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    CLOSED LOOP IMPEDANCE-BASED CARDIAC RESYNCHRONIZATION THERAPY SYSTEMS, DEVICES, AND METHODS
    51.
    发明申请
    CLOSED LOOP IMPEDANCE-BASED CARDIAC RESYNCHRONIZATION THERAPY SYSTEMS, DEVICES, AND METHODS 审中-公开
    基于闭环阻塞的心脏再生治疗系统，装置和方法

    公开(公告)号：US20120165894A1

    公开(公告)日：2012-06-28

    申请号：US13405383

    申请日：2012-02-27

    申请人： Jiang Ding ,  Julio C. Spinelli ,  Yinghong Yu ,  Jeffrey E. Stahmann

    发明人： Jiang Ding ,  Julio C. Spinelli ,  Yinghong Yu ,  Jeffrey E. Stahmann

    IPC分类号： A61N1/368

    CPC分类号： A61N1/3627 ,  A61B5/053 ,  A61N1/36521 ,  A61N1/3682 ,  A61N1/3684

    摘要： This document discusses, among other things, systems, devices, and methods measure an impedance and, in response, adjust an atrioventricular (AV) delay or other cardiac resynchronization therapy (CRT) parameter that synchronizes left and right ventricular contractions. A first example uses parameterizes a first ventricular volume against a second ventricular volume during a cardiac cycle, using a loop area to create a synchronization fraction (SF). The CRT parameter is adjusted in closed-loop fashion to increase the SF. A second example measures a septal-freewall phase difference (PD), and adjusts a CRT parameter to decrease the PD. A third example measures a peak-to-peak volume or maximum rate of change in ventricular volume, and adjusts a CRT parameter to increase the peak-to-peak volume or maximum rate of change in the ventricular volume.

    摘要翻译： 本文件还讨论了系统，设备和方法测量阻抗，并作为响应调整房室（AV）延迟或同步左心室收缩和右心室收缩的其他心脏再同步治疗（CRT）参数。 第一个例子是使用循环区域创建同步分数（SF），在心动周期中使用第一心室容积对第二心室容积进行参数化。 CRT参数以闭环方式调整以增加SF。 第二个例子是测量隔层相位差（PD），并调整CRT参数以减少PD。 第三个例子测量峰 - 峰体积或最大心室容积变化率，并调整CRT参数以增加心室容积的峰 - 峰体积或最大变化率。

    AUTOMATIC DETERMINATION OF CHRONOTROPIC INCOMPETENCE USING ATRIAL PACING AT REST
    52.
    发明申请
    AUTOMATIC DETERMINATION OF CHRONOTROPIC INCOMPETENCE USING ATRIAL PACING AT REST 有权
    自动确定在休息时使用ATRON PACON的CHRONOTROPIC INCOMPETENCE

    公开(公告)号：US20120130440A1

    公开(公告)日：2012-05-24

    申请号：US13290362

    申请日：2011-11-07

    申请人： Yinghong Yu ,  Donald L. Hopper ,  Jiang Ding ,  James O. Gilkerson

    发明人： Yinghong Yu ,  Donald L. Hopper ,  Jiang Ding ,  James O. Gilkerson

    IPC分类号： A61N1/365

    CPC分类号： A61N1/3682

    摘要： An apparatus comprises an implantable cardiac signal sensing circuit that provides an electrical cardiac signal representative of cardiac activity of a subject, an implantable therapy circuit that delivers electrical pacing stimulation energy to a heart of a subject, and a controller circuit. The controller circuit includes a chronotropic incompetence detection circuit that initiates pacing of an atrium of the subject at a rate higher than a device-indicated rate or a sensed intrinsic rate, monitor the AV interval, initiates an increase in the pacing rate while continuing the monitoring of the AV interval, calculates a change in AV intervals between a highest paced rate used in the monitoring and a lowest paced rate used in the monitoring, and indicates that the AV intervals are evidence of chronotropic incompetence when the calculated change in the AV intervals exceeds a specified threshold AV interval change value.

