公开(公告)号：US20170127988A1

公开(公告)日：2017-05-11

申请号：US15337947

申请日：2016-10-28

申请人： Nongjian Tao ,  Dangdang Shao

发明人： Nongjian Tao ,  Dangdang Shao

IPC分类号： A61B5/1455 ,  A61B5/00 ,  A61B5/0205

摘要： A device for non-contact measurement of blood oxygen saturation (SpO2) in a mammalian subject including a camera and one or more arrays of LEDs each having a first set of LEDs emitting near infrared (NIR), and the second set of LEDs emitting orange light located in an optical path adapted to transmit reflected light from a subject to the camera. A controller transmits a camera trigger to the camera, and is further coupled to transmit control signals to the one or more arrays of LEDs. A processor receives photoplethysmography (PPG) data signal values from the camera. The PPG data signal values are present in the reflected light and include pulsatile and non-pulsatile components. The processor determines SpO2 values from the PPG data signal values from the measured ratios of pulsatile to non-pulsatile components of the PPG signals.

公开(公告)号：US20170038380A1

公开(公告)日：2017-02-09

申请号：US15204738

申请日：2016-07-07

申请人： Nongjian Tao ,  Shaopeng Wang

发明人： Nongjian Tao ,  Shaopeng Wang

IPC分类号： G01N33/557 ,  G01N21/552

摘要： A method and system for analysis of protein interaction kinetics in microarray or whole-cell based formats includes positioning a sensor chip on a prism. The sensor chip is spotted with a plurality of target molecules. A movable printer head deposits a plurality of analyte droplets on predefined regions of the sensor chip surface. A light source transmits light through the prism to excite surface plasmon resonance on the sensor chip surface, whereby the plurality of target molecules bound to the upper surface are changing the SPR resonance angle and therefore the intensity of the reflected beam. A detector receives reflected light transmitted through the prism from the bottom surface. Signals from the detector are received and processed into kinetic data and microarray labeled data to determine molecular interactions and binding kinetic properties for the plurality of analyte droplets.

摘要翻译： 用于分析微阵列或全细胞蛋白质相互作用动力学的方法和系统包括将传感器芯片定位在棱镜上。 传感器芯片被多个目标分子点样。 可移动打印头将多个分析物液滴沉积在传感器芯片表面的预定区域上。 光源通过棱镜透射光以激发传感器芯片表面上的表面等离子体共振，由此结合到上表面的多个靶分子改变SPR谐振角，并因此改变反射光束的强度。 检测器从底面接收透过棱镜的反射光。 来自检测器的信号被接收并处理成动力学数据和微阵列标记的数据，以确定多个分析物液滴的分子相互作用和结合动力学性质。

公开(公告)号：US08926822B2

公开(公告)日：2015-01-06

申请号：US13893181

申请日：2013-05-13

申请人： Nongjian Tao ,  Erica Forzani

发明人： Nongjian Tao ,  Erica Forzani

IPC分类号： G01N27/416 ,  G01N27/27 ,  G01N27/327

CPC分类号： G01N27/27 ,  G01N27/3277

摘要： An integrated sensing device is capable of detecting analytes using electrochemical (EC) and electrical (E) signals. The device introduces synergetic new capabilities and enhances the sensitivity and selectivity for real-time detection of an analyte in complex matrices, including the presence of high concentration of interferences in liquids and in gas phases.

摘要翻译： 集成的感测装置能够使用电化学（EC）和电（E）信号来检测分析物。 该设备引入了协同的新功能，并增强了对复杂基质中分析物的实时检测的灵敏度和选择性，包​​括在液体和气相中存在高浓度的干扰。

公开(公告)号：US08416417B2

公开(公告)日：2013-04-09

申请号：US12989617

申请日：2009-04-24

申请人： Kyle James Foley ,  Nongjian Tao

发明人： Kyle James Foley ,  Nongjian Tao

IPC分类号： G01N21/55

CPC分类号： G01N21/553 ,  G01N21/1717 ,  G01N2021/1721

摘要： Methods and apparatuses for imaging surface impedance.

