公开(公告)号：US20070231798A1

公开(公告)日：2007-10-04

申请号：US11278286

申请日：2006-03-31

申请人： Michael J. Collins

发明人： Michael J. Collins

IPC分类号： C12Q1/68 ,  C12P19/34

CPC分类号： C12Q1/686 ,  C12Q2523/313

摘要： A method of microwave assisted nucleic acid amplification by PCR is disclosed. The method includes denaturing, annealing, and extending a nucleic acid sample, with at least the denaturing and extension steps being carried out under the influence of microwave radiation, while preventing the temperature of the sample from varying more than 40° C. from start to finish, and while maintaining the temperature of the sample from start to finish at no more than 60° C.

摘要翻译： 公开了一种通过PCR进行微波辅助核酸扩增的方法。 该方法包括变性，退火和扩展核酸样品，至少在微波辐射的影响下进行变性和延伸步骤，同时防止样品的温度从开始变为40℃以上 并在不超过60℃的同时保持样品的开始和结束温度。

公开(公告)号：US06917023B2

公开(公告)日：2005-07-12

申请号：US10820916

申请日：2004-04-09

申请人： Brittany L. Hayes ,  Michael J. Collins

发明人： Brittany L. Hayes ,  Michael J. Collins

IPC分类号： B01J19/12 ,  C07B61/00 ,  C40B60/14 ,  H05B6/80 ,  H05B6/74

CPC分类号： H05B6/806 ,  B01J19/126 ,  B01J2219/0006 ,  B01J2219/00094 ,  B01J2219/002 ,  B01J2219/00213 ,  B01J2219/0024 ,  B01J2219/00306 ,  B01J2219/00495 ,  B01J2219/00601 ,  B01J2219/00698 ,  B01J2219/00716 ,  B01J2219/1275 ,  C07B61/00 ,  C40B60/14

摘要： A method is disclosed for carrying out microwave assisted chemical reactions. The method includes the steps of placing reactants in a microwave-transparent vessel, placing the vessel and its contents into a microwave cavity, applying microwave radiation within the cavity and to the vessel and its contents while concurrently externally cooling the vessel conductively.

摘要翻译： 公开了一种用于进行微波辅助化学反应的方法。 该方法包括以下步骤：将反应物置于微波透明的容器中，将容器及其内容物置于微波腔中，在空腔内施加微波辐射，并向容器及其内容物同时外部冷却血管。

公开(公告)号：US06744381B1

公开(公告)日：2004-06-01

申请号：US10184748

申请日：2002-06-28

申请人： Michael J. Collins

发明人： Michael J. Collins

IPC分类号： G08B2100

CPC分类号： G08B13/19669 ,  B64D45/0015 ,  B64D2045/0035 ,  B64D2045/0045 ,  G08B13/1965 ,  G08B15/001 ,  G08B25/016

摘要： An aircraft emergency warning system having a wireless transmitter camouflaged as personal effects. The wireless transmitter is capable of transmitting an alarm signal. A cockpit alarm control system is capable of receiving the transmitted alarm signal. The cockpit alarm control system is capable of outputting an activation signal. An aircraft surveillance system is electrically connected to the cockpit alarm control system. The aircraft surveillance system is capable of responding to the activation signal.

摘要翻译： 具有作为个人作用伪装的无线发射器的飞机紧急警报系统。 无线发射机能够发送报警信号。 驾驶舱报警控制系统能够接收发送的报警信号。 驾驶舱报警控制系统能够输出启动信号。 飞机监控系统电气连接到驾驶舱报警控制系统。 飞机监控系统能够响应激活信号。

公开(公告)号：US06548303B2

公开(公告)日：2003-04-15

申请号：US09603487

申请日：2000-06-23

申请人： Michael J. Collins ,  Edward E. King

发明人： Michael J. Collins ,  Edward E. King

IPC分类号： G01N3306

CPC分类号： G01N24/08 ,  G01N1/44 ,  G01N5/04 ,  G01N24/081 ,  G01N24/085 ,  G01N33/06 ,  G01R33/44

摘要： A method and apparatus for rapidly and accurately determining the fat and oil content of a sample using microwave drying and NMR analysis is disclosed. The method and apparatus incorporate a low mass, porous, hydrophilic and lipophilic sample pad that ensures that the entire sample is subjected to NMR analysis. The method and apparatus according to the invention are suitable for rapidly determining the fat and oil content of samples collected during a production process and for process or quality control.

