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1.发明授权公开(公告)号：US08312836B2
公开(公告)日：2012-11-20
申请号：US12182261
申请日：2008-07-30
申请人： Scott E. Corbeil , Roger Labrecque , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Suzanne Conroy , Brian Sunter , Edward Bromander , Georgette Henrich
发明人： Scott E. Corbeil , Roger Labrecque , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Suzanne Conroy , Brian Sunter , Edward Bromander , Georgette Henrich
CPC分类号： A61M25/0009 , A61F2/86 , A61F2240/001 , A61F2250/0067 , A61M25/0045
摘要： A method, a kit, and an apparatus provide a coating on an implantable medical device. The apparatus includes housing, a sealed reservoir chamber disposed in the housing, a reducing template, and a reservoir access port. The sealed reservoir contains the coating material. The reducing template is sized to receive a medical device therethrough for application of the coating material. A seal breaching mechanism can be provided and adapted to breach the sealed reservoir upon activation of the apparatus. The reservoir access port, which is disposed in the housing, is adapted to fluidly couple the reducing template with the reservoir chamber upon activation of the apparatus for coating the medical device.
摘要翻译： 方法，试剂盒和装置在可植入医疗装置上提供涂层。 该装置包括壳体，设置在壳体中的密封储存室，还原模板和储存器进入端口。 密封的容器包含涂料。 还原模板的尺寸适于接收穿过其中的医疗装置以施加涂层材料。 可以提供密封破裂机构并适于在启动装置时破坏密封储存器。 设置在壳体中的储存器进入端口适于在激活用于涂覆医疗装置的装置时将还原模板与储存室流体联接。
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公开(公告)号：US08001922B2
公开(公告)日：2011-08-23
申请号：US11238554
申请日：2005-09-28
申请人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Suzanne Conroy , Brian Sunter , Georgette Henrich
发明人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Suzanne Conroy , Brian Sunter , Georgette Henrich
IPC分类号： B05C1/00
CPC分类号： A61L31/08 , A61F2/82 , A61F2/86 , A61F2250/0067 , A61K47/10 , A61K47/22 , A61K47/44 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/22 , A61L2300/416 , A61L2300/428 , A61L2300/45 , A61L2300/606 , A61L2300/802 , A61L2420/02 , A61M25/0009 , A61M25/0045
摘要： Devices for the provision of a coating on an implantable medical device are provided. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a therapeutic agent component can also be provided. The devices provide a coating having improved uniformity and coverage which in turn allow for greater control of the amount and dosage of the coating.
摘要翻译： 提供了用于在可植入医疗装置上提供涂层的装置。 涂层包括生物吸收载体组分。 除了生物可吸收载体组分之外，还可以提供治疗剂成分。 这些装置提供具有改进的均匀性和覆盖度的涂层，这又允许更大程度地控制涂层的量和剂量。
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公开(公告)号：US08722132B2
公开(公告)日：2014-05-13
申请号：US13185135
申请日：2011-07-18
申请人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Suzanne Conroy , Brian Sunter , Georgette Henrich
发明人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Suzanne Conroy , Brian Sunter , Georgette Henrich
IPC分类号： B05D3/00
CPC分类号： A61L31/08 , A61F2/82 , A61F2/86 , A61F2250/0067 , A61K47/10 , A61K47/22 , A61K47/44 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/22 , A61L2300/416 , A61L2300/428 , A61L2300/45 , A61L2300/606 , A61L2300/802 , A61L2420/02 , A61M25/0009 , A61M25/0045
摘要： Methods and devices for the provision of a coating on an implantable medical device. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a therapeutic agent component can also be provided. The methods and devices provide a coating having improved uniformity and coverage which in turn allow for greater control of the amount and dosage of the coating.
摘要翻译： 用于在可植入医疗装置上提供涂层的方法和装置。 涂层包括生物吸收载体组分。 除了生物可吸收载体组分之外，还可以提供治疗剂成分。 所述方法和装置提供了具有改进的均匀性和覆盖度的涂层，其又允许更大程度地控制涂层的量和剂量。
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公开(公告)号：US20110274823A1
公开(公告)日：2011-11-10
申请号：US13185135
申请日：2011-07-18
申请人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Suzanne Conroy , Brian Sunter , Georgette Henrich
发明人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Suzanne Conroy , Brian Sunter , Georgette Henrich
CPC分类号： A61L31/08 , A61F2/82 , A61F2/86 , A61F2250/0067 , A61K47/10 , A61K47/22 , A61K47/44 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/22 , A61L2300/416 , A61L2300/428 , A61L2300/45 , A61L2300/606 , A61L2300/802 , A61L2420/02 , A61M25/0009 , A61M25/0045
摘要： Methods and devices for the provision of a coating on an implantable medical device. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a therapeutic agent component can also be provided. The methods and devices provide a coating having improved uniformity and coverage which in turn allow for greater control of the amount and dosage of the coating.
