公开(公告)号：US5888763A

公开(公告)日：1999-03-30

申请号：US367070

申请日：1994-12-30

申请人： Hidesaburo Hanafusa ,  Beatrice S. Knudsen ,  Stephan M. Feller ,  John Kuriyan ,  Xiaodong Wu ,  Jie Zheng ,  David Cowburn

发明人： Hidesaburo Hanafusa ,  Beatrice S. Knudsen ,  Stephan M. Feller ,  John Kuriyan ,  Xiaodong Wu ,  Jie Zheng ,  David Cowburn

IPC分类号： A61K38/00 ,  C07K14/47 ,  C12P21/06 ,  C07H21/00 ,  C12N1/20

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K2319/00

摘要： The present invention relates to regulation and control of cellular processes by SH3-domain binding proteins and peptides. In particular, the invention provides a consensus sequence of a peptide that shows high specificity and affinity for the first SH3 domain of cellular Crk. In specific examples, a number of peptides that contain the consensus are shown to bind c-Crk specifically. The molecular basis for this specificity is examined by crystallography.

摘要翻译： 本发明涉及通过SH3结构域结合蛋白和肽调节和控制细胞过程。 特别地，本发明提供了对细胞Crk的第一SH3结构域显示出高特异性和亲和力的肽的共有序列。 在具体实例中，显示了包含一致性的许多肽特异性结合c-Crk。 通过晶体学检查该特异性的分子基础。

公开(公告)号：US09950192B2

公开(公告)日：2018-04-24

申请号：US14998039

申请日：2014-04-22

申请人： Xiaodong Wu ,  George F Hatoum

发明人： Xiaodong Wu ,  George F Hatoum

IPC分类号： A61N5/00 ,  A61N5/10

CPC分类号： A61N5/1037 ,  A61N5/1049 ,  A61N5/1067 ,  A61N2005/1061

摘要： A method for fiducial-less real-time motion tracking of abdominal tumors based on the correlation between the patient's breathing pattern and the diaphragm/lung border during treatment delivery. This invention utilizes an edge detection technique to delineate the diaphragm/lung border on radiographic images in order to calculate or determine tumor locations in the abdomen. The position of the diaphragm/lung border is synchronized with the breathing pattern obtained from continuous optical monitoring of a patient's respiratory cycle. The real-time optical breathing pattern obtained from monitoring is used to determine or calculate the position of the diaphragm/lung border during treatment delivery. The position of the diaphragm/lung border is then used to determine the tumor location in real-time. The target tumor coordinates generated through this process are used by the treatment delivery system to adjust the radiation beam geometry of the treatment delivery system to follow the tumor in real-time and accurately deliver radiation dose.

公开(公告)号：US20160256708A9

公开(公告)日：2016-09-08

申请号：US13738099

申请日：2013-01-10

申请人： Xiaodong Wu ,  Mansoor M. Ahmed ,  Alan Pollack

发明人： Xiaodong Wu ,  Mansoor M. Ahmed ,  Alan Pollack

IPC分类号： A61N5/10

CPC分类号： A61N5/1031

摘要： A method for high-dose Grid radiotherapy utilizing a three-dimensional (3D) dose lattice formation is described herein. The 3D dose lattice can be achieved by, but not limited to, three technical approaches: 1) non-coplanar focused beams; 2) multileaf collimator (MLC)-based intensity modulated radiation therapy (IMRT) or aperture-modulated arc; and 3) heavy charged particle beam. The configuration of a 3D dose lattice is comprised of the number, location, and dose of dose vertices. The optimal configuration of a 3D dose lattice can be achieved by manual calculations or by automating the calculations for a generic algorithm. The objective of the optimization algorithm is to satisfy three conditions via iteration until they reach their global minimum. With 3D dose lattice, high doses of radiation are concentrated at each lattice vertex within a tumor with drastically lower doses between vertices (peak-to-valley effect), leaving tissue outside of the tumor volume minimally exposed.

