公开(公告)号：US07018405B2

公开(公告)日：2006-03-28

申请号：US09782804

申请日：2001-02-13

申请人： Motasim Sirhan ,  John Yan

发明人： Motasim Sirhan ,  John Yan

IPC分类号： A61F2/06

CPC分类号： A61F2/90 ,  A61F2210/0076 ,  A61F2250/0067 ,  A61L27/54 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/602

摘要： The present invention provides improved devices and methods for minimizing and/or inhibiting restenosis and hyperplasia after intravascular intervention. In particular, the present invention provides luminal prostheses which allow for programmed and controlled methylprednisolone delivery with increased efficacy to selected locations within a patient's vasculature to inhibit restenosis. An intraluminal delivery prosthesis may comprise an expansible structure and means on or within the structure for releasing methylprednisolone into the body lumen to inhibit smooth muscle cell proliferation.

公开(公告)号：US20050268573A1

公开(公告)日：2005-12-08

申请号：US11038377

申请日：2005-01-19

申请人： John Yan

发明人： John Yan

IPC分类号： A61B19/02 ,  A61F2/00 ,  A61F2/86 ,  A61L2/20 ,  A61L2/26 ,  B65B55/18 ,  B65B55/19 ,  B65D75/38 ,  B65D81/20 ,  B65D81/26 ,  B65B55/02

CPC分类号： B65D81/266 ,  A61B50/30 ,  A61B2050/314 ,  A61F2/0095 ,  A61F2/86 ,  A61L2/206 ,  A61L2/208 ,  A61L2/26 ,  A61L2202/181 ,  A61L2202/24 ,  B65B55/18 ,  B65B55/19 ,  B65D75/38 ,  B65D81/2084

摘要： The invention is directed to the treating, e.g. sterilizing and packaging of medical devices and other articles, particularly such devices and articles which are reactive to oxygen or moisture containing atmospheres. The sterilized package has a container which includes at least one portion which is gas permeable and at least one portion which is gas impermeable and an interior in fluid communication with the gas permeable portion. The container may be sealed by applying an impermeable patch to the permeable portion thereof or by disposing the container in an enclosure formed of impermeable material and sealing the enclosure. After exposing the container to a sterilizing gas, the gas permeable portion may be removed or sealed off from the gas impermeable portion of the container in order to provide a package which is gas impermeable and can protect one or more articles within the interior of the container against environmental gases and moisture.

摘要翻译： 本发明涉及治疗，例如， 消毒和包装医疗器械和其他物品，特别是对含氧气体或含有气体的物质具有反应性的器具和制品。 无菌包装具有容器，该容器包括至少一部分，其是气体可透过的，至少一个部分是气体不可渗透的，以及与气体可透过部分流体连通的内部。 可以通过将不透水贴片施加到其可渗透部分或通过将容器设置在由不可渗透材料形成的外壳中并密封外壳来密封容器。 在将容器暴露于灭菌气体之后，气体可渗透部分可以从容器的气体不可渗透部分去除或密封，以提供不透气的包装，并可以保护容器内部的一个或多个物品 防止环境气体和水分。

公开(公告)号：US06602282B1

公开(公告)日：2003-08-05

申请号：US09565560

申请日：2000-05-04

申请人： John Yan

发明人： John Yan

IPC分类号： A61F206

CPC分类号： A61F2/915 ,  A61F2/91 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2230/0054

摘要： Luminal prostheses comprise adjacent expansible segments, typically serpentine ring segments joined by sigmoidal links. By properly orienting the sigmoidal links and aligning hinge regions on adjacent serpentine rings, enhanced opening characteristics can be obtained. Additionally, by varying the mechanical characteristics of adjacent serpentine rings, program expansion of the luminal prostheses over their lengths may be obtained. The disclosed prostheses also have controllable opening characteristics and can be crimped to small diameters.

摘要翻译： 腔内假体包括相邻的可膨胀段，通常是通过S形连接连接的蛇形环段。 通过适当地定向S形连杆并使相邻蛇形环上的铰链区域对准，可以获得增强的开口特性。 另外，通过改变相邻蛇形环的机械特性，可以获得腔体假体在其长度上的程序膨胀。 所公开的假体还具有可控的开启特性，并且可以卷曲成小直径。

公开(公告)号：US06471980B2

公开(公告)日：2002-10-29

申请号：US09782927

申请日：2001-02-13

申请人： Motasim Sirhan ,  John Yan

发明人： Motasim Sirhan ,  John Yan

IPC分类号： A61F202

CPC分类号： A61F2/90 ,  A61F2/91 ,  A61F2/915 ,  A61F2/95 ,  A61F2002/91533 ,  A61F2210/0076 ,  A61F2250/0067 ,  A61L27/54 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/602

摘要： The present invention provides improved devices and methods for minimizing and/or inhibiting restenosis and hyperplasia after intravascular intervention. In particular, the present invention provides luminal prostheses which allow for programmed and controlled mycophenolic acid delivery with increased efficacy to selected locations within a patient's vasculature to inhibit restenosis. An intraluminal delivery prosthesis may comprise an expansible structure and means on or within the structure for releasing mycophenolic acid at a rate selected to inhibit smooth muscle cell proliferation.

