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公开(公告)号：US20060234981A1
公开(公告)日：2006-10-19
申请号：US11357687
申请日：2006-02-16
申请人： Stephen Baker , Tsutomu Akama , Carolyn Bellinger-Kawahara , Vincent Hernandez , Karin Hold , James Leyden , Kirk Maples , Jacob Plattner , Virginia Sanders , Yong-Kang Zhang
发明人： Stephen Baker , Tsutomu Akama , Carolyn Bellinger-Kawahara , Vincent Hernandez , Karin Hold , James Leyden , Kirk Maples , Jacob Plattner , Virginia Sanders , Yong-Kang Zhang
CPC分类号： C07F5/025 , A61K9/0012 , A61K31/69 , C07F5/02 , C07F5/027
摘要： This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
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公开(公告)号：US20060178356A1
公开(公告)日：2006-08-10
申请号：US11387507
申请日：2006-03-22
申请人： Bing Wang , Yong-Kang Zhang , Jian Chen , Wei Zhang , Jiangao Song , Ughetta Balzo , Lesley Brown , Sekhar Boddupalli , Steven Bobzin , Sylvain Gilat , Guy Miller
发明人： Bing Wang , Yong-Kang Zhang , Jian Chen , Wei Zhang , Jiangao Song , Ughetta Balzo , Lesley Brown , Sekhar Boddupalli , Steven Bobzin , Sylvain Gilat , Guy Miller
IPC分类号： C07F1/08 , A61K31/555 , A61K31/426 , A61K31/4152 , A61K31/444
CPC分类号： C07D213/30 , C07C43/23 , C07C45/30 , C07C45/71 , C07C49/737 , C07C69/94 , C07C205/17 , C07C205/20 , C07C205/22 , C07C205/35 , C07C205/57 , C07C235/42 , C07C255/36 , C07C311/29 , C07C2603/24 , C07D213/53 , C07D231/26 , C07D277/20 , C07D277/24 , C07D295/26 , C07D311/72 , C07F9/4021 , C07C47/575
摘要： Cytoprotective compounds, many of which are phenolic derivatives characterized by a substituted phenol having certain conjugated bonds, are useful in the treatment of certain ischemic or inflammatory conditions, including but not limited to stroke, myocardial infarction, congestive heart failure, and skin disorders characterized by inflammation or oxidative damage. They are also useful in the manufacture of pharmaceutical and cosmetic formulations for the treatment of such conditions.
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公开(公告)号：US20050070503A1
公开(公告)日：2005-03-31
申请号：US10867465
申请日：2004-06-14
申请人： Ving Lee , Stephen Benkovic , Stephen Baker , Kirk Maples , Tsutomu Akama , Yong-Kang Zhang , Rajeshwar Singh , Vittorio Sauro , Chetan Pandit , Zhuoyi Su , Zhixiang Yang
发明人： Ving Lee , Stephen Benkovic , Stephen Baker , Kirk Maples , Tsutomu Akama , Yong-Kang Zhang , Rajeshwar Singh , Vittorio Sauro , Chetan Pandit , Zhuoyi Su , Zhixiang Yang
CPC分类号： C07F5/025
摘要： The structure and preparation of antibiotics incorporating borinic acid complexes are disclosed, especially hydroxyquinoline, imidazole and picolinic acid derivatives, along with compositions of these antibiotics and methods of using the antibiotics and compositions as bactericidal and fungicidal agents as well as therapeutic agents for the treatment of diseases caused by bacteria and fungi.