    摘要翻译： 一种装置包括可植入心脏信号感测电路，其提供代表受试者的心脏活动的电心脏信号，将对该对象的心脏发出电起搏刺激能量的可植入治疗电路以及控制器电路。 控制器电路包括一个变时无能检测电路，其以高于设备指示速率或感测到的固有频率的速率启动对象的心房起搏，监视AV间隔，启动起搏速率的增加，同时继续监视 计算AV监视中使用的最高起搏速率和监视中使用的最低起搏速度之间的AV间隔的变化，并且指示AV间隔是当计算出的AV间隔的变化超过时间间隔无能力的证据 指定的阈值AV间隔变化值。

    THORACIC OR INTRACARDIAC IMPEDANCE DETECTION WITH AUTOMATIC VECTOR SELECTION
    54.
    发明申请
    THORACIC OR INTRACARDIAC IMPEDANCE DETECTION WITH AUTOMATIC VECTOR SELECTION 有权
    用自动矢量选择进行THORACIC或INTRACARDIAC阻抗检测

    公开(公告)号：US20110301471A1

    公开(公告)日：2011-12-08

    申请号：US13185580

    申请日：2011-07-19

    申请人： Jonathan Kwok ,  Kent Lee ,  Jesse W. Hartley ,  Jeffrey E. Stahmann ,  Yinghong Yu ,  Jiang Ding

    发明人： Jonathan Kwok ,  Kent Lee ,  Jesse W. Hartley ,  Jeffrey E. Stahmann ,  Yinghong Yu ,  Jiang Ding

    IPC分类号： A61B5/0205 ,  A61B5/02

    CPC分类号： A61B5/0205 ,  A61B5/053 ,  A61B5/0538 ,  A61N1/36185 ,  A61N1/36521 ,  A61N1/3686

    摘要： Vector selection is automatically achieved via a thoracic or intracardiac impedance signal collected in a cardiac function management device or other implantable medical device that includes a test mode and a diagnostic mode. During a test mode, the device cycles through various electrode configurations for collecting thoracic impedance data. At least one figure of merit is calculated from the impedance data for each such electrode configuration. In one example, only non-arrhythmic beats are used for computing the figure of merit. A particular electrode configuration is automatically selected using the figure of merit. During a diagnostic mode, the device collects impedance data using the selected electrode configuration. In one example, the figure of merit includes a ratio of a cardiac stroke amplitude and a respiration amplitude. Other examples of the figure of merit are also described.

    摘要翻译： 矢量选择通过收集在包括测试模式和诊断模式的心脏功能管理装置或其他可植入医疗装置中的胸部或心内阻抗信号自动实现。 在测试模式期间，器件循环通过各种电极配置来收集胸部阻抗数据。 从每个这样的电极配置的阻抗数据计算至少一个品质因数。 在一个例子中，仅使用非心律失常节拍来计算品质因数。 使用品质因数自动选择特定的电极配置。 在诊断模式下，设备使用所选择的电极配置收集阻抗数据。 在一个示例中，品质因数包括心搏幅度和呼吸振幅的比值。 还描述了品质因数的其它实例。

    Thoracic or intracardiac impedance detection with automatic vector selection
    55.
    发明授权
    Thoracic or intracardiac impedance detection with automatic vector selection 有权
    胸部或心内阻抗检测与自动矢量选择

    公开(公告)号：US08014860B2

    公开(公告)日：2011-09-06

    申请号：US12612204

    申请日：2009-11-04

    申请人： Jonathan Kwok ,  Kent Lee ,  Jesse W. Hartley ,  Jeffrey E. Stahmann ,  Yinghong Yu ,  Jiang Ding

    发明人： Jonathan Kwok ,  Kent Lee ,  Jesse W. Hartley ,  Jeffrey E. Stahmann ,  Yinghong Yu ,  Jiang Ding

    IPC分类号： A61B5/053 ,  A61B5/0295

    CPC分类号： A61B5/0205 ,  A61B5/053 ,  A61B5/0538 ,  A61N1/36185 ,  A61N1/36521 ,  A61N1/3686

    摘要： Vector selection is automatically achieved via a thoracic or intracardiac impedance signal collected in a cardiac function management device or other implantable medical device that includes a test mode and a diagnostic mode. During a test mode, the device cycles through various electrode configurations for collecting thoracic impedance data. At least one figure of merit is calculated from the impedance data for each such electrode configuration. In one example, only non-arrhythmic beats are used for computing the figure of merit. A particular electrode configuration is automatically selected using the figure of merit. During a diagnostic mode, the device collects impedance data using the selected electrode configuration. In one example, the figure of merit includes a ratio of a cardiac stroke amplitude and a respiration amplitude. Other examples of the figure of merit are also described.