摘要翻译： 本发明提供了用于在血管内干预后最小化和/或抑制再狭窄和增生的改进的装置和方法。 特别地，本发明提供了腔内假体，其允许编程和控制的霉酚酸递送，其具有增加的功效，在患者的脉管系统内的选定位置以抑制再狭窄。 腔内递送假体可以包含可膨胀的结构，并且在结构上或内部包含用于以抑制平滑肌细胞增殖的速率释放霉酚酸的装置。

公开(公告)号：US06003386A

公开(公告)日：1999-12-21

申请号：US111538

申请日：1998-07-08

申请人： Robert Guthrie ,  John Yan ,  Rene Luigies

发明人： Robert Guthrie ,  John Yan ,  Rene Luigies

IPC分类号： A61B5/0215 ,  G01F1/34 ,  G01F1/36 ,  G01F1/40 ,  G01F1/78

CPC分类号： G01F1/40 ,  A61B5/02158 ,  G01F1/34 ,  G01F1/36 ,  G01F1/78

摘要： A single, disposable differential transducer having a molded plastic body in which there is a pair of chambers separated by a strain gage electronic chip that flexes in accordance with the difference in the pressures between the two chambers. The plastic housing has inlets to allow communication with the chambers and the overall unit is readily manufactured of inexpensive components that allow disposability of the unit when it has been used on a patient. The pressure transducer chambers are isolasted from each other such that differing locations of the patient may be sensed for pressure at the same time without the risk of inadvertant cross-contamination.

摘要翻译： 具有模制塑料体的单个一次性差动传感器，其中存在由应变计电子芯片隔开的一对腔室，所述应变计电子芯片根据两个腔室之间的压力差而弯曲。 塑料壳体具有允许与腔室连通的入口，并且整体单元容易地由廉价的组件制成，这些部件在单元已被使用在患者身上时可使其处置。 压力传感器室彼此隔离，使得可以同时感测患者的不同位置的压力，而不会有不经意的交叉污染的风险。

公开(公告)号：US5889212A

公开(公告)日：1999-03-30

申请号：US962228

申请日：1997-10-31

申请人： Robert Guthrie ,  John Yan ,  Rene Luigies

发明人： Robert Guthrie ,  John Yan ,  Rene Luigies

IPC分类号： G01F1/88 ,  A61B5/0215 ,  A61B5/03 ,  G01F1/34 ,  G01F1/36 ,  G01F1/40 ,  G01L13/06 ,  G01L9/04

CPC分类号： G01F1/34 ,  A61B5/02158 ,  A61B5/03 ,  G01F1/36 ,  G01F1/40

摘要： A single, disposable differential transducer having a molded plastic body in which there is a pair of chambers separated by a strain gage electronic chip that flexes in accordance with the difference in the pressures between the two chambers. The plastic housing has inlets to allow communication with the chambers and the overall unit is readily manufactured of inexpensive components that allow disposability of the unit when it has been used on a patient. The pressure transducer chambers are isolated from each other such that differing locations of the patient may be sensed for pressure at the same time without the risk of inadvertant cross-contamination.

摘要翻译： 具有模制塑料体的单个一次性差动传感器，其中存在由应变计电子芯片隔开的一对腔室，所述应变计电子芯片根据两个腔室之间的压力差而弯曲。 塑料壳体具有允许与腔室连通的入口，并且整体单元容易地由廉价的组件制成，这些部件在单元已被使用在患者身上时可使其处置。 压力传感器室彼此隔离，使得可以同时感测患者的不同位置的压力而没有不经意的交叉污染的风险。

公开(公告)号：US20080177373A1

公开(公告)日：2008-07-24

申请号：US12016077

申请日：2008-01-17

申请人： Howard Huang ,  John Yan ,  Brett Cryer ,  Motasim Sirhan ,  Vinayak Bhat

发明人： Howard Huang ,  John Yan ,  Brett Cryer ,  Motasim Sirhan ,  Vinayak Bhat

IPC分类号： A61F2/82

CPC分类号： A61L31/14 ,  A61F2/82 ,  A61F2/915 ,  A61F2002/825 ,  A61F2230/0013 ,  A61F2250/0036 ,  A61L31/06 ,  A61L31/148 ,  C08G63/08 ,  Y10T428/13 ,  Y10T428/1352 ,  Y10T428/139 ,  C08L67/04

摘要： An endoprosthesis includes a plurality of serpentine rings having supporting features which increase hoop strength, inhibit recoil, and provide an increased surface area. The supporting features may be formed between adjacent axial struts of the serpentine rings or may be positioned between axial lengths joining the serpentine rings together.

