公开(公告)号：US20100276824A1

公开(公告)日：2010-11-04

申请号：US12834998

申请日：2010-07-13

申请人： John Dallas Pruitt ,  Lynn Cook Winterton ,  Bernhard Seiferling ,  Jüergen Vogt ,  Harald Bothe

发明人： John Dallas Pruitt ,  Lynn Cook Winterton ,  Bernhard Seiferling ,  Jüergen Vogt ,  Harald Bothe

IPC分类号： G02B1/12 ,  G02B1/04

CPC分类号： G02B1/043 ,  B29C33/60

摘要： The instant invention pertains to a method and a fluid composition for producing contact lenses with improved lens quality and with increased product yield. The method of the invention involves adding a phospholipid into a fluid composition including a lens-forming material in an amount sufficient to reduce an averaged mold separation force by at least about 40% in comparison with that without the phospholipids.

公开(公告)号：US20100140114A1

公开(公告)日：2010-06-10

申请号：US12629913

申请日：2009-12-03

申请人： John Dallas Pruitt ,  Lynn Cook Winterton ,  Jared Nelson

发明人： John Dallas Pruitt ,  Lynn Cook Winterton ,  Jared Nelson

IPC分类号： A45C11/04 ,  G02C7/04 ,  B05D5/06 ,  B65B55/02

CPC分类号： B29D11/00067 ,  A61K9/0051 ,  G02B1/043 ,  C08L51/085

摘要： The invention relates to a soft hydrogel contact lens, especially a silicone hydrogel contact lens, which has a capability of delivering a hydrophobic comfort agent into the eye of a wearer. The hydrophobic comfort agent includes without limitation a monoglyceride, a diglyceride, a triglyceride, a glycolipid, a glyceroglycolipid, a sphingolipid, a sphingo-glycolipid, a phospholipid, a fatty acid, a fatty alcohol, a hydrocarbon having a C12-C28 chain in length, a mineral oil, a silicone oil, or a mixture thereof. It can be released from the soft hydrogel contact lens into the eye of a wearer when being worn so as to strengthen and stabilize the tear film lipid layer and alleviate the dryness of the eye.

摘要翻译： 本发明涉及一种柔软的水凝胶隐形眼镜，特别是硅酮水凝胶隐形眼镜，其具有将疏水舒适剂输送到穿戴者的眼睛中的能力。 疏水性舒适剂包括但不限于单甘油酯，甘油二酯，甘油三酯，糖脂，甘油糖脂，鞘脂，鞘糖脂，磷脂，脂肪酸，脂肪醇，具有C12-C28链的烃 长度，矿物油，硅油或其混合物。 当穿着时，它可以从软水凝胶隐形眼镜释放到穿戴者的眼睛中，以加强和稳定泪膜脂质层并减轻眼睛的干燥。

公开(公告)号：US07705067B2

公开(公告)日：2010-04-27

申请号：US12454122

申请日：2009-05-13

申请人： Lynn Cook Winterton ,  Juergen Vogt ,  John Martin Lally ,  Friedrich Stockinger

发明人： Lynn Cook Winterton ,  Juergen Vogt ,  John Martin Lally ,  Friedrich Stockinger

IPC分类号： G02C7/04

CPC分类号： G02B1/043 ,  C08J7/047 ,  G02B1/10

摘要： Biomedical devices, such as ophthalmic lenses, and methods of making such devices having a surface coating including at least one polyionic layer. A preferred method involves spray coating a polycationic material onto a core lens, rinsing and drying the lens, followed by spray coating a polyanionic material, rinsing and drying. The coating process may be applied a plurality of times to achieve a multi-layer coating on the lens surface. A particularly preferred embodiment is a contact lens comprising a highly oxygen permeable hydrophobic core coated with a 5 to 20 bilayers of hydrophilic polyionic materials.

摘要翻译： 生物医学装置，如眼科镜片，以及制造具有包括至少一个聚离子层的表面涂层的装置的方法。 优选的方法包括将聚阳离子材料喷涂到芯晶片上，漂洗和干燥晶状体，然后喷涂聚阴离子材料，冲洗和干燥。 涂覆过程可以多次施加以在透镜表面上实现多层涂层。 特别优选的实施方案是包含涂覆有5至20双亲水性聚离子材料的高透氧性疏水核心的隐形眼镜。

公开(公告)号：US07566746B2

公开(公告)日：2009-07-28

申请号：US11981206

申请日：2007-10-31

申请人： Lynn Cook Winterton ,  Juergen Vogt ,  John Martin Lally ,  Friedrich Stockinger

发明人： Lynn Cook Winterton ,  Juergen Vogt ,  John Martin Lally ,  Friedrich Stockinger

IPC分类号： G02C7/04

CPC分类号： G02B1/043 ,  C08J7/047 ,  G02B1/10

摘要： Biomedical devices, such as ophthalmic lenses, and methods of making such devices having a surface coating including at least one polyionic layer. A preferred method involves spray coating a polycationic material onto a core lens, rinsing and drying the lens, followed by spray coating a polyanionic material, rinsing and drying. The coating process may be applied a plurality of times to achieve a multi-layer coating on the lens surface. A particularly preferred embodiment is a contact lens comprising a highly oxygen permeable hydrophobic core coated with a 5 to 20 bilayers of hydrophilic polyionic materials.

