公开(公告)号：US20050164201A1

公开(公告)日：2005-07-28

申请号：US10517510

申请日：2003-06-09

申请人： Diane Harvey ,  Yi Yang ,  Nancy Kohl

发明人： Diane Harvey ,  Yi Yang ,  Nancy Kohl

IPC分类号： G01N33/50 ,  A61K38/00 ,  A61P25/00 ,  A61P35/00 ,  A61P43/00 ,  C07H21/04 ,  C07K14/47 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/14 ,  C12N15/09 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/574

CPC分类号： C12N9/14 ,  A61K38/00

摘要： An isolated nucleic acid is provided which encodes a novel centromere-associated motor protein, HsCENP-E. Also provided are the purified polypeptide encoded by the nucleic acid sequence, and antibodies immunologically specific for the polypeptide. These biological molecules are useful as markers of cellular proliferation, particularly for the identification of cells in the G2 and M phases of the cell cycle. Methods are provided for using the nucleic acid, protein and antibodies for assessing cellular proliferation in biological fluids and tissue samples, and for detecting the presence of autoantibodies to the protein.

摘要翻译： 提供分离的核酸，其编码新的着丝粒相关运动蛋白HsCENP-E。 还提供了由核酸序列编码的纯化多肽和针对该多肽免疫特异性的抗体。 这些生物分子可用作细胞增殖的标志物，特别是用于鉴定细胞周期的G2和M期的细胞。 提供了使用核酸，蛋白质和抗体来评估生物流体和组织样品中的细胞增殖以及用于检测蛋白质的自身抗体的存在的方法。

公开(公告)号：US20050101595A1

公开(公告)日：2005-05-12

申请号：US10783887

申请日：2004-02-20

申请人： Shao Song Chu ,  Larry Alegria ,  Ted Bleckman ,  Wesley Chong ,  Rohit Kumar Duvadie ,  Lin Li ,  William Romines ,  Yi Yang

发明人： Shao Song Chu ,  Larry Alegria ,  Ted Bleckman ,  Wesley Chong ,  Rohit Kumar Duvadie ,  Lin Li ,  William Romines ,  Yi Yang

IPC分类号： A61K31/427 ,  A61K31/454 ,  A61K31/55 ,  A61P35/00 ,  C07D417/02 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D491/08 ,  C07D513/04

CPC分类号： C07D417/14 ,  C07D417/12 ,  C07D471/04 ,  C07D491/08 ,  C07D513/04

摘要： Aminothiazole compounds with N-containing cycloalkyl at the 2-amino position which are represented by the Formula (I), or a pharmaceutically acceptable prodrug of said compound, pharmaceutically active metabolite or pharmaceutically acceptable salt of said compound, or metabolite thereof, modulate and/or inhibit the cell proliferation and activity of protein kinases. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating malignancies and other disorders by administering effective amounts of such compounds.

摘要翻译： 由式（I）表示的2-氨基位置的含N环烷基的氨基噻唑化合物或所述化合物的药学上可接受的前药，所述化合物或其代谢物的药学活性代谢物或药学上可接受的盐调节和/ 或抑制蛋白激酶的细胞增殖和活性。 本发明还涉及含有这些化合物的药物组合物的治疗或预防用途，以及通过施用有效量的这些化合物来治疗恶性肿瘤和其它病症的方法。

公开(公告)号：US20050049687A1

公开(公告)日：2005-03-03

申请号：US10960328

申请日：2004-10-06

申请人： Yi Yang ,  Farhad Khosravi ,  Himanshu Patel

发明人： Yi Yang ,  Farhad Khosravi ,  Himanshu Patel

IPC分类号： A61F2/92 ,  A61F2/06

CPC分类号： A61F2/91 ,  A61F2/915 ,  A61F2/92 ,  A61F2002/91533 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2220/0008 ,  A61F2220/0016

摘要： A coiled-sheet stent includes a tubular body having a longitudinal axis and a circumference, and a plurality of cylindrical bands formed in the tubular body, each band having a zig-zag pattern including a series of sequential diagonal elements connected to one another and extending about the circumference. A plurality of longitudinal connectors extend between and connect adjacent bands. The diagonal elements have an arcuate shape, all diagonal elements in each band being oriented in either a clockwise or counter-clockwise direction about the circumference. The tubular body is expandable between contracted and enlarged conditions, and the zig-zag pattern is expandable between unstretched and unstretched conditions, the zig-zag pattern being biased towards the stretched condition above a transition temperature, thereby at least partially defining the enlarged condition. A multi-cellular stent structure is also provided that includes a plurality of bat shaped cells formed in a tubular body, each cell defining a head region, a tail region and opposing curved wing regions, and a plurality of connectors extending between and connecting adjacent cells. The head and tail regions of adjacent cells are directly connected to one another, and connectors extend between adjacent wing regions of adjacent cells.