摘要翻译： 公开了包含硼酸络合物的抗生素的结构和制备，特别是羟基喹啉，咪唑和吡啶甲酸衍生物，以及这些抗生素的组合物以及使用抗生素和组合物作为杀菌和杀真菌剂的方法以及用于治疗 细菌和真菌引起的疾病。
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54.发明授权Methods for treating medical dysfunctions and diseases using furan nitrone compounds 失效用呋喃硝酮化合物治疗医疗功能障碍和疾病的方法
公开(公告)号：US6051571A
公开(公告)日：2000-04-18
申请号：US317266
申请日：1999-05-24
IPC分类号： A61K31/341 , A61P9/10 , A61P25/16 , A61P25/28 , A61P29/00 , A61P37/02 , C07D307/64 , A61K31/34
CPC分类号： A61K31/341 , C07D307/64
摘要： Disclosed are methods for treating a patient with an acute central nervous system or cardiovascular disorder or a neurodegenerative, autoimmune or inflammatory disease using a pharmaceutical composition containing a pharmaceutically acceptable carrier and an effective amount of a furan nitrone compound.
摘要翻译： 公开了使用含有药学上可接受的载体和有效量的呋喃硝酮化合物的药物组合物治疗患有急性中枢神经系统或心血管疾病或神经退行性，自身免疫性或炎性疾病的患者的方法。
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55.发明授权.alpha.-aryl-N-alkylnitrones and pharmaceutical compositions containing the same 失效α-芳基-N-烷基硝酮和含有它们的药物组合物
公开(公告)号：US6046232A
公开(公告)日：2000-04-04
申请号：US172763
申请日：1998-10-15
申请人： Judith A. Kelleher , Kirk R. Maples , Alina Dykman , Yong-Kang Zhang , Allan L. Wilcox , Julian Levell
发明人： Judith A. Kelleher , Kirk R. Maples , Alina Dykman , Yong-Kang Zhang , Allan L. Wilcox , Julian Levell
IPC分类号： C07D319/18 , A61K31/04 , A61K31/135 , A61K31/357 , A61K31/36 , A61P1/04 , A61P11/00 , A61P19/02 , A61P21/00 , A61P27/02 , A61P29/00 , A61P37/06 , C07C291/02 , C07C291/04 , A61K31/34
CPC分类号： A61K31/04 , A61K31/36 , C07C291/04 , C07C2101/04 , C07C2101/08 , C07C2101/14 , C07C2101/18 , C07C2103/74
摘要： Disclosed are novel .alpha.-aryl-N-alkylnitrone compounds and pharmaceutical compositions containing such compounds. The disclosed compositions are useful as therapeutics for preventing and/or treating neurodegenerative, autoimmune and inflammatory conditions in mammals and as analytical reagents for detecting free radicals.
摘要翻译： 公开了新的α-芳基-N-烷基硝酮化合物和含有这些化合物的药物组合物。 所公开的组合物可用作预防和/或治疗哺乳动物的神经退行性，自身免疫性和炎症性疾病的治疗剂，以及用作检测自由基的分析试剂。
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56.发明授权Furansulfonic acid derivatives and pharmaceutical compositions containing the same 失效呋喃磺酸衍生物和含有它们的药物组合物
公开(公告)号：US5994396A
公开(公告)日：1999-11-30
申请号：US130347
申请日：1998-08-13
IPC分类号： A61K31/341 , A61K31/4525 , A61P25/00 , A61P25/16 , A61P25/28 , A61P29/00 , A61P37/00 , A61P43/00 , C07D307/64 , C07D307/68 , A61K31/34
CPC分类号： C07D307/68
摘要： Disclosed are furansulfonic acid derivatives and pharmaceutical compositions containing such derivatives. The disclosed compositions are useful for preventing and/or treating neurodegenerative, autoimmune and inflammatory conditions in mammals.
