-
51.发明授权公开(公告)号：US08312836B2
公开(公告)日：2012-11-20
申请号：US12182261
申请日：2008-07-30
申请人： Scott E. Corbeil , Roger Labrecque , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Suzanne Conroy , Brian Sunter , Edward Bromander , Georgette Henrich
发明人： Scott E. Corbeil , Roger Labrecque , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Suzanne Conroy , Brian Sunter , Edward Bromander , Georgette Henrich
CPC分类号： A61M25/0009 , A61F2/86 , A61F2240/001 , A61F2250/0067 , A61M25/0045
摘要： A method, a kit, and an apparatus provide a coating on an implantable medical device. The apparatus includes housing, a sealed reservoir chamber disposed in the housing, a reducing template, and a reservoir access port. The sealed reservoir contains the coating material. The reducing template is sized to receive a medical device therethrough for application of the coating material. A seal breaching mechanism can be provided and adapted to breach the sealed reservoir upon activation of the apparatus. The reservoir access port, which is disposed in the housing, is adapted to fluidly couple the reducing template with the reservoir chamber upon activation of the apparatus for coating the medical device.
摘要翻译： 方法，试剂盒和装置在可植入医疗装置上提供涂层。 该装置包括壳体，设置在壳体中的密封储存室，还原模板和储存器进入端口。 密封的容器包含涂料。 还原模板的尺寸适于接收穿过其中的医疗装置以施加涂层材料。 可以提供密封破裂机构并适于在启动装置时破坏密封储存器。 设置在壳体中的储存器进入端口适于在激活用于涂覆医疗装置的装置时将还原模板与储存室流体联接。
-
52.发明授权Expandable fluoropolymer device for delivery of therapeutic agents and method of making 有权用于递送治疗剂的可扩展含氟聚合物装置和制备方法公开(公告)号：US07740793B2
公开(公告)日：2010-06-22
申请号：US11068680
申请日：2005-02-28
IPC分类号： A61M29/00
CPC分类号： A61M25/1029 , A61L29/041 , A61M25/10 , A61M2025/0057 , A61M2025/105 , A61M2025/1075 , B29C47/00 , B29C47/0023 , B29C55/24 , B29C2049/465 , B29K2027/18 , B29L2022/022 , B29L2031/753 , B32B2305/026 , C08L27/18
摘要： A method of making a radially expandable fluid delivery device includes providing a tube of biocompatible fluoropolymer material with a predetermined porosity based on an extrusion and expansion forming process, applying a radial expansion force to the tube expanding the tube to a predetermined diameter dimension, and removing the radial expansion force. The tube is radially inelastic while sufficiently pliable to be collapsible and inflatable from a collapsed configuration to an expanded configuration upon introduction of an inflation force, such that the expanded configuration occurs upon inflation to the predetermined diameter dimension. The fluid delivery device is constructed of a microporous, biocompatible fluoropolymer material having a microstructure that can provide a controlled, uniform, low-velocity fluid distribution through the walls of the fluid delivery device to effectively deliver fluid to the treatment site without damaging tissue proximate the walls of the device.
摘要翻译： 一种制造可径向膨胀的流体递送装置的方法包括：基于挤出和膨胀成形方法提供具有预定孔隙率的生物相容性氟聚合物材料管，向扩管管的管施加径向膨胀力至预定直径尺寸， 径向膨胀力。 该管是径向无弹性的，同时在引入膨胀力时足够柔软地可从折叠构型膨胀到膨胀构型，使得膨胀构型在膨胀到预定直径尺寸时发生。 流体输送装置由具有微结构的微孔生物相容性含氟聚合物材料构成，微结构可以通过流体输送装置的壁提供受控的，均匀的低速流体分配，以有效地将流体输送到治疗部位，而不会损伤邻近的 设备的墙壁。
-
53.发明授权Method for forming expandable polymers having drugs or agents included therewith 失效形成含有药物或试剂的可发性聚合物的方法公开(公告)号：US06923927B2
公开(公告)日：2005-08-02
申请号：US10807709
申请日：2004-03-23
CPC分类号： A61F2/06
摘要： The invention is directed to methods involving rewetting of expandable polymers with a wettable liquid to allow for enhanced expansion at or below room temperature without breakage, and in some cases, allows one to achieve a greater expansion ratio than that allowed at elevated temperatures using known methods. The wettable liquid can be formed of a drug and/or an agent, such that the resulting polymer contains and emits the drug upon positioning at a target location of a patient body. The expandable polymer can also have the drug or agent added to its structure at a polymer resin preparation stage, through use of an aqueous solution mixed with one or more fluoropolymers, or in a mixing stage. The present invention also allows one to achieve material with unique properties and handling characteristics. These properties included decreased material thickness, increased density, an altered node/fibril morphology, and a more consistent web in the case of flat material. This method is not limited to room temperature conditions and can be applied whenever the expandable polymer material is wet with a wettable liquid, and the expansion is performed at a temperature preferably below the vaporization or boiling points of that liquid.
