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公开(公告)号：US08916600B2
公开(公告)日：2014-12-23
申请号：US13490204
申请日：2012-06-06
申请人： Markus Berger , Hartmut Rehwinkel , Jan Dahmén , Anders Eriksson , Thomas Hansson , Nafizal Hossain , Per Tomas Klingstedt , Matti Lepistö , Stinabritt Nilsson , Martin Hemmerling , Karl Edman
发明人： Markus Berger , Hartmut Rehwinkel , Jan Dahmén , Anders Eriksson , Thomas Hansson , Nafizal Hossain , Per Tomas Klingstedt , Matti Lepistö , Stinabritt Nilsson , Martin Hemmerling , Karl Edman
IPC分类号： A61K31/416 , C07D231/54 , C07D405/14 , C07D409/12 , C07D231/56 , C07D409/14 , C07D403/12 , C07D401/12 , C07D405/12 , C07D401/14 , C07D403/10 , C07D413/12
CPC分类号： C07D409/14 , A61K31/416 , A61K31/4439 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D413/12
摘要： A compound of formula Ia: The present invention relates to novel indazolyl derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments.
摘要翻译： 式Ia化合物：本发明涉及新的吲唑基衍生物，包含该衍生物的药物组合物，制备这种新型衍生物的方法以及使用这些衍生物作为药物。
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公开(公告)号：US20110071194A1
公开(公告)日：2011-03-24
申请号：US12959027
申请日：2010-12-02
申请人： Markus Berger , Jan Dahmén , Karl Edman , Anders Eriksson , Balint Gabos , Thomas Hansson , Martin Hemmerling , Krister Henriksson , Svetlana Ivanova , Matti Lepistö , Darren McKerrecher , Magnus Munck af Rosenschöld , Stinabritt Nilsson , Hartmut Rehwinkel , Camilla Taflin
发明人： Markus Berger , Jan Dahmén , Karl Edman , Anders Eriksson , Balint Gabos , Thomas Hansson , Martin Hemmerling , Krister Henriksson , Svetlana Ivanova , Matti Lepistö , Darren McKerrecher , Magnus Munck af Rosenschöld , Stinabritt Nilsson , Hartmut Rehwinkel , Camilla Taflin
IPC分类号： A61K31/4439 , C07D401/12 , A61P29/00 , A61P11/06
CPC分类号： C07D231/56 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Compounds of formula (I): The present invention relates to novel indazolyl ester or amide derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments
摘要翻译： 式（I）化合物：本发明涉及新的吲唑基酯或酰胺衍生物，包含这些衍生物的药物组合物，制备这种新型衍生物的方法以及使用这些衍生物作为药物
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53.发明申请LINEAR PHENYL-SUBSTITUTED INDAZOLES AND INDOLES, A PROCESS FOR THEIR PRODUCTION AND THEIR USE AS ANTI-INFLAMMATORY AGENTS 审中-公开线性苯基取代的吲哚和吲哚，其生产过程及其作为抗炎剂的用途公开(公告)号：US20080188666A1
公开(公告)日：2008-08-07
申请号：US11936395
申请日：2007-11-07
申请人： Markus Berger , Hartmut Rehwinkel , Heike Schaecke , Matti Lepisto , Karl Edmann
发明人： Markus Berger , Hartmut Rehwinkel , Heike Schaecke , Matti Lepisto , Karl Edmann
IPC分类号： C07D401/04 , C07D231/56 , C07D209/14
CPC分类号： C07D405/12 , C07D231/56 , C07D401/04 , C07D405/14
摘要： The present invention relates to the compounds of formula I, processes for their production and their use as anti-inflammatory agents.
摘要翻译： 本发明涉及式I化合物，其制备方法及其作为抗炎剂的用途。
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公开(公告)号：US08143290B2
公开(公告)日：2012-03-27
申请号：US12959027
申请日：2010-12-02
申请人： Markus Berger , Jan Dahmén , Karl Edman , Anders Eriksson , Balint Gabos , Thomas Hansson , Martin Hemmerling , Krister Henriksson , Svetlana Ivanova , Matti Lepistö , Darren McKerrecher , Magnus Munck af Rosenschöld , Stinabritt Nilsson , Hartmut Rehwinkel , Camilla Taflin
发明人： Markus Berger , Jan Dahmén , Karl Edman , Anders Eriksson , Balint Gabos , Thomas Hansson , Martin Hemmerling , Krister Henriksson , Svetlana Ivanova , Matti Lepistö , Darren McKerrecher , Magnus Munck af Rosenschöld , Stinabritt Nilsson , Hartmut Rehwinkel , Camilla Taflin
IPC分类号： A61K31/4427 , C07D401/02
CPC分类号： C07D231/56 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Compounds of formula (I): The present invention relates to novel indazolyl ester or amide derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments.
