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    Automatic detection of contrast injection
    1.
    发明授权
    Automatic detection of contrast injection 有权
    自动检测造影剂注射

    公开(公告)号：US08655041B2

    公开(公告)日：2014-02-18

    申请号：US13211716

    申请日：2011-08-17

    申请人： Matthias John ,  Rui Liao ,  Michelle xiaohong Yan ,  Wei You

    发明人： Matthias John ,  Rui Liao ,  Michelle xiaohong Yan ,  Wei You

    IPC分类号： G06K9/00

    CPC分类号： G06T7/0014 ,  A61B6/481 ,  A61B6/487 ,  A61B6/504 ,  G06T2207/10121 ,  G06T2207/30048 ,  G06T2207/30101

    摘要： A method for automatically detecting the presence of contrast in an x-ray image includes acquiring an x-ray image prior to administration of contrast. A background image is estimated based on the x-ray image. The contrast is administered. A set of x-ray images is acquired. The background image is subtracted from the set of images. Image intensity is determined for each of the subtracted images. The subtracted images having highest image intensity are selected. A predefined shape model is fitted to the selected subtracted images. The fitting of the predefined shape model is used to fit the shape model to each of the subtracted images. A feature value is calculated for each image frame based on pixel intensities of each pixel fitted to the shape model for the corresponding subtracted image. An image frame of peak contrast is determined by selecting the image frame with the greatest feature value.

    摘要翻译： 用于自动检测x射线图像中的对比度的存在的方法包括在施加对比度之前获取X射线图像。 基于x射线图像估计背景图像。 对比度被管理。 获取一组X射线图像。 从图像集中减去背景图像。 确定每个减影图像的图像强度。 选择具有最高图像强度的减影图像。 预定义的形状模型适合于所选择的减影图像。 使用预定义形状模型的拟合来将形状模型拟合到每个相减图像。 基于适合于相应减法图像的形状模型的每个像素的像素强度，针对每个图像帧计算特征值。 通过选择具有最大特征值的图像帧来确定峰值对比度的图像帧。

    AUTOMATIC DETECTION OF CONTRAST INJECTION
    2.
    发明申请
    AUTOMATIC DETECTION OF CONTRAST INJECTION 有权
    自动检测对比度注射

    公开(公告)号：US20120128226A1

    公开(公告)日：2012-05-24

    申请号：US13211716

    申请日：2011-08-17

    申请人： Matthias John ,  Rui Liao ,  Michelle xiaohong Yan ,  Wei You

    发明人： Matthias John ,  Rui Liao ,  Michelle xiaohong Yan ,  Wei You

    IPC分类号： G06K9/00

    CPC分类号： G06T7/0014 ,  A61B6/481 ,  A61B6/487 ,  A61B6/504 ,  G06T2207/10121 ,  G06T2207/30048 ,  G06T2207/30101

    摘要： A method for automatically detecting the presence of contrast in an x-ray image includes acquiring an x-ray image prior to administration of contrast. A background image is estimated based on the x-ray image. The contrast is administered. A set of x-ray images is acquired. The background image is subtracted from the set of images. Image intensity is determined for each of the subtracted images. The subtracted images having highest image intensity are selected. A predefined shape model is fitted to the selected subtracted images. The fitting of the predefined shape model is used to fit the shape model to each of the subtracted images. A feature value is calculated for each image frame based on pixel intensities of each pixel fitted to the shape model for the corresponding subtracted image. An image frame of peak contrast is determined by selecting the image frame with the greatest feature value.

    摘要翻译： 用于自动检测x射线图像中的对比度的存在的方法包括在施加对比度之前获取X射线图像。 基于x射线图像估计背景图像。 对比度被管理。 获取一组X射线图像。 从图像集中减去背景图像。 确定每个减影图像的图像强度。 选择具有最高图像强度的减影图像。 预定义的形状模型适合于所选择的减影图像。 使用预定义形状模型的拟合来将形状模型拟合到每个相减图像。 基于适合于相应减法图像的形状模型的每个像素的像素强度，针对每个图像帧计算特征值。 通过选择具有最大特征值的图像帧来确定峰值对比度的图像帧。

    Spatio-Temporal Analysis for Automatic Contrast Injection Detection on Angiography During Trans-Catheter Aortic Valve Implantation
    4.
    发明申请
    Spatio-Temporal Analysis for Automatic Contrast Injection Detection on Angiography During Trans-Catheter Aortic Valve Implantation 有权
    跨导管主动脉瓣植入时血管造影自动对比注射检测的时空分析

    公开(公告)号：US20120134553A1

    公开(公告)日：2012-05-31

    申请号：US13283793

    申请日：2011-10-28

    申请人： Rui Liao ,  Michelle Xiaohong Yan ,  Wei You

    发明人： Rui Liao ,  Michelle Xiaohong Yan ,  Wei You

    IPC分类号： G06K9/00

    CPC分类号： G06T7/0016 ,  G06K2209/05 ,  G06T2207/10121 ,  G06T2207/30104

    摘要： A method that includes generating a contrast feature curve for a medical image sequence including a plurality of frames, where the contrast feature curve represents contrast feature values of the frames. The method further includes detecting a peak in the contrast feature curve, and determining whether the peak corresponds to at least one of contrast injection in an aortic root, contrast injection in a balloon, and a non-contrast injected region.

