公开(公告)号：US20080274959A1

公开(公告)日：2008-11-06

申请号：US11794068

申请日：2005-12-16

Applicant: Bradley A. Haltli ,  Haiyin He ,  Ying Huang ,  Sridhar Krishna Rabindran ,  Jiang Wu ,  Min He

Inventor： Bradley A. Haltli ,  Haiyin He ,  Ying Huang ,  Sridhar Krishna Rabindran ,  Jiang Wu ,  Min He

IPC: A61K38/16 ,  C07H21/04 ,  C12N15/63 ,  C12N1/21 ,  C12N1/15 ,  C12P21/00 ,  C07H17/08 ,  C07K14/37 ,  G01N33/566 ,  C12N1/14 ,  G01N33/53 ,  A61P35/00

CPC classification number: C12N15/52

Abstract: The present invention provides a chromoprotein produced by Actinomadura sp. 21G792, as well as amino acid and nucleic acid sequences of the apoprotein component of the chromoprotein and of components of the biosynthetic pathway for the chromophore. The present invention is useful for developing pharmaceutical and treating diseases such as cancer or bacterial infections.

Abstract translation: 本发明提供由放线菌属（Actinomadura sp。）生产的色素蛋白 21G792，以及发色蛋白的脱辅基蛋白组分的氨基酸和核酸序列以及发色团的生物合成途径的组分。 本发明可用于开发药物和治疗诸如癌症或细菌感染的疾病。

公开(公告)号：US20080139264A1

公开(公告)日：2008-06-12

申请号：US11608843

申请日：2006-12-10

Applicant: Min He ,  Xin Wen

Inventor： Min He ,  Xin Wen

IPC: A63F9/24

CPC classification number: G07F17/3288 ,  G06Q50/34 ,  G07F17/32

Abstract: A computer device for off-track wagering includes a communication device to receive a location of a racing animal in a race track from a remote computer system; a computer memory to store a representation of the race track; and a display device to display the representation of the race track and a symbol representing the racing animal in the representation of the race track in accordance with the location in the racing animal in the race track.

Abstract translation: 一种用于越野投注的计算机装置，包括：从远程计算机系统在赛道中接收赛车的位置的通信装置; 用于存储赛道的表示的计算机存储器; 以及显示装置，用于根据赛道动物在赛道中的位置显示赛道的表示和表示赛车动物的符号。

公开(公告)号：US20080004433A1

公开(公告)日：2008-01-03

申请号：US11879719

申请日：2007-07-18

Applicant: Dirksen Bussiere ,  Min He ,  Vincent Le ,  Johanna Jansen ,  S. Chin ,  Eric Martin

Inventor： Dirksen Bussiere ,  Min He ,  Vincent Le ,  Johanna Jansen ,  S. Chin ,  Eric Martin

IPC: C07K14/00 ,  C07K1/00 ,  G06G7/48

CPC classification number: C12N9/1205 ,  A61K38/00 ,  C07K2299/00

Abstract: The invention provides the three-dimensional structure of a construct of glycogen synthase kinase 3 (GSK3); crystals of a construct of glycogen synthase kinase 3-β (GSK3-β) containing the protein's catalytic kinase domain; a method for crystallizing the protein construct to provide a GSK3 crystal sufficient for structure determination; and a method for using the GSK3 construct's three-dimensional structure for the identification of possible therapeutic compounds in the treatment of various disease conditions mediated by GSK3 activity.

Abstract translation: 本发明提供了糖原合酶激酶3（GSK3）构建体的三维结构; 含有蛋白质催化激酶结构域的糖原合成酶激酶3-β（GSK3-β）构建体的晶体; 使蛋白质构建体结晶以提供足以进行结构测定的GSK3晶体的方法; 以及使用GSK3构建体的三维结构来鉴定可能的治疗化合物以治疗由GSK3活性介导的各种疾病状况的方法。

公开(公告)号：US20070091913A1

公开(公告)日：2007-04-26

申请号：US11253647

申请日：2005-10-20

Applicant: Min He ,  Saranagati Chatterjee ,  Puneet Jain

Inventor： Min He ,  Saranagati Chatterjee ,  Puneet Jain

IPC: H04L12/43

CPC classification number: H04L45/12 ,  H04J3/12 ,  H04J2203/0023 ,  H04J2203/0053 ,  H04J2203/0066 ,  H04J2203/0069

Abstract: A method, computer software program, and system provides automatic selection of time slots in time-division multiplexed connections. A network is mapped, and source and destination nodes are selected, as well as a route between them. Appropriate time slots are selected in a time-division multiplexed signal between the selected nodes, and a connection between the two nodes is automatically created, based at least in part on information related to the selected routes and time slots.

