公开(公告)号：US10370726B2

公开(公告)日：2019-08-06

申请号：US15487124

申请日：2017-04-13

Applicant: Mayo Foundation for Medical Education and Research

Inventor： David A. Ahlquist ,  William R. Taylor ,  John B. Kisiel ,  Tracy C. Yab ,  Douglas W. Mahoney

IPC: C07H21/04 ,  C12Q1/68 ,  C12Q1/6886 ,  G16H50/20 ,  G06F19/00

Abstract: Provided herein is technology for colorectal neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of colorectal neoplasia in 1) individuals at, older or younger than 50 years of age, or 2) individuals having Lynch Syndrome.

公开(公告)号：US20180258498A1

公开(公告)日：2018-09-13

申请号：US15978565

申请日：2018-05-14

Applicant: Mayo Foundation for Medical Education and Research ,  EXACT SCIENCES DEVELOPMENT COMPANY, LLC

Inventor： David A. Ahlquist ,  John B. Kisiel ,  William R. Taylor ,  Tracy C. Yab ,  Douglas W. Mahoney ,  Graham P. Lidgard ,  Hatim T. Allawi

IPC: C12Q1/6886

Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as pancreatic and colorectal cancer.

公开(公告)号：US10030272B2

公开(公告)日：2018-07-24

申请号：US15054860

申请日：2016-02-26

Applicant: Mayo Foundation for Medical Education and Research

Inventor： David A. Ahlquist ,  William R. Taylor ,  John B. Kisiel ,  Douglas W. Mahoney ,  Tracy C. Yab

IPC: C12Q1/6886

CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/154

Abstract: Provided herein is technology for gastrointestinal neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of gastrointestinal neoplasm, and classifying the site location of such a gastrointestinal neoplasm (e.g., a colorectal region, a pancreaticobiliary region, a gastroesophageal region).

公开(公告)号：US10006093B2

公开(公告)日：2018-06-26

申请号：US15252966

申请日：2016-08-31

Applicant: Mayo Foundation for Medical Education and Research ,  EXACT SCIENCES DEVELOPMENT COMPANY, LLC

Inventor： David A. Ahlquist ,  William R. Taylor ,  John B. Kisiel ,  Tracy C. Yab ,  Douglas W. Mahoney ,  Hatim T. Allawi

IPC: C07H21/04 ,  C12Q1/68 ,  C12Q1/6886

CPC classification number: C12Q1/6886 ,  C12Q2600/154 ,  C12Q2600/16

Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as gastric cancer.

公开(公告)号：US20170335401A1

公开(公告)日：2017-11-23

申请号：US15471337

申请日：2017-03-28

Applicant: Exact Sciences Corporation ,  Mayo Foundation for Medical Education and Research

Inventor： Hatim Allawi ,  Graham P. Lidgard ,  Maria Giakoumopoulos ,  David A. Ahlquist ,  William R. Taylor ,  Douglas Mahoney

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q1/6806 ,  C12Q2600/154 ,  C12Q2600/16

Abstract: Provided herein is technology for lung neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of lung cancer.

公开(公告)号：US20160305946A1

公开(公告)日：2016-10-20

申请号：US15197105

申请日：2016-06-29

Applicant: Mayo Foundation for Medical Education and Research

Inventor： William R. Taylor ,  Jonathan J. Harrington ,  Patrick S. Quint ,  Hongzhi Zou ,  Harold S. Bergen, III ,  David I. Smith ,  David A. Ahlquist

IPC: G01N33/574

CPC classification number: C12Q1/6886 ,  C12Q1/37 ,  C12Q1/40 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Y302/01001 ,  C12Y304/2107 ,  G01N33/57407 ,  G01N33/57419 ,  G01N33/57438 ,  G01N2333/928 ,  G01N2333/966 ,  G01N2560/00

Abstract: This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided.

公开(公告)号：US20140274748A1

公开(公告)日：2014-09-18

申请号：US14206596

申请日：2014-03-12

Applicant: Mayo Foundation for Medical Education and Research

Inventor： David A. Ahlquist ,  John B. Kisiel ,  William R. Taylor ,  Tracy C. Yab ,  Douglas W. Mahoney

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/154

Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as pancreatic and colorectal cancer.

Abstract translation: 本文提供了涉及检测瘤形成的技术，特别但并非排他地涉及用于检测恶变和恶性肿瘤如胰腺癌和结肠直肠癌的方法，组合物和相关用途。

公开(公告)号：US20130244235A1

公开(公告)日：2013-09-19

申请号：US13773791

申请日：2013-02-22

Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

Inventor： David A. Ahlquist ,  William R. Taylor ,  Tracy C. Yab ,  John B. Kisiel

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/154 ,  C12Q2600/158

Abstract: The present invention provides methods and materials related to the detection of colorectal neoplasia (CRN) associated with inflammatory bowel disease (IBD). The present invention provides markers specific for colorectal neoplasia associated with inflammatory bowel disease in or associated with a subject's stool sample. In particular, the present invention provides methods and materials for identifying mammals (e.g., humans) having colorectal neoplasia associated with inflammatory bowel disease by detecting the presence and level of indicators of colorectal neoplasia such as, for example, epigenetic alterations (e.g., DNA methylation) (e.g., CpG methylation) (e.g., CpG methylation in coding or regulatory regions of BMP3, NDRG4, vimentin, EYA4) in DNA from a stool sample obtained from the mammal.

Abstract translation: 本发明提供与检测与炎性肠病（IBD）相关的结肠直肠肿瘤（CRN）相关的方法和材料。 本发明提供了与受试者粪便样品中或与其相关的炎症性肠病相关的结肠直肠肿瘤特异性标志物。 特别地，本发明提供了用于通过检测结肠直肠瘤形成指标的存在和水平（例如表观遗传学改变）（例如DNA甲基化）来鉴定具有与炎症性肠病相关的结肠直肠肿瘤的哺乳动物（例如，人）的方法和材料 ）（例如，CpG甲基化）（例如，BMP3，NDRG4，波形蛋白，EYA4的编码区或调节区中的CpG甲基化）来自哺乳动物的粪便样品。

公开(公告)号：US20240182980A1

公开(公告)日：2024-06-06

申请号：US18489096

申请日：2023-10-18

Applicant: Mayo Foundation for Medical Education and Research ,  Exact Sciences Corporation

Inventor： David A. Ahlquist ,  John B. Kisiel ,  William R. Taylor ,  Tracy C. Yab ,  Douglas W. Mahoney ,  Graham P. Lidgard ,  Hatim T. Allawi

IPC: C12Q1/6886

CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/154

Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as pancreatic and colorectal cancer.

公开(公告)号：US20230272482A1

公开(公告)日：2023-08-31

申请号：US18062419

申请日：2022-12-06

Applicant: Mayo Foundation for Medical Education and Research

Inventor： William R. Taylor ,  Jonathan J. Harrington ,  Patrick S. Quint ,  Hongzhi Zou ,  Harold R. Bergen, III ,  David I. Smith ,  David A. Ahlquist

IPC: C12Q1/6886 ,  C12Q1/37 ,  C12Q1/40 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  C12Q1/37 ,  C12Q1/40 ,  G01N33/57407 ,  G01N33/57419 ,  G01N33/57438 ,  C12Y302/01001 ,  C12Y304/2107 ,  C12Q2600/156 ,  C12Q2600/154 ,  G01N2333/928 ,  G01N2333/966 ,  G01N2560/00 ,  C12Q2600/158

Abstract: This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided.