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51.发明申请DOUBLE-STRANDED RIBONUCLEIC ACID WITH INCREASED EFFECTIVENESS IN AN ORGANISM 审中-公开双重有效的抗坏血酸在有机体中具有更高的有效性公开(公告)号：US20100280102A1
公开(公告)日：2010-11-04
申请号：US12816994
申请日：2010-06-16
CPC分类号： C12N15/1135 , C12N15/111 , C12N15/1137 , C12N2310/14 , C12N2330/30
摘要： The present invention relates to a method for the targeted selection of a double-stranded ribonucleic acid (dsRNA) consisting of two single strands that exhibits increased effectiveness in inhibiting the expression of a target gene by means of RNA interference, wherein at least end of the dsRNA comprises a nucleotide overhang of 1 to 4 unpaired nucleotides in length; wherein the unpaired nucleotide adjacent to the terminal nucleotide pair comprises a purine base; and wherein the terminal nucleotide pair on both ends of the dsRNA is a G-C pair, or at least two of the last four consecutive terminal nucleotide pairs are G-C pairs.
摘要翻译： 本发明涉及一种靶向选择双链核糖核酸（dsRNA）的方法，所述双链核糖核酸（dsRNA）由两条单链组成，其通过RNA干扰显示增强的抑制靶基因表达的有效性，其中至少 dsRNA包含长度为1至4个不成对核苷酸的核苷酸突出端; 其中与所述末端核苷酸对相邻的未配对核苷酸包含嘌呤碱基; 并且其中dsRNA两端的末端核苷酸对是G-C对，或者最后四个连续的末端核苷酸对中的至少两个是G-C对。
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公开(公告)号：US07745418B2
公开(公告)日：2010-06-29
申请号：US11959936
申请日：2007-12-19
CPC分类号： C12N15/1131 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to a double-stranded ribonucleic acid (dsRNA) having a nucleotide sequence which is less that 30 nucleotides in length and which is substantially identical to at least a part of a 3′-untranslated region (3′-UTR) of a (+) strand RNA virus, such as HCV, as well as pharmaceutical compositions comprising the dsRNA, together with a pharmaceutically acceptable carrier. The pharmaceutical compositions are useful for treating infections and diseases caused by the replication or activity of the (+) strand RNA virus, as well as methods for inhibiting viral replication.
摘要翻译： 本发明涉及具有长度小于30个核苷酸的核苷酸序列的双链核糖核酸（dsRNA），并且其基本上与3'非翻译区（3'-UTR）的至少一部分相同 （+）链RNA病毒，例如HCV，以及包含dsRNA的药物组合物，以及药学上可接受的载体。 药物组合物可用于治疗由（+）链RNA病毒的复制或活性引起的感染和疾病以及用于抑制病毒复制的方法。
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53.发明申请Method and apparatus for representing myocardial tissues in different states of damage 有权用于表示不同损伤状态的心肌组织的方法和装置公开(公告)号：US20080038197A1
公开(公告)日：2008-02-14
申请号：US11890400
申请日：2007-08-06
摘要： The invention relates to a method for differentially representing myocardial tissue in different states of damage, comprising the following steps: administering a myocardium-suitable contrast agent to a patient under examination; entering at least one patient-specific parameter affecting the speed of uptake by and elimination from the myocardium of said contrast agent; calculating a point in time after administration of the contrast agent at which a difference between a contrast agent content in necrotic myocardial tissue and a contrast agent content in non-necrotic myocardial tissue attains a maximum value, on the basis of the at least one patient-specific parameter, and carrying out, at the point in time calculated, a late-phase CT scan for accentuation of necrotic myocardial tissue compared to non-necrotic myocardial tissue. The invention likewise relates to apparatus, in particular for carrying out the method. A clean copy of the abstract that incorporates the above amendments is provided herewith on a separate page.
摘要翻译： 本发明涉及用于差异代表不同损伤状态的心肌组织的方法，包括以下步骤：向被检查的患者施用适合心肌的造影剂; 输入至少一个影响所述造影剂的心肌的摄取速度和消除速度的患者特异性参数; 计算施用造影剂之后的时间点，其中所述造影剂中的坏死心肌组织中的造影剂含量与非坏死性心肌组织中的造影剂含量之间的差异达到最大值，基于至少一个患者 - 具体参数，并且在计算的时间点进行与非坏死心肌组织相比的坏死心肌组织的晚期CT扫描。 本发明同样涉及装置，特别是用于实施该方法。 包含上述修订的摘要的干净的副本将提供在单独的页面上。
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54.发明申请公开(公告)号：US20070275465A1
公开(公告)日：2007-11-29
申请号：US10560336
申请日：2004-06-14
IPC分类号： C07H21/02
CPC分类号： C12N15/1135 , C12N15/111 , C12N15/1137 , C12N2310/14 , C12N2330/30
摘要： The invention concerns a method for the targeted selection of a double-stranded ribonucleic acid (dsRNA) consisting of two single strands that exhibits increased effectiveness in inhibiting the expression of a target gene by means of RNA interference, whereby the sequences of the single strands of the dsRNA are selected in such a way that on both ends of the dsRNA the last complementary nucleotide pair is a G-C, or at least two of the last four complementary nucleotide pairs are G-C pairs; whereby the dsRNA exhibits a single-stranded overhang consisting of 1 to 4 unpaired nucleotides at the first end, and no overhang at the second end; whereby the unpaired nucleotide of the single-stranded overhang that is directly adjacent to the last complementary nucleotide pair contains a purine base.
摘要翻译： 本发明涉及一种靶向选择双链核糖核酸（dsRNA）的方法，该双链核糖核酸（dsRNA）由两条单链组成，其通过RNA干扰显示增强的抑制靶基因表达的有效性，由此单链 选择dsRNA，使得在dsRNA的两端，最后一个互补核苷酸对是GC，或者最后四个互补核苷酸对中的至少两个是GC对; 由此dsRNA在第一端显示由1至4个不成对核苷酸组成的单链突出端，并且在第二末端没有突出端; 其中与最后的互补核苷酸对直接相邻的单链突出端的不成对核苷酸包含嘌呤碱基。
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55.发明申请公开(公告)号：US20070238964A1
公开(公告)日：2007-10-11
申请号：US11725377
申请日：2007-03-19
申请人： Matthias John , Norbert Rahn
发明人： Matthias John , Norbert Rahn
IPC分类号： A61B5/05
CPC分类号： A61B6/032 , A61B8/12 , A61B8/5238 , G06T11/008
摘要： The invention relates to a method and a device for locally-resolved visualization of the reconstruction quality, especially of the coverage of a target volume to be recorded as an image and reproduced in a three-dimensional reconstruction volume presentation, especially in the human body, by two-dimensional and/or three-dimensional images covering subareas of the volume recorded by a recording device arranged inside the target volume, with which the three-dimensional reconstruction volume presentation is created, with the subareas of the target volume covered by the individual images being determined and a visual locally-resolved presentation of the reconstruction quality, especially of the coverage, being created and output as a function of the subarea coverage.
摘要翻译： 本发明涉及一种用于本地解析的重建质量可视化的方法和装置，特别是要被记录为图像并在三维重建体积呈现中特别是在人体中再现的目标体积的覆盖范围， 通过覆盖由配置在目标体积内的记录装置记录的体积的二维和/或三维图像，三维重建体积呈现被创建，其中目标体积的子区域由个体覆盖 图像被确定，并且重建质量，特别是覆盖范围的视觉局部解决呈现被创建并作为子区域覆盖的函数而被输出。
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公开(公告)号：US20050074757A1
公开(公告)日：2005-04-07
申请号：US10384463
申请日：2003-03-07
申请人： Roland Kreutzer , Stefan Limmer , Matthias John
发明人： Roland Kreutzer , Stefan Limmer , Matthias John
IPC分类号： A61K38/00 , A61P35/00 , C12N7/01 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/1131 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a mutant gene, comprising a complementary RNA strand having a complementary region that is substantially complementary to a portion of the mutant gene, and which is partially complementary to the corresponding wild-type gene. The invention further relates to a pharmaceutical composition comprising the dsRNA and a pharmaceutically acceptable carrier. The pharmaceutical compositions are useful for inhibiting the expression of a target mutant gene, as well as for treating diseases caused by expression of the target gene. The invention also relates to methods for inhibiting the expression of a target mutant gene, as well as methods for treating diseases caused by the expression of the target gene.
摘要翻译： 本发明涉及用于抑制突变基因表达的双链核糖核酸（dsRNA），其包含互补RNA链，其具有与突变基因的一部分基本上互补的互补区，并且其部分互补于 相应的野生型基因。 本发明还涉及包含dsRNA和药学上可接受的载体的药物组合物。 药物组合物可用于抑制靶突变基因的表达，以及用于治疗由靶基因表达引起的疾病。 本发明还涉及抑制靶突变基因表达的方法，以及用于治疗由靶基因表达引起的疾病的方法。
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公开(公告)号：US10390780B2
公开(公告)日：2019-08-27
申请号：US13554435
申请日：2012-07-20
申请人： Jing Feng Han , Matthias John
发明人： Jing Feng Han , Matthias John
摘要： A computer-implemented method for temporal up-to-date representation of a moving section of a body is provided. A first x-ray image data record is provided containing the moving section in a specific movement phase and a first 2D x-ray image and a 3D x-ray image superimposed and registered with one another. 2D x-ray images are repeatedly recorded each containing the moving section. 3D ultrasound images are repeatedly recorded each containing the moving section. Extended 2D x-ray images are created from the 2D x-ray images using the first x-ray images data record. The 3D ultrasound images are used as intermediaries for movement correction. The extended 2D images are displayed.
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公开(公告)号：US20150015582A1
公开(公告)日：2015-01-15
申请号：US13941815
申请日：2013-07-15
申请人： Markus Kaiser , Matthias John
发明人： Markus Kaiser , Matthias John
CPC分类号： G06T7/344 , G06T2207/10072 , G06T2207/10121 , G06T2207/10124 , G06T2207/30021 , G06T2207/30048
摘要： A method of 2D-3D image registration is presented. The method includes accessing a two dimensional image of a subject having an object therein, accessing a three dimensional image data of the subject with the object f, generating a plurality of mesh models from the three dimensional image data, wherein the plurality of mesh models comprise a first mesh model having a first attenuation coefficient and a second mesh model having a second attenuation coefficient, rendering the first mesh model and the second mesh model with a projection geometry of the two dimensional image to obtain a resultant image, iteratively comparing the resultant image with the two dimensional image using a similarity measure, and registering the two dimensional image with the resultant image.
摘要翻译： 提出了2D-3D图像配准的方法。 该方法包括访问其中具有对象的对象的二维图像，利用对象f访问对象的三维图像数据，从三维图像数据生成多个网格模型，其中多个网格模型包括 具有第一衰减系数的第一网格模型和具有第二衰减系数的第二网格模型，使用所述二维图像的投影几何形状渲染所述第一网格模型和所述第二网格模型以获得合成图像，迭代地比较所得到的图像 使用相似度测量的二维图像，并且使用所得到的图像来记录二维图像。
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59.发明申请公开(公告)号：US20140200261A1
公开(公告)日：2014-07-17
申请号：US14041011
申请日：2013-09-30
申请人： Stephen G. Hoge , Tirtha Chakraborty , Joshua P. Frederick , Matthias John , Antonin de Fougerolles
发明人： Stephen G. Hoge , Tirtha Chakraborty , Joshua P. Frederick , Matthias John , Antonin de Fougerolles
CPC分类号： C07K14/47 , A61K31/7105 , A61K31/711 , A61K38/00 , A61K48/0058 , C12N15/113 , C12N15/85 , C12N2310/141
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of signal-sensor polynucleotides, primary transcripts and mmRNA molecules.
摘要翻译： 本发明涉及用于制备，制造和治疗性使用信号传感器多核苷酸，初级转录物和mmRNA分子的组合物和方法。
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公开(公告)号：US08655041B2
公开(公告)日：2014-02-18
申请号：US13211716
申请日：2011-08-17
申请人： Matthias John , Rui Liao , Michelle xiaohong Yan , Wei You
发明人： Matthias John , Rui Liao , Michelle xiaohong Yan , Wei You
IPC分类号： G06K9/00
CPC分类号： G06T7/0014 , A61B6/481 , A61B6/487 , A61B6/504 , G06T2207/10121 , G06T2207/30048 , G06T2207/30101
摘要： A method for automatically detecting the presence of contrast in an x-ray image includes acquiring an x-ray image prior to administration of contrast. A background image is estimated based on the x-ray image. The contrast is administered. A set of x-ray images is acquired. The background image is subtracted from the set of images. Image intensity is determined for each of the subtracted images. The subtracted images having highest image intensity are selected. A predefined shape model is fitted to the selected subtracted images. The fitting of the predefined shape model is used to fit the shape model to each of the subtracted images. A feature value is calculated for each image frame based on pixel intensities of each pixel fitted to the shape model for the corresponding subtracted image. An image frame of peak contrast is determined by selecting the image frame with the greatest feature value.
摘要翻译： 用于自动检测x射线图像中的对比度的存在的方法包括在施加对比度之前获取X射线图像。 基于x射线图像估计背景图像。 对比度被管理。 获取一组X射线图像。 从图像集中减去背景图像。 确定每个减影图像的图像强度。 选择具有最高图像强度的减影图像。 预定义的形状模型适合于所选择的减影图像。 使用预定义形状模型的拟合来将形状模型拟合到每个相减图像。 基于适合于相应减法图像的形状模型的每个像素的像素强度，针对每个图像帧计算特征值。 通过选择具有最大特征值的图像帧来确定峰值对比度的图像帧。
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