公开(公告)号：US20100233352A1

公开(公告)日：2010-09-16

申请号：US12728584

申请日：2010-03-22

申请人： Robert D. Black ,  Jeffrey C. Leung

发明人： Robert D. Black ,  Jeffrey C. Leung

IPC分类号： B05D7/00 ,  B05C11/00

CPC分类号： A61M37/0069 ,  A61N5/1027 ,  A61N2005/1023

摘要： A low-dose-rate (LDR) brachytherapy device having a spatiotemporal radiation profile includes an elongated body having a radioactive material in a spatial pattern to provide a spatial radiation profile with a radiation intensity that varies along a length of the elongated body. The radioactive material includes at least first and second radioisotopes having at least first and second respective decay profiles that together provide a temporal radiation profile that is different from the first and second decay profiles. The spatial radiation profile and the temporal radiation profile form a net spatiotemporal radiation profile configured to provide a radiotherapy plan for a patient.

摘要翻译： 具有时空辐射轮廓的低剂量率（LDR）近距离放射治疗装置包括具有空间图案的放射性材料的细长体，以提供具有沿细长体的长度变化的辐射强度的空间辐射分布。 放射性材料至少包括具有至少第一和第二相应的衰变曲线的第一和第二放射性同位素，它们一起提供不同于第一和第二衰变曲线的时间辐射分布。 空间辐射分布和时间辐射分布形成净空间时间辐射谱，配置成为患者提供放射治疗计划。

公开(公告)号：US07686756B2

公开(公告)日：2010-03-30

申请号：US11846075

申请日：2007-08-28

申请人： Robert D. Black ,  Jeffrey C. Leung

发明人： Robert D. Black ,  Jeffrey C. Leung

IPC分类号： A61N5/00

CPC分类号： A61M37/0069 ,  A61N5/1027 ,  A61N2005/1023

摘要： A low-dose-rate (LDR) brachytherapy device having a spatiotemporal radiation profile includes an elongated body having a radioactive material in a spatial pattern to provide a spatial radiation profile with a radiation intensity that varies along a length of the elongated body. The radioactive material includes at least first and second radioisotopes having at least first and second respective decay profiles that together provide a temporal radiation profile that is different from the first and second decay profiles. The spatial radiation profile and the temporal radiation profile form a net spatiotemporal radiation profile configured to provide a radiotherapy plan for a patient.

摘要翻译： 具有时空辐射轮廓的低剂量率（LDR）近距离放射治疗装置包括具有空间图案的放射性材料的细长体，以提供具有沿细长体的长度变化的辐射强度的空间辐射分布。 放射性材料至少包括具有至少第一和第二相应的衰变曲线的第一和第二放射性同位素，它们一起提供不同于第一和第二衰变曲线的时间辐射分布。 空间辐射分布和时间辐射分布形成净空间时间辐射谱，配置成为患者提供放射治疗计划。

公开(公告)号：US06773450B2

公开(公告)日：2004-08-10

申请号：US10216516

申请日：2002-08-09

申请人： Jeffrey C. Leung ,  Gregory Ruff ,  Andrew Kaplan

发明人： Jeffrey C. Leung ,  Gregory Ruff ,  Andrew Kaplan

IPC分类号： A61B1704

CPC分类号： A61B17/06166 ,  A61B17/0401 ,  A61B17/064 ,  A61B17/1146 ,  A61B2017/0412 ,  A61B2017/0427 ,  A61B2017/0462 ,  A61B2017/06057 ,  A61B2017/06176 ,  Y10S606/908 ,  Y10S606/91

摘要： A suture anchor for approximating tissue to bone comprises an anchor member for securing the suture anchor to the bone and a plurality of sutures mounted to the anchor member so that the sutures extend outwardly from the anchor member. Each suture has a sharp pointed end for penetrating the tissue and a plurality of barbs which permit movement of the sutures through the tissue in one direction of movement of the pointed end and prevent movement of the sutures relative to the tissue in the opposite direction. The ends of the sutures are inserted and pushed through the tissue along a curvilinear path in a direction away from the bone. The sutures are drawn from exit points longitudinally spaced from the points of insertion and reinserted and advanced along a curvilinear path in the direction away from the bone. The sutures are drawn through the tissue while approximating the tissue adjacent the bone along the suture and leaving a length of the sutures in the tissue. The exit and entry points of two of the sutures are adjacent and the paths of the sutures substantially mirror one another.

