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1.发明授权公开(公告)号：US09358377B2
公开(公告)日：2016-06-07
申请号：US12728584
申请日：2010-03-22
申请人： Robert D. Black , Jeffrey C. Leung
发明人： Robert D. Black , Jeffrey C. Leung
CPC分类号： A61M37/0069 , A61N5/1027 , A61N2005/1023
摘要： A low-dose-rate (LDR) brachytherapy device having a spatiotemporal radiation profile includes an elongated body having a radioactive material in a spatial pattern to provide a spatial radiation profile with a radiation intensity that varies along a length of the elongated body. The radioactive material includes at least first and second radioisotopes having at least first and second respective decay profiles that together provide a temporal radiation profile that is different from the first and second decay profiles. The spatial radiation profile and the temporal radiation profile form a net spatiotemporal radiation profile configured to provide a radiotherapy plan for a patient.
摘要翻译： 具有时空辐射轮廓的低剂量率（LDR）近距离放射治疗装置包括具有空间图案的放射性材料的细长体，以提供具有沿细长体的长度变化的辐射强度的空间辐射分布。 放射性材料至少包括具有至少第一和第二相应的衰变曲线的第一和第二放射性同位素，它们一起提供不同于第一和第二衰变曲线的时间辐射分布。 空间辐射分布和时间辐射分布形成净空间时间辐射谱，配置成为患者提供放射治疗计划。
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2.发明申请公开(公告)号：US20100233352A1
公开(公告)日：2010-09-16
申请号：US12728584
申请日：2010-03-22
申请人： Robert D. Black , Jeffrey C. Leung
发明人： Robert D. Black , Jeffrey C. Leung
CPC分类号： A61M37/0069 , A61N5/1027 , A61N2005/1023
摘要： A low-dose-rate (LDR) brachytherapy device having a spatiotemporal radiation profile includes an elongated body having a radioactive material in a spatial pattern to provide a spatial radiation profile with a radiation intensity that varies along a length of the elongated body. The radioactive material includes at least first and second radioisotopes having at least first and second respective decay profiles that together provide a temporal radiation profile that is different from the first and second decay profiles. The spatial radiation profile and the temporal radiation profile form a net spatiotemporal radiation profile configured to provide a radiotherapy plan for a patient.
摘要翻译： 具有时空辐射轮廓的低剂量率（LDR）近距离放射治疗装置包括具有空间图案的放射性材料的细长体，以提供具有沿细长体的长度变化的辐射强度的空间辐射分布。 放射性材料至少包括具有至少第一和第二相应的衰变曲线的第一和第二放射性同位素，它们一起提供不同于第一和第二衰变曲线的时间辐射分布。 空间辐射分布和时间辐射分布形成净空间时间辐射谱，配置成为患者提供放射治疗计划。
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3.发明授权公开(公告)号：US07686756B2
公开(公告)日：2010-03-30
申请号：US11846075
申请日：2007-08-28
申请人： Robert D. Black , Jeffrey C. Leung
发明人： Robert D. Black , Jeffrey C. Leung
IPC分类号： A61N5/00
CPC分类号： A61M37/0069 , A61N5/1027 , A61N2005/1023
摘要： A low-dose-rate (LDR) brachytherapy device having a spatiotemporal radiation profile includes an elongated body having a radioactive material in a spatial pattern to provide a spatial radiation profile with a radiation intensity that varies along a length of the elongated body. The radioactive material includes at least first and second radioisotopes having at least first and second respective decay profiles that together provide a temporal radiation profile that is different from the first and second decay profiles. The spatial radiation profile and the temporal radiation profile form a net spatiotemporal radiation profile configured to provide a radiotherapy plan for a patient.
摘要翻译： 具有时空辐射轮廓的低剂量率（LDR）近距离放射治疗装置包括具有空间图案的放射性材料的细长体，以提供具有沿细长体的长度变化的辐射强度的空间辐射分布。 放射性材料至少包括具有至少第一和第二相应的衰变曲线的第一和第二放射性同位素，它们一起提供不同于第一和第二衰变曲线的时间辐射分布。 空间辐射分布和时间辐射分布形成净空间时间辐射谱，配置成为患者提供放射治疗计划。
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公开(公告)号：US09655772B2
公开(公告)日：2017-05-23
申请号：US13525817
申请日：2012-06-18
申请人： Lanty L. Smith , Lesco L. Rogers , Robert D. Black
发明人： Lanty L. Smith , Lesco L. Rogers , Robert D. Black
CPC分类号： A61F7/12 , A61B2018/00875 , A61F7/007 , A61F2007/0005 , A61F2007/0075 , A61F2007/0093 , A61F2007/0095 , A61F2007/0096 , A61F2007/0296 , A61N1/36036 , A61N2/002 , A61N2/006
摘要： An in-ear stimulation device for administering caloric stimulation to the ear canal of a subject includes (a) first and second earpieces configured to be insertable into the ear canals of the subject; (b) at least first and second thermoelectric devices thermally coupled to respective ones of the first and second earpieces; (c) a first heat sink thermally coupled to the first thermoelectric device opposite the first earpiece and a second heat sink thermally coupled to the second thermoelectric device opposite the second earpiece; and (d) a controller comprising a waveform generator in communication with the first and second thermoelectric devices, the waveform generator configured to generate a first control signal to control a first caloric output to the first thermoelectric device and a second control signal to control a second caloric output to the second caloric device.
