公开(公告)号：US20080228316A1

公开(公告)日：2008-09-18

申请号：US11622662

申请日：2007-01-12

申请人： John K. Stevens ,  Paul Waterhouse ,  Michael J. Vandenberg

发明人： John K. Stevens ,  Paul Waterhouse ,  Michael J. Vandenberg

IPC分类号： G06F7/00 ,  B65G1/02 ,  B65D19/38

CPC分类号： B65G1/1378 ,  B65G1/1371 ,  B65G2201/0258 ,  B65G2201/0261 ,  B65G2203/046 ,  B65G2209/04

摘要： A warehousing system includes a container for storing at least one item, a first electronic (e.g., radio frequency identification (RFID)) module associated with the first container, and a controller which wirelessly communicates with first electronic module, for directing a transfer of said at least one item to and/or from said first container. The inventive system may include, for example, a hybrid retail/warehouse system which includes a facility having a shelving area, and a picking area adjacent to the shelving area, and a layout so as to minimize a picking area and a walking distance between a picking area and a shelving area.

摘要翻译： 仓储系统包括用于存储至少一个物品的容器，与第一容器相关联的第一电子（例如射频识别（RFID））模块，以及与第一电子模块无线通信的控制器，用于指示所述 至少一个物品到和/或来自所述第一容器。 本发明的系统可以包括例如包括具有搁置区域的设施和与搁架区域相邻的拾取区域的混合零售/仓库系统，以及布局，以便使采摘区域和步骤之间的距离最小化 采摘区域和搁置区域。

公开(公告)号：US20080275530A1

公开(公告)日：2008-11-06

申请号：US11560338

申请日：2006-11-15

申请人： John K. Stevens ,  Paul Waterhouse

发明人： John K. Stevens ,  Paul Waterhouse

IPC分类号： A61N1/00

CPC分类号： A61F2/3609 ,  A61B17/1659 ,  A61F2/36 ,  A61F2/367 ,  A61F2/3676 ,  A61F2002/3067 ,  A61F2002/3625 ,  A61F2250/0002 ,  A61F2310/00017 ,  A61F2310/00023

摘要： A metal surgical implant has a first antenna wrapped around an elongated portion, the first antenna electrically coupled with circuitry, all tuned to a frequency below 450 kilohertz. The assembly is substantially sterile. A second antenna may also be wrapped around the elongated portion, also electrically coupled with the circuitry. The implant may be a hip implant.

摘要翻译： 金属手术植入物具有围绕细长部分缠绕的第一天线，第一天线与电路电耦合，全部调谐到低于450千赫兹的频率。 该组件基本上是无菌的。 第二天线也可以缠绕在细长部分周围，也与电路电耦合。 植入物可以是髋关节植入物。

公开(公告)号：US06110339A

公开(公告)日：2000-08-29

申请号：US973932

申请日：1997-12-16

申请人： Thomas D. Yager ,  Paul Waterhouse ,  Alexandre M. Izmailov ,  Bruno Maruzzo ,  John K. Stevens ,  Marina T. Larson

发明人： Thomas D. Yager ,  Paul Waterhouse ,  Alexandre M. Izmailov ,  Bruno Maruzzo ,  John K. Stevens ,  Marina T. Larson

IPC分类号： G01N27/447

CPC分类号： G01N27/44704 ,  G01N27/44773 ,  G01N27/44791 ,  Y10T436/143333

摘要： Separation matrices useful in the formation of solid-state mm- to cm-scale devices for the rapid, high-resolution separation of single-stranded DNA ladder bands generated by the Sanger dideoxy- or Maxam/Gilbert chemical DNA sequencing procedures are formed from a solid support (1) having a plurality of posts (4) disposed on a first major surface thereof to form an obstacle course of posts (4) and pores (5). The posts are arranged in a regular X, Y array and are separated one from another by a distance of 100 nm or less, preferably 10 to 30 nm, and are optionally separated into lanes 2. The separation matrix can be manufactured by first forming a mold, preferably a reusable mold using lithography techniques. The mold is the reverse of the desired pattern of posts and pores of the obstacle course, and is used for casting the obstacle course. The cast obstacle course is then fused to a solid support and separated from the mold. Alternatively, the separation matrix can be formed from a polymer which undergoes specific and quantifiable swelling in the presence of a selected chemical compound. In this case, the matrix is cast on a mold in a conventional manner with a spacing between posts greater than the desired final spacing of 100 nm or less. For use, a buffer solution saturated with the specific chemical agent that controls swelling is added, causing the posts to swell to a defined amount to achieve the desired separation.

