公开(公告)号：US20090291461A1

公开(公告)日：2009-11-26

申请号：US12468440

申请日：2009-05-19

申请人： Hiroyuki EBINUMA ,  Hirokazu Yago ,  Yuka Akimoto ,  Osamu Miyazaki ,  Takashi Kadowaki ,  Toshimasa Yamauchi ,  Kazuo Hara

发明人： Hiroyuki EBINUMA ,  Hirokazu Yago ,  Yuka Akimoto ,  Osamu Miyazaki ,  Takashi Kadowaki ,  Toshimasa Yamauchi ,  Kazuo Hara

IPC分类号： G01N33/53

CPC分类号： G01N33/74 ,  G01N2800/042 ,  G01N2800/32

摘要： Kits and methods for selectively assaying a target adiponectin multimer in a biological sample. Such methods accurately evaluate the relationship between a disease and adiponectin through selective assay of adiponectin multimers and provide information that cannot be obtained through measurement of the total amount of adiponectin alone. A method for selectively assaying a target adiponectin multimer in a biological sample comprising distinguishing target adiponectin multimer from the other adiponectin multimers by using a protease and/or an antibody.

摘要翻译： 用于选择性测定生物样品中目标脂联素多聚体的试剂盒和方法。 这种方法通过脂联素多聚体的选择性测定来准确地评估疾病与脂联素之间的关系，并提供通过单独测量脂连蛋白的总量不能获得的信息。 一种用于选择性测定生物样品中的目标脂联素多聚体的方法，包括通过使用蛋白酶和/或抗体将目标脂连蛋白多聚体与其它脂联素多聚体区分开。

公开(公告)号：US20080027314A1

公开(公告)日：2008-01-31

申请号：US10576595

申请日：2004-10-22

申请人： Osamu Miyazaki ,  Hiromitsu Hayashi

发明人： Osamu Miyazaki ,  Hiromitsu Hayashi

IPC分类号： A61B6/03

CPC分类号： G06F19/321 ,  G06F19/00 ,  G06T7/0012

摘要： A scope of medical treatment as an object of medical treatment is predetermined, and an image for treatment region considered as already completed treatment in the course of medical treatment is acquired.Time up to completion of the whole scope of intended treatment regions is estimated on the basis of the already completed treatment region.Further, any changes of sites under treatment are displayed by color indication.Still further, the time up to completion of medical treatment is determined in a way easy to understand by simulating an image of treatment completion with respect to multiple treatment periods.By virtue of these characteristics, not only can an improvement of medical treatment accuracy be attained but also the total time and exposure for medical treatment can be minimized.

摘要翻译： 作为治疗对象的医疗处理的范围是预先确定的，并且获得了在治疗过程中被认为已经完成治疗的治疗区域的图像。 按照已经完成的治疗区域的估计，预计治疗区域的整个时期到期。 此外，通过颜色显示来显示处理地点的任何变化。 此外，通过模拟相对于多个治疗周期的治疗完成的图像，以易于理解的方式确定完成治疗的时间。 由于这些特征，不仅能够提高医疗精度，还可以将医疗的总时间和暴露最小化。

公开(公告)号：US20080009077A1

公开(公告)日：2008-01-10

申请号：US11722998

申请日：2005-12-27

申请人： Masanao Matsuo ,  Hiroyuki Ebinuma ,  Osamu Miyazaki ,  Kyoko Tanaka ,  Akiko Suzuki

发明人： Masanao Matsuo ,  Hiroyuki Ebinuma ,  Osamu Miyazaki ,  Kyoko Tanaka ,  Akiko Suzuki

IPC分类号： G01N33/566 ,  C07K16/36 ,  C12N5/12

CPC分类号： C07K16/18 ,  C07K14/745 ,  C07K14/75 ,  G01N33/86 ,  G01N2333/75 ,  G01N2800/224

摘要： The present invention is directed to a monoclonal antibody against a soluble fibrin, which specifically recognizes a conformation-changed site newly occurred in a C-terminal region of an Aα-chain of the soluble fibrin formed through thrombin digestion of fibrinogen. The present invention is also directed to a hybridoma which produces the antibody, an immunological assay method employing the antibody, and a method for evaluating hypercoagulability in a test sample by measuring the soluble fibrin level in the sample with the assay method. Through employment of the monoclonal antibody of the present invention, soluble fibrin on which plasmin has not acted, which reflects exclusively initial hypercoagulability, can be specifically detected.

摘要翻译： 本发明涉及针对可溶性纤维蛋白的单克隆抗体，其特异性识别通过纤维蛋白原的凝血酶消化形成的可溶性纤维蛋白的Aalpha链的C末端区域中新发生的构象改变部位。 本发明还涉及产生抗体的杂交瘤，使用抗体的免疫测定方法，以及通过使用测定方法测量样品中的可溶性纤维蛋白水平来评估测试样品中的高凝状态的方法。 通过使用本发明的单克隆抗体，可以特异性检测仅反映初始高凝状态的纤维蛋白溶酶未起作用的可溶性纤维蛋白。

公开(公告)号：US20070053270A1

公开(公告)日：2007-03-08

申请号：US11495907

申请日：2006-07-28

申请人： Tetsuo Ueyama ,  Osamu Miyazaki ,  Yukio Watanabe ,  Yasuo Nakata ,  Tomio Mashiyama

发明人： Tetsuo Ueyama ,  Osamu Miyazaki ,  Yukio Watanabe ,  Yasuo Nakata ,  Tomio Mashiyama

IPC分类号： G11B7/135

CPC分类号： G11B7/1353 ,  G11B7/0903

摘要： An optical pickup device has a semiconductor laser emitting light which is in turn branched via a diffraction grating into at least three beams of light including a main beam and two sub beams which are in turn condensed via an objective lens on an optical disk at a guide groove and reflected by the optical disk to provide three reflections of light which are in turn received by detectors, each divided into two regions, respectively, to generate a tracking error signal. The diffraction grating is divided into three regions including a first region, a second region and a third region located intermediate therebetween, each having a periodical structure out of phase, the periodical structure having grating grooves in a direction determined depending on the phase of the second region to incline relative to a direction perpendicular to the guide groove of the optical disk.

摘要翻译： 光学拾取装置具有发射光的半导体激光器，该半导体激光器又通过衍射光栅分支成至少三束光束，所述至少三束光包括主光束和两个子光束，所述至少三个光束又通过物镜在光盘上以引导 凹槽并由光盘反射以提供三次反射的光，这些反射又被检测器接收，每个被分成两个区域以产生跟踪误差信号。 衍射光栅分为三个区域，包括第一区域，第二区域和位于其间的第三区域，每个区域具有异相的周期性结构，该周期结构具有根据第二区域的相位确定的方向的光栅槽 区域相对于垂直于光盘的引导槽的方向倾斜。

公开(公告)号：US20070025228A1

公开(公告)日：2007-02-01

申请号：US11496814

申请日：2006-07-31

申请人： Kazunori Matsubara ,  Shinzoh Murakami ,  Tetsuo Ueyama ,  Kazuhiro Tsuchida ,  Yukio Watanabe ,  Osamu Miyazaki

发明人： Kazunori Matsubara ,  Shinzoh Murakami ,  Tetsuo Ueyama ,  Kazuhiro Tsuchida ,  Yukio Watanabe ,  Osamu Miyazaki

IPC分类号： G11B7/135

CPC分类号： G11B7/1353

摘要： There is provided an optical pickup apparatus that can obtain a stable servo signal by reducing stray light generated by diffraction in a recording layer other than a recording layer on which light is condensed. A hologram element provided in an optical pickup apparatus for recording information onto a recording medium and/or reproducing information on the recording medium by use of light includes fourth and fifth divisions where at least first-order diffracted light among diffracted light beams obtained by reflection and diffraction on a recording layer other than a light-condensed recording layer on which light is condensed by an objective lens so as not to be directed toward first and second light-receiving elements for detecting focus position information and third to eighth light-receiving elements for detecting track position information.

摘要翻译： 提供了一种光拾取装置，其可以通过减少除了聚光的记录层之外的记录层中的衍射产生的杂散光，从而获得稳定的伺服信号。 提供在用于通过使用光将信息记录在记录介质上和/或在记录介质上再现信息的光学拾取装置中的全息元件包括第四和第五分割，其中至少一级衍射光通过反射和 除了聚光记录层之外的记录层上的衍射，其中光被物镜聚光，以便不被指向用于检测聚焦位置信息的第一和第二光接收元件和用于检测聚焦位置信息的第三至第八光接收元件 检测轨迹位置信息。

公开(公告)号：US07090502B2

公开(公告)日：2006-08-15

申请号：US11118403

申请日：2005-05-02

申请人： Masahiro Ono ,  Shigeru Kondou ,  Kazuhiro Nishikawa ,  Kazuto Nishida ,  Hiroyuki Inoue ,  Osamu Miyazaki ,  Hiroshi Takeda ,  Tsuneyuki Ejima

发明人： Masahiro Ono ,  Shigeru Kondou ,  Kazuhiro Nishikawa ,  Kazuto Nishida ,  Hiroyuki Inoue ,  Osamu Miyazaki ,  Hiroshi Takeda ,  Tsuneyuki Ejima

IPC分类号： H01R12/00 ,  H05K1/00

CPC分类号： H05K1/144 ,  H01L2224/16225 ,  H01L2924/19105 ,  H01R12/52 ,  H05K3/3426 ,  H05K2201/042 ,  H05K2201/10189 ,  H05K2201/10424 ,  H05K2201/2018

摘要： The present invention includes a plurality of lead terminals made of a conductive material having spring elasticity; and insulative housing that buries a part of the region of lead terminal and fixedly retains a plurality of lead terminals in an arrangement having been set in advance. Lead terminal is composed of a buried part that is a part of lead terminal buried in housing; bottom end joint that is extended from one end of the buried part, is exposed through bottom end surface of housing, and extracted in width direction of bottom end surface; and flexibly changing part that is exposed from another end of the buried part through one wall surface orthogonal to bottom end surface, and is extended along this wall surface to top end surface facing to bottom end surface, being spaced from wall surface and top end surface.

摘要翻译： 本发明包括由具有弹性弹性的导电材料制成的多个引线端子; 绝缘壳体，其埋设引线端子区域的一部分，并且在预先设置的布置中固定地保持多个引线端子。 引线端子由掩埋在壳体中的引线端子的一部分构成; 从埋藏部分的一端延伸的底端接头通过壳体的底端表面暴露，并在底端表面的宽度方向上提取; 以及通过与底端表面正交的一个壁面暴露于埋藏部分的另一端的柔性变化部分，并且沿着该壁表面延伸到面向底端表面的顶端表面，与壁表面和顶端表面间隔开 。

公开(公告)号：US20060169520A1

公开(公告)日：2006-08-03

申请号：US11323140

申请日：2005-12-30

申请人： Osamu Miyazaki

发明人： Osamu Miyazaki

IPC分类号： B62D5/06

CPC分类号： B62D5/083

摘要： An oil pressure regulating valve of rotary type comprising a valve body and a valve spool is constructed inside a housing having a cylindrical shape. An oil supply port for supplying pressure oil fed from an oil pressure generation source is formed at a position having an offset toward one side relative to the center axis of the housing. A communicating hole in a deep inside of the oil supply port in communication with the inside of the housing is an elongate hole which is long in the direction of offset. As a result, in a hydraulic power steering apparatus, flow sound is reduced effectively that is generated when the pressure oil fed from the oil pressure generation source is supplied to the oil pressure regulating valve inside the housing. Accordingly, quiet operation is achieved.

摘要翻译： 包括阀体和阀芯的旋转式油压调节阀被构造在具有圆柱形状的壳体内。 用于供给从油压产生源供给的压力油的供油口形成在相对于壳体的中心轴线的一侧偏移的位置。 与油箱内部相通的供油口深内侧的连通孔是在偏移方向上长的长孔。 结果，在液压动力转向装置中，当从油压发生源供给的压力油被供给到壳体内的油压调节阀时产生的流量声有效地降低。 因此，实现安静的操作。

公开(公告)号：US20060165211A1

公开(公告)日：2006-07-27

申请号：US10524341

申请日：2003-08-28

申请人： Taiga Goto ,  Osamu Miyazaki ,  Koichi Hirokawa

发明人： Taiga Goto ,  Osamu Miyazaki ,  Koichi Hirokawa

IPC分类号： H05G1/60 ,  A61B6/00 ,  G01N23/00 ,  G21K1/12

CPC分类号： G06T11/005 ,  A61B6/027 ,  A61B6/032 ,  A61B6/4085 ,  G06T2211/421

摘要： A tomograph which determines projection data phase range capable of back projection for each reconfigured voxel with an arbitrary value larger than π so that the absolute values of cone angles at the ends of this phase range is minimized, calculates an approximate straight line for a curve indicating the position of a radiation source with respect to the channel direction position of parallel beam projection data obtained by a parallel beam of a parallel shape viewed from the go-around axis direction generated from the radiation source, and based on the determined projection data range capable of back projection, three-dimension back projects the parallel beam projection data subjected to filter processing created through a filter correction to the back projection region corresponding to the region in concern along the approximate irradiation trace of the radiation beam calculated using the calculated approximate straight line, thereby suppressing generation of the distortion attributed to data discontinuity, simplifying an arcsin calculation and significantly increasing the processing speed of the tomograph.