摘要翻译： 用于近似组织到骨骼的缝合锚固件包括用于将缝线锚固件固定到骨上的锚固构件和安装到锚定构件上的多个缝合线，使得缝线从锚定构件向外延伸。 每个缝合线具有用于穿透组织的尖锐尖端和多个倒钩，其允许缝合线在尖端的一个运动方向上穿过组织移动，并且防止缝线相对于组织在相反方向上的移动。 缝合线的端部沿着远离骨头的方向沿着曲线路径插入并推动穿过组织。 缝合线从与插入点纵向间隔开的出口点抽取并重新插入并且沿着远离骨骼的方向沿着曲线路径前进。 缝合线穿过组织，同时沿着缝合线近似骨骼附近的组织，并在组织中留下一定长度的缝合线。 两条缝合线的出口和入口点相邻，并且缝合线的路径基本相互镜像。

公开(公告)号：US06376019B1

公开(公告)日：2002-04-23

申请号：US09951609

申请日：2001-09-14

申请人： Jeffrey C. Leung

发明人： Jeffrey C. Leung

IPC分类号： B05D310

CPC分类号： A61B17/00491 ,  A61B2017/00862 ,  B05C17/002 ,  B05D1/26 ,  B05D1/34

摘要： An applicator tip for dispensing a polymerizable and/or cross-linkable material which is porous, absorbent or adsorbent and includes a polymerization or cross-linking initiator. The initiator initiates polymerization or cross-linking when the polymerizable and/or cross-linkable material is dispensed through the applicator tip. The polymerizable and/or cross-linkable material may be applied to a variety of substrates.

摘要翻译： 用于分配可聚合和/或可交联材料的涂抹器尖端，其是多孔的，吸收性的或吸附性的并且包括聚合或交联引发剂。 当可聚合和/或可交联材料通过施用器尖端分配时，引发剂引发聚合或交联。 可聚合和/或可交联的材料可以施加到各种基材上。

公开(公告)号：US5328687A

公开(公告)日：1994-07-12

申请号：US040618

申请日：1993-03-31

申请人： Jeffrey C. Leung ,  Jeffrey G. Clark

发明人： Jeffrey C. Leung ,  Jeffrey G. Clark

IPC分类号： A61L24/00 ,  A61L24/06 ,  C09J4/00 ,  A61K31/74 ,  A61K9/14 ,  C08F120/44 ,  C08F222/34

CPC分类号： A61L24/06 ,  C09J4/00 ,  Y10S514/963

摘要： A biocompatible monomer composition contains (A) at least one monomer of the formula:CHR.dbd.CXYwherein X and Y are each strong electron withdrawing groups, and R is H or, provided that X and Y are both cyano groups, a C.sub.1 -C.sub.4 alkyl group; and (B) an effective amount of at least one biocompatible agent effective to reduce active formaldehyde concentration levels, preferably a formaldehyde scavenger compound. The monomer is preferably an alpha-cyanoacrylate. The formaldehyde scavenger compound may be in microencapsulated or non-microencapsulated form. The composition can be applied to a variety of materials and is particularly suitable as in vivo tissue adhesive. A method of joining together in vivo two surfaces, e.g., body tissues, includes (a) applying to at least one of the surfaces a composition containing 1) at least one monomer, preferably an alpha-cyanoacrylate, which forms a polymer whose in vivo biodegradation produces formaldehyde; and 2) an effective amount of at least one biocompatible agent effective to reduce active formaldehyde concentration levels, preferably a formaldehyde scavenger; and (b) maintaining the surfaces in contact until the composition polymerizes.