摘要翻译： 生物医学装置，如眼科镜片，以及制造具有包括至少一个聚离子层的表面涂层的装置的方法。 优选的方法包括将聚阳离子材料喷涂到芯晶片上，漂洗和干燥晶状体，然后喷涂聚阴离子材料，冲洗和干燥。 涂覆过程可以多次施加以在透镜表面上实现多层涂层。 特别优选的实施方案是包含涂覆有5至20双亲水性聚离子材料的高透氧性疏水核心的隐形眼镜。

公开(公告)号：US20080260804A1

公开(公告)日：2008-10-23

申请号：US12214321

申请日：2008-06-18

申请人： Carol Ann Morris ,  Manal M. Gabriel ,  Yongxing Qiu ,  Lynn Cook Winterton ,  John Martin Lally ,  Marcia Kay Ash ,  Fiona Patricia Carney ,  Courtney Flem Morgan

发明人： Carol Ann Morris ,  Manal M. Gabriel ,  Yongxing Qiu ,  Lynn Cook Winterton ,  John Martin Lally ,  Marcia Kay Ash ,  Fiona Patricia Carney ,  Courtney Flem Morgan

IPC分类号： A01N25/34 ,  A01N33/12 ,  A61K38/40 ,  G01N19/02

CPC分类号： G02B1/043 ,  A61L27/34 ,  A61L31/10

摘要： The present invention provides a medical device, preferably a contact lens, which comprises an antimicrobial coating including at least one layer of polyquat of formula (I) or (II). The antimicrobial coating on the medical device of the invention has a high antimicrobial efficacy against microorganisms including Gram-positive and Gram-negative bacterial, a low toxicity, low coefficient of friction, and increased hydrophilicity while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial coating thereon.

摘要翻译： 本发明提供一种医疗装置，优选隐形眼镜，其包括抗微生物涂层，其包含至少一层式（I）或（II）的聚四氢叶酸。 本发明的医疗装置上的抗微生物涂层对微生物具有高抗微生物效果，包括革兰氏阳性和革兰氏阴性细菌，低毒性，低摩擦系数和增加的亲水性，同时保持所需的体积特性如氧气渗透性和 透镜材料的离子透过率。 这种透镜可用作延长佩戴的隐形眼镜。 此外，本发明提供了制造其上具有抗微生物涂层的医疗装置，优选隐形眼镜的方法。

公开(公告)号：US07402318B2

公开(公告)日：2008-07-22

申请号：US10287091

申请日：2002-11-04

申请人： Carol Ann Morris ,  Manal M. Gabriel ,  Yongxing Qiu ,  Lynn Cook Winterton ,  John Martin Lally ,  Marcia Kay Ash ,  Fiona Patricia Carney ,  Courtney Flem Morgan

发明人： Carol Ann Morris ,  Manal M. Gabriel ,  Yongxing Qiu ,  Lynn Cook Winterton ,  John Martin Lally ,  Marcia Kay Ash ,  Fiona Patricia Carney ,  Courtney Flem Morgan

IPC分类号： A61F13/00

CPC分类号： G02B1/043 ,  A61L27/34 ,  A61L31/10

摘要： The present invention provides a medical device, preferably a contact lens, which comprises an antimicrobial coating including at least one layer of polyquat of formula (I) or (II). The antimicrobial coating on the medical device of the invention has a high antimicrobial efficacy against microorganisms including Gram-positive and Gram-negative bacterial, a low toxicity, low coefficient of friction, and increased hydrophilicity while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial coating thereon.

公开(公告)号：US10155349B2

公开(公告)日：2018-12-18

申请号：US12629913

申请日：2009-12-03

申请人： John Dallas Pruitt ,  Lynn Cook Winterton ,  Jared Nelson

发明人： John Dallas Pruitt ,  Lynn Cook Winterton ,  Jared Nelson

IPC分类号： A61K9/00 ,  B29D11/00 ,  G02B1/04

摘要： The invention relates to a soft hydrogel contact lens, especially a silicone hydrogel contact lens, which has a capability of delivering a hydrophobic comfort agent into the eye of a wearer. The hydrophobic comfort agent includes without limitation a monoglyceride, a diglyceride, a triglyceride, a glycolipid, a glyceroglycolipid, a sphingolipid, a sphingo-glycolipid, a phospholipid, a fatty acid, a fatty alcohol, a hydrocarbon having a C12-C28 chain in length, a mineral oil, a silicone oil, or a mixture thereof. It can be released from the soft hydrogel contact lens into the eye of a wearer when being worn so as to strengthen and stabilize the tear film lipid layer and alleviate the dryness of the eye.