摘要翻译： 公开了含有这些衍生物的呋喃磺酸衍生物和药物组合物。 所公开的组合物可用于预防和/或治疗哺乳动物中的神经退行性，自身免疫性和炎性疾病。
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公开(公告)号：US09346834B2
公开(公告)日：2016-05-24
申请号：US13503016
申请日：2010-10-19
申请人： Huchen Zhou , Dazhong Ding , Daoan Sun , Yasheen Zhou , Yong-Kang Zhang , Jacob J. Plattner
发明人： Huchen Zhou , Dazhong Ding , Daoan Sun , Yasheen Zhou , Yong-Kang Zhang , Jacob J. Plattner
IPC分类号： C07F5/02
CPC分类号： C07F5/025
摘要： This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
摘要翻译： 本发明尤其提供了可用于治疗原生动物感染的新化合物，含有这些化合物的药物组合物，以及这些化合物与至少一种另外的治疗有效药物的组合。
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公开(公告)号：US08722917B2
公开(公告)日：2014-05-13
申请号：US13356488
申请日：2012-01-23
申请人： Stephen J. Baker , Tsutomu Akama , Michael Richard Kevin Alley , Stephen J. Benkovic , Michael Dipierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zagar , Yong-Kang Zhang , Huchen Zhou
发明人： Stephen J. Baker , Tsutomu Akama , Michael Richard Kevin Alley , Stephen J. Benkovic , Michael Dipierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zagar , Yong-Kang Zhang , Huchen Zhou
IPC分类号： C07F5/04
CPC分类号： C07F5/025 , A61K9/0012 , A61K9/08 , A61K31/69 , A61K31/70 , A61K31/7076 , A61K47/10 , C07F5/04 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00 , Y02A50/473
摘要： This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
摘要翻译： 本发明涉及可用于治疗真菌感染的化合物，更具体地涉及甲真菌病和/或皮肤真菌感染的局部治疗。 本发明涉及对真菌具有活性的化合物，并具有允许化合物与患者接触时达到感染真菌的皮肤，指甲，毛发，爪或蹄特定部位的性质。 特别地，本发明化合物具有促进钉板穿透的物理化学性质。
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公开(公告)号：US08461135B2
公开(公告)日：2013-06-11
申请号：US13236543
申请日：2011-09-19
申请人： Tsutomu Akama , Yong-Kang Zhang , Charles Z. Ding , Jacob J. Plattner , Kirk R. Maples , Yvonne Freund , Virginia Sanders , Yi Xia , Stephen J. Baker , James A. Nieman , Xiaosong Lu , Marcelo Sales , Rashmi Sharma , Rajeshwar Singh , Robert T. Jacobs , Daitao Chen , Michael Richard Kevin Alley
发明人： Tsutomu Akama , Yong-Kang Zhang , Charles Z. Ding , Jacob J. Plattner , Kirk R. Maples , Yvonne Freund , Virginia Sanders , Yi Xia , Stephen J. Baker , James A. Nieman , Xiaosong Lu , Marcelo Sales , Rashmi Sharma , Rajeshwar Singh , Robert T. Jacobs , Daitao Chen , Michael Richard Kevin Alley
CPC分类号： C07F5/025 , A61K31/69 , C07F5/04 , Y02A50/411
摘要： Compounds and methods of treating anti-inflammatory conditions are disclosed.
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60.发明授权公开(公告)号：US08106031B2
公开(公告)日：2012-01-31
申请号：US11743665
申请日：2007-05-02
申请人： Ving Lee , Jacob J. Plattner , Stephen J. Benkovic , Stephen J. Baker , Kirk R. Maples , Carolyn Bellinger-Kawahara , Tsutomu Akama , Yong-Kang Zhang , Rajeshwar Singh , Vittorio A. Sauro
发明人： Ving Lee , Jacob J. Plattner , Stephen J. Benkovic , Stephen J. Baker , Kirk R. Maples , Carolyn Bellinger-Kawahara , Tsutomu Akama , Yong-Kang Zhang , Rajeshwar Singh , Vittorio A. Sauro
CPC分类号： C07F5/025
摘要： Compositions and methods of use of boron derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by fungi, yeast, bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.
摘要翻译： 公开了用于治疗由真菌，酵母，细菌或病毒引起的疾病的治疗剂的硼衍生物，包括苯并恶唑，苯并唑并苯并噻唑的组合物和方法，以及合成所述试剂及其组合物的方法。
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