摘要翻译： 式（I）化合物：本发明涉及新的吲唑基酯或酰胺衍生物，包含这些衍生物的药物组合物，制备这种新型衍生物的方法以及使用这些衍生物作为药物。
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55.发明申请TETRAHYDRONAPHTHALENYLAMIDES, A PROCESS FOR THEIR PRODUCTION AND THEIR USE AS ANTI-INFLAMMATORY AGENTS 审中-公开四氢萘甲酰胺，其生产方法及其作为抗炎剂的用途公开(公告)号：US20080200519A1
公开(公告)日：2008-08-21
申请号：US12032067
申请日：2008-02-15
申请人： Markus BERGER , Hartmut Rehwinkel , Heike Schacke , Ekkehard May , Werner Skuballa , Hermann Kunzer
发明人： Markus BERGER , Hartmut Rehwinkel , Heike Schacke , Ekkehard May , Werner Skuballa , Hermann Kunzer
IPC分类号： A61K31/4439 , C07D231/38 , C07D401/04 , A61K31/4192 , A61P29/00 , C07D249/04 , A61K31/415
CPC分类号： C07D231/40 , C07D207/34 , C07D233/90 , C07D249/06 , C07D401/04
摘要： The present invention relates to the compounds of formula I, processes for their production and their use as anti-inflammatory agents.
摘要翻译： 本发明涉及式I化合物，其制备方法及其作为抗炎剂的用途。
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56.发明申请Tetrahydronaphthalene derivates, processes for preparing them and their use as antiinflammatory agents 失效四氢萘衍生物，其制备方法及其作为抗炎剂的用途公开(公告)号：US20070225290A1
公开(公告)日：2007-09-27
申请号：US11717782
申请日：2007-03-14
IPC分类号： A61K31/517 , A61K31/502 , A61K31/4704 , A61K31/366
CPC分类号： C07D215/227 , C07D209/34 , C07D215/38 , C07D215/60 , C07D217/24 , C07D231/56 , C07D237/32 , C07D239/74 , C07D265/02 , C07D311/76
摘要： The invention relates to multiply substituted tetrahydronaphthalene derivatives of the formula (Ia) to processes for preparing them and to their use as antiinflammatory agents.
摘要翻译： 本发明涉及式（Ia）的多取代四氢萘衍生物用于制备它们的方法及其作为抗炎剂的用途。
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![5-[(3,3,3-trifluoro-2-hydroxy-1-arylpropyl)amino]-1H-quinolin-2-ones, a process for their production and their use as anti-inflammatory agents](/abs-image/US/2013/03/12/US08394958B2/abs.jpg.150x150.jpg)
57.发明授权5-[(3,3,3-trifluoro-2-hydroxy-1-arylpropyl)amino]-1H-quinolin-2-ones, a process for their production and their use as anti-inflammatory agents 有权5 - [（3,3,3-三氟-2-羟基-1-芳基丙基）氨基] -1H-喹啉-2-酮，其制备方法及其作为抗炎剂公开(公告)号：US08394958B2
公开(公告)日：2013-03-12
申请号：US12275392
申请日：2008-11-21
申请人： Markus Berger , Hartmut Rehwinkel , Thomas Zollner , Ekkehard May , Jorma Hassfeld , Heike Schacke
发明人： Markus Berger , Hartmut Rehwinkel , Thomas Zollner , Ekkehard May , Jorma Hassfeld , Heike Schacke
IPC分类号： C07D215/38
CPC分类号： C07D215/38 , C07C45/00 , C07C45/58 , C07C45/71 , C07C49/82 , C07C49/84 , C07D303/32 , C07D405/12 , C07C47/575 , C07C47/565
摘要： The present invention relates to compounds of formula I, processes for their production and their use as anti-inflammatory agents.
