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51.发明申请公开(公告)号：US20080188487A1
公开(公告)日：2008-08-07
申请号：US12020637
申请日：2008-01-28
IPC分类号： A61K31/497 , C07D403/02
CPC分类号： C07D209/42 , C07D401/04 , C07D403/06
摘要： The present invention relates to compounds of formula I wherein A, G and R1 to R3 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物，其中A，G和R 1至R 3如在说明书和权利要求书中所定义，及其药学上可接受的盐。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US20070244125A1
公开(公告)日：2007-10-18
申请号：US11784041
申请日：2007-04-05
IPC分类号： A61K31/4045 , C07D209/02
CPC分类号： C07D401/06 , C07D209/42 , C07D401/14 , C07D403/06 , C07D405/12 , C07D487/04 , C07D491/113
摘要： The present invention relates to compounds of formula I wherein G and R1 to R5 and R12 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物，其中G和R 1至R 5和R 12如在说明书和权利要求书中所定义， 及其药学上可接受的盐。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US20070167436A1
公开(公告)日：2007-07-19
申请号：US11649532
申请日：2007-01-04
IPC分类号： A61K31/496 , A61K31/495 , A61K31/551 , C07D405/02 , C07D243/08 , C07D241/04
CPC分类号： C07D295/185 , C07D209/08 , C07D209/44 , C07D211/38 , C07D211/46 , C07D213/74 , C07D213/84 , C07D215/08 , C07D217/04 , C07D241/04 , C07D241/20 , C07D243/08 , C07D261/14 , C07D295/215 , C07D309/14
摘要： The present invention relates to compounds of formula I wherein s, R1a and R1 to R3 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物，其中s，R 1a和R 1至R 3如在说明书和权利要求书中所定义， 及其药学上可接受的盐。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US20070135416A1
公开(公告)日：2007-06-14
申请号：US11605899
申请日：2006-11-29
IPC分类号： A61K31/551 , A61K31/498 , C07D487/14
CPC分类号： C07D487/04 , C07D471/14
摘要： The present invention relates to compounds of formula I wherein A, G, r and R1 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物，其中A，G，r和R 1至R 5如在说明书和权利要求书中所定义，及其药学上可接受的盐。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US20120232084A1
公开(公告)日：2012-09-13
申请号：US13478144
申请日：2012-05-23
IPC分类号： A61K31/498 , A61P25/00 , A61P25/22 , A61P25/18 , A61P25/28 , A61P25/24 , A61P25/16 , A61P25/14 , A61P25/30 , A61P25/08 , A61P3/04 , A61P3/10 , A61P11/06 , A61P25/06 , A61P1/00 , C07D403/12
CPC分类号： C07D413/12 , C07D403/12 , C07D413/14 , C07D417/12
摘要： The present invention is concerned with novel sulfonamides of formula I wherein R1, R2, Ar, Hetaryl, m and n are as described in the description and claims. The compounds are orexin receptor antagonists, useful in the treatment of disorders, in which orexin pathways are involved.
摘要翻译： 本发明涉及式I的新型磺酰胺，其中R 1，R 2，Ar，杂芳基，m和n如说明书和权利要求中所述。 这些化合物是食欲素受体拮抗剂，可用于治疗食欲素途径参与的病症。
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公开(公告)号：US08227613B2
公开(公告)日：2012-07-24
申请号：US12484552
申请日：2009-06-15
申请人： Jean-Michel Adam , Johannes Aebi , Alfred Binggeli , Luke Green , Guido Hartmann , Hans P. Maerki , Patrizio Mattei , Fabienne Ricklin , Olivier Roche
发明人： Jean-Michel Adam , Johannes Aebi , Alfred Binggeli , Luke Green , Guido Hartmann , Hans P. Maerki , Patrizio Mattei , Fabienne Ricklin , Olivier Roche
IPC分类号： C07D211/68 , A61K31/445
CPC分类号： C07D401/06 , C07D401/14 , C07D471/04
摘要： The invention is concerned with novel heteroaryl carboxamide derivatives of formula (I), wherein m, X, Y, R1, R2, R3 and R4 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are antagonists of CCR-2 receptor, CCR-5 receptor and/or CCR-3 receptor and can be used as medicaments.
摘要翻译： 本发明涉及式（I）的新型杂芳基羧酰胺衍生物，其中m，X，Y，R 1，R 2，R 3和R 4如说明书和权利要求书中所定义，以及其生理上可接受的盐。 这些化合物是CCR-2受体，CCR-5受体和/或CCR-3受体的拮抗剂，可用作药物。
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公开(公告)号：US08071586B2
公开(公告)日：2011-12-06
申请号：US12499120
申请日：2009-07-08
申请人： Johannes Aebi , Alfred Binggeli , Luke Green , Guido Hartmann , Hans P. Maerki , Patrizio Mattei , Fabienne Ricklin , Olivier Roche
发明人： Johannes Aebi , Alfred Binggeli , Luke Green , Guido Hartmann , Hans P. Maerki , Patrizio Mattei , Fabienne Ricklin , Olivier Roche
IPC分类号： A61K31/496 , A61K31/551 , A61K31/554 , C07D401/06 , C07D405/14 , C07D417/06 , C07D401/12 , C07D403/06
CPC分类号： C07D403/06 , C07D241/08 , C07D243/08 , C07D285/36 , C07D401/06 , C07D401/12 , C07D405/14
摘要： The invention is concerned with novel heterocyclyl compounds of formula (I) wherein A, X, Y1, Y2, Y3, R3, R4, R5, R6, R7, R8, R9, R10, m, n and p are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are antagonists of CCR2 receptor, CCR5 receptor and/or CCR3 receptor and can be used as medicaments.