摘要翻译： 螺旋片支架包括具有纵向轴线和圆周的管状体，以及形成在管状体中的多个圆柱形带，每个带具有包括一系列相互连接并延伸的顺序对角线元件的之字形图案 围绕圆周。 多个纵向连接器在相邻带之间延伸并连接相邻带。 对角元件具有弓形形状，每个带中的所有对角元件围绕圆周以顺时针或逆时针方向定向。 管状体在收缩和扩大的条件之间是可膨胀的，并且之字形图案可在未拉伸和未拉伸状态之间扩展，之字形图案被偏压到高于转变温度的拉伸状态，从而至少部分限定扩大状态。 还提供了一种多细胞支架结构，其包括形成在管状体中的多个蝙蝠形细胞，每个细胞限定头部区域，尾部区域和相对的弯曲翼状区域，以及在相邻细胞之间延伸并连接相邻细胞的多个连接器 。 相邻单元的头部和尾部区域彼此直接连接，并且连接器在相邻单元的相邻机翼区域之间延伸。

公开(公告)号：US06720346B2

公开(公告)日：2004-04-13

申请号：US10190219

申请日：2002-07-05

申请人： Shao Song Chu ,  Larry Andrew Alegria ,  Ted Michael Bleckman ,  Wesley Kwan Mung Chong ,  Rohit K. Duvadie ,  Lin Li ,  Siegfried Heinz Reich ,  William Henry Romines, III ,  Michael B. Wallace ,  Yi Yang

发明人： Shao Song Chu ,  Larry Andrew Alegria ,  Ted Michael Bleckman ,  Wesley Kwan Mung Chong ,  Rohit K. Duvadie ,  Lin Li ,  Siegfried Heinz Reich ,  William Henry Romines, III ,  Michael B. Wallace ,  Yi Yang

IPC分类号： A61K31425

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D277/42 ,  C07D417/12 ,  C07D491/10

摘要： Aminothiazole compounds with mono-/di-substituted benzamide are represented by the Formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable prodrugs, pharmaceutically active metabolites, and pharmaceutically acceptable salts of said metabolites are described. These agents modulate and/or inhibit the cell proliferation and activity of protein kinases and are useful as pharmaceuticals for treating malignancies and other disorders.

摘要翻译： 描述了具有单 - 二取代苯甲酰胺的氨基噻唑化合物由式（I）表示，并且描述了其药学上可接受的盐，药学上可接受的前药，药学活性代谢物和所述代谢物的药学上可接受的盐。这些试剂调节和/或抑制 蛋白激酶的细胞增殖和活性，并且可用作治疗恶性肿瘤和其它疾病的药物。

公开(公告)号：US06312463B1

公开(公告)日：2001-11-06

申请号：US09495827

申请日：2000-02-01

申请人： Jonathan M. Rourke ,  Yi Yang

发明人： Jonathan M. Rourke ,  Yi Yang

IPC分类号： A61F204

CPC分类号： A61F2/01 ,  A61F2/856 ,  A61F2/90 ,  A61F2/91 ,  A61F2/92 ,  A61F2002/018 ,  A61F2210/0019 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2230/0006 ,  A61F2230/0069

摘要： A prosthesis for treating a body passage includes a micro-porous tubular element and a support element. The tubular element is formed from a thin-walled sheet having a wall thickness of 25 micrometers or less, preferably a coiled-sheet exhibiting temperature-activated shape memory properties. The mesh pattern includes a plurality of openings in the sheet having a maximum dimension of not more than about 200 micrometers, thereby acting as a filter trapping embolic material while facilitating endothelial growth therethrough. The support element includes a plurality of struts, preferably having a thickness of 100-150 micrometers. The support element is preferably an independent component from the tubular element. Alternatively, the support element may be attached to or integrally formed as part of the tubular element. The tubular and support elements are placed on a catheter in contracted conditions and advanced endoluminally to a treatment location within a body passage. The tubular element is deployed, and the support element is expanded to an enlarged condition at the treatment location to engage an interior surface of the tubular element, thereby securing the tubular element and holding the lumen of the treatment location open.

摘要翻译： 用于治疗身体通道的假体包括微孔管状元件和支撑元件。 管状元件由壁厚为25微米或更小的薄壁片形成，优选呈现温度激活形状记忆性的卷曲片。 网格图案包括片材中的多个开口，其具有不大于约200微米的最大尺寸，从而用作过滤器捕获栓塞材料，同时促进通过其中的内皮生长。 支撑元件包括多个支柱，优选具有100-150微米的厚度。 支撑元件优选地是与管状元件独立的部件。 或者，支撑元件可以作为管状元件的一部分附接或一体地形成。 管状和支撑元件在收缩状态下放置在导管上，并且在体内通过内部处理位置进一步前进。 管状元件被展开，并且支撑元件在治疗位置处被扩张到扩大的状态以接合管状元件的内表面，由此固定管状元件并将治疗位置的内腔保持打开。