    摘要翻译： 一种方法，其包括生成包括多个帧的医学图像序列的对比度特征曲线，其中所述对比度特征曲线表示所述帧的对比特征值。 该方法还包括检测对比度特征曲线中的峰值，以及确定该峰值是否对应于主动脉根部中的对比度注入，气球中的对比度注入和非对比度注入区域中的至少一种。

    System and method for guiding transcatheter aortic valve implantations based on interventional C-Arm CT imaging
    5.
    发明授权
    System and method for guiding transcatheter aortic valve implantations based on interventional C-Arm CT imaging 有权
    基于介入性C臂CT成像指导经导管主动脉瓣植入的系统和方法

    公开(公告)号：US08494245B2

    公开(公告)日：2013-07-23

    申请号：US12945045

    申请日：2010-11-12

    申请人： Rui Liao ,  Yefeng Zheng ,  Matthias John ,  Alois Nöttling ,  Jan Boese ,  Uwe Kirschstein

    发明人： Rui Liao ,  Yefeng Zheng ,  Matthias John ,  Alois Nöttling ,  Jan Boese ,  Uwe Kirschstein

    IPC分类号： G06K9/00

    CPC分类号： G06T19/00 ,  A61B6/032 ,  A61B6/4441 ,  A61B6/481 ,  A61B6/487 ,  A61B6/503 ,  A61B6/504 ,  A61B6/5235 ,  A61B6/54 ,  G06K2209/051 ,  G06T7/12 ,  G06T7/149 ,  G06T2207/10081 ,  G06T2207/20124 ,  G06T2207/30101 ,  G06T2219/028

    摘要： A method for guiding transcatheter aortic valve implantations includes receiving an interventional 3D image of an aortic root reconstructed from a sequence of 2D images acquired from a C-arm computed tomography (CT) system being rotated about a patient through a predetermined number of degrees, segmenting the aortic root and detecting aortic root landmarks in the 3D image, where the aortic root landmarks include three lowest points of aortic root cusps, two coronary artery ostia, and three commissures points where the cusps meet, cropping an area inside the segmented aortic root out of the 3D volume for volume rendering, centering the 3D image on an intersection of two orthogonal planes, each containing the two detected coronary ostia, that are orthogonal to a plane spanned by three lowest points of the aortic root cusps, and volume rendering the 3D cropped aortic root image together with the detected landmarks onto a 2D image.

    摘要翻译： 用于引导经导管主动脉瓣植入的方法包括接收从从围绕患者旋转预定数量度的C臂计算机断层摄影（CT）系统获取的2D图像序列重建的主动脉根部的介入3D图像，分割 主动脉根部并检测主动脉根部地标，其中主动脉根部地标包括主动脉根尖三个最低点，两个冠状动脉口和三个连接点，其中尖峰相遇，切除分段主动脉根部内的区域 的体积渲染的3D体积，将3D图像定位在两个正交平面的交点上，每个正交平面包含两个检测到的冠状动脉，与主动脉根尖的三个最低点跨越的平面垂直，并且体积渲染3D 将主动脉根部图像与检测到的标记一起裁剪到2D图像上。

    2D-2D FUSION FOR INTERVENTIONAL GUIDANCE IN TRANS-CATHETER AORTIC VALVE IMPLANTATION
    6.
    发明申请
    2D-2D FUSION FOR INTERVENTIONAL GUIDANCE IN TRANS-CATHETER AORTIC VALVE IMPLANTATION 有权
    用于传导导管动态阀植入的传统指导的2D-2D融合

    公开(公告)号：US20130057569A1

    公开(公告)日：2013-03-07

    申请号：US13534675

    申请日：2012-06-27

    申请人： Rui Liao ,  Yinxiao Liu ,  Matthias John

    发明人： Rui Liao ,  Yinxiao Liu ,  Matthias John

    IPC分类号： G06K9/36 ,  G09G5/02

    CPC分类号： A61B6/00 ,  A61B6/12 ,  A61B6/463 ,  A61B6/481 ,  A61B6/487 ,  A61B6/503 ,  A61B6/504 ,  A61B6/5235 ,  G06K9/34 ,  G06K9/6215 ,  G06K9/6289 ,  G06T3/0068 ,  G06T5/50 ,  G06T2207/10121 ,  G06T2207/20076 ,  G06T2207/30048 ,  G06T2207/30104

