine atom thus obtained are completely colorless and transparent in appearance, and they have properties and performances quite similar to those of the fresh oils.

摘要翻译： 含有氟原子的合成润滑剂的废油与含有与废油相容的氟原子的溶剂混合，从而导致废油中含有的污染物浮起到混合溶液中的上部区域。 通过蒸发，蒸馏等从下层的溶液中除去含有氟原子的溶剂。 由此获得的含有氟原子的合成润滑剂的再生油在外观上是完全无色透明的，它们具有与新鲜油相似的性能和性能。

公开(公告)号：US09138434B2

公开(公告)日：2015-09-22

申请号：US14002533

申请日：2012-03-12

申请人： Toshihiro Nishimura ,  Hirotaka Teranishi ,  Masako Yoshida ,  Yasunori Ueno ,  Kiyoshi Kasai

发明人： Toshihiro Nishimura ,  Hirotaka Teranishi ,  Masako Yoshida ,  Yasunori Ueno ,  Kiyoshi Kasai

IPC分类号： A61K31/496 ,  C07D495/04 ,  A61K45/06 ,  A61K31/4365 ,  A61K31/444 ,  A61K31/4545

CPC分类号： A61K31/496 ,  A61K31/4365 ,  A61K31/444 ,  A61K31/4545 ,  A61K45/06 ,  C07D495/04 ,  A61K2300/00

摘要： The present invention provides compounds represented by the general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 is cyano or the like; R2 and R3 are hydrogen or the like; R4 is C1-6 alkyl or the like; R5 is C1-6 alkyl, halo-C1-6 alkyl, cycloalkyl, cycloalkyl-C1-6 alkyl, aralkyl or the like; R6 and R7 are each hydrogen, C1-6 alkyl, halo-C1-6 alkyl, cycloalkyl, C1-6 alkoxy-C1-6 alkyl, R12R13N—C1-6 alkyl or the like, which exhibit potent dopamine D2 receptor stimulating activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.

摘要翻译： 本发明提供由通式（I）表示的化合物或其药学上可接受的盐，其中R 1为氰基等; R2和R3是氢等; R4是C1-6烷基等; R 5是C 1-6烷基，卤代C 1-6烷基，环烷基，环烷基-C 1-6烷基，芳烷基等; R 6和R 7各自为氢，C 1-6烷基，卤代C 1-6烷基，环烷基，C 1-6烷氧基-C 1-6烷基，R 12 R 13 N-C 1-6烷基等，其表现出有效的多巴胺D2受体刺激活性。 本发明还提供含有所述化合物的药物组合物及其用途。

公开(公告)号：US20140243311A1

公开(公告)日：2014-08-28

申请号：US14002533

申请日：2012-03-12

申请人： Toshihiro Nishimura ,  Hirotaka Teranshi ,  Masako Yoshida ,  Yasunori Ueno ,  Kiyoshi Kasai

发明人： Toshihiro Nishimura ,  Hirotaka Teranshi ,  Masako Yoshida ,  Yasunori Ueno ,  Kiyoshi Kasai

IPC分类号： A61K31/496 ,  A61K31/4365 ,  A61K45/06 ,  C07D495/04

CPC分类号： A61K31/496 ,  A61K31/4365 ,  A61K31/444 ,  A61K31/4545 ,  A61K45/06 ,  C07D495/04 ,  A61K2300/00

摘要： The present invention provides compounds represented by the general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 is cyano or the like; R2 and R3 are hydrogen or the like; R4 is C1-6 alkyl or the like; R5 is C1-6 alkyl, halo-C1-6 alkyl, cycloalkyl, cycloalkyl-C1-6 alkyl, aralkyl or the like; R6 and R7 are each hydrogen, C1-6 alkyl, halo-C1-6 alkyl, cycloalkyl, C1-6 alkoxy-C1-6 alkyl, R12R13N—C1-6 alkyl or the like, which exhibit potent dopamine D2 receptor stimulating activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.

摘要翻译： 本发明提供由通式（I）表示的化合物或其药学上可接受的盐，其中R 1是氰基等; R2和R3是氢等; R4是C1-6烷基等; R 5是C 1-6烷基，卤代C 1-6烷基，环烷基，环烷基-C 1-6烷基，芳烷基等; R 6和R 7各自为氢，C 1-6烷基，卤代C 1-6烷基，环烷基，C 1-6烷氧基-C 1-6烷基，R 12 R 13 N-C 1-6烷基等，其表现出有效的多巴胺D2受体刺激活性。 本发明还提供含有所述化合物的药物组合物及其用途。