摘要翻译： 本发明涉及式（I）的新型杂环基化合物，其中A，X，Y1，Y2，Y3，R3，R4，R5，R6，R7，R8，R9，R10，m，n和p如 描述和权利要求书以及其生理上可接受的盐。 这些化合物是CCR2受体，CCR5受体和/或CCR3受体的拮抗剂，可用作药物。
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公开(公告)号：US08067598B2
公开(公告)日：2011-11-29
申请号：US12056324
申请日：2008-03-27
申请人： Luca Gobbi , Henner Knust , Parichehr Malherbe , Matthias Nettekoven , Emmanuel Pinard , Olivier Roche , Mark Rogers-Evans
发明人： Luca Gobbi , Henner Knust , Parichehr Malherbe , Matthias Nettekoven , Emmanuel Pinard , Olivier Roche , Mark Rogers-Evans
IPC分类号： C07D471/04 , C07D513/04 , A61K31/4365 , A61K31/437 , A61K31/4375
CPC分类号： C07D471/04 , C07D495/04
摘要： The present invention relates to compounds of formula wherein R1, R2, R3, and R4 are as defined herein and hetaryl is a one or two ring-membered heteroaromatic ring system, connected to the carbon atoms of the piperidine group selected from the group consisting of or to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. These compounds are orexin receptor antagonists and may be useful in the treatment of disorders in which orexin pathways are involved, like sleep disorders.
摘要翻译： 本发明涉及下式的化合物，其中R 1，R 2，R 3和R 4如本文所定义，杂芳基是与哌啶基团的碳原子连接的一个或两个环 - 元杂芳族环系统，所述哌啶基团的碳原子选自 或其药学上合适的酸加成盐，旋光纯对映异构体，外消旋体或非对映体混合物。 这些化合物是食欲素受体拮抗剂，并且可用于治疗涉及食欲素途径的疾病，例如睡眠障碍。
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公开(公告)号：US07977358B2
公开(公告)日：2011-07-12
申请号：US12173847
申请日：2008-07-16
申请人： Johannes Aebi , Alfred Binggeli , Luke Green , Guido Hartmann , Hans P. Maerki , Patrizio Mattei , Fabienne Ricklin , Olivier Roche
发明人： Johannes Aebi , Alfred Binggeli , Luke Green , Guido Hartmann , Hans P. Maerki , Patrizio Mattei , Fabienne Ricklin , Olivier Roche
IPC分类号： A61K31/454 , C07D401/14
CPC分类号： C07D231/14 , C07D401/04 , C07D403/06
摘要： The invention is concerned with novel pyrazol derivatives of formula (I), wherein R1, R2, R3, R4, X and Y are as defined herein, as well as physiologically acceptable salts thereof. These compounds are antagonists of CCR-2 receptor and/or CCR-5 receptor and can be used as medicaments.
摘要翻译： 本发明涉及式（I）的新型吡唑衍生物，其中R 1，R 2，R 3，R 4，X和Y如本文所定义，以及其生理上可接受的盐。 这些化合物是CCR-2受体和/或CCR-5受体的拮抗剂，可用作药物。
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公开(公告)号：US07897627B2
公开(公告)日：2011-03-01
申请号：US12334559
申请日：2008-12-15
IPC分类号： A61K31/517 , A61K31/506 , A61K31/501 , A61K31/498 , A61K31/4439 , A61K31/427 , A61K31/428 , A61K31/4245 , A61K31/423 , C07D417/14 , C07D417/12 , C07D413/14 , C07D413/12 , C07D409/14 , C07D405/14 , C07D401/14 , C07D403/12 , C07D403/14
CPC分类号： C07D413/12 , C07D401/12 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D498/04
摘要： The present invention relates to compounds of formula wherein Ar, Het, R1 and n are as defined herein and to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. Compounds of formula I are orexin receptor antagonists and are useful in the treatment of sleep apnea, narcolepsy, insomnia, parasomnia, jet lag syndrome, circadian rhythms disorder and sleep disorders associated with neurological diseases.
摘要翻译： 本发明涉及下式的化合物其中Ar，Het，R 1和n如本文所定义，并且与药学上合适的酸加成盐，光学纯对映异构体，外消旋物或非对映体混合物相关。 式I化合物是食欲蛋白受体拮抗剂，可用于治疗睡眠呼吸暂停，发作性睡病，失眠，睡眠不正，夜间综合征，昼夜节律障碍和与神经疾病相关的睡眠障碍。
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