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公开(公告)号：US20110178136A1
公开(公告)日：2011-07-21
申请号：US13077414
申请日：2011-03-31
申请人： Allison L. Marlow , Eli Wallace , Jeongbeob Seo , Joseph P. Lyssikatos , Hong Woon Yang , James Blake
发明人： Allison L. Marlow , Eli Wallace , Jeongbeob Seo , Joseph P. Lyssikatos , Hong Woon Yang , James Blake
IPC分类号： A61K31/4412 , C07D213/80 , C07D213/82 , C07D213/84 , A61P29/00 , A61P35/00
CPC分类号： C07D213/80 , A61K31/437 , A61K31/4412 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/50 , A61K31/501 , A61K31/5025 , A61K31/5377 , A61K45/06 , C07D209/46 , C07D213/82 , C07D215/48 , C07D231/56 , C07D237/24 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , A61K2300/00
摘要： Disclosed are amino acid and phosphate prodrugs of compounds of the Formula V wherein R1, R2, R7, R8 and R9, and W are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, and inflammatory conditions in mammals. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases and inflammatory conditions in mammals and pharmaceutical compositions containing such compounds.
摘要翻译： 公开了式V化合物的氨基酸和磷酸酯前药，其中R 1，R 2，R 7，R 8和R 9和W如说明书中所定义。 这些化合物是MEK抑制剂，可用于治疗哺乳动物中的过度增生性疾病，如癌症和炎症以及炎性病症。 还公开了使用这些化合物治疗哺乳动物的过度增殖性疾病和炎性病症的方法以及含有这些化合物的药物组合物。
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52.发明授权Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof 有权二氢吡啶和二氢哒嗪衍生物作为MEK的抑制剂及其使用方法公开(公告)号：US07732616B2
公开(公告)日：2010-06-08
申请号：US11435562
申请日：2006-05-17
申请人： Allison L. Marlow , Eli M. Wallace , Jeongbeob Seo , Joseph P. Lyssikatos , Hong Woon Yang , James Blake
发明人： Allison L. Marlow , Eli M. Wallace , Jeongbeob Seo , Joseph P. Lyssikatos , Hong Woon Yang , James Blake
IPC分类号： C07D213/00
CPC分类号： C07D213/78 , C07D209/46 , C07D213/80 , C07D213/82 , C07D215/48 , C07D231/56 , C07D237/24 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04
摘要： Disclosed are compounds of the Formulas I and V and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8 and R9, W, X and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
摘要翻译： 公开了式I和V的化合物及其药学上可接受的盐和前药，其中R1，R2，R7，R8和R9，W，X和Y如说明书中所定义。 这些化合物是MEK抑制剂，可用于治疗哺乳动物和炎性病症中的过度增殖性疾病，例如癌症和炎症。 还公开了使用这些化合物治疗哺乳动物中过度增殖性疾病的方法和含有这些化合物的药物组合物。
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公开(公告)号：US20080280957A1
公开(公告)日：2008-11-13
申请号：US11914433
申请日：2006-05-17
申请人： Allison L. Marlow , Eli M. Wallace , Jeongbeob Seo , Joseph P. Lyssikatos , Hoog Woon Yang , James Blake , Richard Anthony Storey , Rebecca Jane Booth , John David Pittam , John Leonard , Mark Richard Fielding
发明人： Allison L. Marlow , Eli M. Wallace , Jeongbeob Seo , Joseph P. Lyssikatos , Hoog Woon Yang , James Blake , Richard Anthony Storey , Rebecca Jane Booth , John David Pittam , John Leonard , Mark Richard Fielding
IPC分类号： A61K31/4412 , C07D213/63 , A61P35/00
CPC分类号： C07D237/24 , C07D213/80 , C07D213/82 , C07D213/84 , C07D213/85
摘要： Disclosed are MEK inhibitors useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
摘要翻译： 公开了可用于治疗哺乳动物和炎性病症中过度增殖性疾病如癌症和炎症的MEK抑制剂。 还公开了使用这些化合物治疗哺乳动物中过度增殖性疾病的方法和含有这些化合物的药物组合物。
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公开(公告)号：US20080067166A1
公开(公告)日：2008-03-20
申请号：US11901129
申请日：2007-09-14
申请人： Duane Yoder , James Blake , Roberto Nevarez
发明人： Duane Yoder , James Blake , Roberto Nevarez
CPC分类号： A21B1/26 , A21B1/48 , A47J37/044 , Y02P60/83
摘要： An oven for heating, cooking, or toasting a food product. The oven can comprise a conveyor for conveying the food product, and a parabolically shaped top surface with a plurality of reflectors connected thereto, to direct heat back toward the conveyor. The oven can also comprise a fan for circulating air within the oven cavity. The oven can also comprise a controller that can place the oven in an energy savings mode, when it detects that the oven is not in use. The controller can place the oven in energy savings mode by adjusting the speed of, or shutting off the conveyor, or by adjusting the amount of energy supplied to heating elements disposed within the oven.