摘要翻译： 用于在可植入医疗装置上提供涂层的方法和装置。 涂层包括生物吸收载体组分。 除了生物可吸收载体组分之外，还可以提供治疗剂成分。 所述方法和装置提供了具有改进的均匀性和覆盖度的涂层，其又允许更大程度地控制涂层的量和剂量。
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公开(公告)号：US08367099B2
公开(公告)日：2013-02-05
申请号：US11525390
申请日：2006-09-22
申请人： Steve A. Herweck , Thomas M. Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Keith M. Faucher , Philip McNamara , Roger Labrecque , Suzanne Conroy , Trevor Carlton
发明人： Steve A. Herweck , Thomas M. Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Keith M. Faucher , Philip McNamara , Roger Labrecque , Suzanne Conroy , Trevor Carlton
IPC分类号： A61L15/16
CPC分类号： B65B55/18 , A61B2017/00004 , A61B2017/320044 , A61B2090/0816 , A61F2/0059 , A61F2/0095 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/14 , A61L2/186 , A61L2/206 , A61L2/208 , A61L31/00 , A61L31/145 , A61L31/148 , A61L2202/24 , B26F1/18 , B29C39/02 , B65B31/04 , Y10T83/0481
摘要： A bio-absorbable stand-alone film is derived at least in part from fatty acids. The bio-absorbable stand-alone film can have anti-adhesive, anti-inflammatory, non-inflammatory, and wound healing properties, and can additionally include one or more therapeutic agents incorporated therein. The stand-alone film has one or more perforations or depressions formed therein. Corresponding methods of making the bio-absorbable stand-alone film with one or more perforations or depressions include molding, cutting, carving, puncturing or otherwise suitable methods to create the perforations or depressions in the bio-absorbable stand-alone film. The resulting stand-alone film is bioabsorbable.
摘要翻译： 生物可吸收的独立膜至少部分地由脂肪酸衍生。 生物吸收性独立膜可以具有抗粘连性，抗炎性，非炎性和伤口愈合性，并且还可以包括一种或多种掺入其中的治疗剂。 独立膜具有形成在其中的一个或多个穿孔或凹陷。 使具有一个或多个穿孔或凹陷的生物吸收性独立薄膜的相应方法包括成型，切割，雕刻，穿刺或以其它方式适当地在生物吸收性独立薄膜中产生穿孔或凹陷的方法。 所得到的独立膜是生物可吸收的。
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公开(公告)号：US09000040B2
公开(公告)日：2015-04-07
申请号：US12364763
申请日：2009-02-03
申请人： Keith M. Faucher , Hui Tang , Paul Martakos , Steve A. Herweck , Theodore Karwoski , Allison Sullivan , Greg Melville , Scott E. Corbeil
发明人： Keith M. Faucher , Hui Tang , Paul Martakos , Steve A. Herweck , Theodore Karwoski , Allison Sullivan , Greg Melville , Scott E. Corbeil
IPC分类号： A61K31/20 , A61K31/4353 , A61L31/16 , A61F2/82
CPC分类号： A61L31/08 , A61F2/82 , A61F2250/0067 , A61K31/4353 , A61L31/148 , A61L31/16 , A61L2300/404 , A61L2300/606 , A61L2420/06 , A61L2430/00
摘要： Fatty acid-based, pre-cure-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.
摘要翻译： 描述了基于脂肪酸的预固化衍生的生物材料，制备生物材料的方法以及将其用作药物递送载体的方法。 脂肪酸衍生的生物材料可以单独使用或与医疗装置组合使用以释放和局部递送一种或多种治疗剂。 还提供了形成和调整所述生物材料的性质的方法以及使用所述生物材料治疗哺乳动物的损伤的方法。
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公开(公告)号：US09012506B2
公开(公告)日：2015-04-21
申请号：US12325546
申请日：2008-12-01
申请人： Keith M. Faucher , Hui Tang , Joseph Ferraro , Paul Martakos , Steve A. Herweck , Theodore Karwoski , Scott E. Corbeil
发明人： Keith M. Faucher , Hui Tang , Joseph Ferraro , Paul Martakos , Steve A. Herweck , Theodore Karwoski , Scott E. Corbeil
IPC分类号： A61K31/20 , A61K31/225 , A61K31/355 , A61L29/08 , A61L29/16 , A61L31/08 , A61L31/16
CPC分类号： A61L31/08 , A61K31/225 , A61K31/355 , A61L29/08 , A61L29/16 , A61L31/148 , A61L31/16 , A61L2300/22
摘要： Fatty acid-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.
