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公开(公告)号：US5593968A
公开(公告)日：1997-01-14
申请号：US285040
申请日：1994-08-02
申请人： Peter Turecek , Eibl Johann , Hans-Peter Schwarz
发明人： Peter Turecek , Eibl Johann , Hans-Peter Schwarz
CPC分类号： C12N9/6432 , C12Y304/21006 , A61K38/00 , Y10S514/834 , Y10S530/829 , Y10S530/83
摘要： A virus-inactivated Factor-Xa preparation with at least 100 units coagulation factor activity per mg protein is described, wherein this preparation is produced by activation of a corresponding starting material and subsequent treatment for the inactivation of infectious agents, particularly viruses. By incubation, the preparation obtained in this manner is transformed into a stable beta-Factor Xa preparation. In addition, the use of the present preparation for the treatment of hemophilia A inhibitor patients is disclosed.
摘要翻译： 描述了具有至少100单位凝血因子活性/ mg蛋白质的病毒灭活因子-Xa制剂，其中该制剂通过活化相应的起始物质和随后的感染因子，特别是病毒灭活的处理而产生。 通过孵育，将以这种方式获得的制剂转化成稳定的β因子Xa制剂。 此外，公开了本发明制剂用于治疗血友病A抑制剂患者的用途。
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52.发明授权Kit for measuring the thrombin generation in a sample of a patient's blood or plasma 有权用于测量患者血液或血浆样品中凝血酶产生的试剂盒公开(公告)号：US08735086B2
公开(公告)日：2014-05-27
申请号：US13539154
申请日：2012-06-29
IPC分类号： C12Q1/56
CPC分类号： A61K31/66 , C12Q1/56 , G01N33/86 , G01N2333/745
摘要： The invention provides a kit for measuring the thrombin generation in a sample of a patient's blood or plasma, or in a sample of clotting factors. The kit contains lyophilized tissue factor/phospholipid-complex and a lyophilized mixture containing a thrombin-substrate and CaCl2. The invention also provides processes for preparing the reagents for the kit. The kit can be used in a method for measuring the thrombin generation in a sample, wherein it is possible to detect changes in thrombin generation kinetics, for example after administration of inhibitor bypassing agents to a patient who has developed inhibitors to an exogenous clotting factor such as Factor VIII.
摘要翻译： 本发明提供了一种用于测量患者血液或血浆样品或凝血因子样品中的凝血酶产生的试剂盒。 该试剂盒含有冻干组织因子/磷脂复合物和含有凝血酶底物和CaCl 2的冻干混合物。 本发明还提供了用于制备试剂盒的试剂的方法。 该试剂盒可以用于测量样品中凝血酶产生的方法，其中可以检测凝血酶产生动力学的变化，例如在将抑制剂旁路剂施用于已经开发出外源凝血因子的抑制剂的患者之后 作为因子VIII。
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53.发明授权Methods for the inactivation of microorganisms in biological fluids, flow through reactors and methods of controlling the light sum dose to effectively inactivate microorganisms in batch reactors 有权生物流体中微生物灭活的方法，流经反应器的方法和控制光总剂量以有效灭活间歇反应器中的微生物的方法公开(公告)号：US08377375B2
公开(公告)日：2013-02-19
申请号：US13100570
申请日：2011-05-04
申请人： Heinz Anderle , Peter Matthiessen , Hans-Peter Schwarz , Peter Turecek , Thomas Kreil , Daniel R. Boggs
发明人： Heinz Anderle , Peter Matthiessen , Hans-Peter Schwarz , Peter Turecek , Thomas Kreil , Daniel R. Boggs
CPC分类号： A61L2/10 , A23L3/26 , A23L3/28 , A61L2/0011 , A61L2/28 , G01N21/33 , H05B3/0052
摘要： The present invention relates to a method for determining an effective dose of monochromatic or polychromatic light from one or more light sources to inactivate microorganisms present in a biological fluid, preferably a non-transparent fluid. Moreover, there is provided a method for the inactivation of microorganism in a biological fluid in a flow-through-reactor. Moreover, the invention advantageously provides a flow-through-reactor with one or more thermostated light sources. The invention further provides a method of controlling the light sum dose of monochromatic or polychromatic light emitted from one or more light sources to effectively inactivate microorganisms present in a biological fluid in a batch reactor.