公开(公告)号：US06305802B1

公开(公告)日：2001-10-23

申请号：US09372718

申请日：1999-08-11

申请人： Jeffrey H. Roffman ,  Michael J. Collins ,  Brett A. Davis ,  Denwood F. Ross, III

发明人： Jeffrey H. Roffman ,  Michael J. Collins ,  Brett A. Davis ,  Denwood F. Ross, III

IPC分类号： A61B300

CPC分类号： G02C7/04 ,  G02C2202/22

摘要： A system and method is provided for integrating corneal topographic data and ocular wavefront data with primary ametropia measurements to create a soft contact lens design. Corneal topographic data is used to design a better fitting soft contact lens by achieving a contact lens back surface which is uniquely matched to a particular corneal topography, or which is an averaged shape based on the particular corneal topography. In the case of a uniquely matched contact lens back surface, the unique back surface design also corrects for the primary and higher order optical aberrations of the cornea. Additionally, ocular wavefront analysis is used to determine the total optical aberration present in the eye. The total optical aberration, less any corneal optical aberration corrected utilizing the contact lens back surface, is corrected via the contact lens front surface design. The contact lens front surface is further designed to take into account the conventional refractive prescription elements required for a particular eye. As a result, the lens produced exhibits an improved custom fit, optimal refractive error correction and vision.

摘要翻译： 提供了一种系统和方法，用于将角膜地形数据和眼波前数据与原始屈光不正测量结合在一起，以创建柔软的隐形眼镜设计。 角膜地形数据用于通过实现与特定角膜形貌独特匹配的隐形眼镜后表面，或者基于特定角膜形貌的平均形状来设计更好的软性隐形眼镜。 在独特匹配的隐形眼镜后表面的情况下，独特的后表面设计也可纠正角膜的主要和高阶光学像差。 另外，眼波前分析用于确定眼睛中存在的总光学像差。 通过隐形眼镜前表面设计校正总光学像差，减少使用隐形眼镜后表面校正的任何角膜光学像差。 隐形眼镜前表面进一步被设计成考虑特定眼睛所需的常规折射处方元件。 结果，所制造的镜片表现出改进的定制配合，最佳的屈光不正的校正和视觉。

公开(公告)号：US06286083B1

公开(公告)日：2001-09-04

申请号：US09112000

申请日：1998-07-08

申请人： Kenneth T. Chin ,  Jerome J. Johnson ,  Phillip M. Jones ,  Robert A. Lester ,  Gary J. Piccirillo ,  Jeffrey C. Stevens ,  Michael J. Collins ,  C. Kevin Coffee

发明人： Kenneth T. Chin ,  Jerome J. Johnson ,  Phillip M. Jones ,  Robert A. Lester ,  Gary J. Piccirillo ,  Jeffrey C. Stevens ,  Michael J. Collins ,  C. Kevin Coffee

IPC分类号： G06F1318

CPC分类号： G06F13/1605

摘要： A computer system includes an adaptive memory arbiter for prioritizing memory access requests, including a self-adjusting, programmable request-priority ranking system. The memory arbiter adapts during every arbitration cycle, reducing the priority of any request which wins memory arbitration. Thus, a memory request initially holding a low priority ranking may gradually advance in priority until that request wins memory arbitration. Such a scheme prevents lower-priority devices from becoming “memory-starved.” Because some types of memory requests (such as refresh requests and memory reads) inherently require faster memory access than other requests (such as memory writes), the adaptive memory arbiter additionally integrates a nonadjustable priority structure into the adaptive ranking system which guarantees faster service to the most urgent requests. Also, the adaptive memory arbitration scheme introduces a flexible method of adjustable priority-weighting which permits selected devices to transact a programmable number of consecutive memory accesses without those devices losing request priority.

摘要翻译： 计算机系统包括用于对存储器访问请求进行优先级的自适应存储器仲裁器，包括自调整可编程请求优先级排序系统。 存储器仲裁器在每个仲裁周期内进行调整，从而降低获取内存仲裁的任何请求的优先级。 因此，初始保持低优先级排序的存储器请求可以逐渐提前优先，直到该请求赢得存储器仲裁。 这样的方案可防止低优先级的设备变得“记忆不足”。 因为某些类型的存储器请求（例如刷新请求和存储器读取）固有地需要比其他请求（诸如存储器写入）更快的存储器访问，所以自适应存储器仲裁器另外将不可调整的优先级结构集成到自适应排名系统中，从而保证更快的服务 最迫切的要求。 此外，自适应存储器仲裁方案引入了可调整优先权重的灵活方法，其允许所选择的设备在没有丢失请求优先级的情况下处理可编程数量的连续存储器访问。