摘要翻译： 本发明涉及包括用可湿性液体再湿润可膨胀聚合物以允许在室温或低于室温下增强膨胀而不破裂的方法，并且在某些情况下允许使用已知方法获得比在升高的温度下更大的膨胀比 。 可湿性液体可以由药物和/或药剂形成，使得所得聚合物在定位在患者身体的目标位置时含有和释放药物。 可膨胀聚合物还可以通过使用与一种或多种含氟聚合物混合的水溶液，或在混合阶段中，在聚合物树脂制备阶段将药物或试剂加入到其结构中。 本发明还可以实现具有独特性质和处理特性的材料。 这些性质包括材料厚度减小，密度增加，节点/原纤维形态改变，以及在平坦材料情况下更一致的网。 该方法不限于室温条件，只要可膨胀聚合物材料用可湿性液体润湿，并且膨胀在优选低于该液体的蒸发或沸点的温度下进行。
-
54.发明授权Methods of making controlled porosity expanded polytetrafluoroethylene products and fabrication 失效制造控制孔隙率膨胀聚四氟乙烯产品和制造方法
公开(公告)号：US5980799A
公开(公告)日：1999-11-09
申请号：US98195
申请日：1998-06-16
IPC分类号： A61F2/06 , A61L27/16 , A61L27/56 , B29C47/00 , B29C55/00 , B29C69/00 , B29D23/00 , B29K27/12 , B29K105/04 , D02J1/06 , B29C55/22
CPC分类号： B29D23/001 , A61F2/06 , A61L27/16 , A61L27/56 , B01D67/0027 , B01D69/02 , B01D69/12 , B01D71/36 , B29C47/0004 , B29C47/0021 , B29C55/005 , B01D2325/02 , B29C47/0023 , B29C47/0026 , B29C47/0042 , B29C47/0057 , B29C47/062 , B29C47/065 , B29K2027/18 , B29K2105/04 , B29L2023/005 , B29L2023/007 , Y10T428/139 , Y10T428/1397 , Y10T428/24273 , Y10T428/249986 , Y10T428/24999 , Y10T428/249992 , Y10T428/31544
摘要： A method of forming porous articles with a varying pore distribution by extrusion from a billet with a varying lubricant distribution. A single-polymer polytetrafluoroethylene is extruded and then stretched and sintered to provide a differential porous PTFE structure composed of fibers and nodes connected to one another by these fibers. The microfibrous structure has a portion within the cross-section that possesses a different pore size, accompanied by a different node and fiber geometry, than adjacent areas within that cross section. In a vascular graft, the pores taper inwardly, providing a fluid-tight lumen wall structure that prevents leakage, yet promotes cellular ingrowth and natural tissue regeneration. A node structure of radially-oriented plates provides flexibility, suture strength, and enhanced protection against collapse.
摘要翻译： 通过从具有变化的润滑剂分布的坯料挤出形成具有不同孔分布的多孔制品的方法。 挤出单聚合物聚四氟乙烯，然后进行拉伸和烧结，以提供由纤维和由这些纤维相互连接的节点组成的差异多孔PTFE结构。 微纤维结构在横截面内具有与该截面内的相邻区域不同的孔径的部分，伴随不同的节点和纤维几何形状。 在血管移植物中，孔向内逐渐变细，提供流体密封的腔壁结构，其防止泄漏，但促进细胞向内生长和天然组织再生。 径向定向板的节点结构提供柔性，缝合强度和增强的防止塌陷的保护。
-
公开(公告)号：US5824050A
公开(公告)日：1998-10-20
申请号：US760115
申请日：1996-12-03
IPC分类号： A61F2/00 , A61F2/06 , A61F2/10 , A61F2/24 , A61F2/88 , A61L27/16 , A61L27/34 , A61L27/40 , A61F2/04
CPC分类号： A61F2/07 , A61F2/06 , A61L27/16 , A61L27/34 , A61L27/40 , A61F2/105 , A61F2/2412 , A61F2/88 , A61F2002/072 , A61F2240/001
摘要： The wall of a prosthesis has a region which modulates communication through the porosity of the wall. The prosthesis is unitary, but may be assembled in successive bodies which are coalesced, so that the porous microstructure changes distinctly at stages through the thickness dimension of the wall. One embodiment is formed entirely of fluoropolymer, and has at least one surface adapted to support tissue regeneration and ingrowth. The modulation region is a stratum of high water entry pressure that reduces pulsatile hydraulic pressure transmission, or locally alters fluid-born-distribution of biological material through the wall and allows more natural gradients for tissue regeneration and growth in the outer region of the wall.