    摘要： A method for fusing 2D fluoroscopic images with 2D angiographic images for real-time interventional procedure guidance includes using a 2-dimensional angiographic image to detect injection of a contrast agent into an anatomical structure, where the contrast agent first appears in a detected image frame, subtracting a background image from the detected image frame and binarizing the subtracted image frame to segment the anatomical structure from the subtracted image frame, registering the segmented anatomical structure with a predefined shape model of the anatomical structure to generate an anatomical mask, generating an anatomical probability map from the anatomical mask using intensity information from the subtracted image frame, where the anatomical probability map expresses a probability of a pixel in the subtracted image frame belonging to the anatomical structure, and fusing the angiographic image with one or more subsequently acquired 2-dimensional fluoroscopic images of the anatomical structure using the anatomical probability map.

    摘要翻译： 用于将2D荧光图像与2D血管造影图像融合以用于实时介入手术指导的方法包括使用二维血管造影图像来检测造影剂的注射到解剖结构中，其中造影剂首先出现在检测到的图像帧中， 从检测到的图像帧中减去背景图像并对相减的图像帧进行二值化以从减除的图像帧分割解剖结构，使用解剖结构的预定义形状模型登记分割的解剖结构以生成解剖学掩模，产生解剖概率 使用来自所述相减图像帧的强度信息从所述解剖掩模映射，其中所述解剖概率图表示属于所述解剖结构的所述减去的图像帧中的像素的概率，并且将所述血管造影图像与一个或多个随后获取的二维 透视图像的肛门 omical结构使用解剖概率图。

    SYSTEM AND METHOD FOR GUIDING TRANSCATHETER AORTIC VALVE IMPLANTATIONS BASED ON INTERVENTIONAL C-ARM CT IMAGING
    7.
    发明申请
    SYSTEM AND METHOD FOR GUIDING TRANSCATHETER AORTIC VALVE IMPLANTATIONS BASED ON INTERVENTIONAL C-ARM CT IMAGING 有权
    基于传统C-ARM CT成像的导管动脉瓣植入系统及方法

    公开(公告)号：US20110222750A1

    公开(公告)日：2011-09-15

    申请号：US12945045

    申请日：2010-11-12

    申请人： Rui Liao ,  Yefeng Zheng ,  Matthias John ,  Alois Nöttling ,  Jan Boese ,  Uwe Kirschstein

    发明人： Rui Liao ,  Yefeng Zheng ,  Matthias John ,  Alois Nöttling ,  Jan Boese ,  Uwe Kirschstein

    IPC分类号： G06K9/00

    CPC分类号： G06T19/00 ,  A61B6/032 ,  A61B6/4441 ,  A61B6/481 ,  A61B6/487 ,  A61B6/503 ,  A61B6/504 ,  A61B6/5235 ,  A61B6/54 ,  G06K2209/051 ,  G06T7/12 ,  G06T7/149 ,  G06T2207/10081 ,  G06T2207/20124 ,  G06T2207/30101 ,  G06T2219/028

    摘要： A method for guiding transcatheter aortic valve implantations includes receiving an interventional 3D image of an aortic root reconstructed from a sequence of 2D images acquired from a C-arm computed tomography (CT) system being rotated about a patient through a predetermined number of degrees, segmenting the aortic root and detecting aortic root landmarks in the 3D image, where the aortic root landmarks include three lowest points of aortic root cusps, two coronary artery ostia, and three commissures points where the cusps meet, cropping an area inside the segmented aortic root out of the 3D volume for volume rendering, centering the 3D image on an intersection of two orthogonal planes, each containing the two detected coronary ostia, that are orthogonal to a plane spanned by three lowest points of the aortic root cusps, and volume rendering the 3D cropped aortic root image together with the detected landmarks onto a 2D image.

    摘要翻译： 用于引导经导管主动脉瓣植入的方法包括接收从从围绕患者旋转预定数量度的C臂计算机断层摄影（CT）系统获取的2D图像序列重建的主动脉根部的介入3D图像，分割 主动脉根部并检测主动脉根部地标，其中主动脉根部地标包括主动脉根尖三个最低点，两个冠状动脉口和三个连接点，其中尖峰相遇，切除分段主动脉根部内的区域 的体积渲染的3D体积，将3D图像定位在两个正交平面的交点上，每个正交平面包含两个检测到的冠状动脉，与主动脉根尖的三个最低点跨越的平面垂直，并且体积渲染3D 将主动脉根部图像与检测到的标记一起裁剪到2D图像上。