摘要翻译： 本发明涉及一种用于确定来自一种或多种光源的有效剂量的单色或多色光以灭活存在于生物流体中，优选非透明流体中的微生物的方法。 此外，提供了在流通反应器中的生物流体中的微生物灭活的方法。 此外，本发明有利地提供具有一个或多个恒温光源的流通反应器。 本发明还提供一种控制从一个或多个光源发射的单色或多色光的光总量的方法，以有效地灭活间歇反应器中存在于生物流体中的微生物。
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54.发明申请MODIFIED RECOMBINANT FACTOR VIII AND VON WILLEBRAND FACTOR AND METHODS OF USE 审中-公开改性重组因子VIII和VON WILLEBRAND因子及其使用方法公开(公告)号：US20120322737A1
公开(公告)日：2012-12-20
申请号：US13452612
申请日：2012-04-20
申请人： Hans-Peter Schwarz , Peter Turecek
发明人： Hans-Peter Schwarz , Peter Turecek
CPC分类号： A61K38/37 , A61K47/60 , A61K47/61 , C07K14/755 , C08G65/329 , C08H1/00 , C08L63/00 , C08L2203/02
摘要： The present invention provides novel methods of increasing the survival of a coagulation protein by inhibiting the interaction with a clearance receptor. The invention also provides methods of preparing compositions that inhibit coagulation protein clearance receptors. Conjugated coagulation proteins, including compositions and formulations thereof, are also provided by the present invention.
摘要翻译： 本发明提供了通过抑制与间隙受体的相互作用来增加凝血蛋白的存活的新方法。 本发明还提供了制备抑制凝血蛋白清除受体的组合物的方法。 共轭凝血蛋白，包括其组合物和制剂，也由本发明提供。
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55.发明授权Methods for differentiating plasma-derived protein from recombinant protein in a sample 有权在样品中从重组蛋白质中分离血浆来源的蛋白质的方法公开(公告)号：US08114633B2
公开(公告)日：2012-02-14
申请号：US12341098
申请日：2008-12-22
申请人： Alfred Weber , Peter Turecek , Hans-Peter Schwarz
发明人： Alfred Weber , Peter Turecek , Hans-Peter Schwarz
CPC分类号： G01N33/6842 , G01N2333/4724 , G01N2333/755 , Y10S436/827 , Y10T436/10 , Y10T436/105831 , Y10T436/106664
摘要： The present invention relates, in general, to methods for detecting and quantitating plasma-derived protein and recombinant protein in a sample based on the difference in protein glycosylation, when the plasma protein and the recombinant protein are essentially the same protein.
摘要翻译： 本发明一般涉及当血浆蛋白质和重组蛋白质基本上相同的蛋白质时，基于蛋白质糖基化的差异，在样品中检测和定量血浆衍生的蛋白质和重组蛋白质的方法。
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56.发明授权Methods for the inactivation of microorganisms in biological fluids, flow through reactors and methods of controlling the light sum dose to effectively inactivate microorganisms in batch reactors 有权生物流体中微生物灭活的方法，流经反应器的方法和控制光总剂量以有效灭活间歇反应器中的微生物的方法公开(公告)号：US07993580B2
公开(公告)日：2011-08-09
申请号：US10924579
申请日：2004-08-24
申请人： Heinz Anderle , Peter Matthiessen , Hans-Peter Schwarz , Peter Turecek , Thomas Kreil , Daniel R. Boggs
发明人： Heinz Anderle , Peter Matthiessen , Hans-Peter Schwarz , Peter Turecek , Thomas Kreil , Daniel R. Boggs
CPC分类号： A61L2/10 , A23L3/26 , A23L3/28 , A61L2/0011 , A61L2/28 , G01N21/33 , H05B3/0052
摘要： The present invention relates to a method for determining an effective dose of monochromatic or polychromatic light from one or more light sources to inactivate microorganisms present in a biological fluid, preferably a non-transparent fluid. Moreover, there is provided a method for the inactivation of microorganism in a biological fluid in a flow-through-reactor. Moreover, the invention advantageously provides a flow-through-reactor with one or more thermostated light sources. The invention further provides a method of controlling the light sum dose of monochromatic or polychromatic light emitted from one or more light sources to effectively inactivate microorganisms present in a biological fluid in a batch reactor.