摘要翻译： 本文描述了利用三维（3D）剂量格子形成的大剂量网格放射治疗方法。 3D剂量网格可以通过但不限于三种技术方法来实现：1）非共面聚焦束; 2）基于多叶准直器（MLC）的强度调制放射治疗（IMRT）或孔径调制电弧; 和3）重带电粒子束。 3D剂量网格的配置由剂量顶点的数量，位置和剂量组成。 3D剂量网格的最佳配置可以通过手动计算或通过自动化一般算法的计算来实现。 优化算法的目的是通过迭代满足三个条件，直到达到其全局最小值。 使用3D剂量网格，高剂量的辐射集中在肿瘤内的每个晶格顶点，顶点之间具有非常低的剂量（峰 - 谷效应），使组织在肿瘤体外的最低限度暴露。

公开(公告)号：US08825137B2

公开(公告)日：2014-09-02

申请号：US12045000

申请日：2008-03-09

申请人： Xiaodong Wu

发明人： Xiaodong Wu

IPC分类号： A61B5/05 ,  A61B6/04 ,  A61N5/10

CPC分类号： A61B6/0421 ,  A61N5/1016 ,  A61N5/1049

摘要： A method and apparatus for precisely reproducing the position of a vaginal cylinder in relation to a patient to ensure that a planned radiation dose can be delivered with high precision to the intended treatment target volumes. Treatment delivery is carried out by using an image-guided system to locate the position of the vaginal cylinder and comparing it to the coordinate of the vaginal cylinder obtained in the treatment plan. The displacement in the position of the vaginal cylinder from the treatment plan is corrected by calculating the transformation matrix and entering the resulting value into a position adjusting assembly which is attached to vaginal cylinder. The position adjusting assembly adjusts the vaginal cylinder to exactly reproduce its location relative to the patient's anatomy, eliminating geometric and dosimetric error.

摘要翻译： 一种用于精确地再现相对于患者的阴道圆柱体的位置以确保可以高精度地将计划的辐射剂量递送到预期治疗目标体积的方法和装置。 通过使用图像引导系统来定位阴道圆柱体的位置并将其与处理计划中获得的阴道圆柱体的坐标进行比较来进行治疗递送。 通过计算变换矩阵并将结果值输入到连接到阴道圆柱体上的位置调节组件来校正阴道圆柱体从治疗计划中的位置的位移。 位置调整组件调节阴道圆柱体，以恰当地再现其相对于患者解剖结构的位置，消除几何和剂量误差。

公开(公告)号：US20140194667A1

公开(公告)日：2014-07-10

申请号：US13738099

申请日：2013-01-10

申请人： Xiaodong Wu ,  Mansoor M. Ahmed ,  Alan Pollack

发明人： Xiaodong Wu ,  Mansoor M. Ahmed ,  Alan Pollack

IPC分类号： A61N5/10

CPC分类号： A61N5/1031

摘要： A method for high-dose Grid radiotherapy utilizing a three-dimensional (3D) dose lattice formation is described herein. The 3D dose lattice can be achieved by, but not limited to, three technical approaches: 1) non-coplanar focused beams; 2) multileaf collimator (MLC)-based intensity modulated radiation therapy (IMRT) or aperture-modulated arc; and 3) heavy charged particle beam. The configuration of a 3D dose lattice is comprised of the number, location, and dose of dose vertices. The optimal configuration of a 3D dose lattice can be achieved by manual calculations or by automating the calculations for a generic algorithm. The objective of the optimization algorithm is to satisfy three conditions via iteration until they reach their global minimum. With 3D dose lattice, high doses of radiation are concentrated at each lattice vertex within a tumor with drastically lower doses between vertices (peak-to-valley effect), leaving tissue outside of the tumor volume minimally exposed.

摘要翻译： 本文描述了利用三维（3D）剂量格子形成的大剂量网格放射治疗方法。 3D剂量网格可以通过但不限于三种技术方法来实现：1）非共面聚焦束; 2）基于多叶准直器（MLC）的强度调制放射治疗（IMRT）或孔径调制电弧; 和3）重带电粒子束。 3D剂量网格的配置由剂量顶点的数量，位置和剂量组成。 3D剂量网格的最佳配置可以通过手动计算或通过自动化一般算法的计算来实现。 优化算法的目的是通过迭代满足三个条件，直到达到其全局最小值。 使用3D剂量网格，高剂量的辐射集中在肿瘤内的每个晶格顶点，顶点之间具有非常低的剂量（峰 - 谷效应），使组织在肿瘤体外的最低限度暴露。