公开(公告)号：US07942592B2

公开(公告)日：2011-05-17

申请号：US12659113

申请日：2010-02-25

申请人： Koji Sawanobori ,  Toshihiro Nishimura

发明人： Koji Sawanobori ,  Toshihiro Nishimura

IPC分类号： G03B9/02

CPC分类号： G03B9/02

摘要： A camera diaphragm device in which two diaphragm blades, that is, first and second diaphragm blades having respective first and second diaphragm aperture portions whose diameters differ from each other is provided. The diaphragm blades are mounted to blade mounting shafts provided close to each other and in a standing manner, and are separately reciprocatingly rotated by driving pins of respective rotors. When the diaphragm device is set in a minimum diaphragm aperture control state, not only is the first diaphragm blade having the first aperture portion for restricting the minimum diaphragm aperture moved to an aperture portion, but also the second diaphragm blade having the second aperture portion for restricting an intermediate diaphragm aperture is moved to the aperture portion from the same direction. An area of the aperture portion that cannot be covered by only the first diaphragm blade is covered by the second diaphragm blade.

摘要翻译： 提供一种相机隔膜装置，其中提供两个光阑叶片，即具有彼此直径彼此不同的相应的第一和第二光阑孔径部分的第一和第二光阑叶片。 隔膜叶片安装到彼此靠近并且以立式的方式设置的叶片安装轴，并且通过各个转子的驱动销而分开地往复运动。 当隔膜装置设置在最小的光圈孔径控制状态时，不仅具有用于限制最小光阑孔径的第一开口部分的第一光阑叶片移动到开口部分，而且具有第二光阑叶片的第二光阑叶片具有用于 限制中间隔膜孔径从同一方向移动到开口部分。 只有第一光阑叶片不能覆盖的开口部分的区域被第二光阑叶片覆盖。

公开(公告)号：US20100220993A1

公开(公告)日：2010-09-02

申请号：US12659113

申请日：2010-02-25

申请人： Koji Sawanobori ,  Toshihiro Nishimura

发明人： Koji Sawanobori ,  Toshihiro Nishimura

IPC分类号： G03B9/02

CPC分类号： G03B9/02

摘要： A camera diaphragm device in which two diaphragm blades, that is, first and second diaphragm blades having respective first and second diaphragm aperture portions whose diameters differ from each other is provided. The diaphragm blades are mounted to blade mounting shafts provided close to each other and in a standing manner, and are separately reciprocatingly rotated by driving pins of respective rotors. When the diaphragm device is set in a minimum diaphragm aperture control state, not only is the first diaphragm blade having the first aperture portion for restricting the minimum diaphragm aperture moved to an aperture portion, but also the second diaphragm blade having the second aperture portion for restricting an intermediate diaphragm aperture is moved to the aperture portion from the same direction. An area of the aperture portion that cannot be covered by only the first diaphragm blade is covered by the second diaphragm blade.

摘要翻译： 提供一种相机隔膜装置，其中提供两个光阑叶片，即具有彼此直径彼此不同的相应的第一和第二光阑孔径部分的第一和第二光阑叶片。 隔膜叶片安装到彼此靠近并且以立式的方式设置的叶片安装轴，并且通过各个转子的驱动销而分开地往复运动。 当隔膜装置设置在最小的光圈孔径控制状态时，不仅具有用于限制最小光阑孔径的第一开口部分的第一光阑叶片移动到开口部分，而且具有第二光阑叶片的第二光阑叶片具有用于 限制中间隔膜孔径从同一方向移动到开口部分。 只有第一光阑叶片不能覆盖的开口部分的区域被第二光阑叶片覆盖。

公开(公告)号：US07655633B2

公开(公告)日：2010-02-02

申请号：US10540519

申请日：2003-12-19

申请人： Hideki Fujikura ,  Toshihiro Nishimura ,  Kenji Katsuno ,  Masayuki Isaji

发明人： Hideki Fujikura ,  Toshihiro Nishimura ,  Kenji Katsuno ,  Masayuki Isaji

IPC分类号： A01N43/04 ,  A61K31/70 ,  C07H15/24

CPC分类号： C07H17/02 ,  A61K31/706

摘要： The present invention provides nitrogen-containing heterocyclic derivatives represented by the general formula: wherein X1 represents N or CR1; X2 represents N or CR2; X3 represents N or CR3; X4 represents N or CR4; and with the proviso that one or two of X1 to X4 represent N; R represents optionally substituted C3-8 cycloalkyl, optionally substituted C6-10 aryl, etc.; R1 to R4 represent H, a halogen atom, etc.) or pharmaceutically acceptable salts thereof, or prodrugs thereof, which exert an excellent inhibitory activity in human SGLT2 and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications, obesity or the like, pharmaceutical compositions comprising the same, and medicinal uses thereof.