摘要翻译： PCT No.PCT / US96 / 09999 Sec。 371日期：1997年12月16日 102（e）日期1997年12月16日PCT提交1996年6月7日PCT公布。 出版物WO96 / 42012 PCT 日期1996年12月27日用于形成固态mm至cm尺度装置的分离基质用于快速，高分辨率分离由Sanger双脱氧或Maxam / Gilbert化学DNA测序产生的单链DNA梯形带 步骤由具有设置在其第一主表面上的多个柱（4）的固体支撑件（1）形成，以形成柱（4）和孔（5）的障碍物路线。 柱以规则的X，Y阵列布置，并且彼此分离一个距离为100nm或更小，优选为10至30nm，并且任选地分离成通道2.分离基体可以通过首先形成 模具，优选使用光刻技术的可重复使用的模具。 模具与障碍物路线的柱和孔的期望图案相反，并且用于铸造障碍物路线。 然后将铸造的障碍物道路融合到固体支撑物并与模具分离。 或者，分离基质可以由在所选择的化合物存在下经历特异性和可定量溶胀的聚合物形成。 在这种情况下，基体以常规方式在模具上铸造，柱之间的间距大于期望的最终间距为100nm或更小。 为了使用，加入饱和了特定化学试剂的缓冲溶液以控制溶胀，导致柱膨胀至规定的量以达到所需的分离。

公开(公告)号：US08659396B2

公开(公告)日：2014-02-25

申请号：US11462981

申请日：2006-08-07

申请人： John K. Stevens ,  Paul Waterhouse ,  Florin Tarcoci

发明人： John K. Stevens ,  Paul Waterhouse ,  Florin Tarcoci

IPC分类号： G08B13/184

CPC分类号： G06K7/0008 ,  G06K7/10039 ,  G06K7/10069 ,  G06K7/10316 ,  G06K7/10336

摘要： An area-reading antenna (in RF linkage with myriad RF tags) is dynamically tuned. It may be dynamically tuned as to its transmission of a power/clock field, or dynamically tuned as to its transmission of a data signal, or dynamically tuned as to its reception of a data signal, or some combination of all three. In this way, a base station has an improved ability to communicate with a greater fraction of the RF tags within its reading area, despite detuning of individual tags due to proximity of detuning influences such as metal or liquids.

摘要翻译： 动态地调整区域读取天线（与无数RF标签的RF联动）。 可以动态调整其功率/时钟域的传输，或者动态地调整其数据信号的传输，或者动态地调整其数据信号的接收，或三者的某种组合。 以这种方式，尽管由于诸如金属或液体的失谐影响的接近，基站在其读取区域内具有与更大部分的RF标签通信的改善的能力。

公开(公告)号：US20100271010A1

公开(公告)日：2010-10-28

申请号：US12768582

申请日：2010-04-27

申请人： John K. Stevens ,  Paul Waterhouse

发明人： John K. Stevens ,  Paul Waterhouse

IPC分类号： H01L43/06

CPC分类号： B23Q17/006 ,  B23Q17/003

摘要： A tool sensor detects the presence of a tool and optionally identifies that tool as the correct tool for placement in the sensor. The tool sensor may be in the form of a pad, with openings sized to fit the tool, and may have designated locations for a plurality of tools, in which each tool is identified as being the correct tool for its location on or in the sensor.

摘要翻译： 工具传感器检测工具的存在，并可选择将该工具识别为用于放置在传感器中的正确工具。 工具传感器可以是垫的形式，其开口尺寸适于装配工具，并且可以具有用于多个工具的指定位置，其中每个工具被识别为用于其位于传感器上或传感器中的正确工具 。

公开(公告)号：US07609662B2

公开(公告)日：2009-10-27

申请号：US11610128

申请日：2006-12-13

申请人： John K. Stevens ,  Paul Waterhouse ,  David Cramer

发明人： John K. Stevens ,  Paul Waterhouse ,  David Cramer

IPC分类号： H04B7/00

CPC分类号： H04L29/12216 ,  H04L29/12113 ,  H04L29/12933 ,  H04L61/1541 ,  H04L61/2007 ,  H04L61/6068 ,  H04L67/04 ,  H04L67/12 ,  H04W8/26 ,  H04W52/0212 ,  H04W76/10 ,  H04W80/04 ,  H04W92/24 ,  Y02D70/166

摘要： The system employs full transceivers, each having peer-to-peer, client/server, and IP networking capabilities, and covering open-area ranges of up to 100 feet. The system uses Low Frequency for data communications so it can achieve both low cost (less costly than many RF-ID tags) and long battery life (10-15 years). Additionally, since these tags have batteries, static RAM maybe be added at very low cost, as well as sensors, LED's displays etc.