公开(公告)号：US11519586B2

公开(公告)日：2022-12-06

申请号：US16967574

申请日：2019-01-11

申请人： Yi Yang

发明人： Yi Yang

IPC分类号： F21V13/04 ,  F21V5/02 ,  F21V5/04 ,  F21V7/00 ,  F21Y115/30

摘要： A lamp is provided that includes a light source (1101) including at least one light emitting point (S0); and a light receiving device located between the light source (1101) and the optical path of a collimating optical element (1104, 3104), the light receiving device at least includes at least two light guides (1102, 1103, 3302), for respectively collecting light beams (1301, 1303, 3301, 3303) emitted at different angles from the light emitting point (S0) of the light source (1101), and respectively directing the collected light beams (1301, 1303, 3301, 3303) to the collimating optical element (1104, 3104) in a reflective or refractive manner, after which the light beams forming parallel light after the collimation of the collimating optical element (1104, 3104); and further includes a mirror array (1105, 3105) for reflecting the parallel light to form a reflected light spot array.

公开(公告)号：USD938639S1

公开(公告)日：2021-12-14

申请号：US29773874

申请日：2021-03-12

申请人： Yi Yang

设计人： Yi Yang

公开(公告)号：US10261389B2

公开(公告)日：2019-04-16

申请号：US15630235

申请日：2017-06-22

申请人： Scott Skirlo ,  Cheryl Marie Sorace-Agaskar ,  Marin Soljacic ,  Simon Verghese ,  Jeffrey S. Herd ,  Paul William Juodawlkis ,  Yi Yang ,  Dirk Robert Englund ,  Mihika Prabhu

发明人： Scott Skirlo ,  Cheryl Marie Sorace-Agaskar ,  Marin Soljacic ,  Simon Verghese ,  Jeffrey S. Herd ,  Paul William Juodawlkis ,  Yi Yang ,  Dirk Robert Englund ,  Mihika Prabhu

IPC分类号： G02F1/295 ,  G02F1/313 ,  G02F1/31

摘要： An integrated optical beam steering device includes a planar dielectric lens that collimates beams from different inputs in different directions within the lens plane. It also includes an output coupler, such as a grating or photonic crystal, that guides the collimated beams in different directions out of the lens plane. A switch matrix controls which input port is illuminated and hence the in-plane propagation direction of the collimated beam. And a tunable light source changes the wavelength to control the angle at which the collimated beam leaves the plane of the substrate. The device is very efficient, in part because the input port (and thus in-plane propagation direction) can be changed by actuating only log2 N of the N switches in the switch matrix. It can also be much simpler, smaller, and cheaper because it needs fewer control lines than a conventional optical phased array with the same resolution.

公开(公告)号：US09906950B2

公开(公告)日：2018-02-27

申请号：US13979219

申请日：2012-01-04

申请人： Yi Yang

发明人： Yi Yang

IPC分类号： H04W12/02 ,  H04W36/00 ,  H04W12/04 ,  H04W84/04

CPC分类号： H04W12/02 ,  H04W12/04 ,  H04W36/0038 ,  H04W84/047

摘要： Disclosed are a method and device for security isolation. The method comprises: when a relay device receives a handover request message, if the handover request message contains reestablishment information for another cell, then when a user equipment is successfully handed over to a cell of the relay device or is successfully reestablished in the cell of the relay device, the relay device requesting a piece of key information from core network equipment. In embodiments of the present invention, the probability of successful reestablishment during UE handover is increased, and the probability of handover failure is reduced, also, as the key is isolated, communication security of the user is ensured.

公开(公告)号：US09629040B2

公开(公告)日：2017-04-18

申请号：US13984907

申请日：2012-02-09

申请人： Wei Bao ,  Yali Zhao ,  Yi Yang ,  Guoqing Li

发明人： Wei Bao ,  Yali Zhao ,  Yi Yang ,  Guoqing Li

IPC分类号： H04W36/00 ,  H04W24/02 ,  H04W36/08 ,  H04W84/04 ,  H04W88/04 ,  H04W88/08 ,  H04W64/00 ,  H04W84/00

CPC分类号： H04W36/0083 ,  H04W24/02 ,  H04W36/08 ,  H04W64/003 ,  H04W84/005 ,  H04W84/047 ,  H04W88/04 ,  H04W88/08

摘要： Disclosed are a method and device for configuring a Donor base station or a Donor cell for a mobile relay node. The method includes: an operation administration and maintenance (OAM) system obtains position information about a mobile relay node (RN) and determines a standby Donor base station or a standby Donor cell which can be accessed by the mobile RN according to the position information thereof; and the OAM system indicates the standby Donor base station or the standby Donor cell to a serving Donor base station of the mobile RN or indicates the standby Donor base station or the standby Donor cell to the serving Donor base station of the mobile RN through the mobile RN, so that the serving Donor base station of the mobile RN selects a target Donor base station or a target Donor cell for the mobile RN. By way of the present invention, the DeNB or the Donor Cell can be configured for the mobile RN when the mobile RN is moving.