摘要翻译： 生物相容性单体组合物含有（A）至少一种下式的单体：CHR = CXY其中X和Y各自为强吸电子基团，R为H，或者X和Y均为氰基，C1-C4 烷基; 和（B）有效量的至少一种有效降低活性甲醛浓度水平的生物相容剂，优选甲醛清除剂化合物。 单体优选为α-氰基丙烯酸酯。 甲醛清除剂化合物可以是微囊化或非微囊化形式。 组合物可以应用于各种材料，并且特别适合作为体内组织粘合剂。 在体内将两个表面（例如身体组织）接合在一起的方法包括（a）向至少一个表面施用包含1）至少一种形成其体内聚合物的单体，优选α-氰基丙烯酸酯的组合物 生物降解产生甲醛; 和2）有效量的至少一种有效降低活性甲醛浓度水平的生物相容剂，优选甲醛清除剂; 和（b）保持表面接触直到组合物聚合。

公开(公告)号：US08690914B2

公开(公告)日：2014-04-08

申请号：US12849977

申请日：2010-08-04

申请人： Jeffrey C. Leung ,  Gregory Ruff ,  Andrew Kaplan

发明人： Jeffrey C. Leung ,  Gregory Ruff ,  Andrew Kaplan

IPC分类号： A61B17/04

CPC分类号： A61B17/06166 ,  A61B17/0401 ,  A61B17/064 ,  A61B17/1146 ,  A61B2017/0412 ,  A61B2017/0427 ,  A61B2017/0462 ,  A61B2017/06057 ,  A61B2017/06176 ,  Y10S606/908 ,  Y10S606/91

摘要： A suture system has a suture with a first plurality of barbs located adjacent to a first end and a second plurality of barbs located adjacent to a second end, and a body located between the first plurality of barbs and the second plurality of barbs. The body provides an anchor that can hold tissue relative to the first end and the second end of the suture. The body can slide and be positioned on said suture.

摘要翻译： 缝线系统具有缝合线，其具有邻近第一端定位的第一多个倒钩和邻近第二端定位的第二多个倒钩以及位于第一多个倒钩和第二多个倒钩之间的主体。 身体提供可以相对于缝合线的第一端和第二端保持组织的锚固件。 身体可以滑动并定位在所述缝合线上。

公开(公告)号：US08652170B2

公开(公告)日：2014-02-18

申请号：US12849960

申请日：2010-08-04

申请人： Jeffrey C. Leung ,  Gregory Ruff ,  Andrew Kaplan

发明人： Jeffrey C. Leung ,  Gregory Ruff ,  Andrew Kaplan

IPC分类号： A61B17/04

CPC分类号： A61B17/06166 ,  A61B17/0401 ,  A61B17/064 ,  A61B17/1146 ,  A61B2017/0412 ,  A61B2017/0427 ,  A61B2017/0462 ,  A61B2017/06057 ,  A61B2017/06176 ,  Y10S606/908 ,  Y10S606/91

摘要： A suture system has a double ended barbed suture with a first plurality of barbs located adjacent to a first end and a second plurality of barbs located adjacent to a second end, and a body located between the first plurality of barbs and the second plurality of barbs. The body provides an anchor that can hold tissue relative to the first end and the second end of the suture. The body can slide and be positioned on said suture.

摘要翻译： 缝线系统具有双端有倒钩的缝合线，其具有邻近第一端的第一多个倒钩和邻近第二端定位的第二多个倒钩，以及位于第一多个倒钩和第二多个倒钩之间的主体 。 身体提供可以相对于缝合线的第一端和第二端保持组织的锚固件。 身体可以滑动并定位在所述缝合线上。

公开(公告)号：US20100298879A1

公开(公告)日：2010-11-25

申请号：US12849977

申请日：2010-08-04

申请人： Jeffrey C. Leung ,  Gregory Ruff ,  Andrew Kaplan

发明人： Jeffrey C. Leung ,  Gregory Ruff ,  Andrew Kaplan

IPC分类号： A61B17/04

CPC分类号： A61B17/06166 ,  A61B17/0401 ,  A61B17/064 ,  A61B17/1146 ,  A61B2017/0412 ,  A61B2017/0427 ,  A61B2017/0462 ,  A61B2017/06057 ,  A61B2017/06176 ,  Y10S606/908 ,  Y10S606/91

摘要： A suture system has a suture with a first plurality of barbs located adjacent to a first end and a second plurality of barbs located adjacent to a second end, and a body located between the first plurality of barbs and the second plurality of barbs. The body provides an anchor that can hold tissue relative to the first end and the second end of the suture. The body can slide and be positioned on said suture.