公开(公告)号：US06279065B1

公开(公告)日：2001-08-21

申请号：US09090271

申请日：1998-06-03

申请人： Kenneth T. Chin ,  Jerome J. Johnson ,  Phillip M. Jones ,  Robert A. Lester ,  Gary J. Piccirillo ,  C. Kevin Coffee ,  Michael J. Collins

发明人： Kenneth T. Chin ,  Jerome J. Johnson ,  Phillip M. Jones ,  Robert A. Lester ,  Gary J. Piccirillo ,  C. Kevin Coffee ,  Michael J. Collins

IPC分类号： G06F1338

CPC分类号： G06F13/4239 ,  G06F13/4059

摘要： A computer system includes a CPU and a memory device coupled by a bridge logic unit. CPU to memory write requests (including the data to be written) are temporarily stored in a queue in the bridge logic unit. The bridge logic unit preferably begins a write cycle to the memory device before all of the write data has been stored in the queue and available to the memory device. By beginning the memory cycle as early as possible, the total amount of time required to store all of the write data in the queue and then de-queue the data from the queue is reduced. Consequently, many CPU to memory write transactions are performed more efficiently and generally with less latency than previously possible.

摘要翻译： 计算机系统包括CPU和由桥逻辑单元耦合的存储器件。 CPU到存储器写入请求（包括要写入的数据）暂时存储在桥逻辑单元的队列中。 在所有写入数据已经被存储在队列中并且可用于存储器装置之前，桥逻辑单元优选地开始到存储器装置的写周期。 通过尽早开始内存循环，减少了将所有写数据存储在队列中，然后从队列中取消队列数据所需的总时间。 因此，许多CPU到存储器写入事务被更有效地执行，并且通常以比先前可能的更少的延迟来执行。

公开(公告)号：US06247102B1

公开(公告)日：2001-06-12

申请号：US09047876

申请日：1998-03-25

申请人： Kenneth T. Chin ,  Jerome J. Johnson ,  Phillip M. Jones ,  Robert A. Lester ,  Gary J. Piccirillo ,  Jeffrey C. Stevens ,  C. Kevin Coffee ,  Michael J. Collins ,  John Larson

发明人： Kenneth T. Chin ,  Jerome J. Johnson ,  Phillip M. Jones ,  Robert A. Lester ,  Gary J. Piccirillo ,  Jeffrey C. Stevens ,  C. Kevin Coffee ,  Michael J. Collins ,  John Larson

IPC分类号： G06F1314

CPC分类号： G06F13/1642 ,  G06F13/4036

摘要： A computer system includes a CPU, a memory device, two expansion buses, and a bridge logic unit coupling together the CPU, the memory device and the expansion buses. The CPU couples to the bridge logic unit via a CPU bus and the memory device couples to the bridge logic unit via a memory bus. The bridge logic unit generally routes bus cycle requests from one of the four buses to another of the buses while concurrently routing bus cycle requests to another pair of buses. The bridge logic unit preferably includes four interfaces, one each to the CPU, memory device and the two expansion buses. Each pair of interfaces are coupled by at least one queue; write requests are stored (or “posted”) in write queues and read data are stored in read queues. Because each interface can communicate concurrently with all other interfaces via the read and write queues, the possibility exists that a first interface cannot access a second interface because the second interface is busy processing read or write requests from a third interface, thus starving the first interface for access to the second interface. To remedy this starvation problem, the bridge logic unit prevents the third interface from posting additional write requests to its write queue, thereby permitting the first interface access to the second interface. Further, read cycles may be retried from one interface to allow another interface to complete its bus transactions.

摘要翻译： 计算机系统包括CPU，存储器件，两个扩展总线以及将CPU，存储器件和扩展总线耦合在一起的桥逻辑单元。 CPU通过CPU总线耦合到桥逻辑单元，存储器件通过存储器总线耦合到桥逻辑单元。 桥接逻辑单元通常将总线周期请求从四条总线之一路由到另一条总线，同时将总线周期请求转发到另一对总线。 桥逻辑单元优选地包括四个接口，每个接口连接到CPU，存储设备和两个扩展总线。 每对接口由至少一个队列耦合; 写入请求在写入队列中被存储（或“发布”），并且读取数据被存储在读取队列中。 因为每个接口可以通过读写队列与所有其他接口同时进行通信，所以存在第一接口无法访问第二接口的可能性，因为第二接口正忙于处理来自第三接口的读或写请求，从而使第一接口 用于访问第二个接口。 为了解决这个饥饿问题，桥接逻辑单元防止第三接口向其写入队列发布额外的写入请求，从而允许第一接口访问第二接口。 此外，可以从一个接口重试读周期，以允许另一接口完成其总线事务。