摘要翻译： 本发明涉及式I化合物，其制备方法及其作为抗炎剂的用途。
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公开(公告)号：US08211930B2
公开(公告)日：2012-07-03
申请号：US12468561
申请日：2009-05-19
申请人： Markus Berger , Hartmut Rehwinkel , Jan Dahmén , Anders Eriksson , Thomas Hansson , Nafizal Hossain , Per Tomas Klingstedt , Matti Lepistö , Stinabritt Nilsson , Martin Hemmerling , Karl Edman
发明人： Markus Berger , Hartmut Rehwinkel , Jan Dahmén , Anders Eriksson , Thomas Hansson , Nafizal Hossain , Per Tomas Klingstedt , Matti Lepistö , Stinabritt Nilsson , Martin Hemmerling , Karl Edman
IPC分类号： A61K31/416 , C07D231/54
CPC分类号： C07D409/14 , A61K31/416 , A61K31/4439 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D413/12
摘要： A compound of formula Ia: The present invention relates to novel indazolyl derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments
摘要翻译： 式Ia化合物：本发明涉及新的吲唑基衍生物，包含该衍生物的药物组合物，制备这种新型衍生物的方法以及使用这些衍生物作为药物。
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公开(公告)号：US20100197644A1
公开(公告)日：2010-08-05
申请号：US12643504
申请日：2009-12-21
申请人： Markus Berger , Jan Dahmén , Karl Edman , Anders Eriksson , Balint Gabos , Thomas Hansson , Martin Hemmerling , Krister Henriksson , Svetlana Ivanova , Matti Lepistö , Darren McKerrecher , Magnus Munck af Rosenschöld , Stinabritt Nilsson , Hartmut Rehwinkel , Camilla Taflin
发明人： Markus Berger , Jan Dahmén , Karl Edman , Anders Eriksson , Balint Gabos , Thomas Hansson , Martin Hemmerling , Krister Henriksson , Svetlana Ivanova , Matti Lepistö , Darren McKerrecher , Magnus Munck af Rosenschöld , Stinabritt Nilsson , Hartmut Rehwinkel , Camilla Taflin
IPC分类号： A61K31/56 , A61K31/5377 , A61K31/501 , A61K31/506 , A61K31/4709 , A61K31/4439 , A61K31/4245 , A61K31/427 , A61K31/428 , A61K31/422 , A61K31/4196 , A61K31/4184 , A61K31/4178 , A61K31/416 , C07D413/10 , C07D403/04 , C07D403/12 , C07D215/12 , C07D401/12 , C07D271/02 , C07D417/12 , C07D277/587 , C07D263/38 , C07D263/40 , C07D249/12 , C07D235/26 , C07D233/90 , C07D231/56 , A61P29/00 , A61P11/06
CPC分类号： C07D231/56 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Compounds of formula (I): The present invention relates to novel indazolyl ester or amide derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments
摘要翻译： 式（I）化合物：本发明涉及新的吲唑基酯或酰胺衍生物，包含这些衍生物的药物组合物，制备这种新衍生物的方法以及使用这些衍生物作为药物
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公开(公告)号：US20100087489A1
公开(公告)日：2010-04-08
申请号：US12468561
申请日：2009-05-19
申请人： Markus Berger , Hartmut Rehwinkel , Jan Dahmén , Anders Eriksson , Thomas Hansson , Nafizal Hossain , Per Tomas Klingstedt , Matti Lepistö , Stinabritt Nilsson , Martin Hemmerling , Karl Edman
发明人： Markus Berger , Hartmut Rehwinkel , Jan Dahmén , Anders Eriksson , Thomas Hansson , Nafizal Hossain , Per Tomas Klingstedt , Matti Lepistö , Stinabritt Nilsson , Martin Hemmerling , Karl Edman
IPC分类号： A61K31/4439 , C07D231/56 , C07D401/14 , A61K31/416 , A61P29/00
CPC分类号： C07D409/14 , A61K31/416 , A61K31/4439 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D413/12
摘要： A compound of formula Ia: The present invention relates to novel indazolyl derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments
摘要翻译： 式Ia化合物：本发明涉及新的吲唑基衍生物，包含该衍生物的药物组合物，制备这种新型衍生物的方法以及使用这些衍生物作为药物。
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