摘要翻译： 该系统采用完整的收发器，每个收发器具有点对点，客户端/服务器和IP网络功能，并覆盖高达100英尺的开放范围。 该系统使用低频进行数据通信，因此可以实现低成本（比许多RF-ID标签更便宜）和更长的电池寿命（10-15年）。 另外，由于这些标签具有电池，所以可以以非常低的成本添加静态RAM，以及传感器，LED显示器等。

公开(公告)号：US06261430B1

公开(公告)日：2001-07-17

申请号：US09505659

申请日：2000-02-17

申请人： Thomas D. Yager ,  Paul Waterhouse ,  Alexandre M. Izmailov ,  Bruno C. Maruzzo ,  John K. Stevens ,  Marina T. Larson

发明人： Thomas D. Yager ,  Paul Waterhouse ,  Alexandre M. Izmailov ,  Bruno C. Maruzzo ,  John K. Stevens ,  Marina T. Larson

IPC分类号： G01N2726

CPC分类号： G01N27/44773 ,  G01N27/44704 ,  G01N27/44791

摘要： A microelectrophoresis chip comprises a substrate in which there are formed one or more channels, one channel for each sample to be evaluated. The channels extend for the length of the chip, a distance of generally around 1 cm, and are about 1 to 10 &mgr;m wide and 1 to 10 &mgr;m in depth. The channels are filled with a homogeneous separation matrix which acts as an obstacle to the electrophoretic migration of the charged molecules. Microelectrodes disposed in the channels are used to induce an electric filed within the homogeneous separation medium. When a voltage is applied across two or more of the microelectrodes, the charged molecules are induced to move and separate according to the electric field density, the type of solvent film, and the charge, shape and size of the charged molecule. The chip may further comprise detectors, such as light polarization detectors, fluorescence emission detectors, biosensors, electrochemical sensors or other microcomponents which may include sites for enzymatic or chemical manipulation of the moved or separated charged molecules.

摘要翻译： 微电泳芯片包括其中形成一个或多个通道的基底，每个待评估样品的通道一个通道。 通道延长芯片的长度，通常约1厘米的距离，宽度约为1至10微米，深度为1至10毫米。 通道充满均匀的分离基质，其作为电荷分子的电泳迁移的障碍。 设置在通道中的微电极用于诱导均匀分离介质内的电场。 当电压施加到两个或更多个微电极上时，根据电场密度，溶剂膜的类型和带电分子的电荷，形状和尺寸，诱导带电分子移动和分离。 芯片还可以包括诸如光偏振检测器，荧光发射检测器，生物传感器，电化学传感器或其它微元件的检测器，其可以包括用于酶或分离带电分子的酶或化学操作的位点。

公开(公告)号：US6005663A

公开(公告)日：1999-12-21

申请号：US849662

申请日：1997-08-18

申请人： Paul Waterhouse ,  John A. Renfrew ,  John K. Stevens

发明人： Paul Waterhouse ,  John A. Renfrew ,  John K. Stevens

IPC分类号： G01N21/64 ,  G01N27/447 ,  G01N21/00

CPC分类号： G01N27/44721

摘要： Improved detection methods and apparatus which may be used individually or in combinations enhance the ability of the electrophoresis apparatus to detect fluorophore-labeled materials in short periods of time. One such apparatus comprises a housing adapted to receive an electrophoresis gel holder; an excitation source of electromagnetic radiation having a frequency effective to induce emission of electromagnetic radiation from the fluorophore; a plurality of optical fibers for delivering electromagnetic radiation from the excitation source to a linear array of excitation/detection sites on the gel holder, optical switching means for sequentially directing electromagnetic radiation into one of several pre-defined groups of the optical fibers; detection means such as a photomultiplier tube, or an array of photomultiplier tubes for detecting emission from the fluorophore induced by a radiation from the excitation source; and means for correlating a detected emission with the switching of the excitation electromagnetic radiation such that a given emission may be linked with the excitation/detection site being irradiated. For example, the optical switching means may alternate between directing radiation from the source into every other optical fiber, or may provide radiation in rotation to every third or fourth fiber. Alternatively, a spot array generation grating can be used for dividing an incident beam of coherent radiation into an array of excitation beamlets and directing each excitation beamlets to an excitation/detection site on the electrophoresis gel. Light emitting diode disposed to deliver excitation energy to an array of excitation/detection sites may also be used. This latter form of the apparatus is particularly advantageous due to the low costs of light emitting diodes (LEDs) compared to coherent light sources (e.g. lasers).