公开(公告)号：US20140050990A1

公开(公告)日：2014-02-20

申请号：US13641705

申请日：2011-02-16

申请人： Fang Yuan ,  Martin William Payne ,  Xiaodong Wu

发明人： Fang Yuan ,  Martin William Payne ,  Xiaodong Wu

IPC分类号： H01M10/0565 ,  H01M10/058 ,  H01M10/0525

CPC分类号： H01M10/058 ,  H01G11/56 ,  H01M2/361 ,  H01M10/0525 ,  H01M10/0565 ,  H01M2300/0085 ,  Y02E60/13 ,  Y10T29/49108

摘要： A gel electrolyte, a preparing method thereof, a gel electrolyte battery and a preparing method thereof are provided. The gel electrolyte comprises a non-aqueous solvent and a gel constituent, wherein the non-aqueous solvent comprises lithium salt, and the gel constituent comprises polyethylene glycol compounds with unsaturated double bonds, ester monomers with unsaturated double bonds, silane coupling agents and thermal initiators. The preparing method of the gel electrolyte battery includes preparing non-aqueous solvent containing lithium salts; dividing the prepared non-aqueous solvent containing lithium salts into two parts; adding initiators to one part to obtain a gel electrolyte part A; adding monomers and coupling agents to the other part to obtain a gel electrolyte part B; mixing the gel electrolyte part A and the gel electrolyte part B to obtain a gel electrolyte; injecting the obtained gel electrolyte into a dried battery and allowing the battery standing for 16 to 24 hours so as to sufficiently distribute the gel electrolyte inside the battery, and finally in-situ thermally polymerizing the gel electrolyte.

摘要翻译： 提供凝胶电解质，其制备方法，凝胶电解质电池及其制备方法。 凝胶电解质包含非水溶剂和凝胶成分，其中非水溶剂包括锂盐，凝胶组分包含具有不饱和双键的聚乙二醇化合物，具有不饱和双键的酯单体，硅烷偶联剂和热引发剂 。 凝胶电解质电池的制备方法包括制备含有锂盐的非水溶剂; 将制备的含有锂盐的非水溶剂分为两部分; 将引发剂加入一部分以获得凝胶电解质部分A; 向其他部分加入单体和偶联剂以获得凝胶电解质部分B; 混合凝胶电解质部分A和凝胶电解质部分B以获得凝胶电解质; 将获得的凝胶电解质注入干燥的电池中，并使电池静置16至24小时，以充分分配电池内的凝胶电解质，最后使凝胶电解质原位热聚合。

公开(公告)号：US08571278B2

公开(公告)日：2013-10-29

申请号：US12291803

申请日：2008-11-13

申请人： Milan Sonka ,  Xiaodong Wu ,  Yin Yin ,  Xiangmin Zhang

发明人： Milan Sonka ,  Xiaodong Wu ,  Yin Yin ,  Xiangmin Zhang

IPC分类号： G06K9/00

CPC分类号： G06K9/4638 ,  G06K9/6224 ,  G06T7/11 ,  G06T7/12 ,  G06T2207/10072 ,  G06T2207/30048 ,  G06T2207/30101

摘要： A system and methods for the efficient segmentation of globally optimal surfaces representing object boundaries in volumetric datasets is provided. An optical surface detection system and methods are provided that are capable of simultaneously detecting multiple interacting surfaces in which the optimality is controlled by the cost functions designed for individual surfaces and by several geometric constraints defining the surface smoothness and interrelations. The present invention includes surface segmentation using a layered graph-theoretic approach that optimally segments multiple interacting surfaces of a single object using a pre-segmentation step, after which the segmentation of all desired surfaces of the object are performed simultaneously in a single optimization process.

摘要翻译： 提供了一种用于在体数据集中表示对象边界的全局最优表面的有效分割的系统和方法。 提供了一种光学表面检测系统和方法，其能够同时检测多个相互作用的表面，其中最优性由为各个表面设计的成本函数以及限定表面平滑度和相互关系的若干几何约束来控制。 本发明包括使用分层图理论方法的表面分割，其使用预分割步骤最佳地分割单个对象的多个交互表面，之后在单个优化过程中同时执行对象的所有期望表面的分割。

