公开(公告)号：US07872004B2

公开(公告)日：2011-01-18

申请号：US11767021

申请日：2007-06-22

申请人： Motohide Satoh ,  Hisateru Aramaki ,  Masaki Yamashita ,  Masafumi Inoue ,  Hiroshi Kawakami ,  Hisashi Shinkai ,  Hiroshi Nakamura ,  Yuji Matsuzaki ,  Shuichi Wamaki

发明人： Motohide Satoh ,  Hisateru Aramaki ,  Masaki Yamashita ,  Masafumi Inoue ,  Hiroshi Kawakami ,  Hisashi Shinkai ,  Hiroshi Nakamura ,  Yuji Matsuzaki ,  Shuichi Wamaki

IPC分类号： A61K31/5377 ,  A61K31/4709 ,  C07D413/02 ,  C07D215/00

CPC分类号： C07D215/56 ,  C07D401/10 ,  C07D413/10 ,  C07D417/10

摘要： The present invention relates to a compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, or a solvate thereof, and a pharmaceutical composition, an anti-HIV agent and an HIV integrase inhibitor containing such compound. The compound of the present invention has an HIV integrase inhibitory activity, and is useful as an anti-HIV agent, or as an agent for the prophylaxis or treatment of AIDS. In addition, by the combined use with other anti-HIV agents such as a protease inhibitor, a reverse transcriptase inhibitor and the like, it can be a more effective anti-HIV agent. Because it shows integrase-specific high inhibitory activity, the compound can be a pharmaceutical agent safe on human body, which causes only a fewer side effects.

摘要翻译： 本发明涉及由下式[I]表示的化合物，其中每个符号如说明书中所定义，或其药学上可接受的盐，或其溶剂合物，药物组合物，抗HIV剂和HIV 含有这种化合物的整合酶抑制剂。 本发明的化合物具有HIV整合酶抑制活性，可用作抗HIV剂，或用作预防或治疗AIDS的药剂。 此外，通过与其它抗HIV剂如蛋白酶抑制剂，逆转录酶抑制剂等的组合使用，它可以是更有效的抗HIV剂。 因为它显示出整合酶特异性的高抑制活性，所以化合物可以是对人体安全的药剂，其副作用较小。

公开(公告)号：US20100317427A1

公开(公告)日：2010-12-16

申请号：US12868916

申请日：2010-08-26

申请人： Masaaki OZAKI ,  Takahisa Kaneko ,  Ken Nishioka ,  Tsuneo Uchida ,  Hiroshi Kawakami ,  Yoshio Aoki ,  Takashi Yamaguchi

发明人： Masaaki OZAKI ,  Takahisa Kaneko ,  Ken Nishioka ,  Tsuneo Uchida ,  Hiroshi Kawakami ,  Yoshio Aoki ,  Takashi Yamaguchi

IPC分类号： A63F13/00

CPC分类号： G07F17/3225 ,  G07F17/3206 ,  G07F17/3211 ,  G07F17/3288

摘要： A game machines has a back side display unit composed of reels for displaying back patterns, and a front side display unit composed of transparent EL panels for displaying overlapping patterns overlapping with the back patterns. The back side display unit and the front side display unit are disposed not to produce blind spot regions of the back patterns. The game machine can provide various overlapping patterns with good visibility and a high game selection capability to a player.

摘要翻译： 游戏机具有由用于显示背面图案的卷轴构成的背面显示单元，以及由透明EL面板组成的前侧显示单元，用于显示与背部图案重叠的重叠图案。 背面显示单元和前侧显示单元不会产生背部图案的盲点区域。 游戏机可以向玩家提供具有良好可见性和高游戏选择能力的各种重叠模式。

公开(公告)号：US07672357B2

公开(公告)日：2010-03-02

申请号：US11456827

申请日：2006-07-11

申请人： Takehiro Nakamura ,  Junichiro Hagiwara ,  Etsuhiro Nakano ,  Koji Ohno ,  Seizo Onoe ,  Akihiro Higashi ,  Motoshi Tamura ,  Masatomo Nakano ,  Hiroshi Kawakami ,  Hiroki Morikawa

发明人： Takehiro Nakamura ,  Junichiro Hagiwara ,  Etsuhiro Nakano ,  Koji Ohno ,  Seizo Onoe ,  Akihiro Higashi ,  Motoshi Tamura ,  Masatomo Nakano ,  Hiroshi Kawakami ,  Hiroki Morikawa