摘要翻译： 用于加热，烹饪或烘烤食品的烤箱。 烤箱可以包括用于输送食品的输送机和具有与其连接的多个反射器的抛物线形的顶表面，以将热量引导回输送机。 烘箱还可以包括用于在烤箱腔内循环空气的风扇。 烤箱还可以包括一个控制器，当控制器检测到烤箱不使用时，可以将烤箱置于节能模式。 控制器可以通过调节输送机的速度或切断输送机，或者调节供应给设在烘箱内的加热元件的能量的量来将烘箱置于节能模式。
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公开(公告)号：US20070137478A1
公开(公告)日：2007-06-21
申请号：US11699145
申请日：2007-01-29
申请人： VanEric Stein , Michael Carolan , Christopher Chen , Phillip Armstrong , Harold Wahle , Theodore Ohrn , Kurt Kneidel , Keith Rackers , James Blake , Shankar Nataraj , Rene Hendrik Elias van Doom , Merrill Wilson
发明人： VanEric Stein , Michael Carolan , Christopher Chen , Phillip Armstrong , Harold Wahle , Theodore Ohrn , Kurt Kneidel , Keith Rackers , James Blake , Shankar Nataraj , Rene Hendrik Elias van Doom , Merrill Wilson
IPC分类号： B01D53/22
CPC分类号： B01D69/141 , B01D53/22 , B01D53/228 , B01D63/082 , B01D71/024 , B01D2313/14 , B01D2319/02 , B01D2323/12 , C01B13/0251 , C01B2210/0046
摘要： An ion transport membrane system comprising (a) a pressure vessel having an interior, an exterior, an inlet, and an outlet; (b) a plurality of planar ion transport membrane modules disposed in the interior of the pressure vessel and arranged in series, each membrane module comprising mixed metal oxide ceramic material and having an interior region and an exterior region, wherein any inlet and any outlet of the pressure vessel are in flow communication with exterior regions of the membrane modules; and (c) one or more gas manifolds in flow communication with interior regions of the membrane modules and with the exterior of the pressure vessel. The ion transport membrane system may be utilized in a gas separation device to recover oxygen from an oxygen-containing gas or as an oxidation reactor to oxidize compounds in a feed gas stream by oxygen permeated through the mixed metal oxide ceramic material of the membrane modules.
摘要翻译： 一种离子传输膜系统，包括（a）具有内部，外部，入口和出口的压力容器; （b）多个平面离子传递膜组件，其设置在所述压力容器的内部并且串联布置，每个膜组件包括混合的金属氧化物陶瓷材料并具有内部区域和外部区域，其中任何入口和任何出口 压力容器与膜组件的外部区域流动连通; 和（c）与膜组件的内部区域和压力容器的外部流动连通的一个或多个气体歧管。 离子传输膜系统可用于气体分离装置中以从含氧气体或氧化反应器回收氧气，以通过渗透通过膜组件的混合金属氧化物陶瓷材料的氧气氧化进料气流中的化合物。
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公开(公告)号：US20070112038A1
公开(公告)日：2007-05-17
申请号：US11435562
申请日：2006-05-17
申请人： Allison Marlow , Eli Wallace , Jeongbeob Seo , Joseph Lyssikatos , Hong Yang , James Blake
发明人： Allison Marlow , Eli Wallace , Jeongbeob Seo , Joseph Lyssikatos , Hong Yang , James Blake
IPC分类号： C07D213/84 , C07D213/63 , A61K31/44
CPC分类号： C07D213/78 , C07D209/46 , C07D213/80 , C07D213/82 , C07D215/48 , C07D231/56 , C07D237/24 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04
摘要： Disclosed are compounds of the Formulas I and V and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8 and R9, W, X and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
摘要翻译： 公开了式I和V的化合物及其药学上可接受的盐和前药，其中R 1，R 2，R 7，R 7， SUP> 8和R 9，W，X和Y如说明书中所定义。 这些化合物是MEK抑制剂，可用于治疗哺乳动物和炎性病症中的过度增殖性疾病，例如癌症和炎症。 还公开了使用这些化合物治疗哺乳动物中过度增殖性疾病的方法和含有这些化合物的药物组合物。
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公开(公告)号：US07095910B2
公开(公告)日：2006-08-22
申请号：US10355464
申请日：2003-01-31
申请人： James Blake , Charles Lange
发明人： James Blake , Charles Lange
CPC分类号： G02B6/2821
摘要： An exemplary WDM coupling device may include optical fibers. The coupling device may also include region(s) having varying coefficients of thermal expansion. During a temperature variation, one or more of the region(s) may alter in size to substantially cancel temperature-dependent changes associated with the WDM coupling device.
摘要翻译： 示例性的WDM耦合装置可以包括光纤。 耦合装置还可以包括具有变化的热膨胀系数的区域。 在温度变化期间，该区域中的一个或多个可以改变尺寸以基本上消除与WDM耦合装置相关联的温度依赖性变化。
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