-
56.发明授权Expandable fluoropolymer device for delivery of therapeutic agents and method of making 有权用于递送治疗剂的可扩展含氟聚合物装置和制备方法公开(公告)号：US09050442B2
公开(公告)日：2015-06-09
申请号：US12820938
申请日：2010-06-22
IPC分类号： A61M31/00 , A61M25/10 , A61L29/04 , B29C55/24 , A61M25/00 , B29C47/00 , B29C49/46 , B29K27/18 , B29L22/02 , B29L31/00
CPC分类号： A61M25/1029 , A61L29/041 , A61M25/10 , A61M2025/0057 , A61M2025/105 , A61M2025/1075 , B29C47/00 , B29C47/0023 , B29C55/24 , B29C2049/465 , B29K2027/18 , B29L2022/022 , B29L2031/753 , B32B2305/026 , C08L27/18
摘要： A method of making a radially expandable fluid delivery device includes providing a tube of biocompatible fluoropolymer material with a predetermined porosity based on an extrusion and expansion forming process, applying a radial expansion force to the tube expanding the tube to a predetermined diameter dimension, and removing the radial expansion force. The tube is radially inelastic while sufficiently pliable to be collapsible and inflatable from a collapsed configuration to an expanded configuration upon introduction of an inflation force, such that the expanded configuration occurs upon inflation to the predetermined diameter dimension. The fluid delivery device is constructed of a microporous, biocompatible fluoropolymer material having a microstructure that can provide a controlled, uniform, low-velocity fluid distribution through the walls of the fluid delivery device to effectively deliver fluid to the treatment site without damaging tissue proximate the walls of the device.
摘要翻译： 一种制造可径向膨胀的流体递送装置的方法包括：基于挤出和膨胀成形方法提供具有预定孔隙率的生物相容性氟聚合物材料管，向扩管管的管施加径向膨胀力至预定直径尺寸， 径向膨胀力。 该管是径向无弹性的，同时在引入膨胀力时足够柔软地可从折叠构型膨胀到膨胀构型，使得膨胀构型在膨胀到预定直径尺寸时发生。 流体输送装置由具有微结构的微孔生物相容性含氟聚合物材料构成，微结构可以通过流体输送装置的壁提供受控的，均匀的低速流体分配，以有效地将流体输送到治疗部位，而不会损伤邻近的 设备的墙壁。
-
公开(公告)号：US07637886B2
公开(公告)日：2009-12-29
申请号：US10131396
申请日：2002-04-22
IPC分类号： A61M29/00
CPC分类号： A61L29/041 , A61M25/10 , B29C47/00 , B29C47/0023 , B29C55/24 , B29C2049/465 , B29K2027/18 , B29L2022/022 , B29L2031/753 , B32B2305/026 , Y10T428/1376 , C08L27/18
摘要： A radially expandable device having a body constructed of a generally inelastic, expanded fluoropolymer material is described. The body is deployable upon application of a radial expansion force from a reduced diameter, collapsed configuration to an expanded configuration having a pre-defined and fixed increased diameter. The body has a singular, unitary construction of generally homogenous material that is characterized by a seamless construction of expanded fluoropolymer material, such as expanded polytetrafluoroethylene (ePTFE), and is preferably constructed through an extrusion and expansion process. The body is further characterized by a microstructure of nodes interconnected by fibrils in which substantially all the nodes of the body are oriented generally perpendicularly to the longitudinal axis of the body. The monolithic construction of the body and the orientation of the nodes, perpendicular to the longitudinal axis of the body, yields a radially expandable device that predictably and dependably expands to a predefined, fixed maximum diameter that is generally independent of the expansion force used to radially expand the device. In addition, the microstructure of nodes interconnected by fibrils provides at least one predetermined flow rate of fluid therethrough over a range of fluid pressures.