摘要翻译： 内置假体包括多个蛇形环，其具有增强箍强度，抑制后坐力并提供增加的表面积的支撑特征。 支撑特征可以形成在蛇形环的相邻轴向支柱之间，或者可以位于将蛇形环连接在一起的轴向长度之间。

公开(公告)号：US20080142942A1

公开(公告)日：2008-06-19

申请号：US11612992

申请日：2006-12-19

申请人： Yong Du ,  John Yan

发明人： Yong Du ,  John Yan

IPC分类号： H01L23/02 ,  H01L21/00

CPC分类号： H01L25/50 ,  H01L25/0657 ,  H01L2224/32145 ,  H01L2224/32225 ,  H01L2224/48227 ,  H01L2225/0651 ,  H01L2225/06575

摘要： A method and apparatus are provided for multi-chip packaging. A multi-chip package (100) includes a substrate (105) and a plurality of semiconductor dice (110, 120, 130). A first semiconductor die (110) is physically coupled to an upper face of the substrate (105), the first semiconductor die (110) being a smallest one of the plurality of semiconductor dice (110, 120, 130).

摘要翻译： 提供了用于多芯片封装的方法和装置。 多芯片封装（100）包括基板（105）和多个半导体晶片（110,120,130）。 第一半导体管芯（110）物理耦合到衬底（105）的上表面，第一半导体管芯（110）是多个半导体管芯（110,120,130）中的最小的一个。

公开(公告)号：US20070142898A1

公开(公告)日：2007-06-21

申请号：US11680439

申请日：2007-02-28

申请人： Motasim Sirhan ,  John Yan

发明人： Motasim Sirhan ,  John Yan

IPC分类号： A61F2/06

CPC分类号： A61F2/90 ,  A61F2210/0076 ,  A61F2250/0067 ,  A61L27/54 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/602

摘要： The present invention provides improved devices and methods for minimizing and/or inhibiting restenosis and hyperplasia after intravascular intervention. In particular, the present invention provides luminal prostheses which allow for programmed and controlled mizoribine delivery with increased efficacy to selected locations within a patient's vasculature to inhibit restenosis. An intraluminal delivery prosthesis may comprise an expansible structure and means on or within the structure for releasing mizoribine into the body lumen to inhibit smooth muscle cell proliferation.

摘要翻译： 本发明提供了用于在血管内干预后最小化和/或抑制再狭窄和增生的改进的装置和方法。 特别地，本发明提供了腔内假体，其允许程序化和受控的咪唑立宾递送，其具有增加的功效，以在患者脉管系统内的选定位置抑制再狭窄。 管腔内输送假体可以包括可释放的结构和在结构上或内部的装置，用于将咪唑立宾释放到体腔中以抑制平滑肌细胞增殖。

公开(公告)号：US20060178738A1

公开(公告)日：2006-08-10

申请号：US11398826

申请日：2006-04-05

申请人： John Yan ,  Randy Chan

发明人： John Yan ,  Randy Chan

IPC分类号： A61F2/06

CPC分类号： A61F2/82 ,  A61F2/0077 ,  A61F2/07 ,  A61F2/92 ,  A61F2002/072 ,  A61F2002/075 ,  A61F2250/0067 ,  A61L31/10 ,  A61L33/0011 ,  A61L2420/08 ,  Y10S623/921

摘要： An implantable stent is coated with a material that attracts heparin and with which heparin forms a bond. The stent is exposed to a heparin containing solution just prior to implantation or is first implanted and then exposed to heparinized blood. As heparin becomes detached from the stent, the implantation site is exposed to heparin to restore an effective level and thereby prevent thrombosis.

摘要翻译： 可植入支架涂覆有吸引肝素并与肝素形成结合的材料。 支架在植入之前暴露于含有肝素的溶液，或者首先植入，然后暴露于肝素化血液。 随着肝素从支架脱离，植入部位暴露于肝素以恢复有效水平，从而防止血栓形成。