IPC分类号： H04B1/707

CPC分类号： H04W88/08 ,  H04B7/2618 ,  H04B7/2628 ,  H04B2201/70701 ,  H04B2201/70703 ,  H04J13/00 ,  H04J13/0022 ,  H04J13/0029 ,  H04J13/0077 ,  H04J13/10 ,  H04J13/16 ,  H04W52/08 ,  H04W52/12 ,  H04W52/16 ,  H04W52/24 ,  H04W52/241 ,  H04W52/248 ,  H04W52/322 ,  H04W52/325 ,  H04W52/40 ,  H04W52/50 ,  H04W52/56 ,  H04W52/60 ,  H04W92/10 ,  H04W92/12

摘要： A base station including a transmitting and receiving amplifier for amplifying CDMA signals exchanged with a mobile station; a radio stage connected to the transmitting and receiving amplifier for carrying out D/A conversion of a transmitted signal that undergoes baseband spreading, followed by quadrature modulation, and for carrying out quasi-coherent detection of a received signal, followed by A/D conversion; a baseband signal processor connected with the radio stage for carrying out baseband signal processing of the transmitted signal and the received signal; a transmission interface connected with the baseband signal processor for implementing interface with external channels; and a base station controller for carrying out control such as management of radio channels and establishment and release of the radio channels. The base station communicates with the external channels by mapping logical channels into physical channels. The CDMA signals are spread using a short code and a long code.

公开(公告)号：US07663496B2

公开(公告)日：2010-02-16

申请号：US11952097

申请日：2007-12-06

申请人： Hiroshi Kawakami ,  Kazuhiro Kurahara

发明人： Hiroshi Kawakami ,  Kazuhiro Kurahara

IPC分类号： G08B21/00

CPC分类号： G01L19/003

摘要： In a pressure switch, a joint coupling holder is mounted via an opening in a case constituting a housing. A plurality of engagement pawls that make up the joint coupling holder engages with a bottom of the case. Further, by inserting a cap into a recess of the joint coupling holder, the engaged state of the engagement pawls is maintained, whereby the housing, which is made from a resin material, and the joint coupling holder are strongly and rigidly connected together.

摘要翻译： 在压力开关中，通过构成壳体的壳体中的开口安装接头联接架。 构成接合连接架的多个接合爪与壳体的底部接合。 此外，通过将盖插入接头联接器保持器的凹部中，保持接合爪的接合状态，由此由树脂材料制成的壳体和接头联接器保持器牢固且刚性地连接在一起。

公开(公告)号：US20100021445A1

公开(公告)日：2010-01-28

申请号：US12525172

申请日：2008-02-29

申请人： Hiroshi Kawakami ,  Yasuhiko Shiinoki ,  Yukio Kadooka

发明人： Hiroshi Kawakami ,  Yasuhiko Shiinoki ,  Yukio Kadooka

IPC分类号： A61K35/74 ,  C12N1/20 ,  A61P3/00 ,  A61P3/04

CPC分类号： A23C19/054 ,  A23C9/1234 ,  A23C9/18 ,  A23K10/18 ,  A23L33/135 ,  A23Y2220/49 ,  A61K35/744 ,  A61K35/747

摘要： Provide a visceral fat reducing agent for reducing the diseases and conditions associated with the metabolic syndrome which represents a condition where various risk factors such as those for hypertension, hyperlipemia, glucose tolerance dysfunction, etc., have accumulated, or simply reducing an accumulation of visceral fat, wherein the effective ingredient of said visceral fat reducing agent includes fungus bodies of lactic bacteria, especially lactic bacteria belonging to the Lactobacillus sp. and Lactococcus sp. and/or cultures thereof, while also providing a beverage, food or feed containing said visceral fat reducing agent.

摘要翻译： 提供一种内脏减脂剂，用于减少与代谢综合征相关的疾病和病症，代谢综合征是各种危险因素如高血压，高脂血症，葡萄糖耐量异常等积累的危险因素，或简单地减少内脏积累 脂肪，其中所述内脏脂肪还原剂的有效成分包括乳酸菌的真菌体，特别是属于乳杆菌属的乳酸菌。 和乳球菌属 和/或其培养物，同时还提供含有所述内脏脂肪还原剂的饮料，食品或饲料。

公开(公告)号：US20100021444A1

公开(公告)日：2010-01-28

申请号：US12439728

申请日：2007-08-30

申请人： Hiroshi Kawakami ,  Satoshi Higurashi ,  Hiroaki Matsuyama

发明人： Hiroshi Kawakami ,  Satoshi Higurashi ,  Hiroaki Matsuyama

IPC分类号： A61K35/76 ,  C12N1/20

CPC分类号： A23C9/1234 ,  A23C19/0323 ,  A23K10/16 ,  A23K10/18 ,  A23K50/40 ,  A23L2/52 ,  A23L33/135 ,  A23V2002/00 ,  A23Y2220/37 ,  A23Y2220/39 ,  A61K35/747 ,  A23V2250/064 ,  A23V2200/332