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5.发明申请READERS AND COMPUTER PROGRAM PRODUCTS THAT COOPERATE WITH SINGLE-USE EXTERNAL DOSIMETERS FOR USE IN RADIATION THERAPIES 审中-公开与单次使用外用药剂配合用于放射治疗的读者和计算机程序产品公开(公告)号：US20110161012A1
公开(公告)日：2011-06-30
申请号：US13041906
申请日：2011-03-07
CPC分类号： G01T1/026 , A61N5/1048 , A61N5/1071 , A61N2005/1072
摘要： Methods, systems, devices, and computer program products include positioning single-use radiation sensor patches that have adhesive means onto the skin of a patient to evaluate the radiation dose delivered during a treatment session. The sensor patches are configured to be minimally obtrusive and operate without the use of externally extending power cords or lead wires.
摘要翻译： 方法，系统，装置和计算机程序产品包括将具有粘合剂的一次性辐射传感器贴片定位到患者的皮肤上，以评估在治疗期间递送的辐射剂量。 传感器贴片配置为最低限度地突出，并且不使用外部扩展的电源线或引线进行操作。
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6.发明授权Disposable single-use external dosimeters for detecting radiation in fluoroscopy and other medical procedures/therapies 有权一次性一次性外用剂量计，用于检测荧光透视和其他医疗程序/治疗中的辐射公开(公告)号：US07966054B2
公开(公告)日：2011-06-21
申请号：US10865430
申请日：2004-06-10
IPC分类号： A61B5/05
CPC分类号： G01T1/026 , A61N5/1048 , A61N5/1071 , A61N2005/1072
摘要： Methods, systems, devices, and computer program products include positioning single-use radiation sensor patches that have adhesive onto the skin of a patient to evaluate the radiation dose delivered during a medical procedure or treatment session. The sensor patches are configured to be relatively unobtrusive and operate during radiation without the use of externally extending power cords or lead wires.
摘要翻译： 方法，系统，设备和计算机程序产品包括将具有粘合剂的单次使用的辐射传感器贴片定位在患者的皮肤上，以评估在医疗过程或治疗期间递送的辐射剂量。 传感器贴片被配置为相对不引人注意并且在辐射期间操作，而不使用外部延伸的电源线或引线。
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7.发明授权Readers that cooperate with single-use internal dosimeters for detecting radiation in medical procedures/therapies 失效与一次性内部剂量计配合使用以在医疗程序/疗法中检测辐射的读者公开(公告)号：US07897927B2
公开(公告)日：2011-03-01
申请号：US12354461
申请日：2009-01-15
IPC分类号： G01T1/02
CPC分类号： G01T1/026 , A61N5/1048 , A61N5/1071 , A61N2005/1072
摘要： Methods, systems, devices, and computer program products include positioning single-use radiation internal dosimeters with MOSFETs into a patient to evaluate the radiation dose delivered during a medical procedure or treatment session. The MOSFETs can be unpowered during irradiation.
摘要翻译： 方法，系统，设备和计算机程序产品包括将具有MOSFET的单次使用辐射内部剂量计定位到患者中以评估在医疗过程或治疗期间递送的辐射剂量。 MOSFET在照射过程中可以无功。
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8.发明申请IN VIVO FLUORESCENCE SENSORS, SYSTEMS, AND RELATED METHODS OPERATING IN CONJUNCTION WITH FLUORESCENT ANALYTES 有权荧光荧光传感器，系统和相关方法与荧光分析仪相结合公开(公告)号：US20090180962A1
公开(公告)日：2009-07-16
申请号：US12389012
申请日：2009-02-19
申请人： Robert D. Black , Natasha Bolick
发明人： Robert D. Black , Natasha Bolick
IPC分类号： A61B10/00
CPC分类号： A61K49/0041 , A61B5/0002 , A61B5/0071 , A61B5/0084 , A61B5/417 , A61K49/0058
摘要： Methods, systems, devices and computer program product include: (i) administering a fluorescent analyte to a subject; (ii) repetitively emitting excitation light from an implanted sensor over a desired monitoring period; (iii) detecting fluorescence intensity in response to the excitation light using the implanted sensor that outputs the excitation light; and (iv) using data associated with the detected fluorescence intensity to perform at least one of: (a) calculate the concentration or dose of the analyte received proximate to the implanted sensor site; (b) evaluate the pharmacodynamic or pharmacokinetic activity of the fluorescent analyte; (c) confirm Ab attachment to a tumor site; (d) monitor a non-target site to confirm it is not unduly affected by a therapy; (e) monitor for changes in cellular properties; (f) use the calculated dose or concentration data to adjust or customize a therapeutic amount of the analyte administered to the subject; (g) confirm micelle concentration at a target site and then stimulate toxin release based on the confirmation; and (h) monitor for the expression of a protein produced from a gene therapy modification.In particular embodiments, the intensity of the excitation signals emitted to the localized tissue can be varied in a predetermined manner to generate optical profiling data of the response of the tissue proximate the sensor.