    摘要翻译： 矢量选择通过收集在包括测试模式和诊断模式的心脏功能管理装置或其他可植入医疗装置中的胸部或心内阻抗信号自动实现。 在测试模式期间，器件循环通过各种电极配置来收集胸部阻抗数据。 从每个这样的电极配置的阻抗数据计算至少一个品质因数。 在一个例子中，仅使用非心律失常节拍来计算品质因数。 使用品质因数自动选择特定的电极配置。 在诊断模式下，设备使用所选择的电极配置收集阻抗数据。 在一个示例中，品质因数包括心搏幅度和呼吸振幅的比值。 还描述了品质因数的其它实例。

    Method and apparatus for optimizing stroke volume during DDD resynchronization therapy using adjustable atrio-ventricular delays
    56.
    发明授权
    Method and apparatus for optimizing stroke volume during DDD resynchronization therapy using adjustable atrio-ventricular delays 有权
    使用可调节的心房延迟在DDD再同步治疗期间优化卒中量的方法和装置

    公开(公告)号：US07974695B2

    公开(公告)日：2011-07-05

    申请号：US11567933

    申请日：2006-12-07

    申请人： Yinghong Yu ,  Jiang Ding ,  Julio C. Spinelli ,  Andrew P. Kramer

    发明人： Yinghong Yu ,  Jiang Ding ,  Julio C. Spinelli ,  Andrew P. Kramer

    IPC分类号： A61N1/365

    CPC分类号： A61N1/3627 ,  A61N1/36564 ,  A61N1/3682

    摘要： A pacing system for providing optimal hemodynamic cardiac function for parameters such as ventricular synchrony or contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.

    摘要翻译： 用于为诸如心室同步或收缩性（收缩期左心室压力峰值或LV + dp / dt）之间的参数提供最佳血液动力学心脏功能或行程体积（主动脉脉压）的起搏系统，用于计算心室间期延迟 心室起搏脉冲的最佳时机。 该系统为多个血液动力学参数的近似最佳起搏提供了选择。 该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。

    Method, apparatus, and system to optimize cardiac preload based on measured pulmonary artery pressure
    57.
    发明授权
    Method, apparatus, and system to optimize cardiac preload based on measured pulmonary artery pressure 有权
    基于测量的肺动脉压力来优化心脏预压的方法，装置和系统

    公开(公告)号：US07957802B2

    公开(公告)日：2011-06-07

    申请号：US11894082

    申请日：2007-08-20

    申请人： Abhilash Patangay ,  Jiang Ding ,  Jonathan T. Kwok ,  Barun Maskara ,  Yinghong Yu

    发明人： Abhilash Patangay ,  Jiang Ding ,  Jonathan T. Kwok ,  Barun Maskara ,  Yinghong Yu

    IPC分类号： A61N1/362

    CPC分类号： A61N1/36564 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

    摘要： Optimizing cardiac preload based on measured pulmonary artery pressure involves varying, for each repetition of an acute burst protocol, a parameter of pacing applied to a patient's heart during the acute burst protocol. Pulmonary artery pressure is measured during the repetitions of the acute burst protocol. The length of the repetitions is chosen so that the patient's baroreflex system does not adjust to the varied parameter of pacing during the repetitions of the acute burst protocol. An optimum ventricular preload is determined based on the measured pulmonary artery pressure. Pacing therapy is provided using a value of the parameter that is selected based on the determination of optimum ventricular preload.

    摘要翻译： 基于测量的肺动脉压优化心脏预压，对于急性突发协议的每个重复，涉及在急性突发协议期间应用于患者心脏的起搏参数的变化。 在急性突发方案的重复期间测量肺动脉压。 选择重复的长度，使得患者的压力反射系统在急性突发协议的重复期间不适应起搏的不同参数。 基于测量的肺动脉压力确定最佳心室预负荷。 使用基于最佳心室预压的确定选择的参数的值提供起搏治疗。

    METHOD AND SYSTEM FOR SETTING CARDIAC RESYNCHRONIZATION THERAPY PARAMETERS
    58.
    发明申请
    METHOD AND SYSTEM FOR SETTING CARDIAC RESYNCHRONIZATION THERAPY PARAMETERS 有权
    用于设置心脏再生治疗参数的方法和系统