摘要翻译： 本发明涉及一种用于确定来自一种或多种光源的有效剂量的单色或多色光以灭活存在于生物流体中，优选非透明流体中的微生物的方法。 此外，提供了在流通反应器中的生物流体中的微生物灭活的方法。 此外，本发明有利地提供具有一个或多个恒温光源的流通反应器。 本发明还提供了一种控制从一个或多个光源发射的单色或多色光的光总量的方法，以有效地灭菌间歇反应器中存在于生物流体中的微生物。
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公开(公告)号：US07807435B2
公开(公告)日：2010-10-05
申请号：US11202349
申请日：2005-08-11
IPC分类号： C12N9/99
CPC分类号： C07K14/8125
摘要： The present invention relates to a method for the purification of alpha-1 proteinase inhibitor (a1PI) from protein fractions. More specifically, the invention relates to an improved method for the purification of alpha-1 proteinase inhibitor (a1PI), wherein the yield of a1PI can be increased by thawing the starting material and incubating it for several hours before subjecting it to a washing step.
摘要翻译： 本发明涉及从蛋白质级分纯化α-1蛋白酶抑制剂（a1PI）的方法。 更具体地说，本发明涉及一种纯化α-1蛋白酶抑制剂（a1PI）的改进方法，其中可以通过解冻起始物质并将其孵育数小时，然后使其进行洗涤步骤，从而增加a1PI的产率。
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58.发明申请RECOMBINANT VON WILLEBRAND FACTOR AS MOLECULAR WEIGHT MARKER FOR MASS SPECTROMETRY ANALYSES 审中-公开重组VON WILLEBRAND因子作为分子量标记用于质谱分析公开(公告)号：US20100155588A1
公开(公告)日：2010-06-24
申请号：US12639619
申请日：2009-12-16
申请人： Jasmin Kemptner , Martina Marchetti-Deschmann , Roland Mueller , Andreas Ivens , Peter Turecek , Hans-Peter Schwarz , Guenter Allmaier
发明人： Jasmin Kemptner , Martina Marchetti-Deschmann , Roland Mueller , Andreas Ivens , Peter Turecek , Hans-Peter Schwarz , Guenter Allmaier
CPC分类号： G01N33/6851 , G01N2333/755 , H01J49/164
摘要： Methods for determining molecular mass of at least 150 kDa of an analyte of interest using MALDI mass spectrometry in combination with a recombinant von Willebrand factor (rVWF) molecular weight marker are disclosed. More specifically, monomeric and multimeric rVWF are used for external and internal calibration of mass spectra applied for analytes having high molecular weights above 150 kDa.
摘要翻译： 公开了使用MALDI质谱联用重组血管性血友病因子（rVWF）分子量标记物来确定目标分析物的至少150kDa的分子量的方法。 更具体地，单体和多聚rVWF用于外部和内部校准用于分子量高于150kDa的分析物的质谱。
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59.发明授权Methods of treating blood coagulation disorders using a pharmaceutical preparation comprising vWF propeptide 有权使用包含vWF前肽的药物制剂治疗血液凝固障碍的方法公开(公告)号：US07557188B2
公开(公告)日：2009-07-07
申请号：US11218406
申请日：2005-09-02
申请人： Hans-Peter Schwarz , Katalin Varadi , Peter Turecek , Hendrik Coenraad Hemker , Suzette Lucette Beguin
发明人： Hans-Peter Schwarz , Katalin Varadi , Peter Turecek , Hendrik Coenraad Hemker , Suzette Lucette Beguin
CPC分类号： A61K38/37
摘要： Described is a pharmaceutical preparation for treating blood coagulation disorders comprising an effective amount of vWF propeptide as well as a method for producing such a preparation.
摘要翻译： 描述了一种用于治疗凝血障碍的药物制剂，其包含有效量的vWF前肽以及制备这种制剂的方法。
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公开(公告)号：US20070037270A1
公开(公告)日：2007-02-15
申请号：US11202349
申请日：2005-08-11
IPC分类号： C12N9/99
CPC分类号： C07K14/8125
摘要： The present invention relates to a method for the purification of alpha-1 proteinase inhibitor (a1PI) from protein fractions. More specifically, the invention relates to an improved method for the purification of alpha-1 proteinase inhibitor (a1PI), wherein the yield of a1PI can be increased by thawing the starting material and incubating it for several hours before subjecting it to a washing step.
摘要翻译： 本发明涉及从蛋白质级分纯化α-1蛋白酶抑制剂（a1PI）的方法。 更具体地说，本发明涉及一种纯化α-1蛋白酶抑制剂（a1PI）的改进方法，其中可以通过解冻起始物质并将其孵育数小时，然后使其进行洗涤步骤，从而增加a1PI的产率。
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