公开(公告)号：US07852257B2

公开(公告)日：2010-12-14

申请号：US11961480

申请日：2007-12-20

申请人： Xiaodong Wu ,  Leslie K. Green ,  James N. Helland

发明人： Xiaodong Wu ,  Leslie K. Green ,  James N. Helland

IPC分类号： G01S13/00

CPC分类号： G01S13/56 ,  G01S7/023 ,  G01S13/222 ,  G08B13/2491 ,  G08B29/24

摘要： A microwave motion sensor for protecting an area comprises an oscillator configured to generate a plurality of microwave signals, a random pulse generator configured to set a random pulse period for each transmitted microwave signal, an antenna configured to transmit the microwave signals and to receive reflected signals, and a signal processor coupled to the antenna through other circuitry, said signal processor is configured to process the reflected signals to determine a presence of a moving object in the protected area.

摘要翻译： 一种用于保护区域的微波运动传感器包括：一个被配置为产生多个微波信号的振荡器，一个随机脉冲发生器，被配置成为每个发送的微波信号设置一个随机脉冲周期;一个天线，被配置为传送微波信号并接收反射信号 以及通过其他电路耦合到天线的信号处理器，所述信号处理器被配置为处理所述反射信号以确定所述保护区域中的移动物体的存在。

公开(公告)号：US20100283660A1

公开(公告)日：2010-11-11

申请号：US11968094

申请日：2007-12-31

申请人： Xiaodong Wu ,  James N. Helland ,  Leslie K. Green

发明人： Xiaodong Wu ,  James N. Helland ,  Leslie K. Green

IPC分类号： G01S13/56

CPC分类号： G01S13/56 ,  G01S7/36 ,  G01S13/86 ,  H01Q21/062

摘要： A motion sensing method and apparatus includes a housing enclosing a microwave motion sensor including an antenna, and a security system. The antenna may be a patch antenna which includes microwave radiating elements for transmitting and receiving a microwave signal for sensing motion. A reflector is attached to the housing and positioned above the antenna for downward shaping of the microwave signal. The microwave radiating elements together with the reflector provide a radiation pattern where a main beam is transmitted in a direction orthogonal to a surface of the antenna and a sided lobe is transmitted downward in amplitude below the microwave motion sensor. An alarm circuit indicates when the microwave sensor detects motion in armed mode, and a masking circuit indicates when the microwave sensor detects motion in a mask zone when the security system is unarmed. A second sensor may be positioned beneath the microwave motion sensor.

摘要翻译： 运动感测方法和装置包括：包围微波运动传感器的壳体，包括天线和安全系统。 天线可以是贴片天线，其包括用于发送和接收用于感测运动的微波信号的微波辐射元件。 反射器附接到壳体并且位于天线上方，用于微波信号的向下成形。 微波辐射元件与反射器一起提供辐射图，其中主波束在与天线的表面正交的方向上传输，并且双波瓣在微波运动传感器下方的振幅下方传输。 报警电路指示微波传感器何时在武装模式下检测到运动，并且屏蔽电路指示当安全系统未装备时微波传感器何时检测到掩模区域中的运动。 第二传感器可以位于微波运动传感器下方。

公开(公告)号：US20100188569A1

公开(公告)日：2010-07-29

申请号：US12691441

申请日：2010-01-21

申请人： Jason Meiners ,  James Nave ,  Xiaodong Wu ,  Hyunkeun Kim ,  Todd Hiers

发明人： Jason Meiners ,  James Nave ,  Xiaodong Wu ,  Hyunkeun Kim ,  Todd Hiers

IPC分类号： H04N7/01

CPC分类号： H04N7/0806 ,  H04N7/015 ,  H04N21/234 ,  H04N21/2365 ,  H04N21/4347 ,  H04N21/44

摘要： This invention is a video line encapsulation protocol which allows multiple low definition video streams to be combined into a single super frame of high definition video data. Each super frame is formed of individual lines from plural lower definition video input signals. The high definition video frames include meta data in each line identifying the video input source, line and frame. This meta data enables the super frames to be separated into their component input signals within a video processing digital signal processor.

摘要翻译： 本发明是允许将多个低清晰度视频流组合成高清晰度视频数据的单个超帧的视频行封装协议。 每个超级帧由多个低分辨率视频输入信号的各个线形成。 高分辨率视频帧包括识别视频输入源，行和帧的每行中的元数据。 该元数据使超帧能够在视频处理数字信号处理器内分离成其分量输入信号。