    公开(公告)号：US20110106202A1

    公开(公告)日：2011-05-05

    申请号：US12987700

    申请日：2011-01-10

    申请人： Jiang Ding ,  Yinghong Yu ,  Bruce H. KenKnight

    发明人： Jiang Ding ,  Yinghong Yu ,  Bruce H. KenKnight

    IPC分类号： A61N1/368

    CPC分类号： A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

    摘要： A method or system for computing and/or setting optimal cardiac resynchronization pacing parameters as derived from intrinsic conduction data is presented. The intrinsic conduction data includes intrinsic atrio-ventricular and interventricular delay intervals which may be collected via the sensing channels of an implantable cardiac device. Among the parameters which may be optimized in this manner are an atrio-ventricular delay interval and a biventricular offset interval. In one of its aspects, the invention provides for computing optimum pacing parameters for patients having some degree of AV block or with atrial conduction deficits. Another aspect of the invention relates to a pacing mode and configuration for providing cardiac resynchronization therapy to patients with a right ventricular conduction disorder.

    摘要翻译： 提出了一种用于计算和/或设置从内在传导数据导出的最佳心脏再同步起搏参数的方法或系统。 内在传导数据包括可通过可植入心脏装置的感测通道收集的本征心室和室间延迟间隔。 可以以这种方式优化的参数是心房延迟间隔和双心室偏移间隔。 在其一个方面，本发明提供了对具有一定程度的AV阻滞或具有心房传导缺陷的患者计算最佳起搏参数。 本发明的另一方面涉及用于向患有右心室传导障碍的患者提供心脏再同步治疗的起搏模式和配置。

    Rheology Control Agents
    59.
    发明申请
    Rheology Control Agents 有权
    流变控制剂

    公开(公告)号：US20100204376A1

    公开(公告)日：2010-08-12

    申请号：US12758864

    申请日：2010-04-13

    申请人： Christian Peter Lenges ,  Yanhui Niu ,  Yu-Ling Hsiao ,  Jiang Ding ,  Robert John Barsotti ,  Renee J. Kelly ,  Robert James Butera ,  Young H. Kim

    发明人： Christian Peter Lenges ,  Yanhui Niu ,  Yu-Ling Hsiao ,  Jiang Ding ,  Robert John Barsotti ,  Renee J. Kelly ,  Robert James Butera ,  Young H. Kim

    IPC分类号： C09D7/12 ,  C07C271/24 ,  C07C271/22

    CPC分类号： C07C275/16 ,  C07C275/10 ,  C07C275/18 ,  C07C275/24

    摘要： The present invention provides for a rheology control agent that includes a following compound represented by the following formula: wherein A, B, C and D equal CH2, CHR, NH, or O, and A, B, C and D may be the same or different and at least one of A and B equals NH and at least one of C and D equals NH; and wherein R1, R2, and R3 may be the same or different and represent a linear, branched, hyper-branched, or dendritic ether, polyether or hydrocarbon based chain, optionally forming at least one carbon-based ring, being saturated or unsaturated and R2 represents linear or branched alkylenes, ethers, polyethers, or polyester linkages and at least one of R1, R2, and R3 comprises an ester group or an amide group which is branched off from the main chain; excluded from Formula (1) is a compound wherein R2 is CH2—CH2—CH2—CH2—CH(C(O)OCH3), A, B, C, and D are equal to NH and R1 and R3 are both equal to a linear octyl hydrocarbon chain; the rheology control agent is suitable for solvent-borne and water-borne coating composition having improved rheology control useful for OEM refinishing or repainting the exterior of automobile and truck bodies and parts thereof.

    摘要翻译： 本发明提供一种流变控制剂，其包含由下式表示的以下化合物：其中A，B，C和D等于CH 2，CHR，NH或O，A，B，C和D可以相同 或不同且A和B中的至少一个等于NH，C和D中的至少一个等于NH; 并且其中R 1，R 2和R 3可以相同或不同，表示直链，支链，超支化或树枝状醚，聚醚或烃基链，任选地形成至少一个饱和或不饱和的碳基环， R2表示直链或支链亚烷基，醚，聚醚或聚酯键，R 1，R 2和R 3中的至少一个包含从主链分支的酯基或酰胺基; 从式（1）中排除的是其中R 2是CH 2 -CH 2 -CH 2 -CH 2 -CH（C（O）OCH 3），A，B，C和D等于NH并且R 1和R 3均等于 直链辛基烃链; 流变控制剂适用于具有改进的流变控制的溶剂型和水性涂料组合物，其可用于OEM修补或重新涂刷汽车和卡车车身及其部件的外部。