摘要翻译： 描述了脂肪酸衍生的生物材料，制备生物材料的方法以及将其用作药物递送载体的方法。 脂肪酸衍生的生物材料可以单独使用或与医疗装置组合使用以释放和局部递送一种或多种治疗剂。 还提供了形成和调整所述生物材料的性质的方法以及使用所述生物材料治疗哺乳动物的损伤的方法。
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公开(公告)号：US20090181937A1
公开(公告)日：2009-07-16
申请号：US12325546
申请日：2008-12-01
申请人： Keith M. Faucher , Hui Tang , Joseph Ferraro , Paul Martakos , Steve A. Herweck , Theodore Karwoski , Scott E. Corbeil
发明人： Keith M. Faucher , Hui Tang , Joseph Ferraro , Paul Martakos , Steve A. Herweck , Theodore Karwoski , Scott E. Corbeil
IPC分类号： A61K31/20 , A61K31/395 , A61P41/00
CPC分类号： A61L31/08 , A61K31/225 , A61K31/355 , A61L29/08 , A61L29/16 , A61L31/148 , A61L31/16 , A61L2300/22
摘要： Fatty acid-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.
摘要翻译： 描述了脂肪酸衍生的生物材料，制备生物材料的方法以及将其用作药物递送载体的方法。 脂肪酸衍生的生物材料可以单独使用或与医疗装置组合使用以释放和局部递送一种或多种治疗剂。 还提供了形成和调整所述生物材料的性质的方法以及使用所述生物材料治疗哺乳动物的损伤的方法。
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公开(公告)号：US08962023B2
公开(公告)日：2015-02-24
申请号：US11236943
申请日：2005-09-28
申请人： Roger Labrecque , Philip McNamara , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Keith Faucher , Thomas M. Swanick
发明人： Roger Labrecque , Philip McNamara , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Keith Faucher , Thomas M. Swanick
IPC分类号： A61K9/00 , A61L27/54 , A61F13/02 , A61K9/06 , A61K31/225 , A61K31/355 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/08 , A61L2/20 , A61L27/36 , A61L27/52 , A61L31/00 , A61L31/10 , A61L31/14 , A61F2/06 , B05D3/06
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A method of UV curing and corresponding resulting non-polymeric cross-linked gel are provided. The cross-linked gel can be combined with a medical device structure. The cross-linked gel can provide anti-adhesion characteristics, in addition to improved healing and anti-inflammatory response. The cross-linked gel is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel derived from at least one fatty acid compound. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent. The curing method can vary the application of UV light in both intensity and duration to achieve a desired amount of cross-linking forming the gel.
摘要翻译： 提供UV固化方法和相应的所得非聚合交联凝胶。 交联凝胶可以与医疗装置结构组合。 除了改善愈合和抗炎反应之外，交联凝胶还可提供抗粘附特性。 交联凝胶通常由天然存在的油或部分天然存在的油形成的油组合物形成，其至少部分固化形成由至少一种脂肪酸化合物衍生的交联凝胶。 此外，油组合物可以包括治疗剂组分，例如药物或其它生物活性剂。 固化方法可以改变UV光在强度和持续时间上的应用，以实现形成凝胶的所需量的交联。
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公开(公告)号：US08722077B2
公开(公告)日：2014-05-13
申请号：US13593656
申请日：2012-08-24
申请人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck
发明人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck
CPC分类号： A61L31/08 , A61F2/82 , A61F2/86 , A61F2250/0067 , A61K47/10 , A61K47/22 , A61K47/44 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/22 , A61L2300/416 , A61L2300/428 , A61L2300/45 , A61L2300/606 , A61L2300/802 , A61L2420/02 , A61M25/0009 , A61M25/0045
摘要： A coated medical device and a method of providing a coating on an implantable medical device result in a medical device having a bio-absorbable coating. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a therapeutic agent component can also be provided. The coated medical device is implantable in a patient to effect controlled delivery of the coating, including the therapeutic agent, to the patient.
摘要翻译： 涂覆的医疗装置和在可植入医疗装置上提供涂层的方法导致具有生物可吸收涂层的医疗装置。 涂层包括生物吸收载体组分。 除了生物可吸收载体组分之外，还可以提供治疗剂成分。 涂覆的医疗装置可植入患者体内以实现对包括治疗剂在内的涂层的可控输送。
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