摘要翻译： 用于成像表面阻抗的方法和装置。

公开(公告)号：US07785001B2

公开(公告)日：2010-08-31

申请号：US11940953

申请日：2007-11-15

申请人： Nongjian Tao ,  Francis Tsow

发明人： Nongjian Tao ,  Francis Tsow

IPC分类号： G01K11/22 ,  G01N25/00

CPC分类号： G01K7/32

摘要： An apparatus for sensing a change in environmental conditions is disclosed. The apparatus includes a coating or a wire between two surfaces that has a mechanical property changed as a result of a change in the environmental conditions. The change in the mechanical property of the coating or wire results in a change in a vibration characteristic of the apparatus, such as the frequency, phase, amplitude or quality factor. The change in the vibration characteristic can be used to determine the change in the environmental condition.

摘要翻译： 公开了一种用于感测环境条件变化的装置。 该装置包括两个表面之间的涂层或导线，其具有由于环境条件的变化而改变的机械特性。 涂层或导线的力学性能的变化导致装置的振动特性的变化，例如频率，相位，振幅或质量因素。 振动特性的变化可用于确定环境条件的变化。

公开(公告)号：US20080205479A1

公开(公告)日：2008-08-28

申请号：US11940953

申请日：2007-11-15

申请人： Nongjian Tao ,  Francis Tsow

发明人： Nongjian Tao ,  Francis Tsow

IPC分类号： G01K11/22 ,  G01N29/00

CPC分类号： G01K7/32

摘要： An apparatus for sensing a change in environmental conditions is disclosed. The apparatus includes a coating or a wire between two surfaces that has a mechanical property changed as a result of a change in the environmental conditions. The change in the mechanical property of the coating or wire results in a change in a vibration characteristic of the apparatus, such as the frequency, phase, amplitude or quality factor. The change in the vibration characteristic can be used to determine the change in the environmental condition.

摘要翻译： 公开了一种用于感测环境条件变化的装置。 该装置包括两个表面之间的涂层或导线，其具有由于环境条件的变化而改变的机械特性。 涂层或导线的力学性能的变化导致装置的振动特性的变化，例如频率，相位，振幅或质量因素。 振动特性的变化可用于确定环境条件的变化。

公开(公告)号：US20070235348A1

公开(公告)日：2007-10-11

申请号：US11399834

申请日：2006-04-07

申请人： Larry Nagahara ,  Islamshah Amlani ,  Alvaro Aguilar ,  Erica Forzani ,  Xiulan Li ,  Nongjian Tao

发明人： Larry Nagahara ,  Islamshah Amlani ,  Alvaro Aguilar ,  Erica Forzani ,  Xiulan Li ,  Nongjian Tao

IPC分类号： G01F1/64 ,  G01N33/487

CPC分类号： G01N33/5438

摘要： A method is provided for forming a thin film conducting polymer (24) for sensor applications. The method comprises forming at least one pair of electrodes (14, 16) on a substrate (12), the pair of electrodes (14, 16) having an insulating layer (18) positioned therebetween, the insulating layer (18) having a surface (20) opposed to the substrate (12), increasing OH− groups on the surface (20), binding silane molecules (22) to the surface (20), and forming the conducting polymer material (24) on the silane molecules (22) between and in electrical contact with the electrodes (14, 16).

摘要翻译： 提供了一种用于形成用于传感器应用的薄膜导电聚合物（24）的方法。 该方法包括在衬底（12）上形成至少一对电极（14,16），所述一对电极（14,16）具有位于其间的绝缘层（18），所述绝缘层（18）具有表面 （20），与基底（12）相对，增加表面（20）上的OH基团，将硅烷分子（22）结合到表面（20），并形成导电聚合物材料（24） ）在与电极（14,16）电接触的硅烷分子（22）上。

公开(公告)号：US20070217973A1

公开(公告)日：2007-09-20

申请号：US11568209

申请日：2005-05-10

申请人： Nongjian Tao

发明人： Nongjian Tao

IPC分类号： B01L11/00 ,  G10K15/04 ,  H01R43/00

CPC分类号： G01N29/036 ,  G01N29/022 ,  G01N2291/014 ,  G01N2291/0257 ,  Y10T29/49117 ,  Y10T29/49574

摘要： A device for sensing a chemical analyte is disclosed. The device is comprised of a vibrating structure having first and second surfaces and having an associated resonant frequency and a wire coupled between the first and second surfaces of the vibrating structure, wherein the analyte interacts with the wire and causes a change in the resonant frequency of the vibrating structure. The vibrating structure can include a tuning fork. The vibrating structure can be comprised of quartz. The wire can be comprised of polymer. A plurality of vibrating structures are arranged in an array to increase confidence by promoting a redundancy of measurement or to detect a plurality of chemical analytes. A method of making a device for sensing a chemical analyte is also disclosed.