公开(公告)号：US09005492B2

公开(公告)日：2015-04-14

申请号：US12963685

申请日：2010-12-09

申请人： Frank Chang ,  Lynn Cook Winterton

发明人： Frank Chang ,  Lynn Cook Winterton

IPC分类号： B29D11/00 ,  G02B1/04

CPC分类号： G02B1/043 ,  B29D11/00038 ,  B29D11/00048 ,  C08L83/04 ,  C08L101/14

摘要： Described herein are methods for producing silicone hydrogel lenses. The methods involve introducing into a mold a water-based lens-forming composition, curing the lens-forming composition in a mold to form the lens, and removing the lens from the mold. The lens-forming composition comprises (i) a polysiloxane-containing vinylic monomer or macromer, (ii) at least one hydrophilic vinylic monomer, (iii) a surfactant, and, and (iv) water. The surfactant is polysiloxane-containing surfactant that is free of actinically-polymerizable groups and is a copolymer having from about 10% to about 40% by weight of one or more polysiloxane segments and from about 90% to about 60% by weight hydrophilic units and/or segments. The methods permit the use of water as a solvent and reduce the need for organic solvents. Additionally, the lenses produced by the methods can have improved properties such oxygen permeability.

摘要翻译： 本文描述了生产硅酮水凝胶透镜的方法。 所述方法包括向模具中引入基于水的透镜形成组合物，在模具中固化透镜形成组合物以形成透镜，以及从模具中去除透镜。 透镜形成组合物包含（i）含聚硅氧烷的乙烯基单体或大分子单体，（ii）至少一种亲水乙烯基单体，（iii）表面活性剂和（iv）水。 表面活性剂是不含可光化聚合基团的含聚硅氧烷的表面活性剂，并且是具有约10％至约40％重量的一种或多种聚硅氧烷链段和约90％至约60％重量的亲水单元的共聚物，以及 /或段。 该方法允许使用水作为溶剂并减少对有机溶剂的需要。 另外，通过该方法制造的透镜可以具有改善的这种透氧性。

公开(公告)号：US08757367B2

公开(公告)日：2014-06-24

申请号：US13328223

申请日：2011-12-16

申请人： Lynn Cook Winterton ,  Jack C. White

发明人： Lynn Cook Winterton ,  Jack C. White

IPC分类号： A45C11/04

CPC分类号： A45C11/005

摘要： A lens care system and method for venting gas to release pressure from a container, such as generated in peroxide-based lens treatment. A seal formed between a deformable cap and a container cup prevents release of liquid, but deformation of the cap under the influence of pressure generated within the container temporarily releases the seal to permit venting of gas.

摘要翻译： 用于排出气体以从容器释放压力的镜片护理系统和方法，例如在基于过氧化物的镜片处理中产生的。 形成在可变形帽和容器杯之间的密封件防止液体的释放，但是在容器内产生的压力的影响下，帽的变形暂时释放密封件以允许排气。

公开(公告)号：US20120276278A1

公开(公告)日：2012-11-01

申请号：US13547286

申请日：2012-07-12

申请人： Yongxing Qiu ,  Lynn Cook Winterton ,  John Martin Lally ,  Nicholas Kotov ,  Manal M. Gabriel ,  Xinming Qian

发明人： Yongxing Qiu ,  Lynn Cook Winterton ,  John Martin Lally ,  Nicholas Kotov ,  Manal M. Gabriel ,  Xinming Qian

IPC分类号： B05D7/00 ,  B29C39/38

CPC分类号： A61K9/5015 ,  A61K31/14 ,  A61L27/34 ,  A61L27/54 ,  A61L29/106 ,  A61L29/16 ,  A61L31/088 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/45 ,  A61L2300/608 ,  A61L2300/61 ,  A61L2300/624 ,  G02B1/043 ,  Y10T428/31678 ,  Y10T428/31681 ,  Y10T428/31692

摘要： The present invention provides a medical device, preferably a contact lens, which a core material and an antimicrobial metal-containing LbL coating that is not covalently attached to the medical device and can impart to the medical device an increased hydrophilicity. The antimicrobial metal-containing coating on a contact lens of the invention has a high antimicrobial efficacy against microorganisms including Gram-positive and Gram-negative bacterial and a low toxicity, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial metal-containing LbL coating thereon.

摘要翻译： 本发明提供了一种医疗装置，优选隐形眼镜，其中芯材和含抗微生物金属的LbL涂层不共价连接到医疗装置上，并且可以赋予医疗装置增加的亲水性。 本发明的隐形眼镜上的抗微生物金属包衣对于包括革兰氏阳性和革兰氏阴性细菌在内的微生物具有高抗微生物效力，并且具有低毒性，同时保持所需的体积特性，如透氧性和透镜材料的离子渗透性 。 这种透镜可用作延长佩戴的隐形眼镜。 另外，本发明提供了制造其上具有抗微生物金属的LbL涂层的医疗装置，优选隐形眼镜的方法。