公开(公告)号：US06160562A

公开(公告)日：2000-12-12

申请号：US135620

申请日：1998-08-18

申请人： Kenneth T. Chin ,  Clarence K. Coffee ,  Michael J. Collins ,  Jerome J. Johnson ,  Phillip M. Jones ,  Robert A. Lester ,  Gary J. Piccirillo

发明人： Kenneth T. Chin ,  Clarence K. Coffee ,  Michael J. Collins ,  Jerome J. Johnson ,  Phillip M. Jones ,  Robert A. Lester ,  Gary J. Piccirillo

IPC分类号： G06F12/08 ,  G06F13/40 ,  G06F13/14

CPC分类号： G06F12/0879 ,  G06F13/404

摘要： A computer is provided having a bus interface unit coupled between a CPU bus, a PCI bus and/or a graphics bus. The bus interface unit includes controllers linked to the respective buses and further includes a plurality of queues placed within address and data paths linking the various controllers. An interface controller coupled between a peripheral bus (excluding the CPU local bus) determines if an address forwarded from a peripheral device is the first address within a sequence of addresses used to select a set of quad words constituting a cache line. If that address (i.e., target address) is not the first address (i.e., initial address) in that sequence, then the target address is modified so that it becomes the initial address in that sequence. An offset between the target address and the modified address is denoted as a count value. The initial address aligns the reads to a cacheline boundary and stores in successive order the quad words of the cacheline in the queue of the bus interface unit. Quad words arriving in the queue prior to a quad word attributed to the target address are discarded. This ensures the interface controller, and eventually the peripheral device, will read quad words in successive address order, and all subsequently read quad words will also be sent in successive order until the peripheral read transaction is complete.

摘要翻译： 提供一种具有耦合在CPU总线，PCI总线和/或图形总线之间的总线接口单元的计算机。 总线接口单元包括链接到各个总线的控制器，还包括放置在连接各种控制器的地址和数据路径内的多个队列。 耦合在外围总线（不包括CPU本地总线）之间的接口控制器确定从外围设备转发的地址是否是用于选择构成高速缓存行的一组四字的地址序列内的第一地址。 如果该地址（即，目标地址）不是该序列中的第一地址（即，初始地址），则修改目标地址，使其成为该序列中的初始地址。 目标地址与修改地址之间的偏移量表示为计数值。 初始地址将读取对齐到高速缓存行边界，并以连续顺序存储总线接口单元队列中的高速缓存行的四个字。 在归因于目标地址的四字之前到达队列的四字被丢弃。 这确保接口控制器以及最终的外围设备将以连续的地址顺序读取四个字，并且所有随后读取的四字都将以连续的顺序发送，直到外设读取事务完成。

公开(公告)号：US5778433A

公开(公告)日：1998-07-07

申请号：US665244

申请日：1996-06-17

申请人： Michael J. Collins ,  Gary W. Thome

发明人： Michael J. Collins ,  Gary W. Thome

IPC分类号： G06F12/08

CPC分类号： G06F12/0804 ,  G06F12/0897

摘要： An apparatus for monitoring and decoding processor bus cycles and flushing a second level cache upon decoding a special flush acknowledge cycle. The CPU preferably includes an internal cache and a flush input for receiving a signal commanding the CPU to flush its internal cache. After flushing its cache by performing any necessary cycles to write back dirty data to main memory, the CPU performs a special flush acknowledge cycle to inform external devices that the flush procedure has been completed. A cache controller detects the flush acknowledge cycle and provides a flush signal to the second level cache. The cache controller then provides an end of cycle signal to the CPU to indicate that the flush cycle has been acknowledged.

摘要翻译： 一种用于在解码特殊冲洗确认周期时监视和解码处理器总线周期并刷新第二级高速缓存的装置。 CPU优选地包括内部高速缓存和用于接收命令CPU冲洗其内部高速缓存的信号的刷新输入。 通过执行任何必要的循环来刷新脏数据到主存储器后，CPU执行特殊的刷新确认周期，以通知外部设备冲洗过程已经完成。 缓存控制器检测刷新确认周期，并向第二级缓存提供刷新信号。 然后，缓存控制器向CPU提供周期信号的结束以指示冲洗周期已被确认。