摘要翻译： 确定能够以大于pi的任意值对每个重新配置的体素进行反投影的投影数据相位范围的断层图像，使得在该相位范围的末端处的锥角的绝对值最小化，计算出曲线的近似直线， 辐射源相对于由从辐射源产生的从复原轴线方向观察的平行光束的平行光束投影数据的通道方向位置的位置，并且基于所确定的投影数据范围能够 背投影，三维后投影通过滤波器校正产生的滤波处理的平行光束投影数据沿着与所计算的近似直线计算的辐射束的近似照射轨迹相对应的区域的背投影区域 ，从而抑制失真属性的产生 减少数据不连续性，简化了arcsin计算，并显着提高了层析成像的处理速度。

公开(公告)号：US20050180293A1

公开(公告)日：2005-08-18

申请号：US10512188

申请日：2003-04-18

申请人： Tetsuo Ueyama ,  Keiji Sakai ,  Renzaburou Miki ,  Osamu Miyazaki ,  Yukio Watanabe

发明人： Tetsuo Ueyama ,  Keiji Sakai ,  Renzaburou Miki ,  Osamu Miyazaki ,  Yukio Watanabe

IPC分类号： G11B7/1353 ,  G11B7/09 ,  G11B7/095 ,  G11B7/00

CPC分类号： G11B7/1353 ,  G11B7/0903 ,  G11B7/0956

摘要： An optical pickup converts a laser beam from a semiconductor laser (1) into a parallel ray with a collimator lens (2), and divides it into a main beam (30), a sub-beam (+1st order component) (31), and a sub-beam (−1st order component) (32) with a gradient multiple-division type phase difference grating (3). After passing through a beam splitter (4), an objective lens (5) condenses the light beams on a track (61) of an optical disc (6), and the reflected light that has passed through the objective lens 5 is reflected at the beam splitter (4) and is guided into optical detectors (8A, 8B, and 8C) by a condensing lens (7). Accordingly, in a tracking error signal detecting method using the push-pull signals of the main beam and sub-beams, an offset produced by an objective lens shift or a disc tilt can be cancelled at low cost without lowering the efficiency of using light.

摘要翻译： 光学拾取器将来自半导体激光器（1）的激光束用准直透镜（2）转换成平行光线，并将其分割成主光束（30），子光束（+ 1次分量）（31） ，和具有梯度多分割型相位差光栅（3）的子光束（-1阶分量）（32）。 在通过分束器（4）之后，物镜（5）将光束会聚在光盘（6）的轨道（61）上，并且已经通过物镜5的反射光在 分束器（4），并通过聚光透镜（7）被引导到光学检测器（8A，8B和8C）中。 因此，在使用主光束和子光束的推挽信号的跟踪误差信号检测方法中，可以以低成本消除由物镜偏移或盘倾斜产生的偏移而不降低使用光的效率。

公开(公告)号：US20050175143A1

公开(公告)日：2005-08-11

申请号：US10515289

申请日：2003-06-03

申请人： Osamu Miyazaki ,  Taiga Goto ,  Hiroto Kokubun

发明人： Osamu Miyazaki ,  Taiga Goto ,  Hiroto Kokubun

IPC分类号： A61B5/0456 ,  A61B6/00 ,  A61B6/03 ,  G21K1/12

CPC分类号： A61B6/4014 ,  A61B5/0456 ,  A61B6/027 ,  A61B6/032 ,  A61B6/4085 ,  A61B6/4488 ,  A61B6/541

摘要： Three pairs of X-ray tubes (21A-21C) and single- or multiple-row detectors (31A-31C) are mounted on a rotary disc (49) installed in a scanner unit (12) at a rotational phase difference of 120°, and a deviation (offset) ΔZ is set between the three pairs in a rotation axis direction of a subject (16) in accordance with ΔZ=d×N, where d is the thickness of the row of the single- or multiple-row detectors (31A-31C), and N is an offset coefficient. Slice collimators (48A-48C) are provided to X-ray tubes (21A-21C) in the three pairs, and are rotated relative to the subject (16) to provide a high-quality tomographic image with high temporal resolution, less motion artifact and high space resolution.

摘要翻译： 三对X射线管（21A-21C）和单列或多列检测器（31A-31C）以旋转相位安装在安装在扫描仪单元（12）中的旋转盘（49）上 根据DeltaZ = dxN，在被检体（16）的旋转轴方向上的三对之间设定偏差（偏移）ΔZZ，其中d是单次或多次的行的厚度 （31A-31C），N是偏移系数。 将切片准直器（48A-48C）以三对提供给X射线管（21A-21C），并且相对于被摄体（16）旋转，以提供具有高时间分辨率的高质量断层图像 ，较少的运动伪影和高空间分辨率。