摘要翻译： 缝线系统具有缝合线，其具有邻近第一端定位的第一多个倒钩和邻近第二端定位的第二多个倒钩以及位于第一多个倒钩和第二多个倒钩之间的主体。 身体提供可以相对于缝合线的第一端和第二端保持组织的锚固件。 身体可以滑动并定位在所述缝合线上。

公开(公告)号：US06676322B1

公开(公告)日：2004-01-13

申请号：US09409672

申请日：1999-09-30

申请人： Jeffrey C. Leung

发明人： Jeffrey C. Leung

IPC分类号： B43K514

CPC分类号： B05D1/34 ,  B05C17/002 ,  B05D1/26

摘要： An applicator tip for dispensing a polymerizable and/or cross-linkable material which is porous, absorbent or adsorbent and includes a polymerization or cross-linking initiator. The initiator initiates polymerization or cross-linking when the polymerizable and/or cross-linkable material is dispensed through the applicator tip. The polymerizable and/or cross-linkable material may be applied to a variety of substrates.

摘要翻译： 用于分配可聚合和/或可交联材料的涂抹器尖端，其是多孔的，吸收性的或吸附性的并且包括聚合或交联引发剂。 当可聚合和/或可交联材料通过施用器尖端分配时，引发剂引发聚合或交联。 可聚合和/或可交联的材料可以施加到各种基材上。

公开(公告)号：US06565840B1

公开(公告)日：2003-05-20

申请号：US08909845

申请日：1997-08-12

申请人： Jeffrey G. Clark ,  Jeffrey C. Leung

发明人： Jeffrey G. Clark ,  Jeffrey C. Leung

IPC分类号： A61L2500

CPC分类号： A61L24/06 ,  A61B5/14532 ,  A61B5/1455 ,  A61L24/0021 ,  C09J4/00 ,  G01J3/1804 ,  C08L35/04 ,  C08F222/32

摘要： A biocompatible monomer composition includes: (A) at least one monomer, which forms a medically acceptable polymer; (B) at least one plasticizing agent present in the composition in an amount of from 0.5 wt. % to 15 wt. % of the composition; and (C) at least one acidic stabilizing agent having a pKa ionization constant of from about 1 to about 7. The composition can be applied to a variety of materials and is particularly suitable as in vivo tissue adhesive. A method of joining together in vivo two surfaces, e.g., body tissues, includes (a) holding damaged tissue edges together to form abutted tissue surfaces; (b) applying to the abutted tissue surfaces an excessive amount of a composition containing 1) at least one monomer, which forms a medically acceptable biodegradable polymer, 2) at least one plasticizing agent; and 3) at least one acidic stabilizing agent; and (c) maintaining the surfaces in contact until the composition polymerizes to form a thick film of polymerized composition bridging the abutted tissue surfaces.

摘要翻译： 生物相容性单体组合物包括：（A）至少一种形成医学上可接受的聚合物的单体; （B）组合物中存在的至少一种增塑剂的量为0.5wt。 ％至15wt。 ％的组成; 和（C）至少一种具有约1至约7的pKa电离常数的酸性稳定剂。该组合物可以应用于各种材料，并且特别适合作为体内组织粘合剂。 在体内将两个表面（例如身体组织）接合在一起的方法包括（a）将损伤的组织边缘保持在一起以形成邻接的组织表面; （b）向邻接的组织表面施加过量的组合物，其含有1）至少一种形成医学上可接受的生物可降解聚合物的单体，2）至少一种增塑剂; 和3）至少一种酸性稳定剂; 和（c）保持表面接触直到组合物聚合以形成桥接邻接组织表面的聚合组合物的厚膜。