-
58.发明授权Application of a therapeutic substance to a tissue location using an expandable medical device 有权使用可扩张医疗装置将治疗物质施用于组织位置公开(公告)号：US07572245B2
公开(公告)日：2009-08-11
申请号：US10942764
申请日：2004-09-15
申请人： Steve A. Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton
发明人： Steve A. Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton
IPC分类号： A61M31/00
CPC分类号： A61L29/16 , A61L31/16 , A61L2300/606
摘要： A non-polymeric or biological coating applied to radially expandable interventional medical devices provides uniform drug distribution and permeation of the coating and any therapeutic agents mixed therewith into a targeted treatment area within the body. The coating is sterile, and is capable of being carried by a sterile medical device to a targeted tissue location within the body following radial expansion. The therapeutic coating transfers off the medical device due in part to a biological attraction with the tissue and in part to a physical transference from the medical device to the targeted tissue location in contact with the medical device. Thus, atraumatic local tissue transference delivery is achieved for uniform therapeutic agent distribution and controlled bio-absorption into the tissue after placement within a patient's body with a non-inflammatory coating.
摘要翻译： 施加到可径向扩张的介入医疗装置的非聚合或生物涂层提供了涂层和与其混合的任何治疗剂的均匀的药物分布和渗透到体内的目标治疗区域。 涂层是无菌的，并且能够在径向膨胀后由无菌医疗装置携带到身体内的目标组织位置。 治疗涂层部分地由于与组织的生物吸引而部分地转移离开医疗装置，并且部分地从医疗装置到与医疗装置接触的目标组织位置的物理转移。 因此，在用非炎性涂层放置在患者体内之后，实现了不均匀的局部组织转移递送，用于均匀的治疗剂分布和对组织的受控生物吸收。
-
公开(公告)号：US06890463B2
公开(公告)日：2005-05-10
申请号：US10131446
申请日：2002-04-22
CPC分类号： A61F2/06
摘要： The invention is directed to methods involving rewetting of expandable polymers with a wettable liquid to allow for enhanced expansion at or below room temperature without breakage, and in some cases, allows one to achieve a greater expansion ratio than that allowed at elevated temperatures using known methods. The wettable liquid can be formed of a drug and/or an agent, such that the resulting polymer contains and emits the drug upon positioning at a target location of a patient body. The present invention also allows one to achieve material with unique properties and handling characteristics. These properties included decreased material thickness, increased density, an altered node/fibril morphology, and a more consistent web in the case of flat material. This method is not limited to room temperature conditions and can be applied whenever the expandable polymer material is wet with a wettable liquid, and the expansion is performed at a temperature preferably below the vaporization or boiling points of that liquid.
摘要翻译： 本发明涉及包括用可湿性液体再湿润可膨胀聚合物以允许在室温或低于室温下增强膨胀而不破裂的方法，并且在某些情况下允许使用已知方法获得比在升高的温度下更大的膨胀比 。 可湿性液体可以由药物和/或药剂形成，使得所得聚合物在定位在患者身体的目标位置时含有和释放药物。 本发明还可以实现具有独特性质和处理特性的材料。 这些性质包括材料厚度减小，密度增加，节点/原纤维形态改变，以及在平坦材料情况下更一致的网。 该方法不限于室温条件，只要可膨胀聚合物材料用可湿性液体润湿，并且膨胀在优选低于该液体的蒸发或沸点的温度下进行。
-
公开(公告)号：US06416537B1
公开(公告)日：2002-07-09
申请号：US09604382
申请日：2000-06-27
IPC分类号： A61F206
CPC分类号： A61F2/07 , A61F2/06 , A61F2/105 , A61F2/2412 , A61F2/88 , A61F2002/072 , A61F2240/001 , A61L27/16 , A61L27/34 , A61L27/507 , C08L27/18
摘要： A porous tube suitable for use as a vascular graft prosthesis and a method of making it is disclosed. It has a structure of porous polytetrafluoroethylene having a fibrous structure of nodes and fibers connecting the nodes together and an integrated intrawall circumferential support adjacent to areas of variable porosity. This invention provides a polytetrafluoroethylene polymer in a porous form useful as artificial internal organs for, for example vascular bypass, vascular access, and endovascular prosthesis. PTFE walls are found with radial zones of differing porosity are described.
摘要翻译： 公开了适合用作血管移植假体的多孔管及其制造方法。 它具有多孔聚四氟乙烯的结构，其具有连接节点的节点和纤维的纤维结构，以及与可变孔隙度区域相邻的整体的内部周向支撑。 本发明提供一种多孔形式的聚四氟乙烯聚合物，其用作例如血管旁路，血管通路和血管内假体的人造内脏。 发现PTFE壁具有不同孔隙率的径向区域。
-
-
-
-
-
-
-
-
-
搜索结果
92 条记录 (耗时 0.038 秒)