摘要： Disclosed is an agent for accelerating the increase in and/or preventing the decrease in the blood adiponectin level, or a food, beverage or animal feed for accelerating the increase in and/or preventing the decrease in the blood adiponectin level, which comprises a culture or cell of a lactic acid bacterium belonging to the genus Lactobacillus, particularly Lactobacillus gasseri or Lactobacillus helveticus as an active ingredient. Also disclosed is a visceral fat accumulation inhibitor or a food or beverage for inhibiting the accumulation of a visceral fat, which comprises a culture or cell of Lactobacillus helveticus as an active ingredient.

摘要翻译： 公开了用于加速血液中脂联素水平的降低和/或预防血液中脂联素水平降低的药剂，或用于加速血液脂联素水平降低和/或预防血液中脂联素水平降低的食品，饮料或动物饲料的药剂，其包括培养物 或属于乳杆菌属的乳酸菌的细胞，特别是加氏乳杆菌（Lactobacillus gasseri）或瑞士乳杆菌（Lactobacillus helveticus）作为活性成分。 还公开了一种内脏脂肪蓄积抑制剂或用于抑制内脏脂肪积累的食品或饮料，其包含作为活性成分的瑞士乳杆菌的培养物或细胞。

公开(公告)号：US20090266702A1

公开(公告)日：2009-10-29

申请号：US12441969

申请日：2007-09-20

申请人： Takashi Kambe ,  Hitoshi Kihara ,  Norihisa Nara ,  Hiroshi Kawakami

发明人： Takashi Kambe ,  Hitoshi Kihara ,  Norihisa Nara ,  Hiroshi Kawakami

IPC分类号： B01D59/34 ,  B01J19/12

CPC分类号： B01D59/34 ,  B01D59/04 ,  B01D59/50 ,  C01B13/0211 ,  F25J3/08 ,  F25J2210/50 ,  F25J2215/50 ,  F25J2220/90 ,  Y10S62/901 ,  Y10S62/919 ,  Y10S423/07

摘要： A method of enriching a heavy oxygen isotope by distillation of the present invention includes: a first distillation step of feeding oxygen and ozone generated by an ozonizer 12 into a distillation column 13 filled with a diluent gas, and separating the oxygen, and the ozone and the diluent gas; a photodecomposition step of introducing a mixed gas of the ozone and the diluent gas from a bottom of the distillation column into a photoreaction cell 14, and irradiating the mixed gas with a laser light to selectively decompose the ozone containing the heavy oxygen isotope; and a second distillation step of returning non-decomposed ozone and oxygen containing the heavy oxygen isotope to the distillation column, and separating the oxygen, and the ozone and the diluent gas.

摘要翻译： 通过蒸馏富集重氧同位素的方法包括：将由臭氧发生器12产生的氧气和臭氧供给到填充有稀释气体的蒸馏塔13中并将氧气和臭氧分离的第一蒸馏步骤 稀释气体; 将来自蒸馏塔的底部的臭氧和稀释气体的混合气体导入光反应室14的光分解工序，用激光照射混合气体以选择性地分解含有重氧同位素的臭氧; 以及第二蒸馏步骤，将未分解的含有重氧同位素的臭氧和氧气返回到蒸馏塔，以及分离氧气，以及臭氧和稀释气体。

公开(公告)号：US20090253658A1

公开(公告)日：2009-10-08

申请号：US12296222

申请日：2007-04-06

申请人： Reo Tanaka ,  Tomoyuki Isogai ,  Yuko Haruta ,  Susumu Miura ,  Ken Kato ,  Toshimitsu Yoshioka ,  Hiroshi Kawakami ,  Satoshi Higurashi ,  Hiroaki Matsuyama

发明人： Reo Tanaka ,  Tomoyuki Isogai ,  Yuko Haruta ,  Susumu Miura ,  Ken Kato ,  Toshimitsu Yoshioka ,  Hiroshi Kawakami ,  Satoshi Higurashi ,  Hiroaki Matsuyama