摘要翻译： 方法，系统，装置和计算机程序产品包括：（i）向受试者施用荧光分析物; （ii）在期望的监测周期内从植入的传感器重复地发射激发光; （iii）使用输出激发光的植入传感器检测响应于激发光的荧光强度; 和（iv）使用与检测到的荧光强度相关联的数据来执行以下至少之一中的至少一个：（a）计算在植入的传感器位置附近接收的分析物的浓度或剂量; （b）评估荧光分析物的药效学或药代动力学活性; （c）确认Ab附着于肿瘤部位; （d）监测非目标地点，以确认其不会受到治疗的不当影响; （e）监测细胞特性的变化; （f）使用计算的剂量或浓度数据来调整或定制施用于受试者的分析物的治疗量; （g）确定目标部位的胶束浓度，然后根据确认刺激毒素释放; 和（h）监测由基因治疗修饰产生的蛋白质的表达。 在特定实施例中，发射到局部组织的激发信号的强度可以以预定的方式变化，以产生靠近传感器的组织的响应的光学剖面数据。
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9.发明授权In vivo fluorescence sensors, systems, and related methods operating in conjunction with fluorescent analytes 有权体内荧光传感器，系统和与荧光分析物结合操作的相关方法公开(公告)号：US07510699B2
公开(公告)日：2009-03-31
申请号：US10779907
申请日：2004-02-17
申请人： Robert D. Black , Natasha Bolick
发明人： Robert D. Black , Natasha Bolick
IPC分类号： A61B5/00
CPC分类号： A61K49/0041 , A61B5/0002 , A61B5/0071 , A61B5/0084 , A61B5/417 , A61K49/0058
摘要： Methods, systems, devices and computer program product include: (i) administering a fluorescent analyte to a subject; (ii) repetitively emitting excitation light from an implanted sensor over a desired monitoring period; (iii) detecting fluorescence intensity in response to the excitation light using the implanted sensor that outputs the excitation light; and (iv) using data associated with the detected fluorescence intensity to perform at least one of: (a) calculate the concentration or dose of the analyte received proximate to the implanted sensor site; (b) evaluate the pharmacodynamic or pharmacokinetic activity of the fluorescent analyte; (c) confirm Ab attachment to a tumor site; (d) monitor a non-target site to confirm it is not unduly affected by a therapy; (e) monitor for changes in cellular properties; (f) use the calculated dose or concentration data to adjust or customize a therapeutic amount of the analyte administered to the subject; (g) confirm micelle concentration at a target site and then stimulate toxin release based on the confirmation; and (h) monitor for the expression of a protein produced from a gene therapy modification.In particular embodiments, the intensity of the excitation signals emitted to the localized tissue can be varied in a predetermined manner to generate optical profiling data of the response of the tissue proximate the sensor.
摘要翻译： 方法，系统，装置和计算机程序产品包括：（i）向受试者施用荧光分析物; （ii）在期望的监测周期内从植入的传感器重复地发射激发光; （iii）使用输出激发光的植入传感器检测响应于激发光的荧光强度; 和（iv）使用与检测到的荧光强度相关联的数据来执行以下至少之一中的至少一个：（a）计算在植入的传感器位置附近接收的分析物的浓度或剂量; （b）评估荧光分析物的药效学或药代动力学活性; （c）确认Ab附着于肿瘤部位; （d）监测非目标地点，以确认其不会受到治疗的不当影响; （e）监测细胞特性的变化; （f）使用计算的剂量或浓度数据来调整或定制施用于受试者的分析物的治疗量; （g）确定目标部位的胶束浓度，然后根据确认刺激毒素释放; 和（h）监测由基因治疗修饰产生的蛋白质的表达。 在特定实施例中，发射到局部组织的激发信号的强度可以以预定的方式变化，以产生靠近传感器的组织的响应的光学剖面数据。
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10.发明授权Single-use internal dosimeters for detecting radiation in fluoroscopy and other medical procedures/therapies 有权用于检测荧光透视和其他医疗程序/治疗中的辐射的一次性内置剂量计公开(公告)号：US07491942B2
公开(公告)日：2009-02-17
申请号：US10865312
申请日：2004-06-10
IPC分类号： G01T1/02
CPC分类号： G01T1/026 , A61N5/1048 , A61N5/1071 , A61N2005/1072
摘要： Methods, systems, devices, and computer program products include positioning single-use radiation internal dosimeters with MOSFETs into a patient to evaluate the radiation dose delivered during a medical procedure or treatment session. The MOSFETs can be unpowered during irradiation.
摘要翻译： 方法，系统，设备和计算机程序产品包括将具有MOSFET的单次使用辐射内部剂量计定位到患者中以评估在医疗过程或治疗期间递送的辐射剂量。 MOSFET在照射过程中可以无功。
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