摘要翻译： 公开了用于感测化学分析物的装置。 该装置包括具有第一和第二表面并且具有相关联的谐振频率的振动结构和耦合在振动结构的第一和第二表面之间的导线，其中分析物与导线相互作用并导致谐振频率的变化 振动结构。 振动结构可以包括音叉。 振动结构可以由石英组成。 电线可以由聚合物组成。 多个振动结构被布置成阵列以通过促进测量的冗余或检测多个化学分析物来增加置信度。 还公开了一种制造用于感测化学分析物的装置的方法。

公开(公告)号：US20070082408A1

公开(公告)日：2007-04-12

申请号：US11544796

申请日：2006-10-06

申请人： Tianwei Jing ,  Feimeng Zhou ,  Nongjian Tao

发明人： Tianwei Jing ,  Feimeng Zhou ,  Nongjian Tao

IPC分类号： G01N21/00

CPC分类号： G01N21/553 ,  G01N21/05 ,  G01N2021/0346 ,  Y10T436/112499 ,  Y10T436/117497 ,  Y10T436/143333

摘要： An apparatus for detecting one or more substances includes a radiation source emitting a beam of radiation and also includes a material capable of reflecting the beam of radiation with a first characteristic and capable of reflecting the beam of radiation with a second characteristic when the material interacts with the one or more substances. The apparatus also includes two or more radiation detectors to detect the first and second characteristics of the beam of radiation. A first one of the two or more radiation detectors is adjustably aligned to detect the first and second characteristics of the beam of radiation reflected from a first region of the material. A second one of the two or more radiation detectors is adjustably aligned to detect the first and second characteristics of the beam of radiation reflected from a second region of the material.

摘要翻译： 用于检测一种或多种物质的装置包括发射辐射束的辐射源，并且还包括能够以第一特性反射辐射束的材料，并且当物质与 一种或多种物质。 该装置还包括两个或更多个辐射检测器，以检测辐射束的第一和第二特性。 两个或更多个辐射检测器中的第一个可调整地对准以检测从材料的第一区域反射的辐射束的第一和第二特性。 两个或更多个辐射检测器中的第二个可调整地对准以检测从材料的第二区域反射的辐射束的第一和第二特性。

公开(公告)号：US20060232282A1

公开(公告)日：2006-10-19

申请号：US10929134

申请日：2004-08-26

申请人： Nongjian Tao

发明人： Nongjian Tao

IPC分类号： G01R27/08

CPC分类号： G01R27/02 ,  G01N27/3278

摘要： A conductivity measurement system measures conductivity of molecules. A substance to be measured is applied to the first and second electrodes. A potential is applied across the electrodes. A computer-controlled motion controller moves a first electrode relative to a second electrode in discrete steps. In a first step, the electrodes are brought together in physical contact to form a plurality of molecular junctions. The electrodes are separated by a first distance which breaks a first molecular junction. The electrodes are separated by a second distance which breaks a second molecular junction. A conductivity measure is taken at each step. The process of separating the electrodes continues until conductivity measure is zero. The conductivity of one molecule corresponds to a last non-zero conductivity measurement prior to a zero conductivity measurement.

摘要翻译： 电导率测量系统测量分子的电导率。 要测量的物质被施加到第一和第二电极。 在电极上施加电位。 计算机控制的运动控制器以离散步骤相对于第二电极移动第一电极。 在第一步骤中，将电极物理接触在一起形成多个分子结。 电极分开第一距离，破坏第一分子结。 电极分开第二个距离，破坏了第二个分子结。 在每个步骤中进行电导率测量。 分离电极的过程继续进行，直到电导率测量为零。 一个分子的电导率对应于在零电导率测量之前的最后一个非零电导率测量。