IPC分类号： A61K31/66 ,  C07F9/06

CPC分类号： A61K35/20 ,  A23L2/52 ,  A23L33/19 ,  A23V2002/00 ,  A61K31/661 ,  A23V2200/332 ,  A23V2250/1844

摘要： To provide a fat accumulation inhibitor and a food or drink for inhibiting fat accumulation, a visceral fat accumulation inhibitor and a food or drink for inhibiting visceral fat accumulation, or an agent for accelerating increase and/or inhibiting decrease of an adiponectin concentration in blood and a food or drink for accelerating increase and/or inhibiting decrease of an adiponectin concentration in blood.A fat accumulation inhibitor for a fat cell, which comprises a milk-derived phospholipid as an active ingredient, and a food or drink for inhibiting fat accumulation in a fat cell, which comprises a milk-derived phospholipid. A visceral fat accumulation inhibitor comprising a sphingosine-containing phospholipid or a derivative thereof as an active ingredient, and a food or drink for inhibiting visceral fat accumulation. An agent for accelerating increase and/or inhibiting decrease of an adiponectin concentration in blood, which comprises a sphingosine-containing phospholipid or a derivative thereof as an active ingredient, and a food or drink for accelerating increase and/or inhibiting decrease of an adiponectin concentration in blood.

摘要翻译： 提供一种脂肪蓄积抑制剂和用于抑制脂肪蓄积的食物或饮料，内脏脂肪蓄积抑制剂和用于抑制内脏脂肪蓄积的食品或饮料，或用于加速和/或抑制血液中脂联素浓度降低的试剂，以及 用于促进血液中脂联素浓度增加和/或抑制降低的食物或饮料。 一种脂肪蓄积抑制剂，其包含乳源性磷脂作为活性成分的脂肪蓄积抑制剂，以及包含乳源性磷脂的脂肪细胞中抑制脂肪蓄积的食品或饮料。 含有鞘氨醇的磷脂或其衍生物作为活性成分的内脏脂肪蓄积抑制剂和抑制内脏脂肪蓄积的食品或饮料。 用于促进增加和/或抑制血液中脂联素浓度降低的药物，其包含含鞘氨醇的磷脂或其衍生物作为活性成分，以及用于加速和/或抑制脂联素浓度降低的食品或饮料 在血中

公开(公告)号：US20090176693A1

公开(公告)日：2009-07-09

申请号：US12304799

申请日：2007-06-13

申请人： Hiroshi Kawakami ,  Nobuhiro Hanada ,  Susumu Imai

发明人： Hiroshi Kawakami ,  Nobuhiro Hanada ,  Susumu Imai

IPC分类号： A61K38/40 ,  A61P19/00

CPC分类号： A61Q11/00 ,  A23L33/19 ,  A23V2002/00 ,  A61K8/19 ,  A61K8/64 ,  A23V2200/30 ,  A23V2250/54248

摘要： Provided are an agent for maintaining hardness of tooth substances and a food or drink for maintaining the hardness of tooth substances, both of which include lactoferrin and iron-lactoferrin as an active ingredient. Lactoferrin and iron-lactoferrin suppress decalcification of enamel by use or ingestion thereof, and hence is effective for the prevention of dental caries.

摘要翻译： 提供了用于保持牙齿物质的硬度的药剂和用于保持牙齿物质的硬度的食品或饮料，其包括乳铁蛋白和铁 - 乳铁蛋白作为活性成分。 乳铁蛋白和铁 - 乳铁蛋白通过使用或摄取抑制釉质的脱钙，因此对于预防龋齿是有效的。

公开(公告)号：US20090117198A1

公开(公告)日：2009-05-07

申请号：US12302973

申请日：2006-05-31

申请人： Hiroshi Kawakami ,  Satoshi Higurashi ,  Hiroaki Matsuyama

发明人： Hiroshi Kawakami ,  Satoshi Higurashi ,  Hiroaki Matsuyama

IPC分类号： A61K35/20

CPC分类号： A61K35/35 ,  A23C2240/05 ,  A23L2/02 ,  A23L33/10 ,  A23L33/20

摘要： Disclosed is: a visceral fat accumulation inhibitor or a beverage/food for inhibiting the accumulation of a visceral fat, which comprises a fat globule membrane component as an active ingredient; or a agent or beverage/food for promoting the increase in and/or inhibiting the decrease in the blood adiponectin level, which comprises a fat globule membrane component as an active ingredient. A fat globule membrane component can inhibit the accumulation of a visceral fat, and/or can promote the increase in or inhibit the decrease in the blood adiponectin level.

摘要翻译： 公开了一种内脏脂肪蓄积抑制剂或抑制内脏脂肪积聚的饮料/食品，其包含脂肪球膜成分作为活性成分; 或用于促进增加和/或抑制血液中脂联素水平降低的药剂或饮料/食品，其包含脂肪球膜组分作为活性成分。 脂肪球膜组分可以抑制内脏脂肪的积累，和/或可以促进血液中脂联素水平的增加或抑制其降低。