Abstract translation: 一种方法，计算机软件程序和系统提供时分复用连接中的时隙的自动选择。 映射网络，选择源节点和目标节点，以及它们之间的路由。 在所选择的节点之间的时分复用信号中选择合适的时隙，并且至少部分地基于与所选路由和时隙相关的信息，自动创建两个节点之间的连接。

公开(公告)号：US20060106235A1

公开(公告)日：2006-05-18

申请号：US11327876

申请日：2006-01-09

Applicant: Derek Clissold ,  Stuart Craig ,  Rajendrakumar Gadikota ,  Min He ,  Jurjus Jurayj ,  Shahrokh Kazerani ,  Erwin Rannala ,  Pradeep Sharma

Inventor： Derek Clissold ,  Stuart Craig ,  Rajendrakumar Gadikota ,  Min He ,  Jurjus Jurayj ,  Shahrokh Kazerani ,  Erwin Rannala ,  Pradeep Sharma

IPC: C07F7/10 ,  C07D315/00

CPC classification number: C07C45/61 ,  C07C29/03 ,  C07C29/10 ,  C07C45/59 ,  C07C45/62 ,  C07C45/67 ,  C07C231/02 ,  C07C405/00 ,  C07C405/0008 ,  C07C405/0016 ,  C07C2601/08 ,  C07C49/743 ,  C07C49/235 ,  C07C49/217 ,  C07C235/30 ,  C07C35/21

Abstract: A process for the preparation of prostaglandin compounds having the formula (I): wherein A is selected from the group consisting of C1-C6 alkyl groups; C7-C16 aralkyl groups wherein an aryl portion thereof is unsubstituted or substituted with one to three substituents selected from the group consisting of C1-C6 alkyl groups, halo and CF3; and (CH2)nOR′ wherein n is an integer from 1 to 3 and R′ represents a C6-C10 aryl group which is unsubstituted or substituted with one to three substituents selected from the group consisting of C1-C6 alkyl groups, halo and CF3; B is selected from OR″ and NHR″ wherein R″ is C1-C6 alkyl groups; and represents a double bond or a single bond, is disclosed. Novel intermediates are also disclosed.

Abstract translation: 一种制备具有式（I）的前列腺素化合物的方法：其中A选自C 1 -C 6烷基; C 7 -C 16芳烷基，其中芳基部分是未取代的或被一至三个选自C 1 -C 6烷基的取代基取代， -C 6 -C 6烷基，卤素和CF 3; 和（CH 2）n N或OR'，其中n是1至3的整数，R'表示C 6 -C 6烷基， 10个未取代的或被一至三个选自C 1 -C 6烷基的取代基取代的芳基，卤素和CF _{3 ; B选自OR“和NHR”，其中R“是C 1 -C 6烷基; “img id =”custom-character-00001“he =”2.12mm“wi =”4.57mm“file =”US20060106235A1-20060518-P00900.TIF“alt =”custom character“img-content =”character“img- 格式=“tif”/>表示双键或单键。 还公开了新的中间体。}

公开(公告)号：US20050272133A1

公开(公告)日：2005-12-08

申请号：US11143980

申请日：2005-06-03

Applicant: Min He ,  John Hucul ,  Bradley Haltli ,  Melissa Wagenaar ,  Edmund Graziani ,  Mia Summers ,  Kerry Kulowski ,  Kevin Pong

Inventor： Min He ,  John Hucul ,  Bradley Haltli ,  Melissa Wagenaar ,  Edmund Graziani ,  Mia Summers ,  Kerry Kulowski ,  Kevin Pong

IPC: A61K31/407 ,  A61K31/4745 ,  C07D491/14 ,  C07D498/08 ,  C07D498/18 ,  C07H21/04 ,  C12N1/21 ,  C12N9/00 ,  C12N9/10 ,  C12N15/52 ,  C12P17/16 ,  C12P17/18

CPC classification number: C12P17/188 ,  C07D498/08 ,  C12N15/52

Abstract: A polyketide synthase complex composed of polyketide synthase with 15 total modules, a non-ribosomal peptide synthetase with 1 module, and a cytochrome P450 hydroxylase is described. Also provided are novel Streptomyces species and methods of modified Streptomyces species. Further described are novel compounds, 36-ketomeridamycin, C9-deoxomeridamycin, and C9-deoxoprolylmeridamcyin and uses thereof.

Abstract translation: 描述了由具有15个总模块的聚酮化合物合成物组成的聚酮化合物合成酶复合物，具有1个模块的非核糖体肽合成酶和细胞色素P450羟化酶。 还提供了新型链霉菌属物种和修饰链霉菌属物种的方法。 进一步描述的是新型化合物，36-酮阿霉素，C9-脱氧阿霉素和C9-脱氧基亚氨基胞质蛋白及其用途。