公开(公告)号：US5885431A

公开(公告)日：1999-03-23

申请号：US836269

申请日：1997-05-01

申请人： John A. Renfrew ,  Paul Waterhouse ,  John K. Stevens ,  Henryk Zaleski

发明人： John A. Renfrew ,  Paul Waterhouse ,  John K. Stevens ,  Henryk Zaleski

IPC分类号： G01N27/447 ,  G01N27/26

CPC分类号： G01N27/44743 ,  G01N27/44704 ,  G01N27/44747

摘要： An electrophoresis microgel is formed in a gel holder. The gel holder comprises a top substrate, a bottom substrate and a spacer disposed between the top substrate and the bottom substrate. The spacer establishes a separation of from 25 to 250 microns between the top substrate and the bottom substrate. A gel compartment is formed by partially sealing the top substrate to the bottom substrate, while leaving an opening for the introduction of unpolymerized gel. The gel compartment is then filled with an unpolymerized gel, which is polymerized in the gel compartment. Electrodes may be printed on the substrates, may be contacts to an exposed edge of gel, or may be applied through windows cut into one of the substrates. One type of gel holder makes use of graded beads having a diameter of 25 to 250 microns slurried in an adhesive such as an acrylate adhesive as the spacer. The slurry is printed onto the surface of one or both substrates to form a spacer of the desired shape, and then hardened using heat or light. If desired, the spacer can establish lanes within the gel.

摘要翻译： PCT No.PCT / US95 / 14531 Sec。 371日期1997年5月1日 102（e）日期1997年5月1日PCT提交1995年10月31日PCT公布。 出版物WO96 / 日期1996年5月9日在凝胶保持器中形成电泳微凝胶。 凝胶保持器包括顶部基底，底部基底和设置在顶部基底和底部基底之间的间隔物。 间隔物在顶部基底和底部基底之间建立了从25至250微米的间隔。 通过将顶部基底部分地密封到底部基底而形成凝胶室，同时留下用于引入未聚合凝胶的开口。 然后用凝胶隔室填充未聚合的凝胶，其在凝胶隔室中聚合。 电极可以印刷在基底上，可以与凝胶的暴露边缘接触，或者可以通过切割成一个基底的窗口来施加。 一种类型的凝胶保持器使用在诸如丙烯酸酯粘合剂的粘合剂中作为间隔物浆化的直径为25至250微米的分级珠粒。 将浆料印刷到一个或两个基材的表面上以形成所需形状的间隔物，然后使用热或光硬化。 如果需要，间隔物可以在凝胶内建立泳道。

公开(公告)号：US20110106296A1

公开(公告)日：2011-05-05

申请号：US12917277

申请日：2010-11-01

申请人： John K. Stevens ,  Paul Waterhouse ,  Michael J. Vandenberg

发明人： John K. Stevens ,  Paul Waterhouse ,  Michael J. Vandenberg

IPC分类号： G06F7/00 ,  G06K19/06

CPC分类号： B65G1/1378 ,  B65G1/1371 ,  B65G2201/0258 ,  B65G2201/0261 ,  B65G2203/046 ,  B65G2209/04

摘要： A warehousing system includes a container for storing at least one item, a first electronic (e.g,. radio frequency identification (RFID)) module associated with the first container, and a controller which wirelessly communicates with first electronic module, for directing a transfer of said at least one item to and/or from said first container. The inventive system may include, for example, a hybrid retail/warehouse system which includes a facility having a shelving area, and a picking area adjacent to the shelving area, and a layout so as to minimize a picking area and a walking distance between a picking area and a shelving area.

摘要翻译： 仓储系统包括用于存储至少一个物品的容器，与第一容器相关联的第一电子（例如，射频识别（RFID））模块，以及与第一电子模块无线通信的控制器，用于引导 所述至少一个物品到所述第一容器和/或来自所述第一容器。 本发明的系统可以包括例如包括具有搁置区域的设施和与搁架区域相邻的拾取区域的混合零售/仓库系统，以及布局，以便使采摘区域和步骤之间的距离最小化 采摘区域和搁置区域。