摘要翻译： 本发明提供由以下通式表示的含氮杂环衍生物：其中X1表示N或CR1; X2表示N或CR2; X3表示N或CR3; X4表示N或CR4; 并且条件是X1至X4中的一个或两个表示N; R代表任选取代的C 3-8环烷基，任选取代的C 6-10芳基等; R1至R4表示H，卤素原子等）或其药学上可接受的盐或其前药，其在人SGLT2中具有优异的抑制活性，并且可用作预防或治疗与高血糖相关的疾病的药剂，例如 糖尿病，糖尿病并发症，肥胖症等，包含其的药物组合物及其药用用途。

公开(公告)号：US07541341B2

公开(公告)日：2009-06-02

申请号：US10467823

申请日：2002-02-13

申请人： Nobuhiko Fushimi ,  Kazuya Tatani ,  Hideki Fujikura ,  Toshihiro Nishimura ,  Minoru Fujioka ,  Takeshi Nakabayashi ,  Masayuki Isaji

发明人： Nobuhiko Fushimi ,  Kazuya Tatani ,  Hideki Fujikura ,  Toshihiro Nishimura ,  Minoru Fujioka ,  Takeshi Nakabayashi ,  Masayuki Isaji

IPC分类号： A61K31/70 ,  C07H15/00 ,  C07H17/00

CPC分类号： C07H15/203

摘要： The present invention provides glucopyranosyloxybenzylbenzene derivatives represented by the general formula: wherein P represents a hydrogen atom or a group forming a prodrug; R1 represents a hydrogen atom, an optionally substituted amino group, a carbamoyl group, an optionally substituted lower alkyl group, an optionally substituted lower alkoxy group, etc.; R2 represents a hydrogen atom or a lower alkyl group; and R3 represents an optionally substituted lower alkyl group, an optionally substituted lower alkoxy group, an optionally substituted lower alkylthio group, etc., which have an improved oral absorption, and exert an inhibitory activity in human SGLT2, and therefore are useful as drugs for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, or pharmaceutically acceptable salts thereof, and pharmaceutical uses thereof.

摘要翻译： 本发明提供由以下通式表示的吡喃葡萄糖氧基苄基苯衍生物：其中P表示氢原子或形成前药的基团; R1表示氢原子，任选取代的氨基，氨基甲酰基，任选取代的低级烷基，任选取代的低级烷氧基等; R2表示氢原子或低级烷基; R3代表任意取代的低级烷基，任意取代的低级烷氧基，任意取代的低级烷硫基等，它们具有改善的口服吸收，并且在人SGLT2中具有抑制活性，因此可用作 预防或治疗与糖尿病，糖尿病并发症或肥胖症等高血糖相关的疾病或其药学上可接受的盐及其药学用途。

公开(公告)号：US07429568B2

公开(公告)日：2008-09-30

申请号：US11247332

申请日：2005-10-12

申请人： Hideki Fujikura ,  Nobuhiko Fushimi ,  Toshihiro Nishimura ,  Takeshi Nakabayashi ,  Masayuki Isaji

发明人： Hideki Fujikura ,  Nobuhiko Fushimi ,  Toshihiro Nishimura ,  Takeshi Nakabayashi ,  Masayuki Isaji

IPC分类号： A01N43/04 ,  A61K31/70 ,  C07H17/00

CPC分类号： A61K45/06 ,  A61K31/7056 ,  C07H17/02 ,  A61K2300/00

摘要： The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R represents a hydrogen atom, a lower alkyl group or a group forming a prodrug; one of Q and T represents a group represented by the general formula: (wherein P represents a hydrogen atom or a group forming a prodrug), while the other represents a lower alkyl group or a halo(lower alkyl) group; R2 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a halo(lower alkyl) group or a halogen atom; and with the proviso that P does not represent a hydrogen atom when R represents a hydrogen atom or a lower alkyl group, or pharmaceutically acceptable salts thereof, which exert an inhibitory activity in human SGLT2 and have an improved oral absorption, and therefore are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, and pharmaceutically acceptable salts thereof, and pharmaceutical uses thereof.

摘要翻译： 本发明提供由以下通式表示的吡喃葡萄糖氧吡唑衍生物：其中R表示氢原子，低级烷基或形成前药的基团; Q和T之一表示由通式表示的基团：（其中P表示氢原子或形成前药的基团），而另一个表示低级烷基或卤代（低级烷基）基团; R 2表示氢原子，低级烷基，低级烷氧基，低级烷硫基，卤代（低级烷基）或卤素原子; 并且条件是当R表示氢原子或低级烷基时，P不表示氢原子，或其药学上可接受的盐，其在人SGLT2中具有抑制活性并具有改善的口服吸收，因此可用作 用于预防或治疗与高血糖相关的疾病如糖尿病，糖尿病并发症或肥胖症的药剂及其药学上可接受的盐及其药学用途。